The substituted aspartate analogue L-β-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3

Neuropharmacology

Volumn 49, Issue 6, 2005, Pages 850-861

  Esslinger, C Sean ^a   Agarwal, Shailesh ^a   Gerdes, John ^a   Wilson, Paul A ^a   Davis, Erin S ^a   Awes, Alicia N ^a   O'Brien, Erin ^a   Mavencamp, Teri ^a   Koch, Hans P ^a   Poulsen, David J ^a   Rhoderick, Joseph F ^a   Chamberlin, A Richard ^b   Kavanaugh, Michael P ^a   Bridges, Richard J ^a  

^a UNIVERSITY OF MONTANA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Glutamate uptake; Molecular modeling; Neurotransmitter transporter; Pharmacophore model; Transport inhibitors

Indexed keywords

2,3 PYRROLIDINE DICARBOXYLATE; 3 METHYL 2,3 PYRROLIDINE DICARBOXYLATE; ASPARTIC ACID; ASPARTIC ACID DERIVATIVE; BENZYL DERIVATIVE; BETA BENZYLASPARTATE; BETA ERYTHRO BENZYLASPARTATE; BETA THREO BENZYLASPARTATE; BETA THREOHYDROXYLASPARTATE; CARBOXYL GROUP; CYCLOPROPANE DERIVATIVE; DEXTRO ASPARTIC ACID; DEXTRO BETA THREOBENZYLOXYASPARTATE; DEXTRO BETA THREOMETHYLASPARTATE; DICARBOXYLIC ACID DERIVATIVE; EXCITATORY AMINO ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 3; METHYL GROUP; OXYGEN; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG MECHANISM; DRUG POTENCY; ELECTROPHYSIOLOGY; KINETICS; NONHUMAN; OOCYTE; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECORDING; XENOPUS;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ASPARTIC ACID; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY AMINO ACID TRANSPORTER 3; GENE EXPRESSION; MEMBRANE POTENTIALS; MICE; MODELS, MOLECULAR; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; TRANSFECTION; TRITIUM; XENOPUS;

EID: 26944498280     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.08.009     Document Type: Article

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