(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: A potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase

Journal of Medicinal Chemistry

Volumn 39, Issue 4, 1996, Pages 814-816

  Wermuth, C G ^a   Mann, A ^a   Schoenfelder, A ^a   Wright, R A ^a   Johnson, B G ^a   Burnett, J P ^a   Mayne, N G ^a   Schoepp, D D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 AMINO 3 PHOSPHONOPROPIONIC ACID; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 4 (4,4 DIPHENYLBUTYL)GLUTAMIC ACID; 4 PHOSPHONOMETHYLPIPECOLIC ACID; ADENYLATE CYCLASE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; FORSKOLIN; GLUTAMATE RECEPTOR ANTAGONIST; KAINIC ACID; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; FOREBRAIN; HUMAN; HUMAN CELL; ION CURRENT; LIGAND BINDING; NONHUMAN; RAT; RECEPTOR AFFINITY; SECOND MESSENGER;

ADENYLATE CYCLASE; AMINO ACIDS, DICARBOXYLIC; ANIMALS; BINDING, COMPETITIVE; BRAIN; CELL LINE; CELL MEMBRANE; CYCLOLEUCINE; GLUTAMIC ACID; HUMANS; INDICATORS AND REAGENTS; INOSITOL PHOSPHATES; KINETICS; NEUROTOXINS; PHOSPHATIDYLINOSITOLS; RATS; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0030026587     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9508144     Document Type: Article

References (0)