2-substituted-(2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1- yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution

Journal of Medicinal Chemistry

Volumn 41, Issue 3, 1998, Pages 346-357

  Ornstein, Paul L ^a   Bleisch, Thomas J ^a   Arnold, M Brian ^a   Wright, Rebecca A ^a   Johnson, Bryan G ^a   Schoepp, Darryle D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; CYCLOPROPANECARBOXYLIC ACID DERIVATIVE; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLYCINE DERIVATIVE; METABOTROPIC RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG SYNTHESIS; FOREBRAIN; NEUROTRANSMITTER RELEASE; NONHUMAN; RAT; SIGNAL TRANSDUCTION; STEREOISOMERISM;

ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; HUMANS; PROSENCEPHALON; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032576734     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970497w     Document Type: Article

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