The emerging power of chemical genetics

Current Opinion in Cell Biology

Volumn 14, Issue 2, 2002, Pages 155-159

  Specht, Kimberly M ^a   Shokat, Kevan M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; COFILIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN CDC42; PROTEIN TYROSINE KINASE; WISKOTT ALDRICH SYNDROME PROTEIN;

BIOCHEMISTRY; CELL TRANSFORMATION; CHEMICAL GENETICS; HUMAN; INNER EAR; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SENSORY NERVE CELL; SIGNAL TRANSDUCTION;

EID: 0036532116     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(02)00317-4     Document Type: Review

References (18)

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4. Antimitotic natural products and their interactions with tubulin
5. Mechanism of actin-based motility
6. Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin
7. Recent advances in chemical approaches to the study of biological systems
8. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK(-) cell migration
9. The challenges of translating knockout phenotypes into gene function
10. Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue
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12. A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway
13. Design of allele-specific inhibitors to probe protein kinase signaling
14. Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response
15. A chemical-genetic strategy implicates Myosin-1c in adaptation by hair cells
16. Identification of a 120 Kd hair-bundle myosin located near stereociliary tips
17. Myosin Iβ is located at tip link anchors in vestibular hair bundles
18. Visualization of biochemical networks in living cells