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Volumn 9, Issue 3, 2005, Pages 277-284

Chemical library synthesis using convergent approaches

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; SHORT SURVEY; SYNTHESIS;

EID: 20444392074     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2005.04.005     Document Type: Review
Times cited : (23)

References (44)
  • 1
    • 84955110379 scopus 로고    scopus 로고
    • The use of templates in combinatorial chemistry for the solid-phase synthesis of multiple core structure libraries
    • G. Jung Wiley-VCH
    • H. Richter, and A.W. Trautwein The use of templates in combinatorial chemistry for the solid-phase synthesis of multiple core structure libraries G. Jung Combinatorial Chemistry. Synthesis, Analysis, Screening 1999 Wiley-VCH 229 256
    • (1999) Combinatorial Chemistry. Synthesis, Analysis, Screening , pp. 229-256
    • Richter, H.1    Trautwein, A.W.2
  • 2
    • 0035513630 scopus 로고    scopus 로고
    • Comprehensive survey of combinatorial library synthesis: 2000
    • R.E. Dolle Comprehensive survey of combinatorial library synthesis: 2000 J Comb Chem 3 2001 477 517
    • (2001) J Comb Chem , vol.3 , pp. 477-517
    • Dolle, R.E.1
  • 3
    • 3042799070 scopus 로고    scopus 로고
    • A planning strategy for diversity-oriented synthesis
    • M.D. Burke, and S.L. Schreiber A planning strategy for diversity-oriented synthesis Angew Chem Int Ed Engl 43 2004 46 58
    • (2004) Angew Chem Int Ed Engl , vol.43 , pp. 46-58
    • Burke, M.D.1    Schreiber, S.L.2
  • 4
    • 4544326369 scopus 로고    scopus 로고
    • Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates
    • S.J. Taylor, A.M. Taylor, and S.L. Schreiber Synthetic strategy toward skeletal diversity via solid-supported, otherwise unstable reactive intermediates Angew Chem Int Ed Engl 43 2004 1681 1685
    • (2004) Angew Chem Int Ed Engl , vol.43 , pp. 1681-1685
    • Taylor, S.J.1    Taylor, A.M.2    Schreiber, S.L.3
  • 5
    • 0142147275 scopus 로고    scopus 로고
    • Generating diverse skeletons of small molecules combinatorially
    • M.D. Burke, E.M. Berger, and S.L. Schreiber Generating diverse skeletons of small molecules combinatorially Science 302 2003 613 618 In this report, the authors discuss the importance of skeletal diversity and complexity for library synthesis, including strategies to access complex and diverse small molecules using diversity-oriented synthesis.
    • (2003) Science , vol.302 , pp. 613-618
    • Burke, M.D.1    Berger, E.M.2    Schreiber, S.L.3
  • 6
    • 0036008841 scopus 로고    scopus 로고
    • Toward high-throughput synthesis of complex natural product-like compounds in the genomics and proteomics age
    • P. Arya, R. Joseph, and D.T.H. Chou Toward high-throughput synthesis of complex natural product-like compounds in the genomics and proteomics age Chem Biol 9 2002 145 156 The authors review recent examples of parallel synthesis to construct libraries of complex molecules aimed at mimicking known natural products.
    • (2002) Chem Biol , vol.9 , pp. 145-156
    • Arya, P.1    Joseph, R.2    Chou, D.T.H.3
  • 7
    • 0037119336 scopus 로고    scopus 로고
    • From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries
    • R. Breinbauer, I.R. Vetter, and H. Waldmann From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries Angew Chem Int Ed Engl 41 2002 2879 2890
    • (2002) Angew Chem Int Ed Engl , vol.41 , pp. 2879-2890
    • Breinbauer, R.1    Vetter, I.R.2    Waldmann, H.3
  • 8
    • 0032834974 scopus 로고    scopus 로고
    • Convergent automated parallel synthesis
    • D.G. Powers, and D.L. Coffen Convergent automated parallel synthesis Drug Discov Today 4 1999 377 383
    • (1999) Drug Discov Today , vol.4 , pp. 377-383
    • Powers, D.G.1    Coffen, D.L.2
  • 11
    • 0032830563 scopus 로고    scopus 로고
    • Total synthesis of oleandolide
    • T. Hu, N. Takenaka, and J.S. Panek Total synthesis of oleandolide J Am Chem Soc 121 1999 9229 9230
    • (1999) J Am Chem Soc , vol.121 , pp. 9229-9230
    • Hu, T.1    Takenaka, N.2    Panek, J.S.3
  • 12
    • 0037157091 scopus 로고    scopus 로고
    • Total synthesis and stereochemical assignment of the salicylate antitumor macrolide lobatamide C
    • R. Shen, C.T. Lin, and J.A. Porco Jr. Total synthesis and stereochemical assignment of the salicylate antitumor macrolide lobatamide C J Am Chem Soc 124 2002 5650 5651
    • (2002) J Am Chem Soc , vol.124 , pp. 5650-5651
    • Shen, R.1    Lin, C.T.2    Porco Jr., J.A.3
  • 13
    • 0038354572 scopus 로고    scopus 로고
    • Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide
    • J.M. Minguez, S.Y. Kim, K.A. Giuliano, R. Balachandran, C. Madiraju, B.W. Day, and D.P. Curran Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide Bioorg Med Chem 11 2003 3335 3357
    • (2003) Bioorg Med Chem , vol.11 , pp. 3335-3357
    • Minguez, J.M.1    Kim, S.Y.2    Giuliano, K.A.3    Balachandran, R.4    Madiraju, C.5    Day, B.W.6    Curran, D.P.7
  • 14
    • 20444376062 scopus 로고    scopus 로고
    • Convergent combinatorial peptide libraries and their use for identification of epitopes for vaccines against hepatitis C virus. PCT International Application, 2001, WO 0192311.
    • Bertrand G, Gras-Masse H, Bouzidi A: Auriault C: Convergent combinatorial peptide libraries and their use for identification of epitopes for vaccines against hepatitis C virus. PCT International Application, 2001, WO 0192311.
    • Bertrand, G.1    Gras-Masse, H.2    Bouzidi, A.3    Auriault, C.4
  • 16
    • 0029890756 scopus 로고    scopus 로고
    • A convergent solid-phase synthesis of actinomycin analogs-towards implementation of double-combinatorial chemistry
    • G. Tong, and J. Nielsen A convergent solid-phase synthesis of actinomycin analogs-towards implementation of double-combinatorial chemistry Bioorg Med Chem 4 1996 693 698
    • (1996) Bioorg Med Chem , vol.4 , pp. 693-698
    • Tong, G.1    Nielsen, J.2
  • 17
    • 3543025082 scopus 로고    scopus 로고
    • Multistep convergent solution-phase combinatorial synthesis and deletion synthesis deconvolution
    • D.L. Boger, W. Chai, and Q. Jin Multistep convergent solution-phase combinatorial synthesis and deletion synthesis deconvolution J Am Chem Soc 120 1998 7220 7225
    • (1998) J Am Chem Soc , vol.120 , pp. 7220-7225
    • Boger, D.L.1    Chai, W.2    Jin, Q.3
  • 18
    • 0032537026 scopus 로고    scopus 로고
    • Solution-phase combinatorial synthesis: Convergent multiplication of diversity via the olefin metathesis reaction
    • D.L. Boger, and W. Chai Solution-phase combinatorial synthesis: convergent multiplication of diversity via the olefin metathesis reaction Tetrahedron 54 1998 3955 3970
    • (1998) Tetrahedron , vol.54 , pp. 3955-3970
    • Boger, D.L.1    Chai, W.2
  • 19
    • 0033578694 scopus 로고    scopus 로고
    • Convergent solution-phase combinatorial synthesis with multiplication of diversity through rigid biaryl and diarylacetylene couplings
    • D.L. Boger, W. Jiang, and J. Goldberg Convergent solution-phase combinatorial synthesis with multiplication of diversity through rigid biaryl and diarylacetylene couplings J Org Chem 64 1999 7094 7100
    • (1999) J Org Chem , vol.64 , pp. 7094-7100
    • Boger, D.L.1    Jiang, W.2    Goldberg, J.3
  • 20
    • 0141633672 scopus 로고    scopus 로고
    • Solution-phase combinatorial libraries: Modulating cellular signaling by target protein-protein or protein-DNA interactions
    • D.L. Boger, J. Desharnais, and K. Capps Solution-phase combinatorial libraries: modulating cellular signaling by target protein-protein or protein-DNA interactions Angew Chem Int Ed Engl 42 2003 4138 4176 The authors review chemical small molecules that function as protein-protein or protein-DNA interaction inhibitors, including compounds discovered by convergent chemical library synthesis.
    • (2003) Angew Chem Int Ed Engl , vol.42 , pp. 4138-4176
    • Boger, D.L.1    Desharnais, J.2    Capps, K.3
  • 21
    • 0035108247 scopus 로고    scopus 로고
    • Cytokine receptor dimerization and activation: Prospects for small molecule agonists
    • D.L. Boger, and J. Goldberg Cytokine receptor dimerization and activation: prospects for small molecule agonists Bioorg Med Chem 9 2001 557 562
    • (2001) Bioorg Med Chem , vol.9 , pp. 557-562
    • Boger, D.L.1    Goldberg, J.2
  • 22
    • 0037196281 scopus 로고    scopus 로고
    • Erythropoietin mimetics derived from solution phase combinatorial libraries
    • J. Goldberg, Q. Jin, Y. Ambroise, S. Satoh, J. Desharnais, K. Capps, and D.L. Boger Erythropoietin mimetics derived from solution phase combinatorial libraries J Am Chem Soc 124 2002 544 555 The authors report the discovery of the first small-molecule partial agonists of erythropoietin. This study illustrates molecules synthesized using convergent techniques in a medicinal chemistry application.
    • (2002) J Am Chem Soc , vol.124 , pp. 544-555
    • Goldberg, J.1    Jin, Q.2    Ambroise, Y.3    Satoh, S.4    Desharnais, J.5    Capps, K.6    Boger, D.L.7
  • 24
    • 0032834974 scopus 로고    scopus 로고
    • Convergent automated parallel synthesis
    • D.G. Powers, and D.L. Coffen Convergent automated parallel synthesis Drug Discov Today 4 1999 377 383
    • (1999) Drug Discov Today , vol.4 , pp. 377-383
    • Powers, D.G.1    Coffen, D.L.2
  • 27
    • 0032537090 scopus 로고    scopus 로고
    • Solution phase synthesis of a spiro[pyrrolidine-2,3′-oxindole] library via a three component 1,3-dipolar cycloaddition reaction
    • D. Fokas, W.J. Ryan, D.S. Casebier, and D.L. Coffen Solution phase synthesis of a spiro[pyrrolidine-2,3′-oxindole] library via a three component 1,3-dipolar cycloaddition reaction Tetrahedron 39 1998 2235 2238
    • (1998) Tetrahedron , vol.39 , pp. 2235-2238
    • Fokas, D.1    Ryan, W.J.2    Casebier, D.S.3    Coffen, D.L.4
  • 28
    • 0034646370 scopus 로고    scopus 로고
    • Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors
    • D.J. Maly, I.C. Choong, and J.A. Ellman Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors Proc Natl Acad Sci USA 97 2000 2419 2424
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2419-2424
    • Maly, D.J.1    Choong, I.C.2    Ellman, J.A.3
  • 29
    • 0037059901 scopus 로고    scopus 로고
    • Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly
    • J.W. Kehoe, D.J. Maly, D.E. Verdugo, J.I. Armstrong, B.N. Cook, Y.B. Ouyang, K.L. Moore, J.A. Ellman, and C.R. Bertozzi Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly Bioorg Med Chem Lett 12 2002 329 332 The authors describe an example of target-guided convergent chemical library synthesis. Tyrosylprotein sulfotransferase inhibitors were prepared employing convergent fragment coupling via oxime formation.
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 329-332
    • Kehoe, J.W.1    Maly, D.J.2    Verdugo, D.E.3    Armstrong, J.I.4    Cook, B.N.5    Ouyang, Y.B.6    Moore, K.L.7    Ellman, J.A.8    Bertozzi, C.R.9
  • 30
    • 3042689621 scopus 로고    scopus 로고
    • Fragment-based drug discovery
    • D.A. Erlanson, R.S. McDowell, and T. O'Brien Fragment-based drug discovery J Med Chem 47 2004 3463 3481 The authors provide an in-depth review of recent examples of lead fragment coupling as a tool for drug discovery.
    • (2004) J Med Chem , vol.47 , pp. 3463-3481
    • Erlanson, D.A.1    McDowell, R.S.2    O'Brien, T.3
  • 31
    • 0037459026 scopus 로고    scopus 로고
    • Soluble polymer-supported convergent parallel library synthesis
    • J. Ahn, P. Wentworth Jr., and K.D. Janda Soluble polymer-supported convergent parallel library synthesis Chem Comm 2003 480 481 The authors discuss their recent success in employing soluble polymers in convergent synthesis. This technique offers the advantages of soluble polymers in parallel synthesis in the construction of sub-libraries for use in convergent chemical library synthesis.
    • (2003) Chem Comm , pp. 480-481
    • Ahn, J.1    Wentworth Jr., P.2    Janda, K.D.3
  • 32
    • 4944263329 scopus 로고    scopus 로고
    • Solid-phase convergent synthesis of a benzimidazolone library via the combination of two smaller arrays of carboxylic acids and secondary amines
    • I. Bianchi, E. La Porta, D. Barlocco, and L.F. Raveglia Solid-phase convergent synthesis of a benzimidazolone library via the combination of two smaller arrays of carboxylic acids and secondary amines J Comb Chem 6 2004 835 845
    • (2004) J Comb Chem , vol.6 , pp. 835-845
    • Bianchi, I.1    La Porta, E.2    Barlocco, D.3    Raveglia, L.F.4
  • 33
    • 0033964648 scopus 로고    scopus 로고
    • Synthesis of highly substituted 5-(trifluoromethyl)ketoimidazoles using a mixed-solid/solution phase motif
    • B.C. Hamper, K.D. Jerome, G. Yalamanchili, D.M. Walker, R.C. Chott, and D.A. Mischke Synthesis of highly substituted 5-(trifluoromethyl)ketoimidazoles using a mixed-solid/solution phase motif Biotechnol Bioeng 71 2000 28 37
    • (2000) Biotechnol Bioeng , vol.71 , pp. 28-37
    • Hamper, B.C.1    Jerome, K.D.2    Yalamanchili, G.3    Walker, D.M.4    Chott, R.C.5    Mischke, D.A.6
  • 34
    • 0141427680 scopus 로고    scopus 로고
    • Natural product hybrids as new leads for drug discovery
    • L.F. Teitze, H.P. Bell, and S. Chandrasekhar Natural product hybrids as new leads for drug discovery Angew Chem Int Ed Engl 42 2003 3996 4028 The authors provide a review of recent examples of hybrid molecules in drug discovery.
    • (2003) Angew Chem Int Ed Engl , vol.42 , pp. 3996-4028
    • Teitze, L.F.1    Bell, H.P.2    Chandrasekhar, S.3
  • 35
    • 0036430152 scopus 로고    scopus 로고
    • Hybrid systems through natural product leads: An approach towards new molecular entities
    • G. Mehta, and V. Singh Hybrid systems through natural product leads: an approach towards new molecular entities Chem Soc Rev 31 2002 324 334
    • (2002) Chem Soc Rev , vol.31 , pp. 324-334
    • Mehta, G.1    Singh, V.2
  • 36
    • 20444387448 scopus 로고    scopus 로고
    • A powerful antibiotic tool for studying nuclear transport
    • N. Watson, and B. Leptomycin A powerful antibiotic tool for studying nuclear transport LifeSci Q 2 2001 9 11
    • (2001) LifeSci Q , vol.2 , pp. 9-11
    • Watson, N.1    Leptomycin, B.2
  • 37
    • 0027398489 scopus 로고
    • New cytotoxic annonaceous acetogenins: Bullatanocin and cis- and trans-bullatanocinone, from Annona bullata (Annonaceae)
    • Z. Gu, X.-p. Fang, M.J. Rieser, Y.-h. Hui, L.R. Meisbauer, D.L. Smith, K.V. Wood, and J.L. McLaughlin New cytotoxic annonaceous acetogenins: bullatanocin and cis- and trans-bullatanocinone, from Annona bullata (Annonaceae) Tetrahedron 49 1993 747 754
    • (1993) Tetrahedron , vol.49 , pp. 747-754
    • Gu, Z.1    Fang, X.-P.2    Rieser, M.J.3    Hui, Y.-H.4    Meisbauer, L.R.5    Smith, D.L.6    Wood, K.V.7    McLaughlin, J.L.8
  • 38
    • 0028280599 scopus 로고
    • 8-Hydroxymanzamine a a β-carboline alkaloid from a sponge Pachypellina sp
    • T. Ichiba, J.M. Corgiat, P.J. Scheuer, and M. Kelly-Borges 8-Hydroxymanzamine A a β-carboline alkaloid from a sponge Pachypellina sp J Nat Prod 57 1994 168 170
    • (1994) J Nat Prod , vol.57 , pp. 168-170
    • Ichiba, T.1    Corgiat, J.M.2    Scheuer, P.J.3    Kelly-Borges, M.4
  • 41
    • 0030502608 scopus 로고    scopus 로고
    • Synthesis and a preliminary DNA binding study of hybrids of the carbohydrate domain of calicheamicin γ and the aglycone of daunorubicin: Calichearubicins a and B
    • K.M. Depew, S.M. Zeman, S.H. Boyer, D.J. Denhart, N. Ikenoto, S.J. Danishefsky, and D.M. Crothers Synthesis and a preliminary DNA binding study of hybrids of the carbohydrate domain of calicheamicin γ and the aglycone of daunorubicin: calichearubicins A and B Angew Chem Int Ed Engl 35 1996 2797 2800
    • (1996) Angew Chem Int Ed Engl , vol.35 , pp. 2797-2800
    • Depew, K.M.1    Zeman, S.M.2    Boyer, S.H.3    Denhart, D.J.4    Ikenoto, N.5    Danishefsky, S.J.6    Crothers, D.M.7
  • 43
    • 11444263911 scopus 로고    scopus 로고
    • Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines
    • T. Iwamoto, Y. Hiraku, M. Kojima, and S. Kawanishi Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines Arch Biochem Biophys 434 2005 232 240
    • (2005) Arch Biochem Biophys , vol.434 , pp. 232-240
    • Iwamoto, T.1    Hiraku, Y.2    Kojima, M.3    Kawanishi, S.4


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