Selective regulation of gene expression using rationally-modified retinoic acid receptors [16]

Journal of the American Chemical Society

Volumn 121, Issue 9, 1999, Pages 1984-1985

  Koh, John T ^a   Putnam, Marc ^a   Tomic Canic, Marjana ^a,b   McDaniel, Christine M ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LIGAND; RETINOIC ACID; RETINOIC ACID RECEPTOR;

BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA BINDING; DOSE RESPONSE; GENE; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; LETTER; LIGAND BINDING; MOLECULAR MODEL; MUTATION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

EID: 0033541082     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja983988u     Document Type: Letter

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14. HPLC analysis confirms that the amide ligands 2 and 4 were contain less than 0.1% retinoic, which should not provide a significant response at the ligand concentrations tested.
15. Assays were not run at higher ligand concentrations because high ligand concentrations, 10 and 20 μM ligand, affected cell viability.