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Volumn 20, Issue 2, 2006, Pages 121-135

Peroxisome proliferator-activated receptor-γ: Novel therapeutic target linking adiposity, insulin resistance, and atherosclerosis

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPOCYTOKINE; ADIPONECTIN; ANGIOTENSIN RECEPTOR ANTAGONIST; BISPHENOL A BIS(2 HYDROXYPROPYL) ETHER DIMETHACRYLATE; FENOPROFEN; FLUFENAMIC ACID; GW 0072; IBUPROFEN; INDOLE DERIVATIVE; INDOMETACIN; LEPTIN; LG 100641; N (2 BENZOYLPHENYL) O [2 (METHYL 2 PYRIDINYLAMINO)ETHYL]TYROSINE; NETOGLITAZONE; NONSTEROID ANTIINFLAMMATORY AGENT; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; POLYUNSATURATED FATTY ACID; RALOXIFENE; RESISTIN; RETINOID X RECEPTOR; ROSIGLITAZONE; TELMISARTAN; TRIACYLGLYCEROL; TROGLITAZONE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 33646255424     PISSN: 11738804     EISSN: 11738804     Source Type: Journal    
DOI: 10.2165/00063030-200620020-00006     Document Type: Review
Times cited : (20)

References (159)
  • 1
    • 0037223174 scopus 로고    scopus 로고
    • Prevalence of obesity, diabetes, and obesity related health risk factors 2001
    • Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity related health risk factors 2001. JAMA 2003; 289: 76-9
    • (2003) JAMA , vol.289 , pp. 76-79
    • Mokdad, A.H.1    Ford, E.S.2    Bowman, B.A.3
  • 2
    • 0037126526 scopus 로고    scopus 로고
    • Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002; 106: 3143-421
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 3
    • 0037021505 scopus 로고    scopus 로고
    • The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    • Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002; 288: 2709-16
    • (2002) JAMA , vol.288 , pp. 2709-2716
    • Lakka, H.M.1    Laaksonen, D.E.2    Lakka, T.A.3
  • 4
    • 0037469255 scopus 로고    scopus 로고
    • C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: A 8-year follow-up of 14 719 initially healthy American women
    • Ridker PM, Buring JE, Cook NR, et al. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: a 8-year follow-up of 14 719 initially healthy American women. Circulation 2003; 107: 391-7
    • (2003) Circulation , vol.107 , pp. 391-397
    • Ridker, P.M.1    Buring, J.E.2    Cook, N.R.3
  • 5
    • 0037417237 scopus 로고    scopus 로고
    • Treatment for patients with the metabolic syndrome
    • Ginsberg HN. Treatment for patients with the metabolic syndrome. Am J Cardiol 2003; 91 (7A): 29E-39E
    • (2003) Am J Cardiol , vol.91 , Issue.7 A
    • Ginsberg, H.N.1
  • 6
    • 0035094340 scopus 로고    scopus 로고
    • The pleiotropic functions of peroxisome proliferator-activated receptor γ
    • Debril MB, Renaud JP, Fajas L, et al. The pleiotropic functions of peroxisome proliferator-activated receptor γ. J Mol Med 2001; 79: 30-47
    • (2001) J Mol Med , vol.79 , pp. 30-47
    • Debril, M.B.1    Renaud, J.P.2    Fajas, L.3
  • 7
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR-γ)
    • Lehmann JM, Moore LB, Smith-Oliver TA, et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPAR-γ). J Biol Chem 1995; 270: 12953-6
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3
  • 8
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990; 347: 645-50
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 9
    • 0026517010 scopus 로고
    • Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
    • Dreyer C, Krey G, Keller H. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 1992; 68: 879-87
    • (1992) Cell , vol.68 , pp. 879-887
    • Dreyer, C.1    Krey, G.2    Keller, H.3
  • 10
    • 0028321529 scopus 로고
    • Differential expression and activation of family murine peroxisome proliferator-activated receptors
    • U S A
    • Kliewer SA, Forman BM, Blumberg B, et al. Differential expression and activation of family murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A 1994; 91: 7355-9
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 7355-7359
    • Kliewer, S.A.1    Forman, B.M.2    Blumberg, B.3
  • 11
    • 0027191040 scopus 로고
    • cDNA cloning, chromosomal mapping and functional characterization of the human peroxisome proliferator activated receptor
    • Sher T, Yi HF, McBride OW, et al. cDNA cloning, chromosomal mapping and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 1993; 32: 5598-604
    • (1993) Biochemistry , vol.32 , pp. 5598-5604
    • Sher, T.1    Yi, H.F.2    McBride, O.W.3
  • 12
    • 11144310564 scopus 로고    scopus 로고
    • An overview on biological mechanisms of PPARs
    • Kota BP, Huang TH, Roufogalis BD. An overview on biological mechanisms of PPARs. Pharmacol Res 2005; 51 (2): 85-94
    • (2005) Pharmacol Res , vol.51 , Issue.2 , pp. 85-94
    • Kota, B.P.1    Huang, T.H.2    Roufogalis, B.D.3
  • 13
    • 0026705751 scopus 로고
    • Convergence of 9-cis retinoic acid and peroxisome proliferators signaling pathways through heterodimer formation of their receptors
    • Kliewer SA, Umesono K, Noonan DJ, et al. Convergence of 9-cis retinoic acid and peroxisome proliferators signaling pathways through heterodimer formation of their receptors. Nature 1992; 358: 771-4
    • (1992) Nature , vol.358 , pp. 771-774
    • Kliewer, S.A.1    Umesono, K.2    Noonan, D.J.3
  • 14
    • 0027526301 scopus 로고
    • Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor
    • U S A
    • Gearing KL, Gottlicher M, Teboul M, et al. Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proc Natl Acad Sci U S A 1993; 90: 1440-4
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 1440-1444
    • Gearing, K.L.1    Gottlicher, M.2    Teboul, M.3
  • 15
    • 0034650893 scopus 로고    scopus 로고
    • The coregulator exchange in transcriptional functions of nuclear receptors
    • Glass CK, Rosenfeld MG. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 2000; 14 (2): 121-41
    • (2000) Genes Dev , vol.14 , Issue.2 , pp. 121-141
    • Glass, C.K.1    Rosenfeld, M.G.2
  • 16
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999; 20 (5): 649-88
    • (1999) Endocr Rev , vol.20 , Issue.5 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 17
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • Braissant O, Foufelle F, Scotto C, et al. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 1996; 137: 354-66
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3
  • 18
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor α (PPAR-α) in the cellular fasting response: The PPAR α-null mouse as a model of fatty acid oxidation disorders
    • U S A
    • Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor α (PPAR-α) in the cellular fasting response: the PPAR α-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A 1999; 96: 7473-8
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 19
    • 0032479423 scopus 로고    scopus 로고
    • Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor α and γ activators in a tissue-and inducer-specific manner
    • Motojima K, Passilly P, Peters JM, et al. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor α and γ activators in a tissue-and inducer-specific manner. J Biol Chem 1998; 273: 16710-4
    • (1998) J Biol Chem , vol.273 , pp. 16710-16714
    • Motojima, K.1    Passilly, P.2    Peters, J.M.3
  • 20
    • 0035993444 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor agonists, hyperlipidemia and atherosclerosis
    • Vosper H, Khoudoli GA, Graham TL, et al. Peroxisome proliferator-activated receptor agonists, hyperlipidemia and atherosclerosis. Pharmacol Ther 2002; 95: 47-62
    • (2002) Pharmacol Ther , vol.95 , pp. 47-62
    • Vosper, H.1    Khoudoli, G.A.2    Graham, T.L.3
  • 21
    • 0028997684 scopus 로고
    • Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    • Lee SS, Pineau T, Draogo J, et al. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 1995; 15: 3012-22
    • (1995) Mol Cell Biol , vol.15 , pp. 3012-3022
    • Lee, S.S.1    Pineau, T.2    Draogo, J.3
  • 22
    • 0031864456 scopus 로고    scopus 로고
    • Gemfibrozil reduces non-high-density lipoprotein cholesterol in exogenously hypercholesterolemic (ExHC) rats fed a high-cholesterol diet
    • Nagao K, Yoshida S, Nakagiri H, et al. Gemfibrozil reduces non-high-density lipoprotein cholesterol in exogenously hypercholesterolemic (ExHC) rats fed a high-cholesterol diet. Comp Biochem Physiol B Biochem Mol Biol 1998; 120: 579-86
    • (1998) Comp Biochem Physiol B Biochem Mol Biol , vol.120 , pp. 579-586
    • Nagao, K.1    Yoshida, S.2    Nakagiri, H.3
  • 23
    • 0034965596 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in inflammation control
    • Delerive P, Fruchart JC, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol 2001; 169 (3): 453-9
    • (2001) J Endocrinol , vol.169 , Issue.3 , pp. 453-459
    • Delerive, P.1    Fruchart, J.C.2    Staels, B.3
  • 24
    • 0038210248 scopus 로고    scopus 로고
    • Nuclear receptors and the control of metabolism
    • Francis GA, Fayard E, Picard F, et al. Nuclear receptors and the control of metabolism. Annu Rev Physiol 2003; 65: 261-311
    • (2003) Annu Rev Physiol , vol.65 , pp. 261-311
    • Francis, G.A.1    Fayard, E.2    Picard, F.3
  • 25
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann JM, Lenhard JM, Oliver BB, et al. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1997; 272 (6): 3406-10
    • (1997) J Biol Chem , vol.272 , Issue.6 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3
  • 26
    • 1542547460 scopus 로고    scopus 로고
    • Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
    • Benson SC, Pershadsingh HA, Ho CI, et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension 2004; 43 (5): 993-1002
    • (2004) Hypertension , vol.43 , Issue.5 , pp. 993-1002
    • Benson, S.C.1    Pershadsingh, H.A.2    Ho, C.I.3
  • 27
    • 2442451618 scopus 로고    scopus 로고
    • Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
    • Schupp M, Janke J, Clasen R, et al. Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity. Circulation 2004; 109 (17): 2054-7
    • (2004) Circulation , vol.109 , Issue.17 , pp. 2054-2057
    • Schupp, M.1    Janke, J.2    Clasen, R.3
  • 28
    • 8544251308 scopus 로고    scopus 로고
    • Telmisartan: Killing two birds with one stone
    • Doggrell SA. Telmisartan: killing two birds with one stone. Expert Opin Pharmacother 2004; 5 (11): 2397-400
    • (2004) Expert Opin Pharmacother , vol.5 , Issue.11 , pp. 2397-2400
    • Doggrell, S.A.1
  • 29
    • 0028972025 scopus 로고
    • 15-Deoxy-delta 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR-γ
    • Forman BM, Tontonoz P, Chen J, et al. 15-Deoxy-delta 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR-γ. Cell 1995; 83: 803-12
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.M.1    Tontonoz, P.2    Chen, J.3
  • 30
    • 0028972026 scopus 로고
    • A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
    • Kliewer SA, Lenhard JM, Wilson TM, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 1995; 83: 813-9
    • (1995) Cell , vol.83 , pp. 813-819
    • Kliewer, S.A.1    Lenhard, J.M.2    Wilson, T.M.3
  • 31
    • 0033595261 scopus 로고    scopus 로고
    • Interleukin-4 dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase
    • Huang JT, Welch JS, Ricote M, et al. Interleukin-4 dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase. Nature 1999; 400: 378-82
    • (1999) Nature , vol.400 , pp. 378-382
    • Huang, J.T.1    Welch, J.S.2    Ricote, M.3
  • 32
    • 0035132330 scopus 로고    scopus 로고
    • PPAR gamma dependent and independent effects on macrophage gene expression in lipid metabolism and inflammation
    • Chawla A, Barak Y, Nagy L, et al. PPAR gamma dependent and independent effects on macrophage gene expression in lipid metabolism and inflammation. Nat Med 2001; 7: 48-52
    • (2001) Nat Med , vol.7 , pp. 48-52
    • Chawla, A.1    Barak, Y.2    Nagy, L.3
  • 34
    • 26444471700 scopus 로고    scopus 로고
    • A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
    • Pascual G, Fong AL, Ogawa S, et al. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 2005; 437 (7059): 759-63
    • (2005) Nature , vol.437 , Issue.7059 , pp. 759-763
    • Pascual, G.1    Fong, A.L.2    Ogawa, S.3
  • 35
    • 3142716146 scopus 로고    scopus 로고
    • Transcriptional activity of peroxisome proliferator-activated receptor γ is modulated by SUMO-2 modification
    • Ohshima T, Koga H, Shimotohno K, et al. Transcriptional activity of peroxisome proliferator-activated receptor γ is modulated by SUMO-2 modification. J Biol Chem 2004; 279 (28): 29551-7
    • (2004) J Biol Chem , vol.279 , Issue.28 , pp. 29551-29557
    • Ohshima, T.1    Koga, H.2    Shimotohno, K.3
  • 36
    • 0038776380 scopus 로고    scopus 로고
    • Inhibition of adipogenesis through MAP-kinase mediated phosphorylation of PPARγ
    • Hu E, Kim JB, Sarraf P, et al. Inhibition of adipogenesis through MAP-kinase mediated phosphorylation of PPARγ. Science 1996; 274: 2100-3
    • (1996) Science , vol.274 , pp. 2100-2103
    • Hu, E.1    Kim, J.B.2    Sarraf, P.3
  • 37
    • 0029775642 scopus 로고    scopus 로고
    • Insulin and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma
    • Zhang B, Berger J, Zhou G, et al. Insulin and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma. J Biol Chem 1996; 27: 31771-4
    • (1996) J Biol Chem , vol.27 , pp. 31771-31774
    • Zhang, B.1    Berger, J.2    Zhou, G.3
  • 38
    • 0030964085 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase
    • Camp HS, Tafuri SR. Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase. J Biol Chem 1997; 272: 10811-6
    • (1997) J Biol Chem , vol.272 , pp. 10811-10816
    • Camp, H.S.1    Tafuri, S.R.2
  • 39
    • 0032894240 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor gamma-1 and negatively regulates its transcriptional activity
    • Camp HS, Tafuri SR, Leff T. c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor gamma-1 and negatively regulates its transcriptional activity. Endocrinology 1999; 140: 392-7
    • (1999) Endocrinology , vol.140 , pp. 392-397
    • Camp, H.S.1    Tafuri, S.R.2    Leff, T.3
  • 40
    • 0031057517 scopus 로고    scopus 로고
    • Transcriptional activation by peroxisome proliferator activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
    • Adams M, Reginato MJ, Shao D, et al. Transcriptional activation by peroxisome proliferator activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J Biol Chem 1997; 272: 5128-32
    • (1997) J Biol Chem , vol.272 , pp. 5128-5132
    • Adams, M.1    Reginato, M.J.2    Shao, D.3
  • 41
    • 0032569902 scopus 로고    scopus 로고
    • Interdomain communication regulating ligand binding by PPAR gamma
    • Shao D, Rangwala SM, Bailey ST, et al. Interdomain communication regulating ligand binding by PPAR gamma. Nature 1998; 396: 377-80
    • (1998) Nature , vol.396 , pp. 377-380
    • Shao, D.1    Rangwala, S.M.2    Bailey, S.T.3
  • 42
    • 14544272384 scopus 로고    scopus 로고
    • Phosphorylation of PPARs: From molecular characterization to physiological relevance
    • Diradourian C, Girard J, Pegorier JP. Phosphorylation of PPARs: from molecular characterization to physiological relevance. Biochimie 2005; 87 (1): 33-8
    • (2005) Biochimie , vol.87 , Issue.1 , pp. 33-38
    • Diradourian, C.1    Girard, J.2    Pegorier, J.P.3
  • 43
    • 0030835678 scopus 로고    scopus 로고
    • Organization promoter analysis and expression of the human PPAR γ gene
    • Fajas L, Auboeuf D, Raspe E, et al. Organization promoter analysis and expression of the human PPAR γ gene. J Biol Chem 1997; 272: 18779-89
    • (1997) J Biol Chem , vol.272 , pp. 18779-18789
    • Fajas, L.1    Auboeuf, D.2    Raspe, E.3
  • 44
    • 0032582349 scopus 로고    scopus 로고
    • 3 mRNA: A distinct PPARγ mRNA subtype transcribed from an independent promoter
    • 3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter. FEBS Lett 1998; 438: 55-60
    • (1998) FEBS Lett , vol.438 , pp. 55-60
    • Fajas, L.1    Fruchart, J.C.2    Auwerx, J.3
  • 45
    • 0033610079 scopus 로고    scopus 로고
    • Gene expression profile of aging and its retardation by caloric restriction
    • Lee CK, Klopp RG, Weindruch R, et al. Gene expression profile of aging and its retardation by caloric restriction. Science 1999; 285: 1390-3
    • (1999) Science , vol.285 , pp. 1390-1393
    • Lee, C.K.1    Klopp, R.G.2    Weindruch, R.3
  • 46
    • 0031964987 scopus 로고    scopus 로고
    • Depot-specific differences in adipose tissue gene expression in lean and obese subjects
    • Lefebvre AM, Laville M, Vega N, et al. Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 1998; 47: 98-103
    • (1998) Diabetes , vol.47 , pp. 98-103
    • Lefebvre, A.M.1    Laville, M.2    Vega, N.3
  • 47
    • 0030977450 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor gene expression in human tissues: Effects of obesity, weight loss, and regulation by insulin and glucocorticoids
    • Vidal-Puig AJ, Considine RV, Jimenez-Linan M, et al. Peroxisome proliferator activated receptor gene expression in human tissues: effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 1997; 99: 2416-22
    • (1997) J Clin Invest , vol.99 , pp. 2416-2422
    • Vidal-Puig, A.J.1    Considine, R.V.2    Jimenez-Linan, M.3
  • 48
    • 0030972203 scopus 로고    scopus 로고
    • TNF-α mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARγ without effects on Pref-1 expression
    • Xing H, Northrop JP, Grove JR, et al. TNF-α mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARγ without effects on Pref-1 expression. Endocrinology 1997; 138: 2776-83
    • (1997) Endocrinology , vol.138 , pp. 2776-2783
    • Xing, H.1    Northrop, J.P.2    Grove, J.R.3
  • 49
    • 0032006547 scopus 로고    scopus 로고
    • Skeletal muscle peroxisome proliferator activated receptor-γ expression in obesity and non-insulin-dependent diabetes mellitus
    • Kruszynska YT, Mukherjee R, Jow L, et al. Skeletal muscle peroxisome proliferator activated receptor-γ expression in obesity and non-insulin-dependent diabetes mellitus. J Clin Invest 1998; 101: 543-8
    • (1998) J Clin Invest , vol.101 , pp. 543-548
    • Kruszynska, Y.T.1    Mukherjee, R.2    Jow, L.3
  • 50
    • 0001102396 scopus 로고    scopus 로고
    • Troglitazone effects on muscle gene expression in human skeletal muscle of type II diabetes involve upregulation of peroxisome proliferator-activated receptor γ
    • Park KS, Ciaraldi TP, Lindgren K, et al. Troglitazone effects on muscle gene expression in human skeletal muscle of type II diabetes involve upregulation of peroxisome proliferator-activated receptor γ. J Clin Endocrinol Metab 1998; 83: 2830-5
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2830-2835
    • Park, K.S.1    Ciaraldi, T.P.2    Lindgren, K.3
  • 51
    • 0028180070 scopus 로고
    • mPPARγ2: Tissue-specific regulator of an adipocyte enhancer
    • Tontonoz P, Hu E, Graves RA, et al. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 1994; 8 (10): 1224-34
    • (1994) Genes Dev , vol.8 , Issue.10 , pp. 1224-1234
    • Tontonoz, P.1    Hu, E.2    Graves, R.A.3
  • 52
    • 0028988487 scopus 로고
    • PPARγ2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene
    • Tontonoz P, Hu E, Devine J, et al. PPARγ2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 1995; 15 (1): 351-7
    • (1995) Mol Cell Biol , vol.15 , Issue.1 , pp. 351-357
    • Tontonoz, P.1    Hu, E.2    Devine, J.3
  • 53
    • 0030658022 scopus 로고    scopus 로고
    • Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators
    • Nov 7
    • Martin G, Schoonjans K, Lefebvre AM, et al. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. J Biol Chem 1997 Nov 7; 272 (45): 28210-7
    • (1997) J Biol Chem , vol.272 , Issue.45 , pp. 28210-28217
    • Martin, G.1    Schoonjans, K.2    Lefebvre, A.M.3
  • 54
    • 0029791412 scopus 로고    scopus 로고
    • PPARα and PPARγ activators direct a tissue-specific transcriptional response via PPRE in the lipoprotein lipase gene
    • Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, et al. PPARα and PPARγ activators direct a tissue-specific transcriptional response via PPRE in the lipoprotein lipase gene. EMBO J 1996; 15 (19): 5336-48
    • (1996) EMBO J , vol.15 , Issue.19 , pp. 5336-5348
    • Schoonjans, K.1    Peinado-Onsurbe, J.2    Lefebvre, A.M.3
  • 55
    • 0033213637 scopus 로고    scopus 로고
    • PPARγ is required for placental, cardiac and adipose tissue development
    • Barak Y, Nelson MJ, Ong ES. PPARγ is required for placental, cardiac and adipose tissue development. Mol Cell 1999; 4: 585-95
    • (1999) Mol Cell , vol.4 , pp. 585-595
    • Barak, Y.1    Nelson, M.J.2    Ong, E.S.3
  • 56
    • 0033212964 scopus 로고    scopus 로고
    • PPAR γ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    • Kubota N, Terauchi Y, Miki H, et al. PPAR γ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999; 4 (4): 597-609
    • (1999) Mol Cell , vol.4 , Issue.4 , pp. 597-609
    • Kubota, N.1    Terauchi, Y.2    Miki, H.3
  • 57
    • 0033213631 scopus 로고    scopus 로고
    • PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
    • Rosen ED, Sarraf P, Troy AE, et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 1999; 4: 611-7
    • (1999) Mol Cell , vol.4 , pp. 611-617
    • Rosen, E.D.1    Sarraf, P.2    Troy, A.E.3
  • 58
    • 12144291563 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse
    • U S A
    • Imai T, Takakuwa R, Marchand S, et al. Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A 2004; 101: 4543-7
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 4543-4547
    • Imai, T.1    Takakuwa, R.2    Marchand, S.3
  • 59
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR γ2, a lipid-activated transcription factor
    • Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR γ2, a lipid-activated transcription factor. Cell 1994; 79: 1147-56
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 60
    • 0028871780 scopus 로고
    • Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR γ and C/EBPα
    • U S A
    • Hu E, Tontonoz P, Spiegelman BM. Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR γ and C/EBPα. Proc Natl Acad Sci U S A 1995; 92 (21): 9856-60
    • (1995) Proc Natl Acad Sci , vol.92 , Issue.21 , pp. 9856-9860
    • Hu, E.1    Tontonoz, P.2    Spiegelman, B.M.3
  • 61
    • 10644251916 scopus 로고    scopus 로고
    • Peroxisome proliferator-activator receptor-γ calls for activation in moderation: Lessons from genetics and pharmacology
    • Knouff C, Auwerx J. Peroxisome proliferator-activator receptor-γ calls for activation in moderation: lessons from genetics and pharmacology. Endocr Rev 2004; 25: 899-918
    • (2004) Endocr Rev , vol.25 , pp. 899-918
    • Knouff, C.1    Auwerx, J.2
  • 62
    • 0032189782 scopus 로고    scopus 로고
    • Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    • Ristow M, Muller-Wieland D, Pfeiffer A, et al. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med 1998; 339 (14): 953-9
    • (1998) N Engl J Med , vol.339 , Issue.14 , pp. 953-959
    • Ristow, M.1    Muller-Wieland, D.2    Pfeiffer, A.3
  • 63
    • 0031595923 scopus 로고    scopus 로고
    • A Pro 12 Ala substitution in the human peroxisome proliferator-activated receptor gamma 2 is associated with decreased receptor activity, improved insulin sensitivity and lowered body mass index
    • Deeb S, Fajas L, Nemoto M. A Pro 12 Ala substitution in the human peroxisome proliferator-activated receptor gamma 2 is associated with decreased receptor activity, improved insulin sensitivity and lowered body mass index. Nat Genet 1998; 20 (3): 284-7
    • (1998) Nat Genet , vol.20 , Issue.3 , pp. 284-287
    • Deeb, S.1    Fajas, L.2    Nemoto, M.3
  • 64
    • 0032520921 scopus 로고    scopus 로고
    • Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
    • Okuno A, Tamemoto H, Tobe K. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 1998; 101: 1354-61
    • (1998) J Clin Invest , vol.101 , pp. 1354-1361
    • Okuno, A.1    Tamemoto, H.2    Tobe, K.3
  • 65
    • 5344266704 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma: Its role in metabolic syndrome
    • Pakala R, Kuchulakanti P, Rha SW, et al. Peroxisome proliferator-activated receptor gamma: its role in metabolic syndrome. Cardiovasc Radiat Med 2004; 5 (2): 97-103
    • (2004) Cardiovasc Radiat Med , vol.5 , Issue.2 , pp. 97-103
    • Pakala, R.1    Kuchulakanti, P.2    Rha, S.W.3
  • 66
    • 0029862973 scopus 로고    scopus 로고
    • Hyperinsulinemia as an independent risk factor for ischemic heart disease
    • Despres JP, Lamarche B, Mauriege P, et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996; 334: 952-7
    • (1996) N Engl J Med , vol.334 , pp. 952-957
    • Despres, J.P.1    Lamarche, B.2    Mauriege, P.3
  • 67
    • 0343485089 scopus 로고    scopus 로고
    • Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: The 22-year follow-up results of the Helsinki Policemen Study
    • Pyolara M, Miettinen H, Halonen P, et al. Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Arterioscler Thromb Vasc Biol 2000; 20: 538-44
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 538-544
    • Pyolara, M.1    Miettinen, H.2    Halonen, P.3
  • 68
    • 0042330251 scopus 로고    scopus 로고
    • Minireview: The adipocyte; at the crossroads of energy homeostasis, inflammation, and atherosclerosis
    • Rajala MW, Scherer PE. Minireview: the adipocyte; at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003; 144: 3765-73
    • (2003) Endocrinology , vol.144 , pp. 3765-3773
    • Rajala, M.W.1    Scherer, P.E.2
  • 69
    • 0027983920 scopus 로고
    • Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone
    • Nolan JJ, Ludvik B, Beerdsen P, et al. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med 1994; 331: 1188-93
    • (1994) N Engl J Med , vol.331 , pp. 1188-1193
    • Nolan, J.J.1    Ludvik, B.2    Beerdsen, P.3
  • 70
    • 0028598170 scopus 로고
    • Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat
    • Lee MK, Miles PD, Khoursheed M, et al. Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes 1994; 43: 1435-9
    • (1994) Diabetes , vol.43 , pp. 1435-1439
    • Lee, M.K.1    Miles, P.D.2    Khoursheed, M.3
  • 71
    • 0033973843 scopus 로고    scopus 로고
    • Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency
    • Miles PD, Barak Y, He W, et al. Improved insulin-sensitivity in mice heterozygous for PPAR-γ deficiency. J Clin Invest 2000; 105: 287-92
    • (2000) J Clin Invest , vol.105 , pp. 287-292
    • Miles, P.D.1    Barak, Y.2    He, W.3
  • 72
    • 0037364560 scopus 로고    scopus 로고
    • Effect of heterozygous PPAR γ deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding
    • Miles PD, Barak Y, Evans RM. Effect of heterozygous PPAR γ deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. Am J Physiol Endocrinol Metab 2003; 284: E618-26
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Miles, P.D.1    Barak, Y.2    Evans, R.M.3
  • 73
    • 0344630205 scopus 로고    scopus 로고
    • Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice
    • U S A
    • Koutnikova H, Cock TA, Watanabe M, et al. Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A 2003; 100 (24): 14457-62
    • (2003) Proc Natl Acad Sci , vol.100 , Issue.24 , pp. 14457-14462
    • Koutnikova, H.1    Cock, T.A.2    Watanabe, M.3
  • 74
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferators-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
    • U S A
    • He W, Barak Y, Hevener A, et al. Adipose-specific peroxisome proliferators-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A 2003; 100: 15712-7
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3
  • 75
    • 20944439189 scopus 로고    scopus 로고
    • Deletion of PPAR γ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
    • U S A
    • Jones JR, Barrick C, Kim KA, et al. Deletion of PPAR γ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A 2005; 102 (17): 6207-12
    • (2005) Proc Natl Acad Sci , vol.102 , Issue.17 , pp. 6207-6212
    • Jones, J.R.1    Barrick, C.2    Kim, K.A.3
  • 76
    • 0037373008 scopus 로고    scopus 로고
    • Liver-specific disruption of PPAR γ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
    • Matsusue K, Haluzik M, Lambert G, et al. Liver-specific disruption of PPAR γ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 2003; 111 (5): 737-47
    • (2003) J Clin Invest , vol.111 , Issue.5 , pp. 737-747
    • Matsusue, K.1    Haluzik, M.2    Lambert, G.3
  • 77
    • 0141446024 scopus 로고    scopus 로고
    • Liver PPAR γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
    • Gavrilova O, Haluzik M, Matsusue K, et al. Liver PPAR γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem 2003; 278 (36): 34268-76
    • (2003) J Biol Chem , vol.278 , Issue.36 , pp. 34268-34276
    • Gavrilova, O.1    Haluzik, M.2    Matsusue, K.3
  • 78
    • 85047693638 scopus 로고    scopus 로고
    • Muscle-specific PPAR γ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    • Norris AW, Chen L, Fischer SJ, et al. Muscle-specific PPAR γ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest 2003; 112 (4): 608-18
    • (2003) J Clin Invest , vol.112 , Issue.4 , pp. 608-618
    • Norris, A.W.1    Chen, L.2    Fischer, S.J.3
  • 79
    • 0346027235 scopus 로고    scopus 로고
    • Muscle-specific PPAR γ deletion causes insulin resistance
    • Hevener AL, He W, Barak Y, et al. Muscle-specific PPAR γ deletion causes insulin resistance. Nat Med 2003; 9 (12): 1491-7
    • (2003) Nat Med , vol.9 , Issue.12 , pp. 1491-1497
    • Hevener, A.L.1    He, W.2    Barak, Y.3
  • 80
    • 0033965557 scopus 로고    scopus 로고
    • Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
    • Gavrilova O, Marcus-Samuels B, Graham D, et al. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 2000; 105 (3): 271-8
    • (2000) J Clin Invest , vol.105 , Issue.3 , pp. 271-278
    • Gavrilova, O.1    Marcus-Samuels, B.2    Graham, D.3
  • 81
    • 0033708410 scopus 로고    scopus 로고
    • Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
    • Chao L, Marcus-Samuels B, Mason MM, et al. Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J Clin Invest 2000; 106 (10): 1221-8
    • (2000) J Clin Invest , vol.106 , Issue.10 , pp. 1221-1228
    • Chao, L.1    Marcus-Samuels, B.2    Mason, M.M.3
  • 82
    • 0031441286 scopus 로고    scopus 로고
    • Troglitazone action is independent of adipose tissue
    • Burant CF, Sreenan S, Hirano K, et al. Troglitazone action is independent of adipose tissue. J Clin Invest 1997; 100 (11): 2900-8
    • (1997) J Clin Invest , vol.100 , Issue.11 , pp. 2900-2908
    • Burant, C.F.1    Sreenan, S.2    Hirano, K.3
  • 83
    • 0346003777 scopus 로고    scopus 로고
    • Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPAR γ1) overexpression
    • Yu S, Matsusue K, Kashireddy P, et al. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPAR γ1) overexpression. J Biol Chem 2003; 278 (1): 498-505
    • (2003) J Biol Chem , vol.278 , Issue.1 , pp. 498-505
    • Yu, S.1    Matsusue, K.2    Kashireddy, P.3
  • 84
    • 29244465372 scopus 로고    scopus 로고
    • Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    • Nakamuta M, Kohjima M, Morizono S, et al. Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med 2005; 16 (4): 631-5
    • (2005) Int J Mol Med , vol.16 , Issue.4 , pp. 631-635
    • Nakamuta, M.1    Kohjima, M.2    Morizono, S.3
  • 85
    • 20844444779 scopus 로고    scopus 로고
    • Idiosyncratic drug hepatotoxicity
    • Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov 2005; 4 (6): 489-99
    • (2005) Nat Rev Drug Discov , vol.4 , Issue.6 , pp. 489-499
    • Kaplowitz, N.1
  • 86
    • 0034663140 scopus 로고    scopus 로고
    • Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes
    • Arioglu E, Duncan-Morin J, Sebring N, et al. Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Ann Intern Med 2000; 133 (4): 263-74
    • (2000) Ann Intern Med , vol.133 , Issue.4 , pp. 263-274
    • Arioglu, E.1    Duncan-Morin, J.2    Sebring, N.3
  • 87
    • 27744450019 scopus 로고    scopus 로고
    • Review article: The treatment of non-alcoholic steohepatitis with thiazolidinediones
    • Reynaert H, Geerts A, Henrion J. Review article: the treatment of non-alcoholic steohepatitis with thiazolidinediones. Aliment Pharmacol Ther 2005; 22: 897-905
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 897-905
    • Reynaert, H.1    Geerts, A.2    Henrion, J.3
  • 88
    • 0032452225 scopus 로고    scopus 로고
    • Regulatory interactions between lipids and carbohydrates: The glucose fatty acid cycle after 35 years
    • Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 1998; 14 (4): 263-83
    • (1998) Diabetes Metab Rev , vol.14 , Issue.4 , pp. 263-283
    • Randle, P.J.1
  • 89
    • 0030811602 scopus 로고    scopus 로고
    • The insulin sensitizer, BRL 49653, reduces systemic fatty acid supply and utilization and tissue lipid availability in the rat
    • Oakes ND, Camilleri S, Furler SM, et al. The insulin sensitizer, BRL 49653, reduces systemic fatty acid supply and utilization and tissue lipid availability in the rat. Metabolism 1997; 46: 935-42
    • (1997) Metabolism , vol.46 , pp. 935-942
    • Oakes, N.D.1    Camilleri, S.2    Furler, S.M.3
  • 90
    • 0034833667 scopus 로고    scopus 로고
    • Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone
    • Miyazaki Y, Mahankali A, Matsuda M, et al. Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone. Diabetes Care 2001; 24: 710-9
    • (2001) Diabetes Care , vol.24 , pp. 710-719
    • Miyazaki, Y.1    Mahankali, A.2    Matsuda, M.3
  • 91
    • 0029999139 scopus 로고    scopus 로고
    • Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients: Troglitazone Study Group
    • Kumar S, Boulton AJ, Beck-Nielsen H, et al. Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients: Troglitazone Study Group. Diabetologia 1996; 39: 701-9
    • (1996) Diabetologia , vol.39 , pp. 701-709
    • Kumar, S.1    Boulton, A.J.2    Beck-Nielsen, H.3
  • 92
    • 0033123466 scopus 로고    scopus 로고
    • Rosiglitazone monotherapy improves glycaemic control in patients with type 2 diabetes: A twelve-week, randomized, placebo-controlled study
    • Patel J, Anderson RJ, Rappaport EB. Rosiglitazone monotherapy improves glycaemic control in patients with type 2 diabetes: a twelve-week, randomized, placebo-controlled study. Diabetes Obes Metab 1999; 1: 165-72
    • (1999) Diabetes Obes Metab , vol.1 , pp. 165-172
    • Patel, J.1    Anderson, R.J.2    Rappaport, E.B.3
  • 93
    • 0032989265 scopus 로고    scopus 로고
    • A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat
    • Brown KK, Henke BR, Blanchard SG, et al. A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 1999; 48 (7): 1415-24
    • (1999) Diabetes , vol.48 , Issue.7 , pp. 1415-1424
    • Brown, K.K.1    Henke, B.R.2    Blanchard, S.G.3
  • 94
    • 2542491213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma in diabetes and metabolism
    • Rangwala SM, Lazar MA. Peroxisome proliferator-activated receptor gamma in diabetes and metabolism. Trends Pharmacol Sci 2004; 25 (6): 331-6
    • (2004) Trends Pharmacol Sci , vol.25 , Issue.6 , pp. 331-336
    • Rangwala, S.M.1    Lazar, M.A.2
  • 95
    • 0031595111 scopus 로고    scopus 로고
    • PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes
    • Wu Z, Xie Y, Morrison RF, et al. PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes. J Clin Invest 1998; 101: 22-32
    • (1998) J Clin Invest , vol.101 , pp. 22-32
    • Wu, Z.1    Xie, Y.2    Morrison, R.F.3
  • 96
    • 0034737576 scopus 로고    scopus 로고
    • Cloning and characterization of a functional peroxisome proliferator activator receptor-gamma-responsive element in the promoter of the CAP gene
    • Baumann CA, Chokshi N, Saltiel AR, et al. Cloning and characterization of a functional peroxisome proliferator activator receptor-gamma-responsive element in the promoter of the CAP gene. J Biol Chem 2000; 275: 9131-5
    • (2000) J Biol Chem , vol.275 , pp. 9131-9135
    • Baumann, C.A.1    Chokshi, N.2    Saltiel, A.R.3
  • 97
    • 0034611675 scopus 로고    scopus 로고
    • Obesity in the new millennium
    • Freidman JM. Obesity in the new millennium. Nature 2000; 404: 632-4
    • (2000) Nature , vol.404 , pp. 632-634
    • Freidman, J.M.1
  • 98
    • 0036114844 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
    • Petersen KF, Oral EA, Dufour S, et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest 2002; 109: 1345-50
    • (2002) J Clin Invest , vol.109 , pp. 1345-1350
    • Petersen, K.F.1    Oral, E.A.2    Dufour, S.3
  • 99
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura I, Hammer RE, Ikemoto S, et al. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999; 401: 73-6
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3
  • 100
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • Minokoshi Y, Kim Y, Peroni O, et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002; 415: 268-9
    • (2002) Nature , vol.415 , pp. 268-269
    • Minokoshi, Y.1    Kim, Y.2    Peroni, O.3
  • 101
    • 0029894050 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit leptin (ob) expression in 3T3-L1 adipocytes
    • U S A
    • Kallen CB, Lazar MA. Antidiabetic thiazolidinediones inhibit leptin (ob) expression in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 1996; 93: 5793-6
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 5793-5796
    • Kallen, C.B.1    Lazar, M.A.2
  • 102
    • 0000113890 scopus 로고    scopus 로고
    • Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma
    • De Vos P, Lefebvre AM, Miller SG. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. J Clin Invest 1996; 98: 1004-9
    • (1996) J Clin Invest , vol.98 , pp. 1004-1009
    • De Vos, P.1    Lefebvre, A.M.2    Miller, S.G.3
  • 103
    • 0033073540 scopus 로고    scopus 로고
    • The role of TNFα in adipocyte metabolism
    • Sethi JK, Hotamisligil GS. The role of TNFα in adipocyte metabolism. Semin Cell Dev Biol 1999; 10 (1): 19-29
    • (1999) Semin Cell Dev Biol , vol.10 , Issue.1 , pp. 19-29
    • Sethi, J.K.1    Hotamisligil, G.S.2
  • 104
    • 0036189407 scopus 로고    scopus 로고
    • PPARadigms and PPARadoxes: Expanding roles for PPAR γ in the control of lipid metabolism
    • Walzcak R, Tontonoz P. PPARadigms and PPARadoxes: expanding roles for PPAR γ in the control of lipid metabolism. J Lipid Res 2002; 43: 177-86
    • (2002) J Lipid Res , vol.43 , pp. 177-186
    • Walzcak, R.1    Tontonoz, P.2
  • 105
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • Kern PA, Ranganathan S, Li C, et al. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 2001; 280: E745-51
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3
  • 106
    • 0346366979 scopus 로고    scopus 로고
    • Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta (12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways
    • Zingarelli B, Sheehan M, Hake PW, et al. Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta (12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways. J Immunol 2003; 171 (12): 6827-37
    • (2003) J Immunol , vol.171 , Issue.12 , pp. 6827-6837
    • Zingarelli, B.1    Sheehan, M.2    Hake, P.W.3
  • 107
    • 0242299763 scopus 로고    scopus 로고
    • Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: Prevention by rosiglitazone
    • Lagathu C, Bastard JP, Auclair M, et al. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun 2003; 311 (2): 372-9
    • (2003) Biochem Biophys Res Commun , vol.311 , Issue.2 , pp. 372-379
    • Lagathu, C.1    Bastard, J.P.2    Auclair, M.3
  • 108
    • 0037296946 scopus 로고    scopus 로고
    • Adiponectin and resistin: New hormones of white adipose tissue
    • Beltowski J. Adiponectin and resistin: new hormones of white adipose tissue. Med Sci Monit 2003; 9 (2): RA55-61
    • (2003) Med Sci Monit , vol.9 , Issue.2
    • Beltowski, J.1
  • 109
    • 0035462629 scopus 로고    scopus 로고
    • PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    • Maeda N, Takahashi M, Funahashi T, et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001; 50 (9): 2094-9
    • (2001) Diabetes , vol.50 , Issue.9 , pp. 2094-2099
    • Maeda, N.1    Takahashi, M.2    Funahashi, T.3
  • 110
    • 0036789137 scopus 로고    scopus 로고
    • The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects
    • Yu JG, Javorschi S, Hevener AL, et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 2002; 51 (10): 2968-74
    • (2002) Diabetes , vol.51 , Issue.10 , pp. 2968-2974
    • Yu, J.G.1    Javorschi, S.2    Hevener, A.L.3
  • 111
    • 4243645912 scopus 로고    scopus 로고
    • Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: A potential mechanism of insulin sensitization
    • Combs TP, Wagner JA, Berger J, et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 2002; 143: 998-1007
    • (2002) Endocrinology , vol.143 , pp. 998-1007
    • Combs, T.P.1    Wagner, J.A.2    Berger, J.3
  • 112
    • 0035905758 scopus 로고    scopus 로고
    • The hormone resistin links obesity to diabetes
    • Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature 2001; 409 (6818): 307-12
    • (2001) Nature , vol.409 , Issue.6818 , pp. 307-312
    • Steppan, C.M.1    Bailey, S.T.2    Bhat, S.3
  • 113
    • 0242641149 scopus 로고    scopus 로고
    • Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists
    • Way JM, Gorgun CZ, Tong Q, et al. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 2001; 276 (28): 25651-3
    • (2001) J Biol Chem , vol.276 , Issue.28 , pp. 25651-25653
    • Way, J.M.1    Gorgun, C.Z.2    Tong, Q.3
  • 114
    • 0035487109 scopus 로고    scopus 로고
    • Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans
    • Savage DB, Sewter CP, Klenk ES, et al. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 2001; 50 (10): 2199-202
    • (2001) Diabetes , vol.50 , Issue.10 , pp. 2199-2202
    • Savage, D.B.1    Sewter, C.P.2    Klenk, E.S.3
  • 115
    • 0035050460 scopus 로고    scopus 로고
    • Diabetes, hypertension, and cardiovascular disease: An update
    • Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension 2001; 37: 1053-9
    • (2001) Hypertension , vol.37 , pp. 1053-1059
    • Sowers, J.R.1    Epstein, M.2    Frohlich, E.D.3
  • 116
    • 0031724917 scopus 로고    scopus 로고
    • Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: The Insulin Resistance Atherosclerosis Study
    • Wagenknecht LE, D'Agostino Jr RB, Haffner SM, et al. Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the Insulin Resistance Atherosclerosis Study. Diabetes Care 1998; 21: 1812-8
    • (1998) Diabetes Care , vol.21 , pp. 1812-1818
    • Wagenknecht, L.E.1    D'Agostino Jr., R.B.2    Haffner, S.M.3
  • 117
    • 0004442926 scopus 로고    scopus 로고
    • Impaired glucose tolerance, type II diabetes mellitus and carotid atherosclerosis: Prospective results from the Bruneck Study
    • Bonora E, Kiechl S, Oberhollenzer F, et al. Impaired glucose tolerance, type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study. Diabetologia 2000; 43: 156-64
    • (2000) Diabetologia , vol.43 , pp. 156-164
    • Bonora, E.1    Kiechl, S.2    Oberhollenzer, F.3
  • 118
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999; 340: 115-26
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 119
    • 0034603858 scopus 로고    scopus 로고
    • Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
    • Zeng G, Nystrom FH, Ravichandran LV, et al. Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 2000; 101: 1539-45
    • (2000) Circulation , vol.101 , pp. 1539-1545
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, L.V.3
  • 120
    • 0030777901 scopus 로고    scopus 로고
    • Inhibition of MAP kinase blocks insulin-mediated DNA synthesis and transcriptional activation of c-fos by Elk-1 in vascular smooth muscle cells
    • Xi XP, Graf K, Goetze S, et al. Inhibition of MAP kinase blocks insulin-mediated DNA synthesis and transcriptional activation of c-fos by Elk-1 in vascular smooth muscle cells. FEBS Lett 1997; 417: 283-6
    • (1997) FEBS Lett , vol.417 , pp. 283-286
    • Xi, X.P.1    Graf, K.2    Goetze, S.3
  • 121
    • 0031033617 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase activation is involved in platelet-derived growth factor directed migration by vascular smooth muscle cells
    • Graf K, Xi XP, Yang D, et al. Mitogen-activated protein kinase activation is involved in platelet-derived growth factor directed migration by vascular smooth muscle cells. Hypertension 1997; 29: 334-9
    • (1997) Hypertension , vol.29 , pp. 334-339
    • Graf, K.1    Xi, X.P.2    Yang, D.3
  • 122
    • 0032213801 scopus 로고    scopus 로고
    • Regulation of vascular smooth muscle migration by mitogen-activated protein kinase and calcium/calmodulin-dependent protein kinase II signaling pathways
    • Lundberg MS, Curto KA, Bilato C, et al. Regulation of vascular smooth muscle migration by mitogen-activated protein kinase and calcium/calmodulin-dependent protein kinase II signaling pathways. J Mol Cell Cardiol 1998; 30: 2377-89
    • (1998) J Mol Cell Cardiol , vol.30 , pp. 2377-2389
    • Lundberg, M.S.1    Curto, K.A.2    Bilato, C.3
  • 123
    • 0141723637 scopus 로고    scopus 로고
    • Role of endothelial dysfunction in insulin resistance
    • Hsueh WA, Quinones MJ. Role of endothelial dysfunction in insulin resistance. Am J Cardiol 2003; 92: 10J-7J
    • (2003) Am J Cardiol , vol.92
    • Hsueh, W.A.1    Quinones, M.J.2
  • 124
    • 0032560545 scopus 로고    scopus 로고
    • Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low-density lipoprotein
    • U S A
    • Ricote M, Huang J, Fajas L, et al. Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low-density lipoprotein. Proc Natl Acad Sci U S A 1998; 95: 7614-9
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 7614-7619
    • Ricote, M.1    Huang, J.2    Fajas, L.3
  • 125
    • 0033622133 scopus 로고    scopus 로고
    • Inhibition of IκB kinase and IκB phosphorylation by 15-deoxy Δ12,14 prostaglandin J2 in activated murine macrophages
    • Castrillo A, Diaz-Guerra JM, Hortelano S, et al. Inhibition of IκB kinase and IκB phosphorylation by 15-deoxy Δ12,14 prostaglandin J2 in activated murine macrophages. Mol Cell Biol 2000; 20: 1692-8
    • (2000) Mol Cell Biol , vol.20 , pp. 1692-1698
    • Castrillo, A.1    Diaz-Guerra, J.M.2    Hortelano, S.3
  • 126
    • 0035528852 scopus 로고    scopus 로고
    • PPAR γ and atherosclerosis: Effects on cell growth and movement
    • Hsueh WA, Law RE. PPAR γ and atherosclerosis: effects on cell growth and movement. Arterioscler Thromb Vasc Biol 2001; 21: 1891-5
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1891-1895
    • Hsueh, W.A.1    Law, R.E.2
  • 127
    • 0029152375 scopus 로고
    • Isolation of the human peroxisome proliferator activated receptor gamma cDNA: Expression in hematopoietic cells and chromosomal mapping
    • Greene ME, Blumberg B, McBride OW, et al. Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping. Gene Expr 1995; 4: 281-99
    • (1995) Gene Expr , vol.4 , pp. 281-299
    • Greene, M.E.1    Blumberg, B.2    McBride, O.W.3
  • 128
    • 0032540012 scopus 로고    scopus 로고
    • PPAR γ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz P, Nagy L, Alvarez JG, et al. PPAR γ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998; 93: 241-52
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3
  • 129
    • 0033524420 scopus 로고    scopus 로고
    • Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
    • U S A
    • Janowski BA, Grogan MJ, Jones SA, et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A 1999; 96 (1): 266-71
    • (1999) Proc Natl Acad Sci , vol.96 , Issue.1 , pp. 266-271
    • Janowski, B.A.1    Grogan, M.J.2    Jones, S.A.3
  • 130
    • 0032540325 scopus 로고    scopus 로고
    • Oxidised LDL regulates macrophage gene expression through ligand activation of PPAR γ
    • Nagy L, Tontonoz P, Alvarez JGA, et al. Oxidised LDL regulates macrophage gene expression through ligand activation of PPAR γ. Cell 1998; 93: 229-40
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.A.3
  • 131
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote M, Li AC, Wilson TM, et al. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998; 391: 79-82
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Wilson, T.M.3
  • 132
    • 17744376173 scopus 로고    scopus 로고
    • A PPAR γ -LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
    • Chawla A, Boisvert WA, Lee CH, et al. A PPAR γ -LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell 2001; 7: 161-71
    • (2001) Mol Cell , vol.7 , pp. 161-171
    • Chawla, A.1    Boisvert, W.A.2    Lee, C.H.3
  • 133
    • 0036790522 scopus 로고    scopus 로고
    • Regulation and mechanisms of macrophage cholesterol efflux
    • Tall AR, Costet P, Wang N. Regulation and mechanisms of macrophage cholesterol efflux. J Clin Invest 2002; 110: 899-904
    • (2002) J Clin Invest , vol.110 , pp. 899-904
    • Tall, A.R.1    Costet, P.2    Wang, N.3
  • 134
    • 0031888958 scopus 로고    scopus 로고
    • PPAR γ agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C, Ting AT, Seed B. PPAR γ agonists inhibit production of monocyte inflammatory cytokines. Nature 1998; 391: 82-6
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 135
    • 0032988209 scopus 로고    scopus 로고
    • Thiazolidinedione inhibits the production of monocyte chemoattractant protein-1 in cytokine treated human vascular endothelial cells
    • Murao K, Imachi H, Momoi A, et al. Thiazolidinedione inhibits the production of monocyte chemoattractant protein-1 in cytokine treated human vascular endothelial cells. FEBS Lett 1999; 454: 27-30
    • (1999) FEBS Lett , vol.454 , pp. 27-30
    • Murao, K.1    Imachi, H.2    Momoi, A.3
  • 136
    • 0034711678 scopus 로고    scopus 로고
    • Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-γ activators
    • Pasceri V, Wu H, Willerson JT, et al. Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-γ activators. Circulation 2000; 101: 235-8
    • (2000) Circulation , vol.101 , pp. 235-238
    • Pasceri, V.1    Wu, H.2    Willerson, J.T.3
  • 137
    • 0033608242 scopus 로고    scopus 로고
    • Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: A new possible role of PPARγ on vascular endothelial function
    • Satoh H, Tsukamoto K, Hashimoto Y, et al. Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARγ on vascular endothelial function. Biochem Biophys Res Commun 1999; 254: 757-63
    • (1999) Biochem Biophys Res Commun , vol.254 , pp. 757-763
    • Satoh, H.1    Tsukamoto, K.2    Hashimoto, Y.3
  • 138
    • 0034141545 scopus 로고    scopus 로고
    • The nuclear receptor PPARgamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses
    • Clark RB, Bishop-Bailey D, Estrada-Hernandez T, et al. The nuclear receptor PPARgamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. J Immunol 2000; 164: 1364-71
    • (2000) J Immunol , vol.164 , pp. 1364-1371
    • Clark, R.B.1    Bishop-Bailey, D.2    Estrada-Hernandez, T.3
  • 139
    • 0033542091 scopus 로고    scopus 로고
    • Thiazolidinediones down regulate plasminogen activator inhibitor type 1 expression in human vascular endothelial cells: A possible role for PPARγ in endothelial function
    • Kato K, Satoh H, Endo Y, et al. Thiazolidinediones down regulate plasminogen activator inhibitor type 1 expression in human vascular endothelial cells: a possible role for PPARγ in endothelial function. Biochem Biophys Res Commun 1999; 258: 431-5
    • (1999) Biochem Biophys Res Commun , vol.258 , pp. 431-435
    • Kato, K.1    Satoh, H.2    Endo, Y.3
  • 140
    • 0035146287 scopus 로고    scopus 로고
    • Control of vascular cell proliferation and migration by PPAR-gamma: A new approach to the macrovascular complications of diabetes
    • Hsueh WA, Jackson S, Law RE. Control of vascular cell proliferation and migration by PPAR-gamma: a new approach to the macrovascular complications of diabetes. Diabetes Care 2001; 24 (2): 392-7
    • (2001) Diabetes Care , vol.24 , Issue.2 , pp. 392-397
    • Hsueh, W.A.1    Jackson, S.2    Law, R.E.3
  • 141
    • 0344333464 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells
    • Marx N, Schonbeck U, Lazar MA, et al. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ Res 1998; 83: 1097-103
    • (1998) Circ Res , vol.83 , pp. 1097-1103
    • Marx, N.1    Schonbeck, U.2    Lazar, M.A.3
  • 142
    • 0034698074 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ ligands inhibit Rb phosphorylation and G1→S transition in vascular smooth muscle cells
    • Wakino S, Kintscher U, Kim S, et al. Peroxisome proliferator-activated receptor-γ ligands inhibit Rb phosphorylation and G1→S transition in vascular smooth muscle cells. J Biol Chem 2000; 275: 22435-41
    • (2000) J Biol Chem , vol.275 , pp. 22435-22441
    • Wakino, S.1    Kintscher, U.2    Kim, S.3
  • 143
    • 0031729852 scopus 로고    scopus 로고
    • Regulation of cytoskeletal mechanics and cell growth by myosin light chain phosphorylation
    • Cai S, Pestic-Dragovich L, O'Donnell ME, et al. Regulation of cytoskeletal mechanics and cell growth by myosin light chain phosphorylation. Am J Physiol 1998; 275: C1349-56
    • (1998) Am J Physiol , vol.275
    • Cai, S.1    Pestic-Dragovich, L.2    O'Donnell, M.E.3
  • 144
    • 0035201123 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma ligands inhibit nuclear but not cytosolic extracellular signal-regulated kinase/mitogen-activated protein kinase-regulated steps in vascular smooth muscle cell migration
    • Goetze S, Kintscher U, Kim S, et al. Peroxisome proliferator-activated receptor-gamma ligands inhibit nuclear but not cytosolic extracellular signal-regulated kinase/mitogen-activated protein kinase-regulated steps in vascular smooth muscle cell migration. J Cardiovasc Pharmacol 2001; 38: 909-21
    • (2001) J Cardiovasc Pharmacol , vol.38 , pp. 909-921
    • Goetze, S.1    Kintscher, U.2    Kim, S.3
  • 145
    • 0034696412 scopus 로고    scopus 로고
    • Expression and function of PPAR; in rat and human vascular smooth muscle cells
    • Law RE, Goetze S, Xi XP, et al. Expression and function of PPAR; in rat and human vascular smooth muscle cells. Circulation 2000; 101: 1311-8
    • (2000) Circulation , vol.101 , pp. 1311-1318
    • Law, R.E.1    Goetze, S.2    Xi, X.P.3
  • 146
    • 0034332862 scopus 로고    scopus 로고
    • Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non-insulin dependent diabetes mellitus: A serial intravascular ultrasound study
    • Takagi T, Akasaka T, Yamamuro A, et al. Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non-insulin dependent diabetes mellitus: a serial intravascular ultrasound study. J Am Coll Cardiol 2000; 36: 1529-35
    • (2000) J Am Coll Cardiol , vol.36 , pp. 1529-1535
    • Takagi, T.1    Akasaka, T.2    Yamamuro, A.3
  • 147
    • 10744221639 scopus 로고    scopus 로고
    • Thiazolidinedione use, fluid retention, and congestive heart failure: A consensus statement from the American Heart Association and American Diabetes Association
    • Nesto RW, Bell D, Bonow RO, et al. Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care 2004; 27 (1): 256-63
    • (2004) Diabetes Care , vol.27 , Issue.1 , pp. 256-263
    • Nesto, R.W.1    Bell, D.2    Bonow, R.O.3
  • 148
    • 0032484224 scopus 로고    scopus 로고
    • A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties
    • Reginato MJ, Bailey ST, Krakow SL, et al. A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties. J Biol Chem 1998; 273 (49): 32679-84
    • (1998) J Biol Chem , vol.273 , Issue.49 , pp. 32679-32684
    • Reginato, M.J.1    Bailey, S.T.2    Krakow, S.L.3
  • 149
    • 0037405057 scopus 로고    scopus 로고
    • Modulation of PPAR γ activity with pharmaceutical agents: Treatment of insulin resistance and atherosclerosis
    • Wang M, Tafuri S. Modulation of PPAR γ activity with pharmaceutical agents: treatment of insulin resistance and atherosclerosis. J Cell Biochem 2003; 89 (1): 38-47
    • (2003) J Cell Biochem , vol.89 , Issue.1 , pp. 38-47
    • Wang, M.1    Tafuri, S.2
  • 150
    • 0034569799 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors, coactivators and downstream targets
    • Qi C, Zhu Y, Reddy JK. Peroxisome proliferator-activated receptors, coactivators and downstream targets. Cell Biochem Biophys 2000; 32: 187-204
    • (2000) Cell Biochem Biophys , vol.32 , pp. 187-204
    • Qi, C.1    Zhu, Y.2    Reddy, J.K.3
  • 151
    • 0034114625 scopus 로고    scopus 로고
    • Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone
    • Camp HS, Li O, Wise SC, et al. Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone. Diabetes 2000; 49 (4): 539-47
    • (2000) Diabetes , vol.49 , Issue.4 , pp. 539-547
    • Camp, H.S.1    Li, O.2    Wise, S.C.3
  • 152
    • 0033637703 scopus 로고    scopus 로고
    • Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription
    • Shang Y, Hu X, Direnzo J, et al. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 2000; 103 (6): 843-52
    • (2000) Cell , vol.103 , Issue.6 , pp. 843-852
    • Shang, Y.1    Hu, X.2    Direnzo, J.3
  • 153
    • 13044286786 scopus 로고    scopus 로고
    • A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation
    • U S A
    • Oberfield JL, Collins JL, Holmes CP, et al. A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. Proc Natl Acad Sci U S A 1999; 96 (11): 6102-6
    • (1999) Proc Natl Acad Sci , vol.96 , Issue.11 , pp. 6102-6106
    • Oberfield, J.L.1    Collins, J.L.2    Holmes, C.P.3
  • 154
    • 0033766035 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor-γ (PPAR γ) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3t3-l1 adipocytes
    • Mukherjee R, Hoener PA, Jow L, et al. A selective peroxisome proliferator-activated receptor-γ (PPAR γ) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3t3-l1 adipocytes. Mol Endocrinol 2000; 14: 1425-33
    • (2000) Mol Endocrinol , vol.14 , pp. 1425-1433
    • Mukherjee, R.1    Hoener, P.A.2    Jow, L.3
  • 155
    • 0034695479 scopus 로고    scopus 로고
    • A synthetic antagonist for the peroxisome proliferators-activated receptor γ inhibits adipocyte differentiation
    • Wright HM, Clish CB, Mikami T, et al. A synthetic antagonist for the peroxisome proliferators-activated receptor γ inhibits adipocyte differentiation. J Biol Chem 2000; 275: 1873-7
    • (2000) J Biol Chem , vol.275 , pp. 1873-1877
    • Wright, H.M.1    Clish, C.B.2    Mikami, T.3
  • 156
    • 2642557181 scopus 로고    scopus 로고
    • A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity
    • Rocchi S, Paciard F, Vamecq J, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell 2001; 8 (4): 737-47
    • (2001) Mol Cell , vol.8 , Issue.4 , pp. 737-747
    • Rocchi, S.1    Paciard, F.2    Vamecq, J.3
  • 157
    • 12444273748 scopus 로고    scopus 로고
    • Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator
    • Berger JP, Petro AE, Macnaul KL, et al. Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator. Mol Endocrinol 2003; 17 (4): 662-76
    • (2003) Mol Endocrinol , vol.17 , Issue.4 , pp. 662-676
    • Berger, J.P.1    Petro, A.E.2    Macnaul, K.L.3
  • 158
    • 10644293716 scopus 로고    scopus 로고
    • Benzoyl 2-methyl indoles as selective PPAR γ modulators
    • Acton III JJ, Black RM, Jones AB, et al. Benzoyl 2-methyl indoles as selective PPAR γ modulators. Bioorg Med Chem Lett 2005; 15 (2): 357-62
    • (2005) Bioorg Med Chem Lett , vol.15 , Issue.2 , pp. 357-362
    • Acton III, J.J.1    Black, R.M.2    Jones, A.B.3
  • 159
    • 0141920726 scopus 로고    scopus 로고
    • Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity
    • Rangwala SM, Rhoades B, Shapiro JS, et al. Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Dev Cell 2003; 5 (4): 657-63
    • (2003) Dev Cell , vol.5 , Issue.4 , pp. 657-663
    • Rangwala, S.M.1    Rhoades, B.2    Shapiro, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.