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Volumn 20, Issue 5, 2000, Pages 1666-1674

Declines in mRNA expression of different subunits may account for differential effects of aging on agonist and antagonist binding to the NMDA receptor

Author keywords

Aging; Glutamate; In situ hybridization; MRNA; NMDA receptors; NMDA subunits

Indexed keywords

GLUTAMIC ACID; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT;

EID: 0034161293     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-05-01666.2000     Document Type: Article
Times cited : (110)

References (61)
  • 1
    • 0004733179 scopus 로고
    • The effects of age: Normal variation and its relation to disease
    • Asbury AK, McKhann GM, McDonald WI, eds, Philadelphia: Saunders
    • Albert MS, Funkenstein HH (1992) The effects of age: normal variation and its relation to disease. In: Diseases of the nervous system: clinical neurobiology (Asbury AK, McKhann GM, McDonald WI, eds), pp 598-611. Philadelphia: Saunders.
    • (1992) Diseases of the Nervous System: Clinical Neurobiology , pp. 598-611
    • Albert, M.S.1    Funkenstein, H.H.2
  • 2
    • 0024416681 scopus 로고
    • Effects of ketamine on tunnel maze and water maze performance in the rat
    • Alessandri B, Battig K, Welzl H (1989) Effects of ketamine on tunnel maze and water maze performance in the rat. Behav Neural Biol 52:194-212.
    • (1989) Behav Neural Biol , vol.52 , pp. 194-212
    • Alessandri, B.1    Battig, K.2    Welzl, H.3
  • 3
    • 0004733453 scopus 로고
    • NMDA receptors and developmental plasticity in visual neocortex
    • Collingridge GL, Watkins JC, eds, Oxford: Oxford UP
    • Artola A, Singer W (1994) NMDA receptors and developmental plasticity in visual neocortex. In: The NMDA receptor (Collingridge GL, Watkins JC, eds), pp 313-339. Oxford: Oxford UP.
    • (1994) The NMDA Receptor , pp. 313-339
    • Artola, A.1    Singer, W.2
  • 4
    • 0018344553 scopus 로고
    • Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat
    • Barnes CA (1979) Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J Comp Physiol Psychol 93:74-104.
    • (1979) J Comp Physiol Psychol , vol.93 , pp. 74-104
    • Barnes, C.A.1
  • 5
    • 0024162045 scopus 로고
    • Aging and the physiology of spatial memory
    • Barnes CA (1988) Aging and the physiology of spatial memory. Neurobiol Aging 9:563-568.
    • (1988) Neurobiol Aging , vol.9 , pp. 563-568
    • Barnes, C.A.1
  • 6
    • 0022403407 scopus 로고
    • An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses
    • Barnes CA, McNaughton BL (1985) An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses. Behav Neurosci 99:1040-1048.
    • (1985) Behav Neurosci , vol.99 , pp. 1040-1048
    • Barnes, C.A.1    McNaughton, B.L.2
  • 7
    • 0026010932 scopus 로고
    • Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus
    • Bashir Z, Alford S, Davies S, Randall A, Collingridge G (1991) Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus. Nature 349:156-158.
    • (1991) Nature , vol.349 , pp. 156-158
    • Bashir, Z.1    Alford, S.2    Davies, S.3    Randall, A.4    Collingridge, G.5
  • 8
    • 0025197415 scopus 로고
    • NMDA depolarizations and long-term potentiation are reduced in the aged rat neocortex
    • Baskys A, Reynolds J, Carlen P (1990) NMDA depolarizations and long-term potentiation are reduced in the aged rat neocortex. Brain Res 530:142-146.
    • (1990) Brain Res , vol.530 , pp. 142-146
    • Baskys, A.1    Reynolds, J.2    Carlen, P.3
  • 10
    • 0027193830 scopus 로고
    • Age-related alterations in potentiation in the CA1 region in F344 rats
    • Deupree DL, Bradley J, Turner DA (1993) Age-related alterations in potentiation in the CA1 region in F344 rats. Neurobiol Aging 14:249-258.
    • (1993) Neurobiol Aging , vol.14 , pp. 249-258
    • Deupree, D.L.1    Bradley, J.2    Turner, D.A.3
  • 11
    • 0021139951 scopus 로고
    • Spatial learning and motor deficits in aged rats
    • Gage F, Dunnett S, Bjorklund A (1984) Spatial learning and motor deficits in aged rats. Neurobiol Aging 5:43-48.
    • (1984) Neurobiol Aging , vol.5 , pp. 43-48
    • Gage, F.1    Dunnett, S.2    Bjorklund, A.3
  • 12
    • 0027723549 scopus 로고
    • Animal models of normal aging: Relationship between cognitive decline and markers in hippocampal circuitry
    • Gallagher M, Nicolle MM (1993) Animal models of normal aging: relationship between cognitive decline and markers in hippocampal circuitry. Behav Brain Res 57:155-162.
    • (1993) Behav Brain Res , vol.57 , pp. 155-162
    • Gallagher, M.1    Nicolle, M.M.2
  • 13
    • 0030639472 scopus 로고    scopus 로고
    • The use of animal models to study the effects of aging on cognition
    • Gallagher M, Rapp PR (1997) The use of animal models to study the effects of aging on cognition. Annu Rev Psychol 48:339-370.
    • (1997) Annu Rev Psychol , vol.48 , pp. 339-370
    • Gallagher, M.1    Rapp, P.R.2
  • 14
    • 0029871365 scopus 로고    scopus 로고
    • Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor
    • Gallagher MJ, Huang H, Pritchett DB, Lynch DR (1996) Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 271:9603-9611.
    • (1996) J Biol Chem , vol.271 , pp. 9603-9611
    • Gallagher, M.J.1    Huang, H.2    Pritchett, D.B.3    Lynch, D.R.4
  • 15
    • 0029991039 scopus 로고    scopus 로고
    • Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys
    • Gazzaley AH, Siegel SJ, Kordower JH, Mufson EJ, Morrison JH (1996) Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys. Proc Natl Acad Sci USA 93:3121-3125.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3121-3125
    • Gazzaley, A.H.1    Siegel, S.J.2    Kordower, J.H.3    Mufson, E.J.4    Morrison, J.H.5
  • 17
    • 0021719560 scopus 로고
    • Long-term potentiation in the hippocampus involves activation in N-methyl-D-aspartate receptors
    • Harris EW, Ganong A, Cotman CW (1984) Long-term potentiation in the hippocampus involves activation in N-methyl-D-aspartate receptors. Brain Res 323:132-137.
    • (1984) Brain Res , vol.323 , pp. 132-137
    • Harris, E.W.1    Ganong, A.2    Cotman, C.W.3
  • 19
    • 0025367094 scopus 로고
    • MK801 and AP5 impair acquisition, but not retention, of the Morris milk maze
    • Heale V, Harley C (1990) MK801 and AP5 impair acquisition, but not retention, of the Morris milk maze. Pharmacol Biochem Behav 36:145-149.
    • (1990) Pharmacol Biochem Behav , vol.36 , pp. 145-149
    • Heale, V.1    Harley, C.2
  • 20
  • 23
    • 0025000582 scopus 로고
    • Influence of age on NMDA receptor complex in rat brain studied in in vitro autoradiography
    • Kito S, Miyoshi R, Nomoto T (1990) Influence of age on NMDA receptor complex in rat brain studied in in vitro autoradiography. J Histochem Cytochem 38:1725-1731.
    • (1990) J Histochem Cytochem , vol.38 , pp. 1725-1731
    • Kito, S.1    Miyoshi, R.2    Nomoto, T.3
  • 24
    • 0004732661 scopus 로고    scopus 로고
    • Protein and mRNA expression of different NMDA receptor subunits exhibit decline during aging
    • Kuchl-Kovarik MC, Partin KM, Sammonds GE, Magnusson KR (1998) Protein and mRNA expression of different NMDA receptor subunits exhibit decline during aging. Soc Neurosci Abstr 24:2180.
    • (1998) Soc Neurosci Abstr , vol.24 , pp. 2180
    • Kuchl-Kovarik, M.C.1    Partin, K.M.2    Sammonds, G.E.3    Magnusson, K.R.4
  • 26
    • 0030425689 scopus 로고    scopus 로고
    • Inhibition of N-methyl-D-aspartate receptors by haloperidol. Development and pharmacological characterization in native and recombinant receptors
    • Lynch DR, Gallagher MJ (1996) Inhibition of N-methyl-D-aspartate receptors by haloperidol. Development and pharmacological characterization in native and recombinant receptors. J Pharmacol Exp Ther 279:154-161.
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 154-161
    • Lynch, D.R.1    Gallagher, M.J.2
  • 27
    • 0028965922 scopus 로고
    • Pharmacological characterization of heterodimeric NMDA receptors composed of NR1a and 2B subunits: Differences with receptors formed from NR1a and 2A
    • Lynch DR, Lawrence JJ, Lenz S, Anegawa NJ, Dichter M, Pritchett DB (1995) Pharmacological characterization of heterodimeric NMDA receptors composed of NR1a and 2B subunits: differences with receptors formed from NR1a and 2A. J Neurochem 64:1462-1468.
    • (1995) J Neurochem , vol.64 , pp. 1462-1468
    • Lynch, D.R.1    Lawrence, J.J.2    Lenz, S.3    Anegawa, N.J.4    Dichter, M.5    Pritchett, D.B.6
  • 28
    • 0029569127 scopus 로고
    • Differential effects of aging on binding sites of the activated NMDA receptor complex in mice
    • Magnusson KR (1995) Differential effects of aging on binding sites of the activated NMDA receptor complex in mice. Mech Ageing Dev 84:227-243.
    • (1995) Mech Ageing Dev , vol.84 , pp. 227-243
    • Magnusson, K.R.1
  • 29
    • 0032168690 scopus 로고    scopus 로고
    • The aging of glutamate receptors: Correlations between receptor binding and spatial memory performance in C57B1 mice
    • Magnusson KR (1998a) The aging of glutamate receptors: Correlations between receptor binding and spatial memory performance in C57B1 mice. Mech Ageing Dev 104:227-248.
    • (1998) Mech Ageing Dev , vol.104 , pp. 227-248
    • Magnusson, K.R.1
  • 30
    • 0032507530 scopus 로고    scopus 로고
    • The aging of the NMDA receptor complex
    • Magnusson KR (1998b) The aging of the NMDA receptor complex. Front Biosci 3:e70-80.
    • (1998) Front Biosci , vol.3
    • Magnusson, K.R.1
  • 33
    • 0024400244 scopus 로고
    • NMDA receptor antagonists can enhance or impair learning performance in animals
    • Mondadori C, Weiskrantz L, Buerki H, Petschke F, Fagg GE (1989) NMDA receptor antagonists can enhance or impair learning performance in animals. Exp Brain Res 75:449-456.
    • (1989) Exp Brain Res , vol.75 , pp. 449-456
    • Mondadori, C.1    Weiskrantz, L.2    Buerki, H.3    Petschke, F.4    Fagg, G.E.5
  • 36
    • 0001395584 scopus 로고
    • The role of NMDA receptors in learning and memory
    • Collingridge GL, Watkins JC, eds, Oxford: Oxford UP
    • Morris RGM, Davis M (1994) The role of NMDA receptors in learning and memory. In: The NMDA receptor (Collingridge GL, Watkins JC, eds), pp 340-375. Oxford: Oxford UP.
    • (1994) The NMDA Receptor , pp. 340-375
    • Morris, R.G.M.1    Davis, M.2
  • 37
    • 0022650213 scopus 로고
    • Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
    • Morris RGM, Anderson E, Lynch GS, Baudry M (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319:774-776.
    • (1986) Nature , vol.319 , pp. 774-776
    • Morris, R.G.M.1    Anderson, E.2    Lynch, G.S.3    Baudry, M.4
  • 38
    • 0026437728 scopus 로고
    • Molecular diversity of glutamate receptors and implications for brain function
    • Nakanishi S (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258:597-603.
    • (1992) Science , vol.258 , pp. 597-603
    • Nakanishi, S.1
  • 39
    • 0030564956 scopus 로고    scopus 로고
    • In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: Relationship to spatial learning
    • Nicolle MM, Bizon JL, Gallagher M (1996) In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: relationship to spatial learning. Neuroscience 74:741-756.
    • (1996) Neuroscience , vol.74 , pp. 741-756
    • Nicolle, M.M.1    Bizon, J.L.2    Gallagher, M.3
  • 40
    • 0025038338 scopus 로고
    • Hippocampal 3H-CPP binding and spatial learning deficits in aged rats
    • Pelleymounter MA, Beatty G, Gallagher M (1990) Hippocampal 3H-CPP binding and spatial learning deficits in aged rats. Psychobiology 18:298-304.
    • (1990) Psychobiology , vol.18 , pp. 298-304
    • Pelleymounter, M.A.1    Beatty, G.2    Gallagher, M.3
  • 41
    • 0026611928 scopus 로고
    • 3H]MK-801 binding to the NMDA receptor complex, and its modulation in human frontal cortex during development and aging
    • 3H]MK-801 binding to the NMDA receptor complex, and its modulation in human frontal cortex during development and aging. Brain Res 588:277-286.
    • (1992) Brain Res , vol.588 , pp. 277-286
    • Piggott, M.A.1    Perry, E.K.2    Perry, R.H.3    Court, J.A.4
  • 42
    • 0027533027 scopus 로고
    • Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine
    • Pittaluga A, Fedele E, Risiglione C, Raiteri M (1993) Age-related decrease of the NMDA receptor-mediated noradrenaline release in rat hippocampus and partial restoration by D-cycloserine. Eur J Pharmacol 231:129-134.
    • (1993) Eur J Pharmacol , vol.231 , pp. 129-134
    • Pittaluga, A.1    Fedele, E.2    Risiglione, C.3    Raiteri, M.4
  • 43
    • 0028823737 scopus 로고
    • Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells
    • Priestley T, Laughton P, Myers J, le Bourdelles B, Kerby J, Whiting PJ (1995) Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells. Mol Pharmacol 48:841-848.
    • (1995) Mol Pharmacol , vol.48 , pp. 841-848
    • Priestley, T.1    Laughton, P.2    Myers, J.3    Le Bourdelles, B.4    Kerby, J.5    Whiting, P.J.6
  • 44
    • 0023139908 scopus 로고
    • An evaluation of spatial information processing in aged rats
    • Rapp P, Rosenberg R, Gallagher M (1987) An evaluation of spatial information processing in aged rats. Behav Neurosci 101:3-12.
    • (1987) Behav Neurosci , vol.101 , pp. 3-12
    • Rapp, P.1    Rosenberg, R.2    Gallagher, M.3
  • 45
    • 0029821150 scopus 로고    scopus 로고
    • Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
    • Rapp PR, Gallagher M (1996) Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc Natl Acad Sci USA 93:9926-9930.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9926-9930
    • Rapp, P.R.1    Gallagher, M.2
  • 46
    • 0010673819 scopus 로고
    • Molecular biology of NMDA receptors
    • Collingridge GL, Watkins JC, eds, Oxford: Oxford UP
    • Seeburg PH, Monyer H, Sprengel R, Burnashev N (1994) Molecular biology of NMDA receptors. In: The NMDA receptor (Collingridge GL, Watkins JC, eds), pp 147-157. Oxford: Oxford UP.
    • (1994) The NMDA Receptor , pp. 147-157
    • Seeburg, P.H.1    Monyer, H.2    Sprengel, R.3    Burnashev, N.4
  • 47
    • 0343203030 scopus 로고
    • Quantitative analysis of in situ hybridization using image analysis
    • Chesselet M-F, eds, Boston: CRC
    • Smolen AJ, Beaston-Wimmer P (1990) Quantitative analysis of in situ hybridization using image analysis. In: In Situ hybridization histochemistry (Chesselet M-F, eds), pp 175-188. Boston: CRC.
    • (1990) In Situ Hybridization Histochemistry , pp. 175-188
    • Smolen, A.J.1    Beaston-Wimmer, P.2
  • 48
    • 0032516819 scopus 로고    scopus 로고
    • Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-D-aspartate receptor
    • Strack S, Colbran RJ (1998) Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 273:20689-20692.
    • (1998) J Biol Chem , vol.273 , pp. 20689-20692
    • Strack, S.1    Colbran, R.J.2
  • 49
    • 0026082667 scopus 로고
    • Age-related decreases of the N-methyl-D-aspartate receptor complex in the rat cerebral cortex and hippocampus
    • Tamaru M, Yoneda Y, Ogita K, Shimizu J, Nagata Y (1991) Age-related decreases of the N-methyl-D-aspartate receptor complex in the rat cerebral cortex and hippocampus. Brain Res 542:83-90.
    • (1991) Brain Res , vol.542 , pp. 83-90
    • Tamaru, M.1    Yoneda, Y.2    Ogita, K.3    Shimizu, J.4    Nagata, Y.5
  • 51
    • 0021077610 scopus 로고
    • Senile dementia of the Alzheimer's type
    • Terry RD, Katzman R (1983) Senile dementia of the Alzheimer's type. Ann Neurol 14:497-506.
    • (1983) Ann Neurol , vol.14 , pp. 497-506
    • Terry, R.D.1    Katzman, R.2
  • 52
    • 0004517952 scopus 로고    scopus 로고
    • Both NMDA and AMPA receptor subunits are altered in Alzheimer's disease
    • Wang Y-H, Yasuda RP, Mash DC, Wolfe BB (1997) Both NMDA and AMPA receptor subunits are altered in Alzheimer's disease. Soc Neurosci Abstr 23:1895.
    • (1997) Soc Neurosci Abstr , vol.23 , pp. 1895
    • Wang, Y.-H.1    Yasuda, R.P.2    Mash, D.C.3    Wolfe, B.B.4
  • 53
  • 54
    • 0027092373 scopus 로고
    • Developmental-changes in distribution of NMDA receptor channel subunit mRNAs
    • Watanabe M, Inoue Y, Sakimura K, Mishina M (1992) Developmental-changes in distribution of NMDA receptor channel subunit mRNAs. NeuroReport 3:1138-1140.
    • (1992) NeuroReport , vol.3 , pp. 1138-1140
    • Watanabe, M.1    Inoue, Y.2    Sakimura, K.3    Mishina, M.4
  • 55
    • 0027382009 scopus 로고
    • Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain
    • Watanabe M, Inoue Y, Sakimura K, Mishina M (1993) Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain. J Comp Neurol 338:377-390.
    • (1993) J Comp Neurol , vol.338 , pp. 377-390
    • Watanabe, M.1    Inoue, Y.2    Sakimura, K.3    Mishina, M.4
  • 56
    • 0026030866 scopus 로고
    • Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys
    • Wenk GL, Walker LC, Price DL, Cork LC (1991) Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys. Neurobiol Aging 12:93-98.
    • (1991) Neurobiol Aging , vol.12 , pp. 93-98
    • Wenk, G.L.1    Walker, L.C.2    Price, D.L.3    Cork, L.C.4
  • 57
    • 0028122463 scopus 로고
    • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
    • West MJ, Coleman PD, Flood DG, Troncosco JC (1994) Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344:769-772.
    • (1994) Lancet , vol.344 , pp. 769-772
    • West, M.J.1    Coleman, P.D.2    Flood, D.G.3    Troncosco, J.C.4
  • 58
    • 0032544587 scopus 로고    scopus 로고
    • Biphasic changes in the levels of N-methyl-D-aspartate-2 subunits correlate with the induction and persistence of long-term potentiation
    • Williams JM, Mason-Parker SE, Abraham WC, Tate WP (1998) Biphasic changes in the levels of N-methyl-D-aspartate-2 subunits correlate with the induction and persistence of long-term potentiation. Mol Brain Res 60:21-27.
    • (1998) Mol Brain Res , vol.60 , pp. 21-27
    • Williams, J.M.1    Mason-Parker, S.E.2    Abraham, W.C.3    Tate, W.P.4
  • 59
    • 0027525324 scopus 로고
    • Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
    • Williams K (1993) Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol 44:851-859.
    • (1993) Mol Pharmacol , vol.44 , pp. 851-859
    • Williams, K.1
  • 60
    • 0031811331 scopus 로고    scopus 로고
    • Sensitivity of the N-methyl-D-aspartate receptor channel to butyrophenones is dependent on the ∈2 subunit
    • Yamakura T, Sakimura K, Mishina M, Shimoji K (1998) Sensitivity of the N-methyl-D-aspartate receptor channel to butyrophenones is dependent on the ∈2 subunit. Neuropharmacology 37:709-717.
    • (1998) Neuropharmacology , vol.37 , pp. 709-717
    • Yamakura, T.1    Sakimura, K.2    Mishina, M.3    Shimoji, K.4
  • 61
    • 0026560041 scopus 로고
    • Cloning, expression and modulation of a mouse NMDA receptor subunit
    • Yamazaki M, Mori H, Araki K, Mori KJ, Mishina M (1992) Cloning, expression and modulation of a mouse NMDA receptor subunit. FEBS Lett 300:39-45.
    • (1992) FEBS Lett , vol.300 , pp. 39-45
    • Yamazaki, M.1    Mori, H.2    Araki, K.3    Mori, K.J.4    Mishina, M.5


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