Methylation of l-trans-2,4-pyrrolidine dicarboxylate converts the glutamate transport inhibitor from a substrate to a non-substrate inhibitor

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 11, 2002, Pages 3509-3515

  Esslinger, C Sean ^a   Titus, Jody ^b   Koch, Hans P ^a   Bridges, Richard J ^a   Chamberlin, A Richard ^b  

^a UNIVERSITY OF MONTANA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 PYRROLIDINEDICARBOXYLIC ACID; GLUTAMATE TRANSPORTER; NEUROTRANSMITTER UPTAKE INHIBITOR;

ANIMAL CELL; ARTICLE; BIOASSAY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYCLOADDITION; DRUG POTENCY; DRUG SYNTHESIS; FOREBRAIN; METHYLATION; MOLECULAR MODEL; NONHUMAN; PHYSIOLOGY; RAT;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; CARBOXYLIC ACIDS; COMPUTATIONAL BIOLOGY; CYCLIZATION; DICARBOXYLIC ACIDS; EXCITATORY AMINO ACID TRANSPORTER 2; INDICATORS AND REAGENTS; KINETICS; METHYLATION; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROSENCEPHALON; PYRROLIDINES; RATS; SYNAPTOSOMES;

EID: 0036836946     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00250-X     Document Type: Article

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