N-methyl-D-aspartic acid receptor agonists: Resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid

Journal of Medicinal Chemistry

Volumn 39, Issue 1, 1996, Pages 183-190

  Madsen, Ulf ^a   Frydenvang, Karla ^a   Ebert, Bjarke ^a   Johansen, Tommy N ^a   Brehm, Lotte ^a   Krogsgaard Larsen, Povl ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (3 HYDROXY 5 METHYL 4 ISOXAZOLYL)ACETIC ACID; 4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; AMPA RECEPTOR; CINCHONIDINE; GLUTAMIC ACID; IBOTENIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

AGONIST; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; CORPUS CALLOSUM; DIASTEREOISOMER; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STABILITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ACETIC ACIDS; ANIMALS; CEREBRAL CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID AGONISTS; HYDROGEN BONDING; ISOXAZOLES; MOLECULAR STRUCTURE; RATS; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; STEREOISOMERISM;

EID: 0030024147     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950393q     Document Type: Article

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