-
1
-
-
19344372271
-
Systems biology: Its practice and challenges
-
Aderem, A. (2005) Systems biology: its practice and challenges. Cell 121: 511-513.
-
(2005)
Cell
, vol.121
, pp. 511-513
-
-
Aderem, A.1
-
2
-
-
19344372443
-
Systems biology, integrative biology, predictive biology
-
Liu, E.T. (2005) Systems biology, integrative biology, predictive biology. Cell 121: 505-506.
-
(2005)
Cell
, vol.121
, pp. 505-506
-
-
Liu, E.T.1
-
3
-
-
19344375343
-
The meaning of systems biology
-
Kirschner, M.W. (2005) The meaning of systems biology. Cell 121: 503-504.
-
(2005)
Cell
, vol.121
, pp. 503-504
-
-
Kirschner, M.W.1
-
4
-
-
13844296720
-
A systems biology perspective on protein structural dynamics and signal transduction
-
Rousseau, F., Schymkowitz, J. (2005) A systems biology perspective on protein structural dynamics and signal transduction. Curr. Opin. Struct. Biol. 15: 23-30.
-
(2005)
Curr. Opin. Struct. Biol.
, vol.15
, pp. 23-30
-
-
Rousseau, F.1
Schymkowitz, J.2
-
5
-
-
1042298842
-
From large networks to small molecules
-
Sharom, J.R., Bellows, D.S., Tyers, M. (2004) From large networks to small molecules. Curr. Opin. Chem. Biol. 8: 81-90.
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 81-90
-
-
Sharom, J.R.1
Bellows, D.S.2
Tyers, M.3
-
6
-
-
14844318077
-
When kinases meet mathematics: The systems biology of MAPK signalling
-
Kolch, W., Calder, M., Gilbert, D. (2005) When kinases meet mathematics: the systems biology of MAPK signalling. FEBS Lett. 579: 1891-1895.
-
(2005)
FEBS Lett.
, vol.579
, pp. 1891-1895
-
-
Kolch, W.1
Calder, M.2
Gilbert, D.3
-
7
-
-
0142244852
-
Chemical genetics of chlorophyll-mutating barley stains. Comparison between the chlorophyll and gramine content in the strains Primus I, Primus II (gulvit, xanthalba and Xanthaurea), Westergaard's line and a line from the crossing of Goldgerste with Chevalier
-
von Euler, H., Hellstrom, H., Lofgren, N. (1935) Chemical genetics of chlorophyll-mutating barley stains. Comparison between the chlorophyll and gramine content in the strains Primus I, Primus II (gulvit, xanthalba and Xanthaurea), Westergaard's line and a line from the crossing of Goldgerste with Chevalier. Physiol. Chem. 234: 151-164.
-
(1935)
Physiol. Chem.
, vol.234
, pp. 151-164
-
-
Von Euler, H.1
Hellstrom, H.2
Lofgren, N.3
-
8
-
-
0031710509
-
Chemical genetics resulting from a passion for synthetic organic chemistry
-
Schreiber, S.L. (1998) Chemical genetics resulting from a passion for synthetic organic chemistry. Bioorg. Med. Chem. 6: 1127-1152.
-
(1998)
Bioorg. Med. Chem.
, vol.6
, pp. 1127-1152
-
-
Schreiber, S.L.1
-
9
-
-
0033874150
-
Unnatural ligands for engineered proteins: New tools for chemical genetics
-
Bishop, A., Buzko, O., Heyeck-Dumas, S., Jung, I., Kraybill, B., Liu, Y., Shah, K., Ulrich, S., Witucki, L., Yang, F., Zhang, C., Shokat, K.M. (2000) Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu. Rev. Biophys. Biomol. Struct. 29: 577-606.
-
(2000)
Annu. Rev. Biophys. Biomol. Struct.
, vol.29
, pp. 577-606
-
-
Bishop, A.1
Buzko, O.2
Heyeck-Dumas, S.3
Jung, I.4
Kraybill, B.5
Liu, Y.6
Shah, K.7
Ulrich, S.8
Witucki, L.9
Yang, F.10
Zhang, C.11
Shokat, K.M.12
-
10
-
-
0028505040
-
Towards a pharmacological genetics
-
Mitchison, T.J. (1994) Towards a pharmacological genetics. Chem. Biol. 1: 3-6.
-
(1994)
Chem. Biol.
, vol.1
, pp. 3-6
-
-
Mitchison, T.J.1
-
11
-
-
12344252950
-
Medicinal chemistry, metabolic profiling and drug target discovery: A role for metabolic profiling in reverse pharmacology and chemical genetics
-
Harrigan, G.G., Brackett, D.J., Boros, L.G. (2005) Medicinal chemistry, metabolic profiling and drug target discovery: a role for metabolic profiling in reverse pharmacology and chemical genetics. Mini. Rev. Med. Chem. 5: 13-20.
-
(2005)
Mini. Rev. Med. Chem.
, vol.5
, pp. 13-20
-
-
Harrigan, G.G.1
Brackett, D.J.2
Boros, L.G.3
-
12
-
-
5644255983
-
Quality, not quantity: The role of natural products and chemical proteomics in modern drug discovery
-
Piggott, A.M., Karuso, P. (2004) Quality, not quantity: the role of natural products and chemical proteomics in modern drug discovery. Comb. Chem. High Throughput Screen. 7: 607-630.
-
(2004)
Comb. Chem. High Throughput Screen.
, vol.7
, pp. 607-630
-
-
Piggott, A.M.1
Karuso, P.2
-
13
-
-
11144294717
-
Chemical genetics for therapeutic target mining
-
Shim, J.S., Kwon, H.J. (2004) Chemical genetics for therapeutic target mining. Expert. Opin. Ther. Targets 8: 653-661.
-
(2004)
Expert. Opin. Ther. Targets
, vol.8
, pp. 653-661
-
-
Shim, J.S.1
Kwon, H.J.2
-
14
-
-
0041344669
-
Model systems in drug discovery: Chemical genetics meets genomics
-
Carroll, P.M., Dougherty, B., Ross-Macdonald, P., Browman, K., FitzGerald, K. (2003) Model systems in drug discovery: chemical genetics meets genomics. Pharmacol. Ther. 99: 183-220.
-
(2003)
Pharmacol. Ther.
, vol.99
, pp. 183-220
-
-
Carroll, P.M.1
Dougherty, B.2
Ross-Macdonald, P.3
Browman, K.4
Fitzgerald, K.5
-
16
-
-
4544334518
-
Strategies for facilitated forward chemical genetics
-
Khersonsky, S.M., Chang, Y.T. (2004) Strategies for facilitated forward chemical genetics. Chembiochem. 5: 903-908.
-
(2004)
Chembiochem.
, vol.5
, pp. 903-908
-
-
Khersonsky, S.M.1
Chang, Y.T.2
-
17
-
-
0346251243
-
Forward & reverse chemical genetics using SPOS-based combinatorial chemistry
-
Thorpe, D.S. (2003) Forward & reverse chemical genetics using SPOS-based combinatorial chemistry. Comb. Chem. High Throughput Screen. 6: 623-647.
-
(2003)
Comb. Chem. High Throughput Screen.
, vol.6
, pp. 623-647
-
-
Thorpe, D.S.1
-
18
-
-
0037305949
-
Forward chemical genetics: Progress and obstacles on the path to a new pharmacopoeia
-
Lokey, R.S. (2003) Forward chemical genetics: progress and obstacles on the path to a new pharmacopoeia. Curr. Opin. Chem. Biol. 7: 91-96.
-
(2003)
Curr. Opin. Chem. Biol.
, vol.7
, pp. 91-96
-
-
Lokey, R.S.1
-
20
-
-
23044450708
-
Orthogonal chemical genetic approaches for unraveling signaling pathways
-
Shah, K. (2005) Orthogonal chemical genetic approaches for unraveling signaling pathways. IUBMB Life 57: 397-405.
-
(2005)
IUBMB Life
, vol.57
, pp. 397-405
-
-
Shah, K.1
-
21
-
-
0037101904
-
Novel chemical genetic approaches to the discovery of signal transduction inhibitors
-
Shokat, K., Velleca, M. (2002) Novel chemical genetic approaches to the discovery of signal transduction inhibitors. Drug Discov. Today 7: 872-879.
-
(2002)
Drug Discov. Today
, vol.7
, pp. 872-879
-
-
Shokat, K.1
Velleca, M.2
-
22
-
-
20444392074
-
Chemical library synthesis using convergent approaches
-
Beeler, A.B., Schaus, S.E., Porco, J.A., Jr. (2005) Chemical library synthesis using convergent approaches. Curr. Opin. Chem. Biol 9: 277-284.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 277-284
-
-
Beeler, A.B.1
Schaus, S.E.2
Porco Jr., J.A.3
-
23
-
-
0034678033
-
Target-oriented and diversity-oriented organic synthesis in drug discovery
-
Schreiber, S.L. (2000) Target-oriented and diversity-oriented organic synthesis in drug discovery. Science 287: 1964-1969.
-
(2000)
Science
, vol.287
, pp. 1964-1969
-
-
Schreiber, S.L.1
-
24
-
-
20444410443
-
Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries
-
Shang, S., Tan, D.S. (2005) Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries. Curr. Opin. Chem. Biol. 9: 248-258.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 248-258
-
-
Shang, S.1
Tan, D.S.2
-
25
-
-
5644255981
-
Photo-affinity labeling strategies in identifying the protein ligands of bioactive small molecules: Examples of targeted synthesis of drug analog photoprobes
-
Colca, J.R., Harrigan, G.G. (2004) Photo-affinity labeling strategies in identifying the protein ligands of bioactive small molecules: examples of targeted synthesis of drug analog photoprobes. Comb. Chem. High Throughput. Screen. 7: 699-704.
-
(2004)
Comb. Chem. High Throughput. Screen.
, vol.7
, pp. 699-704
-
-
Colca, J.R.1
Harrigan, G.G.2
-
26
-
-
4043121114
-
Computational chemogenomics approaches to systematic knowledge-based drug discovery
-
Mestres, J. (2004) Computational chemogenomics approaches to systematic knowledge-based drug discovery. Curr. Opin. Drug Discov. Devel. 7: 304-313.
-
(2004)
Curr. Opin. Drug Discov. Devel.
, vol.7
, pp. 304-313
-
-
Mestres, J.1
-
27
-
-
11144320699
-
Navigating chemical space for biology and medicine
-
Lipinski, C., Hopkins, A. (2004) Navigating chemical space for biology and medicine. Nature 432: 855-861.
-
(2004)
Nature
, vol.432
, pp. 855-861
-
-
Lipinski, C.1
Hopkins, A.2
-
28
-
-
0036603905
-
Chemical space navigation in lead discovery
-
Oprea, T.I. (2002) Chemical space navigation in lead discovery. Curr. Opin. Chem. Biol. 6: 384-389.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 384-389
-
-
Oprea, T.I.1
-
29
-
-
5644251993
-
Mapping chemical space using molecular descriptors and chemical genetics: Deacetylase inhibitors
-
Haggarty, S.J., Clemons, P.A., Wong, J.C., Schreiber, S.L. (2004) Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors. Comb. Chem. High Throughput Screen. 7: 669-676.
-
(2004)
Comb. Chem. High Throughput Screen.
, vol.7
, pp. 669-676
-
-
Haggarty, S.J.1
Clemons, P.A.2
Wong, J.C.3
Schreiber, S.L.4
-
30
-
-
20444420189
-
Natural product-like chemical space: Search for chemical dissectors of macromolecular interactions
-
Reayi, A., Arya, P. (2005) Natural product-like chemical space: search for chemical dissectors of macromolecular interactions. Curr. Opin. Chem. Biol. 9: 240-247.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 240-247
-
-
Reayi, A.1
Arya, P.2
-
31
-
-
2942590399
-
Libraries from natural product-like scaffolds
-
Boldi, A.M. (2004) Libraries from natural product-like scaffolds. Curr. Opin. Chem. Biol. 8: 281-286.
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 281-286
-
-
Boldi, A.M.1
-
32
-
-
2942565810
-
Natural products and combinatorial chemistry: Back to the future
-
Ortholand, J.Y., Ganesan, A. (2004) Natural products and combinatorial chemistry: back to the future. Curr. Opin. Chem. Biol. 8: 271-280.
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 271-280
-
-
Ortholand, J.Y.1
Ganesan, A.2
-
33
-
-
0036080620
-
A short formal route to (±)-lepadin B using a xanthate-mediated free radical cyclisation/vinylation sequence
-
Tate, E.W., Kulai, C., Zard, S.Z. (2002) A short formal route to (±)-lepadin B using a xanthate-mediated free radical cyclisation/ vinylation sequence. Chemical Communications 13: 1430-1431.
-
(2002)
Chemical Communications
, vol.13
, pp. 1430-1431
-
-
Tate, E.W.1
Kulai, C.2
Zard, S.Z.3
-
34
-
-
33749115510
-
A total synthesis of (+)-Goniodiol using an anomeric oxygen-to-carbon rearrangement
-
Dixon, D.J., Ley, S.V., Tate, E.W. (1998) A total synthesis of (+)-Goniodiol using an anomeric oxygen-to-carbon rearrangement. Journal of the Chemical Society, Perkin Transactions 1 19: 3125-3126.
-
(1998)
Journal of the Chemical Society, Perkin Transactions1
, vol.19
, pp. 3125-3126
-
-
Dixon, D.J.1
Ley, S.V.2
Tate, E.W.3
-
35
-
-
0037189175
-
Efficient construction of polycyclic alkaloid synthetic precursors by a xanthate free radical addition and Mannich cyclisation cascade
-
Tate, E.W., Zard, S.Z. (2002) Efficient construction of polycyclic alkaloid synthetic precursors by a xanthate free radical addition and Mannich cyclisation cascade. Tetrahedron Letters 43: 4683-4686.
-
(2002)
Tetrahedron Letters
, vol.43
, pp. 4683-4686
-
-
Tate, E.W.1
Zard, S.Z.2
-
36
-
-
0037008161
-
The CP molecule labyrinth: A paradigm of how endeavors in total synthesis lead to discoveries and inventions in organic synthesis
-
Nicolaou, K.C., Baran, P.S. (2002) The CP molecule labyrinth: a paradigm of how endeavors in total synthesis lead to discoveries and inventions in organic synthesis. Angew. Chem. Int. Ed. Engl. 41: 2678-2720.
-
(2002)
Angew. Chem. Int. Ed. Engl.
, vol.41
, pp. 2678-2720
-
-
Nicolaou, K.C.1
Baran, P.S.2
-
37
-
-
20444378945
-
The principle of complementarity: Chemical versus biological space
-
Haggarty, S.J. (2005) The principle of complementarity: chemical versus biological space. Curr. Opin. Chem. Biol. 9: 296-303.
-
(2005)
Curr. Opin. Chem. Biol.
, vol.9
, pp. 296-303
-
-
Haggarty, S.J.1
-
38
-
-
0034945422
-
Synthetic peptide mimics of the Bowman-Birk inhibitor protein
-
McBride, J.D., Leatherbarrow, R.J. (2001) Synthetic peptide mimics of the Bowman-Birk inhibitor protein. Curr. Med. Chem. 8: 909-917.
-
(2001)
Curr. Med. Chem.
, vol.8
, pp. 909-917
-
-
McBride, J.D.1
Leatherbarrow, R.J.2
-
39
-
-
0038089976
-
Selection of chymotrypsin inhibitors from a conformationally-constrained combinatorial peptide library
-
McBride, J.D., Freeman, N., Domingo, G.J., Leatherbarrow, R.J. (1996) Selection of chymotrypsin inhibitors from a conformationally-constrained combinatorial peptide library. J. Mol. Biol. 259: 819-827.
-
(1996)
J. Mol. Biol.
, vol.259
, pp. 819-827
-
-
McBride, J.D.1
Freeman, N.2
Domingo, G.J.3
Leatherbarrow, R.J.4
-
40
-
-
25444447991
-
Cyclic peptides, a chemical genetics tool for biologists
-
Horswill, A.R., Benkovic, S.J. (2005) Cyclic peptides, a chemical genetics tool for biologists. Cell Cycle 4: 552-555.
-
(2005)
Cell Cycle
, vol.4
, pp. 552-555
-
-
Horswill, A.R.1
Benkovic, S.J.2
-
41
-
-
0027756895
-
Controlling signal transduction with synthetic ligands
-
Spencer, D.M., Wandless, T.J., Schreiber, S.L., Crabtree, G.R. (1993) Controlling signal transduction with synthetic ligands. Science 262: 1019-1024.
-
(1993)
Science
, vol.262
, pp. 1019-1024
-
-
Spencer, D.M.1
Wandless, T.J.2
Schreiber, S.L.3
Crabtree, G.R.4
-
42
-
-
0028832658
-
Signal transduction in T lymphocytes using a conditional allele of Sos
-
Holsinger, L.J., Spencer, D.M., Austin, D.J., Schreiber, S.L., Crabtree, G.R. (1995) Signal transduction in T lymphocytes using a conditional allele of Sos. Proc. Natl. Acad. Sci. USA 92: 9810-9814.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9810-9814
-
-
Holsinger, L.J.1
Spencer, D.M.2
Austin, D.J.3
Schreiber, S.L.4
Crabtree, G.R.5
-
43
-
-
0030013607
-
Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins
-
Belshaw, P.J., Ho, S.N., Crabtree, G.R., Schreiber, S.L. (1996) Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proc. Natl. Acad. Sci. USA 93: 4604-4607.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4604-4607
-
-
Belshaw, P.J.1
Ho, S.N.2
Crabtree, G.R.3
Schreiber, S.L.4
-
44
-
-
0345255765
-
Targeted chemical disruption of clathrin function in living cells
-
Moskowitz, H.S., Heuser, J., McGraw, T.E., Ryan, T.A. (2003) Targeted chemical disruption of clathrin function in living cells. Mol. Biol. Cell 14: 4437-4447.
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 4437-4447
-
-
Moskowitz, H.S.1
Heuser, J.2
McGraw, T.E.3
Ryan, T.A.4
-
45
-
-
10044266403
-
A small-molecule switch for Golgi sulfotransferases
-
de Graffenried, C.L., Laughlin, S.T., Kohler, J.J., Bertozzi, C.R. (2004) A small-molecule switch for Golgi sulfotransferases. Proc. Natl. Acad. Sci. USA 101: 16715-16720.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 16715-16720
-
-
De Graffenried, C.L.1
Laughlin, S.T.2
Kohler, J.J.3
Bertozzi, C.R.4
-
46
-
-
4344656346
-
Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals
-
Luker, K.E., Smith, M.C., Luker, G.D., Gammon, S.T., Piwnica-Worms, H., Piwnica-Worms, D. (2004) Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc. Natl. Acad. Sci. USA 101: 12288-12293.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 12288-12293
-
-
Luker, K.E.1
Smith, M.C.2
Luker, G.D.3
Gammon, S.T.4
Piwnica-Worms, H.5
Piwnica-Worms, D.6
-
47
-
-
0042431612
-
SIR1, an upstream component in auxin signaling identified by chemical genetics
-
Zhao, Y., Dai, X., Blackwell, H.E., Schreiber, S.L., Chory, J. (2003) SIR1, an upstream component in auxin signaling identified by chemical genetics. Science 301: 1107-1110.
-
(2003)
Science
, vol.301
, pp. 1107-1110
-
-
Zhao, Y.1
Dai, X.2
Blackwell, H.E.3
Schreiber, S.L.4
Chory, J.5
-
48
-
-
6044242219
-
Funneling auxin action: Specificity in signal transduction
-
Weijers, D., Jurgens, G. (2004) Funneling auxin action: specificity in signal transduction. Curr. Opin. Plant Biol. 7: 687-693.
-
(2004)
Curr. Opin. Plant Biol.
, vol.7
, pp. 687-693
-
-
Weijers, D.1
Jurgens, G.2
-
49
-
-
0038606469
-
Yokonolide B, a novel inhibitor of auxin action, blocks degradation of AUX/IAA factors
-
Hayashi, K., Jones, A.M., Ogino, K., Yamazoe, A., Oono, Y., Inoguchi, M., Kondo, H., Nozaki, H. (2003) Yokonolide B, a novel inhibitor of auxin action, blocks degradation of AUX/IAA factors. J. Biol. Chem. 278: 23797-23806.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 23797-23806
-
-
Hayashi, K.1
Jones, A.M.2
Ogino, K.3
Yamazoe, A.4
Oono, Y.5
Inoguchi, M.6
Kondo, H.7
Nozaki, H.8
-
50
-
-
6044269430
-
Membrane trafficking in plants: New discoveries and approaches
-
Carter, C.J., Bednarek, S.Y., Raikhel, N.V. (2004) Membrane trafficking in plants: new discoveries and approaches. Curr. Opin. Plant Biol. 7: 701-707.
-
(2004)
Curr. Opin. Plant Biol.
, vol.7
, pp. 701-707
-
-
Carter, C.J.1
Bednarek, S.Y.2
Raikhel, N.V.3
-
51
-
-
3042552336
-
Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis
-
Zouhar, J., Hicks, G.R., Raikhel, N.V. (2004) Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis. Proc. Natl. Acad. Sci. USA 101: 9497-9501.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 9497-9501
-
-
Zouhar, J.1
Hicks, G.R.2
Raikhel, N.V.3
-
52
-
-
27644530140
-
Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation
-
Dubos, C., Willment, J., Huggins, D., Grant, G.H., Campbell, M.M. (2005) Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation. Plant J. 43: 348-355.
-
(2005)
Plant J.
, vol.43
, pp. 348-355
-
-
Dubos, C.1
Willment, J.2
Huggins, D.3
Grant, G.H.4
Campbell, M.M.5
-
53
-
-
17444381184
-
Chemicals call bacteria, and a new membrane protein machine answers
-
Shokat, K.M. (2005) Chemicals call bacteria, and a new membrane protein machine answers. Cell 121: 163-166.
-
(2005)
Cell
, vol.121
, pp. 163-166
-
-
Shokat, K.M.1
-
54
-
-
0035850868
-
Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin
-
Eggert, U.S., Ruiz, N., Falcone, B.V., Branstrom, A.A., Goldman, R.C., Silhavy, T.J., Kahne, D. (2001) Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin. Science 294: 361-364.
-
(2001)
Science
, vol.294
, pp. 361-364
-
-
Eggert, U.S.1
Ruiz, N.2
Falcone, B.V.3
Branstrom, A.A.4
Goldman, R.C.5
Silhavy, T.J.6
Kahne, D.7
-
55
-
-
17444385981
-
Chemical conditionality: A genetic strategy to probe organelle assembly
-
Ruiz, N., Falcone, B., Kahne, D., Silhavy, T.J. (2005) Chemical conditionality: a genetic strategy to probe organelle assembly. Cell 121: 307-317.
-
(2005)
Cell
, vol.121
, pp. 307-317
-
-
Ruiz, N.1
Falcone, B.2
Kahne, D.3
Silhavy, T.J.4
-
56
-
-
17444381980
-
Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli
-
Wu, T., Malinverni, J., Ruiz, N., Kim, S., Silhavy, T.J., Kahne, D. (2005) Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli. Cell 121: 235-245.
-
(2005)
Cell
, vol.121
, pp. 235-245
-
-
Wu, T.1
Malinverni, J.2
Ruiz, N.3
Kim, S.4
Silhavy, T.J.5
Kahne, D.6
-
57
-
-
19544372802
-
Restoring permeability barrier function to outer membrane
-
Nikaido, H. (2005) Restoring permeability barrier function to outer membrane. Chem. Biol. 12: 507-509.
-
(2005)
Chem. Biol.
, vol.12
, pp. 507-509
-
-
Nikaido, H.1
-
58
-
-
0033583497
-
Arachidonic acid amide inhibitors of gap junction cell-cell communication
-
Boger, D.L., Sato, H., Lerner, A.E., Guan, X., Gilula, N.B. (1999) Arachidonic acid amide inhibitors of gap junction cell-cell communication. Bioorg. Med. Chem. Lett. 9: 1151-1154.
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.9
, pp. 1151-1154
-
-
Boger, D.L.1
Sato, H.2
Lerner, A.E.3
Guan, X.4
Gilula, N.B.5
-
59
-
-
0029004101
-
Chemical characterization of a family of brain lipids that induce sleep
-
Cravatt, B.F., Prospero-Garcia, O., Siuzdak, G., Gilula, N.B., Henriksen, S.J., Boger, D.L., Lerner, R.A. (1995) Chemical characterization of a family of brain lipids that induce sleep. Science 268: 1506-1509.
-
(1995)
Science
, vol.268
, pp. 1506-1509
-
-
Cravatt, B.F.1
Prospero-Garcia, O.2
Siuzdak, G.3
Gilula, N.B.4
Henriksen, S.J.5
Boger, D.L.6
Lerner, R.A.7
-
60
-
-
0035930485
-
Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice
-
Laposky, A.D., Homanics, G.E., Basile, A., Mendelson, W.B. (2001) Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice. Neuroreport 12: 4143-4147.
-
(2001)
Neuroreport
, vol.12
, pp. 4143-4147
-
-
Laposky, A.D.1
Homanics, G.E.2
Basile, A.3
Mendelson, W.B.4
-
61
-
-
27144529566
-
Anandamide acts as an intracellular messenger amplifying Ca(2+) influx via TRPV1 channels
-
van der, S.M., Trevisani, M., Vellani, V., De, P.L., Schiano, M.A., Campi, B., McNaughton, P., Geppetti, P., Di, M. V (2005) Anandamide acts as an intracellular messenger amplifying Ca(2+) influx via TRPV1 channels. EMBO J.
-
(2005)
EMBO J.
-
-
Van Der, S.M.1
Trevisani, M.2
Vellani, V.3
De, P.L.4
Schiano, M.A.5
Campi, B.6
McNaughton, P.7
Geppetti, P.8
Di, M.V.9
-
62
-
-
0030885267
-
Anandamide may mediate sleep induction
-
Mechoulam, R., Fride, E., Hanus, L., Sheskin, T., Bisogno, T., Di, M., V, Bayewitch, M., Vogel, Z. (1997) Anandamide may mediate sleep induction. Nature 389: 25-26.
-
(1997)
Nature
, vol.389
, pp. 25-26
-
-
Mechoulam, R.1
Fride, E.2
Hanus, L.3
Sheskin, T.4
Bisogno, T.5
Di, M.6
Bayewitch, M.7
Vogel, Z.8
-
63
-
-
0028589390
-
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
-
Di, M., V, Fontana, A., Cadas, H., Schinelli, S., Cimino, G., Schwartz, J.C., Piomelli, D. (1994) Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 372: 686-691.
-
(1994)
Nature
, vol.372
, pp. 686-691
-
-
Di, M.1
Fontana, A.2
Cadas, H.3
Schinelli, S.4
Cimino, G.5
Schwartz, J.C.6
Piomelli, D.7
-
64
-
-
0036089489
-
Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo
-
Lichtman, A.H., Hawkins, E.G., Griffin, G., Cravatt, B.F. (2002) Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. J. Pharmacol. Exp. Ther. 302: 73-79.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.302
, pp. 73-79
-
-
Lichtman, A.H.1
Hawkins, E.G.2
Griffin, G.3
Cravatt, B.F.4
-
65
-
-
0029904838
-
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
-
Cravatt, B.F., Giang, D.K., Mayfield, S.P., Boger, D.L., Lerner, R.A., Gilula, N.B. (1996) Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384: 83-87.
-
(1996)
Nature
, vol.384
, pp. 83-87
-
-
Cravatt, B.F.1
Giang, D.K.2
Mayfield, S.P.3
Boger, D.L.4
Lerner, R.A.5
Gilula, N.B.6
-
66
-
-
12944277105
-
Exceptionally potent inhibitors of fatty add amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide
-
Boger, D.L., Sato, H., Lerner, A.E., Hedrick, M.P., Fecik, R.A., Miyauchi, H., Wilkie, G.D., Austin, B.J., Patricelli, M.P., Cravatt, B.F. (2000) Exceptionally potent inhibitors of fatty add amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Proc. Natl. Acad. Sci. USA 97: 5044-5049.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5044-5049
-
-
Boger, D.L.1
Sato, H.2
Lerner, A.E.3
Hedrick, M.P.4
Fecik, R.A.5
Miyauchi, H.6
Wilkie, G.D.7
Austin, B.J.8
Patricelli, M.P.9
Cravatt, B.F.10
-
67
-
-
20144377098
-
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics
-
Boger, D.L., Miyauchi, H., Du, W., Hardouin, C., Fecik, R.A., Cheng, H., Hwang, I., Hedrick, M.P., Leung, D., Acevedo, O., Guimaraes, C.R., Jorgensen, W.L., Cravatt, B.F. (2005) Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. J. Med. Chem. 48: 1849-1856.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 1849-1856
-
-
Boger, D.L.1
Miyauchi, H.2
Du, W.3
Hardouin, C.4
Fecik, R.A.5
Cheng, H.6
Hwang, I.7
Hedrick, M.P.8
Leung, D.9
Acevedo, O.10
Guimaraes, C.R.11
Jorgensen, W.L.12
Cravatt, B.F.13
-
68
-
-
13944263535
-
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: Concurrent optimization of enzyme inhibitor potency and selectivity
-
Leung, D., Du, W., Hardouin, C., Cheng, H., Hwang, I., Cravatt, B.F., Boger, D.L. (2005) Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity. Bioorg. Med. Chem. Lett. 15: 1423-1428.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 1423-1428
-
-
Leung, D.1
Du, W.2
Hardouin, C.3
Cheng, H.4
Hwang, I.5
Cravatt, B.F.6
Boger, D.L.7
-
69
-
-
20444401187
-
Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations
-
Norris, E.H., Giasson, B.I., Hodara, R., Xu, S., Trojanowski, J.Q., Ischiropoulos, H., Lee, V.M. (2005) Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. J. Biol. Chem. 280: 21212-21219.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 21212-21219
-
-
Norris, E.H.1
Giasson, B.I.2
Hodara, R.3
Xu, S.4
Trojanowski, J.Q.5
Ischiropoulos, H.6
Lee, V.M.7
-
70
-
-
0035834360
-
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
-
Conway, K.A., Rochet, J.C., Bieganski, R.M., Lansbury, P.T., Jr. (2001) Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 294: 1346-1349.
-
(2001)
Science
, vol.294
, pp. 1346-1349
-
-
Conway, K.A.1
Rochet, J.C.2
Bieganski, R.M.3
Lansbury Jr., P.T.4
-
71
-
-
0037079077
-
Chemical genetics: A small molecule approach to neurobiology
-
Koh, B., Crews, C.M. (2002) Chemical genetics: a small molecule approach to neurobiology. Neuron 36: 563-566.
-
(2002)
Neuron
, vol.36
, pp. 563-566
-
-
Koh, B.1
Crews, C.M.2
-
72
-
-
0037079065
-
Chemical genetic screening approaches to neurobiology
-
Stockwell, B.R. (2002) Chemical genetic screening approaches to neurobiology. Neuron 36: 559-562.
-
(2002)
Neuron
, vol.36
, pp. 559-562
-
-
Stockwell, B.R.1
-
73
-
-
9344247454
-
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips
-
Huang, J., Zhu, H., Haggarty, S.J., Spring, D.R., Hwang, H., Jin, F., Snyder, M., Schreiber, S.L. (2004) Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc. Natl. Acad. Sci. USA 101: 16594-16599.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 16594-16599
-
-
Huang, J.1
Zhu, H.2
Haggarty, S.J.3
Spring, D.R.4
Hwang, H.5
Jin, F.6
Snyder, M.7
Schreiber, S.L.8
-
74
-
-
18844446425
-
Insights into TOR function and rapamycin response: Chemical genomic profiling by using a high-density cell array method
-
Xie, M.W., Jin, F., Hwang, H., Hwang, S., Anand, V., Duncan, M.C., Huang, J. (2005) Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method. Proc. Natl. Acad. Sci. USA 102: 7215-7220.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 7215-7220
-
-
Xie, M.W.1
Jin, F.2
Hwang, H.3
Hwang, S.4
Anand, V.5
Duncan, M.C.6
Huang, J.7
-
75
-
-
0034306163
-
Chemical genetics: New tools for understanding signalling networks
-
Kellogg, D. (2000) Chemical genetics: new tools for understanding signalling networks. Nat. Cell Biol. 2: E180-E181.
-
(2000)
Nat. Cell Biol.
, vol.2
-
-
Kellogg, D.1
-
76
-
-
0037101904
-
Novel chemical genetic approaches to the discovery of signal transduction inhibitors
-
Shokat, K., Velleca, M. (2002) Novel chemical genetic approaches to the discovery of signal transduction inhibitors. Drug Discov. Today 7: 872-879.
-
(2002)
Drug Discov. Today
, vol.7
, pp. 872-879
-
-
Shokat, K.1
Velleca, M.2
-
77
-
-
0036532116
-
The emerging power of chemical genetics
-
Specht, K.M., Shokat, K.M. (2002) The emerging power of chemical genetics. Curr. Opin. Cell Biol. 14: 155-159.
-
(2002)
Curr. Opin. Cell Biol.
, vol.14
, pp. 155-159
-
-
Specht, K.M.1
Shokat, K.M.2
-
78
-
-
0032568055
-
Design of allele-specific inhibitors to probe protein kinase signaling
-
Bishop, A.C., Shah, K., Liu, Y., Witucki, L., Kung, C., Shokat, K.M. (1998) Design of allele-specific inhibitors to probe protein kinase signaling. Curr. Biol. 8: 257-266.
-
(1998)
Curr. Biol.
, vol.8
, pp. 257-266
-
-
Bishop, A.C.1
Shah, K.2
Liu, Y.3
Witucki, L.4
Kung, C.5
Shokat, K.M.6
-
79
-
-
0033028073
-
Acquisition of inhibitor-sensitive protein kinases through protein design
-
Bishop, A.C., Shokat, K.M. (1999) Acquisition of inhibitor-sensitive protein kinases through protein design. Pharmacol. Ther. 82: 337-346.
-
(1999)
Pharmacol. Ther.
, vol.82
, pp. 337-346
-
-
Bishop, A.C.1
Shokat, K.M.2
-
80
-
-
0034699382
-
A chemical switch for inhibitor-sensitive alleles of any protein kinase
-
Bishop, A.C., Ubersax, J.A., Petsch, D.T., Matheos, D.P., Gray, N.S., Blethrow, J., Shimizu, E., Tsien, J.Z., Schultz, P.G., Rose, M.D., Wood, J.L., Morgan, D.O., Shokat, K.M. (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407: 395-401.
-
(2000)
Nature
, vol.407
, pp. 395-401
-
-
Bishop, A.C.1
Ubersax, J.A.2
Petsch, D.T.3
Matheos, D.P.4
Gray, N.S.5
Blethrow, J.6
Shimizu, E.7
Tsien, J.Z.8
Schultz, P.G.9
Rose, M.D.10
Wood, J.L.11
Morgan, D.O.12
Shokat, K.M.13
-
81
-
-
0035312350
-
Magic bullets for protein kinases
-
Bishop, A.C., Buzko, O., Shokat, K.M. (2001) Magic bullets for protein kinases. Trends Cell Biol. 11: 167-172.
-
(2001)
Trends Cell Biol.
, vol.11
, pp. 167-172
-
-
Bishop, A.C.1
Buzko, O.2
Shokat, K.M.3
-
82
-
-
0042470386
-
Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events
-
Sreenivasan, A., Bishop, A.C., Shokat, K.M., Kellogg, D.R. (2003) Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events. Mol. Cell Biol. 23: 6327-6337.
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 6327-6337
-
-
Sreenivasan, A.1
Bishop, A.C.2
Shokat, K.M.3
Kellogg, D.R.4
-
83
-
-
0035935737
-
Neoceptor concept based on molecular complementarity in GPCRs: A mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides
-
Jacobson, KA, Gao, Z.G., Chen, A., Barak, D., Kim, S.A., Lee, K., Link, A., Rompaey, P.V., van Calenbergh, S., Liang et al. (2001) Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. Journal Of Medicinal Chemistry 44: 4125-4136.
-
(2001)
Journal of Medicinal Chemistry
, vol.44
, pp. 4125-4136
-
-
Jacobson, K.A.1
Gao, Z.G.2
Chen, A.3
Barak, D.4
Kim, S.A.5
Lee, K.6
Link, A.7
Rompaey, P.V.8
Van Calenbergh, S.9
Liang10
-
84
-
-
0031929308
-
Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR
-
Peet, D.J., Doyle, D.F., Corey, D.R., Mangelsdorf, D.J. (1998) Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR. Chemistry & Biology 5: 13-21.
-
(1998)
Chemistry & Biology
, vol.5
, pp. 13-21
-
-
Peet, D.J.1
Doyle, D.F.2
Corey, D.R.3
Mangelsdorf, D.J.4
-
85
-
-
0033541082
-
Selective regulation of gene expression using rationally-modified retinoic acid receptors
-
Koh, J.T., Putnam, M., Tomic-Canic, M., McDaniel, C.M. (1999) Selective regulation of gene expression using rationally-modified retinoic acid receptors. Journal of the American Chemical Society 121: 1984-1985.
-
(1999)
Journal of the American Chemical Society
, vol.121
, pp. 1984-1985
-
-
Koh, J.T.1
Putnam, M.2
Tomic-Canic, M.3
McDaniel, C.M.4
-
86
-
-
0035068096
-
The estrogen receptor: A structure-based approach to the design of new specific hormone-receptor combinations
-
Tedesco, R., Thomas, JA, Katzenellenbogen, B.S., Katzenellenbogen, JA (2001) The estrogen receptor: a structure-based approach to the design of new specific hormone-receptor combinations. Chemistry & Biology 8: 277-287.
-
(2001)
Chemistry & Biology
, vol.8
, pp. 277-287
-
-
Tedesco, R.1
Thomas, J.A.2
Katzenellenbogen, B.S.3
Katzenellenbogen, J.A.4
-
87
-
-
0031940393
-
Controlling signaling with a specifically designed Gi-coupled receptor
-
Coward, P., Wada, H.G., Falk, M.S., Chan, S.D., Meng, F., Akil, H., Conklin, B.R. (1998) Controlling signaling with a specifically designed Gi-coupled receptor. PNAS 95: 352-357.
-
(1998)
PNAS
, vol.95
, pp. 352-357
-
-
Coward, P.1
Wada, H.G.2
Falk, M.S.3
Chan, S.D.4
Meng, F.5
Akil, H.6
Conklin, B.R.7
-
88
-
-
0032966673
-
Conditional expression and signaling of a specifically designed G(i)-coupled receptor in transgenic mice
-
Redfern, C.H., Coward, P., Degtyarev, M.Y., Lee, E.K., Kwa, A.T., Hennighausen, L., Bujard, H., Fishman, G.I., Conklin, B.R. (1999) Conditional expression and signaling of a specifically designed G(i)-coupled receptor in transgenic mice. Nature Biotechnology 17: 165-169.
-
(1999)
Nature Biotechnology
, vol.17
, pp. 165-169
-
-
Redfern, C.H.1
Coward, P.2
Degtyarev, M.Y.3
Lee, E.K.4
Kwa, A.T.5
Hennighausen, L.6
Bujard, H.7
Fishman, G.I.8
Conklin, B.R.9
-
89
-
-
0035845540
-
A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions
-
Peterson, J.R., Lokey, R.S., Mitchison, T.J., Kirschner, M.W. (2001) A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc. Natl. Acad. Sci. USA 98: 10624-10629.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10624-10629
-
-
Peterson, J.R.1
Lokey, R.S.2
Mitchison, T.J.3
Kirschner, M.W.4
-
90
-
-
4644260677
-
Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues
-
Brozinick, J.T., Jr., Hawkins, E.D., Strawbridge, A.B., Elmendorf, J.S. (2004) Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues. J. Biol. Chem. 279: 40699-40706.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 40699-40706
-
-
Brozinick Jr., J.T.1
Hawkins, E.D.2
Strawbridge, A.B.3
Elmendorf, J.S.4
-
91
-
-
7444238614
-
Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived pep tides: Creation of a new tri-functional inhibitor
-
Scarpi, D., McBride, J.D., Leatherbarrow, R.J. (2004) Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived pep tides: creation of a new tri-functional inhibitor. Bioorg. Med. Chem. 12: 6045-6052.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, pp. 6045-6052
-
-
Scarpi, D.1
McBride, J.D.2
Leatherbarrow, R.J.3
-
92
-
-
18044368932
-
Design, synthesis and analysis of novel bicyclic and bifunctional protease inhibitors
-
Jaulent, A.M., Leatherbarrow, R.. (2004) Design, synthesis and analysis of novel bicyclic and bifunctional protease inhibitors. Protein Eng. Des. Sel. 17: 681-687.
-
(2004)
Protein Eng. Des. Sel.
, vol.17
, pp. 681-687
-
-
Jaulent, A.M.1
Leatherbarrow, R.2
-
93
-
-
0035793719
-
The Bowman-Birk inhibitor reactive site loop sequence represents an independent structural beta-hairpin motif
-
Brauer, A.B., Kelly, G., McBride, J.D., Cooke, R.M., Matthews, S.., Leatherbarrow, R.. (2001) The Bowman-Birk inhibitor reactive site loop sequence represents an independent structural beta-hairpin motif. J. Mol.Biol. 306: 799-807.
-
(2001)
J. Mol.Biol.
, vol.306
, pp. 799-807
-
-
Brauer, A.B.1
Kelly, G.2
McBride, J.D.3
Cooke, R.M.4
Matthews, S.5
Leatherbarrow, R.6
-
94
-
-
0029894753
-
Caged compounds of hydrolysis-resistant analogues of cAMP and cGMP: Synthesis and application to cyclic nucleotide-gated channels
-
Hagen, V., Dzeja, C., Frings, S., Bendig, J., Krause, E., Kaupp, U.B. (1996) Caged compounds of hydrolysis-resistant analogues of cAMP and cGMP: synthesis and application to cyclic nucleotide-gated channels. Biochemistry 35: 7762-7771.
-
(1996)
Biochemistry
, vol.35
, pp. 7762-7771
-
-
Hagen, V.1
Dzeja, C.2
Frings, S.3
Bendig, J.4
Krause, E.5
Kaupp, U.B.6
-
95
-
-
0028914923
-
Caged cyclic ADP-ribose. Synthesis and use
-
Aarhus, R., Gee, K., Lee, H.C. (1995) Caged cyclic ADP-ribose. Synthesis and use. J. Biol Chem. 270: 7745-7749.
-
(1995)
J. Biol Chem.
, vol.270
, pp. 7745-7749
-
-
Aarhus, R.1
Gee, K.2
Lee, H.C.3
-
96
-
-
0020438546
-
Relaxation of muscle fibres by photolysis of caged ATP
-
Goldman, Y.E., Hibberd, M.G., McCray, J.A., Trentham, D.R. (1982) Relaxation of muscle fibres by photolysis of caged ATP. Nature 300: 701-705.
-
(1982)
Nature
, vol.300
, pp. 701-705
-
-
Goldman, Y.E.1
Hibberd, M.G.2
McCray, J.A.3
Trentham, D.R.4
-
97
-
-
0029819903
-
Photolabile donors of nitric oxide: Ruthenium nitrosyl chlorides as caged nitric oxide
-
Bettache, N., Carter, T., Corrie, J.E., Ogden, D., Trentham, D.R. (1996) Photolabile donors of nitric oxide: ruthenium nitrosyl chlorides as caged nitric oxide. Methods Enzymol. 268: 266-281.
-
(1996)
Methods Enzymol.
, vol.268
, pp. 266-281
-
-
Bettache, N.1
Carter, T.2
Corrie, J.E.3
Ogden, D.4
Trentham, D.R.5
-
98
-
-
0036009890
-
Photo-control of nitric oxide synthase activity using a caged isoform specific inhibitor
-
Montgomery, H.J., Perdicakis, B., Fishlock, D., Lajoie, G.A., Jervis, E., Guy, G.J. (2002) Photo-control of nitric oxide synthase activity using a caged isoform specific inhibitor. Bioorg. Med. Chem. 10: 1919-1927.
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 1919-1927
-
-
Montgomery, H.J.1
Perdicakis, B.2
Fishlock, D.3
Lajoie, G.A.4
Jervis, E.5
Guy, G.J.6
-
99
-
-
0040953275
-
A new photolabile precursor of glycine with improved properties: A tool for chemical kinetic investigations of the glycine receptor
-
Grewer, C., Jager, J., Carpenter, B.K., Hess, G.P. (2000) A new photolabile precursor of glycine with improved properties: A tool for chemical kinetic investigations of the glycine receptor. Biochemistry 39: 2063-2070.
-
(2000)
Biochemistry
, vol.39
, pp. 2063-2070
-
-
Grewer, C.1
Jager, J.2
Carpenter, B.K.3
Hess, G.P.4
-
100
-
-
0023682272
-
Inactivation and block of calcium channels by photo-released Ca2+ in dorsal root ganglion neurons
-
Morad, M., Davies, N.W., Kaplan, J.H., Lux, H.D. (1988) Inactivation and block of calcium channels by photo-released Ca2+ in dorsal root ganglion neurons. Science 241: 842-844.
-
(1988)
Science
, vol.241
, pp. 842-844
-
-
Morad, M.1
Davies, N.W.2
Kaplan, J.H.3
Lux, H.D.4
-
101
-
-
0024854383
-
Caged-Ca2+: A new agent allowing liberation of free Ca2+ in biological systems by photolysis
-
Grell, E., Lewitzki, E., Ruf, H., Bamberg, E., Ellis-Davies, G.G., Kaplan, J.H., de, W.P. (1989) Caged-Ca2+: a new agent allowing liberation of free Ca2+ in biological systems by photolysis. Cell Mol. Biol. 35: 515-522.
-
(1989)
Cell Mol. Biol.
, vol.35
, pp. 515-522
-
-
Grell, E.1
Lewitzki, E.2
Ruf, H.3
Bamberg, E.4
Ellis-Davies, G.G.5
Kaplan, J.H.6
De, W.P.7
-
102
-
-
1842531328
-
Photolysis of caged phosphatidic acid induces flagellar excision in Chlamydomonas
-
Goedhart, J., Gadella, T.W., Jr. (2004) Photolysis of caged phosphatidic acid induces flagellar excision in Chlamydomonas. Biochemistry 43: 4263-4271.
-
(2004)
Biochemistry
, vol.43
, pp. 4263-4271
-
-
Goedhart, J.1
Gadella Jr., T.W.2
-
103
-
-
0031459422
-
Induction of long-term depression and rebound potentiation by inositol trisphosphate in cerebellar Purkinje neurons
-
Khodakhah, K., Armstrong, C.M. (1997) Induction of long-term depression and rebound potentiation by inositol trisphosphate in cerebellar Purkinje neurons. Proc. Natl. Acad. Sci. USA 94: 14009-14014.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 14009-14014
-
-
Khodakhah, K.1
Armstrong, C.M.2
-
104
-
-
0032580157
-
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
-
Li, W., Llopis, J., Whitney, M., Zlokarnik, G., Tsien, R.Y. (1998) Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature 392: 936-941.
-
(1998)
Nature
, vol.392
, pp. 936-941
-
-
Li, W.1
Llopis, J.2
Whitney, M.3
Zlokarnik, G.4
Tsien, R.Y.5
-
105
-
-
0242721305
-
Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: Lack of evidence for Ins(1,4,5)P3 receptor sensitization
-
Samways, D.S., Li, W.H., Conway, S.J., Holmes, A.B., Bootman, M.D., Henderson, G. (2003) Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization. Biochem. J. 375: 713-720.
-
(2003)
Biochem. J.
, vol.375
, pp. 713-720
-
-
Samways, D.S.1
Li, W.H.2
Conway, S.J.3
Holmes, A.B.4
Bootman, M.D.5
Henderson, G.6
-
106
-
-
0024559489
-
Photolabile precursors of inositol phosphates. Preparation and properties of 1-(2-nitrophenyl)ethyl esters of myo-inositol 1,4,5-trisphosphate
-
Walker, J.W., Feeney, J., Trentham, D.R. (1989) Photolabile precursors of inositol phosphates. Preparation and properties of 1-(2-nitrophenyl)ethyl esters of myo-inositol 1,4,5-trisphosphate. Biochemistry 28: 3272-3280.
-
(1989)
Biochemistry
, vol.28
, pp. 3272-3280
-
-
Walker, J.W.1
Feeney, J.2
Trentham, D.R.3
-
107
-
-
0028829059
-
Confocal imaging and local photolysis of caged compounds: Dual probes of synaptic function
-
Wang, S.S., Augustine, G.J. (1995) Confocal imaging and local photolysis of caged compounds: dual probes of synaptic function. Neuron 15: 755-760.
-
(1995)
Neuron
, vol.15
, pp. 755-760
-
-
Wang, S.S.1
Augustine, G.J.2
-
108
-
-
0030895628
-
Caged cysteine and thiophosaphoryl peptides
-
Pan, P., Bayley, H. (1997) Caged cysteine and thiophosaphoryl peptides. FEBS Lett. 405: 81-85.
-
(1997)
FEBS Lett.
, vol.405
, pp. 81-85
-
-
Pan, P.1
Bayley, H.2
-
109
-
-
0037077687
-
A caged sperm-activating peptide that has a photocleavable protecting group on the backbone amide
-
Tatsu, Y., Nishigaki, T., Darszon, A., Yumoto, N. (2002) A caged sperm-activating peptide that has a photocleavable protecting group on the backbone amide. FEBS Lett. 525: 20-24.
-
(2002)
FEBS Lett.
, vol.525
, pp. 20-24
-
-
Tatsu, Y.1
Nishigaki, T.2
Darszon, A.3
Yumoto, N.4
-
110
-
-
0032539603
-
Signaling pathways underlying eosinophil cell motility revealed by using caged peptides
-
Walker, J.W., Gilbert, S.H., Drummond, R.M., Yamada, M., Sreekumar, R., Carraway, R.E., Ikebe, M., Fay, F.S. (1998) Signaling pathways underlying eosinophil cell motility revealed by using caged peptides. Proc. Natl. Acad. Sci. USA 95: 1568-1573.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1568-1573
-
-
Walker, J.W.1
Gilbert, S.H.2
Drummond, R.M.3
Yamada, M.4
Sreekumar, R.5
Carraway, R.E.6
Ikebe, M.7
Fay, F.S.8
-
111
-
-
0029310574
-
A photogenerated pore-forming protein
-
Chang, C.Y., Niblack, B., Walker, B., Bayley, H. (1995) A photogenerated pore-forming protein. Chem. Biol. 2: 391-400.
-
(1995)
Chem. Biol.
, vol.2
, pp. 391-400
-
-
Chang, C.Y.1
Niblack, B.2
Walker, B.3
Bayley, H.4
-
112
-
-
0029964532
-
Light-directed generation of the actin-activated ATPase activity of caged heavy meromyosin
-
Marriott, G., Heidecker, M. (1996) Light-directed generation of the actin-activated ATPase activity of caged heavy meromyosin. Biochemistry 35: 3170-3174.
-
(1996)
Biochemistry
, vol.35
, pp. 3170-3174
-
-
Marriott, G.1
Heidecker, M.2
-
113
-
-
0035947763
-
Local photorelease of caged thymosin beta4 in locomoting keratocytes causes cell turning
-
Roy, P., Rajfur, Z., Jones, D., Marriott, G., Loew, L., Jacobson, K. (2001) Local photorelease of caged thymosin beta4 in locomoting keratocytes causes cell turning. J. Cell Biol. 153: 1035-1048.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 1035-1048
-
-
Roy, P.1
Rajfur, Z.2
Jones, D.3
Marriott, G.4
Loew, L.5
Jacobson, K.6
-
114
-
-
0034928842
-
Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos
-
Ando, H., Furuta, T., Tsien, R.Y., Okamoto, H. (2001) Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos. Nat. Genet. 28: 317-325.
-
(2001)
Nat. Genet.
, vol.28
, pp. 317-325
-
-
Ando, H.1
Furuta, T.2
Tsien, R.Y.3
Okamoto, H.4
-
115
-
-
0025357516
-
Kinetics and mechanism of DNA repair. Evaluation of caged compounds for use in studies of u.V.-induced DNA repair
-
Meldrum, R.A., Shall, S., Wharton, C.W. (1990) Kinetics and mechanism of DNA repair. Evaluation of caged compounds for use in studies of u.V.-induced DNA repair. Biochem. J. 266: 891-895.
-
(1990)
Biochem. J.
, vol.266
, pp. 891-895
-
-
Meldrum, R.A.1
Shall, S.2
Wharton, C.W.3
-
116
-
-
3543019087
-
Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function
-
Nguyen, A., Rothman, D.M., Stehn, J., Imperiali, B., Yaffe, M.B. (2004) Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function. Nat. Biotechnol. 22: 993-1000.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 993-1000
-
-
Nguyen, A.1
Rothman, D.M.2
Stehn, J.3
Imperiali, B.4
Yaffe, M.B.5
-
117
-
-
0037450782
-
Vibrio harveyi quorum sensing: A coincidence detector for two autoinducers controls gene expression
-
Mok, K.C., Wingreen, N.S., Bassler, B.L. (2003) Vibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression. EMBO J. 22: 870-881.
-
(2003)
EMBO J.
, vol.22
, pp. 870-881
-
-
Mok, K.C.1
Wingreen, N.S.2
Bassler, B.L.3
-
118
-
-
11144288181
-
Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli
-
Xavier, K.B., Bassler, B.L. (2005) Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J. Bacteriol 187: 238-248.
-
(2005)
J. Bacteriol
, vol.187
, pp. 238-248
-
-
Xavier, K.B.1
Bassler, B.L.2
-
119
-
-
0345060796
-
Chemical communication among bacteria
-
Taga, M.E., Bassler, B.L. (2003) Chemical communication among bacteria. Proc. Natl. Acad. Sci. USA 100 Suppl 2: 14549-14554.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, Issue.SUPPL. 2
, pp. 14549-14554
-
-
Taga, M.E.1
Bassler, B.L.2
-
120
-
-
0041806524
-
Bacteria-host communication: The language of hormones
-
Sperandio, V., Torres, A.G., Jarvis, B., Nataro, J.P., Kaper, J.B. (2003) Bacteria-host communication: the language of hormones. Proc. Natl. Acad. Sci. USA 100: 8951-8956.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8951-8956
-
-
Sperandio, V.1
Torres, A.G.2
Jarvis, B.3
Nataro, J.P.4
Kaper, J.B.5
-
121
-
-
0742323556
-
Traffic jams affect plant development and signal transduction
-
Surpin, M., Raikhel, N. (2004) Traffic jams affect plant development and signal transduction. Nat. Rev. Mol. Cell Biol. 5: 100-109.
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 100-109
-
-
Surpin, M.1
Raikhel, N.2
-
122
-
-
0038010068
-
Chemical genetics: Adding to the developmental biology toolbox
-
Yeh, J.R., Crews, C.M. (2003) Chemical genetics: adding to the developmental biology toolbox. Dev. Cell 5: 11-19.
-
(2003)
Dev. Cell
, vol.5
, pp. 11-19
-
-
Yeh, J.R.1
Crews, C.M.2
-
123
-
-
20044362923
-
The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach
-
Jessen, K.A., English, N.M., Yu, W.J., Maliartchouk, S., Archer, S.P., Qiu, L., Brand, R., Kuemmerle, J., Zhang, H.Z., Gehlsen, K., Drewe, J., Tseng, B., Cai, S.X., Kasibhatla, S. (2005) The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach. Mol. Cancer Ther. 4: 761-771.
-
(2005)
Mol. Cancer Ther.
, vol.4
, pp. 761-771
-
-
Jessen, K.A.1
English, N.M.2
Yu, W.J.3
Maliartchouk, S.4
Archer, S.P.5
Qiu, L.6
Brand, R.7
Kuemmerle, J.8
Zhang, H.Z.9
Gehlsen, K.10
Drewe, J.11
Tseng, B.12
Cai, S.X.13
Kasibhatla, S.14
-
124
-
-
18344389335
-
Benzobicyclooctanes as novel inhibitors of TNF-alpha signaling
-
Jackson, R.W., Gelinas, R., Baughman, T.A., Cox, T., Howbert, J.J., Kucera, K.A., Latham, J.A., Ramsdell, F., Singh, D., Darwish, I.S. (2002) Benzobicyclooctanes as novel inhibitors of TNF-alpha signaling. Bioorg. Med. Chem. Lett. 12: 1093-1097.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 1093-1097
-
-
Jackson, R.W.1
Gelinas, R.2
Baughman, T.A.3
Cox, T.4
Howbert, J.J.5
Kucera, K.A.6
Latham, J.A.7
Ramsdell, F.8
Singh, D.9
Darwish, I.S.10
-
125
-
-
0037492366
-
The platelet as a model for chemical genetics
-
Flaumenhaft, R., Sim, D.S. (2003) The platelet as a model for chemical genetics. Chem. Biol. 10: 481-486.
-
(2003)
Chem. Biol.
, vol.10
, pp. 481-486
-
-
Flaumenhaft, R.1
Sim, D.S.2
-
126
-
-
0037264524
-
The GRID: The General Repository for Interaction Datasets
-
Breitkreutz, B.J., Stark, C., Tyers, M. (2003) The GRID: The General Repository for Interaction Datasets. Genome Biology 4: R23.
-
(2003)
Genome Biology
, vol.4
-
-
Breitkreutz, B.J.1
Stark, C.2
Tyers, M.3
-
128
-
-
0034461768
-
Drug-like properties and the causes of poor solubility and poor permeability
-
Lipinski, C.A. (2000) Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 44: 235-249.
-
(2000)
J. Pharmacol. Toxicol. Methods
, vol.44
, pp. 235-249
-
-
Lipinski, C.A.1
-
129
-
-
0037252194
-
Chris Lipinski discusses life and chemistry after the Rule of Five
-
Lipinski, C.A. (2003) Chris Lipinski discusses life and chemistry after the Rule of Five. Drug Discov. Today 8: 12-16.
-
(2003)
Drug Discov. Today
, vol.8
, pp. 12-16
-
-
Lipinski, C.A.1
-
130
-
-
0031984072
-
Trojan peptides: The penetratin system for intracellular delivery
-
Derossi, D., Chassaing, G., Prochiantz, A. (1998) Trojan peptides: the penetratin system for intracellular delivery. Trends Cell Biol. 8: 84-87.
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 84-87
-
-
Derossi, D.1
Chassaing, G.2
Prochiantz, A.3
|