Cysteine scanning of the surroundings of an alkali-ion binding site of the glutamate transporter GLT-1 reveals a conformationally sensitive residue

Journal of Biological Chemistry

Volumn 273, Issue 23, 1998, Pages 14231-14237

  Zarbiv, Ruth ^a   Grunewald, Myriam ^a   Kavanaugh, Michael P ^b   Kanner, Baruch I ^a  

^a HEBREW UNIVERSITY   (Israel)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALI; CARRIER PROTEIN; CYSTEINE; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; ION CHANNEL; MEMBRANE PROTEIN; N ETHYLMALEIMIDE; PROTON; SODIUM ION; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; AMINO ACID TRANSPORT; ARTICLE; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; ION TRANSPORT; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION;

AMINO ACID TRANSPORT SYSTEM X-AG; AMINO ACIDS; ASPARTIC ACID; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; BIOLOGICAL TRANSPORT; CONSERVED SEQUENCE; CYSTEINE; ETHYLMALEIMIDE; HELA CELLS; HUMANS; KAINIC ACID; MESYLATES; MUTAGENESIS, SITE-DIRECTED; POTASSIUM; PROTEIN CONFORMATION; SODIUM; SULFHYDRYL REAGENTS;

EID: 0032486463     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.23.14231     Document Type: Article

References (39)

1. Kanner, B. I., and Schuldiner, S. (1987) CRC Crit. Rev. Biochem. 22, 1-8
2. Nicholls, D. G., and Attwell, D. (1990) Trends Pharmacol. Sci. 11, 462-468
3. Rothstein, J. D., Dykes-Hoberg, M., Pardo, C. A., Bristol, L. A., Jin, L., Kuncl, R. W., Kanai, Y., Hediger, M. A., Wang, Y., Schielke, J. P., and Welty, D. F. (1996) Neuron 16, 675-686
4. Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Twama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., Okagama, S., Kawashima, N., Hori, S., Takimoto, M., and Wada, K. (1997) Science 276, 1699-1702
5. Mennerick, S., and Zorumski, C. F. (1994) Nature 368, 59-62
6. Tong, G., and Jahr, C. E. (1994) Neuron 13, 1195-1203
7. Kanner, B. I., and Sharon, I. (1978) Biochemistry 17, 3949-3953
8. Brew, H., and Attwell, D. (1987) Nature 327, 707-709
9. Wadiche, J. I., Arriza, J. L., Amara, S. G., and Kavanaugh, M. P. (1995) Neuron 14, 1019-1027
10. Zerangue, N., and Kavanaugh, M. P. (1996) Nature 383, 634-637
11. Kanner, B. I., and Bendahan, A. (1982) Biochemistry 21, 6327-6330
12. Pines, G., and Kanner, B. I. (1990) Biochemistry 29, 11209-11214
13. Kavanaugh, M. P., Bendahan, A., Zerangue, N., Zhang, Y., and Kanner, B. I. (1997) J. Biol. Chem. 272, 1703-1708
14. Danbolt, N. C., Pines, G., and Kanner, B. (1990) Biochemistry 29, 6734-6740
15. Danbolt, N. C., Storm-Mathisen, J., and Kanner, B. I. (1992) Neuroscience 51, 295-310
16. Pines, G., Danbolt, N. C., Bjoras, M., Zhang, Y., Bendahan, A., Eide, L., Koepsell, H., Storm-Mathisen, J., Seeberg, E., and Kanner, B. I. (1992) Nature 360, 464-467
17. Storck, T., Schulte, S., Hofmann, K., and Stoffel, W. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 10955-10959
18. Kanai, Y., and Hediger, M. A. (1992) Nature 360, 467-471
19. Fairman, W. A., Vandenberg, R. J., Arriza, J. L., Kavanaugh, M. P., and Amara, S. G. (1995) Nature 375, 599-603
20. Arriza, J. L., Eliasof, S., Kavanaugh, M. P., and Amara, S. G. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 4155-4160
21. Zhang, Y., Bendahan, A., Zarbiv, R., Kavanaugh, M. P., and Kanner, B. I. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 751-755
22. Pines, G., Zhang, Y., and Kanner, B. I. (1995) J. Biol. Chem. 270, 17093-17097
23. Akabas, M., Stauffer, D., Xu, M., and Karlin, A. (1992) Science 258, 307-310
24. Akabas, M. H., Kaufmann, C., Cook, T. A., and Archdeacon, P. (1994) J. Biol. Chem. 269, 14865-14868
25. Kuner, T., Wollmuth, L., Karlin, A., Seeburg, P. H., and Sakmann, B. (1996) Neuron 17, 343-352
26. Keynan, S., Suh, Y.-J., Kanner, B. I., and Rudnick, G. (1992) Biochemistry 31, 1974-1979
27. Fuerst, T. R., Niles, E. G., Studies, F. W., and Moss, B. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 8122-8126
28. Holmgren, M., Liu, Y., Xu, Y., and Yellen, G. (1996) Neuropharmacology 35, 797-804
29. Kunkel, T. A., Roberts, J. D., and Zarkour, R. A. (1987) Methods Enzymol. 154, 367-383
30. Casado, M., Bendahan, A., Zafra, F., Danbolt, N. C., Aragon, C., Gimenez, C., and Kanner, B. I. (1993) J. Biol. Chem. 268, 27313-27317
31. Bendahan, A., and Kanner, B. I. (1993) FEBS Lett. 318, 41-44
32. Arriza, J. L., Fairman, W. A., Wadiche, J. L., Murdoch, G. H., Kavanaugh, M. P., and Amara, S. G. (1994) J. Neurosci. 14, 5559-5569
33. Barbour, B., Brew, H., and Attwell, D. (1991) J. Physiol. 436, 169-193
34. Pocock, J. M., Murphie, H. M., and Nicholls, D. G. (1988) J. Neurochem. 50, 745-751
35. Kimura, T., Ohnuma, M., Sawai, T., and Yamaguchi, A. (1996) Biochemistry 35, 15896-15899
36. Olami, Y., Rimon, A., Gerchman, Y., Rothman, A., and Padan, E. (1997) J. Biol. Chem. 272, 1761-1768
37. Slotboom, D. J., Lolkema, J. S., and Konings, W. N. (1996) J. Biol. Chem. 271, 31317-31321
38. Grunewald, M., and Kanner, B. (1995) J. Biol. Chem. 270, 17017-17024
39. Vandenberg, R. J., Arriza, J. L., Amara, S. G., and Kavanaugh, M. P. (1995) J. Biol. Chem. 270, 17668-17671