Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: Concurrent optimization of enzyme inhibitor potency and selectivity

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 5, 2005, Pages 1423-1428

  Leung, Donmienne ^a   Du, Wu ^a   Hardouin, Christophe ^a   Cheng, Heng ^a   Hwang, Inkyu ^a   Cravatt, Benjamin F ^a   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDASE; ENZYME INHIBITOR; FATTY ACID AMIDASE; HYDROLASE INHIBITOR; OXADIAZOLE DERIVATIVE; OXAZOLE DERIVATIVE; PROTEOME; PYRIDINE DERIVATIVE; SERINE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME PURIFICATION; IC 50;

EID: 13944263535     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.12.085     Document Type: Article

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