Skeletal muscle peroxisome proliferator-activated receptor-γ expression in obesity and non-insulin-dependent diabetes mellitus

Journal of Clinical Investigation

Volumn 101, Issue 3, 1998, Pages 543-548

  Kruszynska, Yolanta T ^a,c   Mukherjee, Ranjan ^b   Jow, Lily ^b   Dana, Sharon ^b   Paterniti Jr , James R ^b   Olefsky, Jerrold M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LIGAND PHARMACEUTICALS INC   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Body fat; Euglycemic clamp; Glucose kinetics; Insulin resistance; MRNA

Indexed keywords

MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR;

ADULT; ARTICLE; BODY FAT; BODY MASS; CLINICAL ARTICLE; GLUCOSE TRANSPORT; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; LIGAND BINDING; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; RECEPTOR GENE; SKELETAL MUSCLE; TARGET CELL; VASTUS LATERALIS MUSCLE;

EID: 0032006547     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1076     Document Type: Article

References (42)

1. Chawla, A., EJ. Schwarz, D.D. Dimaculangan, and A.A. Lazar. 1994. Peroxisome proliferator-activated receptor (PPAR)γ: adipose - predominant expression and induction early in adipocyte differentiation. Endocrinology. 135:798-800.
2. Tontonoz, P., E. Hu, D.A. Graves, A.L. Budauon, and B.M. Speigelman. 1994. mPPARγ2: tissue specific regulator of an adipocyte enhancer. Genes Dev. 8:1224-1234.
3. Issemann, I., and S. Green. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferates. Nature. 347:645-649.
4. Saltiel, A.R., and J.M. Olefsky. 1996. Thiazolidinediones in the treatment of insulin resistance and Type II diabetes. Diabetes. 45:1661-1669.
5. Gearing, K., A. Crickmore, and J. Gustaffson. 1994. Structure of the mouse peroxisome proliferator activated α gene. Bioehem. Biophys. Res. Commun. 99:255-263.
6. Schmidt, A., N. Endo, S. Rutletlge, R. Vogel. D. Shinar, and G. Rodan. 1992. Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acid. Mol. Endocrinol. 6:1634-1641.
7. Zhu, Y., K. Alvares, Q. Huang, M.S. Rao, and J. Reddy. 1993. Cloning of a new member of the peroxisome proliferalor - activated receptor gene family from mouse liver. J. Biol. Chem. 268:26817-26820.
8. Zhu, Y., C. Qi, J.R. Korenberg, X.N. Chen, D. Noya, M.S. Rao, and J. Reddy. 1995. Structural organization of mouse peroxisome - proliferator activated receptor γ(mPPARγ) gene: alternative promoter use and different splicing yield two mPPARγ isoforms. Proc. Natl. Acad. Sci. USA. 92:7921-7925.
9. Mukherjee, R., L. Jow, G.E. Croston, and J.R. Paterniti. 1997. Identification, characterization, and tissue distribution of human peroxisome proliferator-aclivatcd receptor (PPAR) isoforms PPARγ2 versus PPARγ1 and activation with retinoid X receptor agonists and antagonists. J. Biol. Chem. 272:8071-8076.
10. Kliewer, S.A., S.S. Sundseth, S.A. Jones, P.J. Brown, G.B. Wisely, C.S. Koble, P, Devchand, et al. 1997. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator - activated receptors a and γ. Proc. Nutl. Acad. Sci. USA. 94:4318-4323.
11. Gearing, K., M. Gottlicher, E. Widmark, C. Banner, P. Tollet, M. Stromstedt, J. Rafter, R. Berge, and J. Gustafsson. 1994. Fatty acid activation of the peroxisome proliferator activated receptor, a member of the nuclear receptor gene superfamily. J. Nutr. 124:1284-1288.
12. Issemann, I., R. Prince, J. Tugwood, and S. Green. 1993. The peroxisome proliferator activated receptor: retinoid X receptor heterodimer is activated by fatty acid and fibrate hypolipidaemic drugs. J Mol. Endocrinol. 11:37-47.
13. 2. metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell. 83:813-819.
14. Lehmann, J.M., L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator receptor γ (PPARγ). J. Biol. Chem. 270:12953-12956.
15. Wilson, T.M., J.E. Cobb, DJ. Cowan, R.W. Wiethe, I.D. Correa, S.R. Prakash, K.D. Beck, L.B. Moore, S.A. Kliewer, and J.M. Lehmann. 1996. The structure activity relationship between peroxisome-proliferator activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J. Med. Chem. 39:665-668.
16. Kruszynska, Y.T., and J.M. Olefsky. 1996. Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. J. Invest. Med. 44:413-128.
17. Suter, S.L., JJ. Nolan, P. Wallace, B. Gumbiner, and J.M. Olefsky. 1992. Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care. 15:193-203.
18. Nolan, JJ., B. Ludvik, P. Beerdsen, M. Joyce, and J.M. Olefsky. 1994. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med. 331:1188-1193.
19. Sandouk, T., D. Reda, and C. Hofmann, 1993. The antidiabetic agent pioglitazone increases expression of glucose transporters in 3T3-F442A cells by increasing messenger ribonucleic acid transcript stability. Endocrinology. 133: 352-359.
20. Tafuri, S.R. 1996. Troglitazone enhances differentiation, basal glucose uptake, and Glut 1 protein levels in 3T3-L1 adipocytes. Endocrinology. 137: 4706-4712.
21. Ciaraldi, T.P., K. Huber-Khudsen, M. Hickman, and J.M. Olefsky. 1995. Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents. Metabolism. 44:976-982.
22. Park, K.-S., L. Abrams-Carter, S. Mudalier, S. Nikoulina, and R.R. Henry. 1997. Troglitazone effects on gene expression in human skeletal muscle involve regulation of PPARγ. Diabetes. 46(Suppl.):22A. (Abstr.)
23. Vidal-Puig, AJ., R.V. Considine, M. Jimenez-Linan. A. Werman, W.J. Pories, J.F. Caro, and J.S. Flier. 1997. Peroxisome proliferator-activaled receptor gene expression in human tissues: effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J. Clin. Invest. 99:2416-2422.
24. Vidal-Puig, A., M. Jimenez-Linan, B.B. Lowell, A. Hamann, E. Hu, B. Spiegelman, J.S. Flier, and D.E. Moller. 1996. Regulation of PPARγ gene expression by nutrition and obesity in rodents. J. Clin. Invest. 97:2553-2561.
25. DeFronzo, R.A., J.D. Tobin, and R. Andres. 1979. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237:E214-E223.
26. Hother-Nielsen, O., A. Mengel, J. Moller, O. Rasmussen, O. Schmitz, and H. Beck-Nielsen. 1992. Assessment of glucose turnover rates in euglycaemic clamp studies using primed [3-3H]-glucose infusion and labelled or unlabelled glucose infusates. Diabetic Med. 9:840-849.
27. Bergstrom, J. 1962. Muscle electrolytes in man determined by neutron activation analysis on needle biopsy specimen: a study on normal subjects, kidney patients, and patients with chronic diarrhea. Scand. J. Clin. Lab. Invest. 14(Suppl.):1-110.
28. Chomczynski, P., and N, Sacchi, 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
29. Graves, R.A., P. Tontonoz, and B.M. Spiegelman. 1992. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol. Cell. Biol. 12:1202-1208.
30. Somogyi, M.J. 1945. Determination of blood sugar. J. Biol. Chem. 160: 69-73.
31. Desbuquois, B., and G.D. Aurbach. 1971. Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J. Clin. Endocrinol Metab. 33:732-738.
32. Steele, R. 1959. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann. N.Y. Acad. Sci. 82:420-430.
33. Wolfe. R.R. 1984. Tracers in Metabolic Research: Radioisotope/Mass Spectrometry Methods. Alan R. Liss, New York. 81-101.
34. Zhang, B., J. Berger, G. Zhou, A. Elbrecht, S. Biswas, S. White-Carrington, D. Szalkowski, and D.E. Moller. 1996. Insulin- and mitogen-activated protein kinase - mediated phosphorylation and activation of peroxisome proliferator - activated receptor γ. J. Biol. Chem. 271:31771-31774.
35. Tontonoz, P., E. Hu, and B.M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2. a lipid-activated transcription factor. Cell. 79: 1147-1156.
36. Hu, E., P. Tontonoz, and B. Spiegelman. 1995. Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα. proc. Natl. Acad. Sci. USA. 92:9856-9860.
37. Rosenfalck, A.M., T. Almdal, A. Gotfredsen, and J. Hilsted. 1996. Bodycomposition in normal subjects: relation to lipid and glucose variables. Int. J. Obes. 20:1006-1013.
38. Hotamisligil, S.G., and B.M. Spiegelman. 1994. Tumour necrosis factor α: a key component of the obesity-diabetes link. Diabetes. 43:1271-1278.
39. Hotamisligil, G.S., P. Arner, J.F. Caro, R.L. Atkinson, and B.M. Spiegelman. 1995. Increased adipose tissue expression of tumour necrosis factor-α in human obesity and insulin resistance. J. Clin. Invest. 95:2409-2415.
40. Hofmann, C., K. Lorenz, S.S. Braithwaite, J.R. Colca, B.J. Palazuk, G.S. Hotamisligil, and B.M. Spiegelman. 1994. Altered gene expression for tumour necrosis factor-α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology. 134:264-270.
41. Saghizadeh, M., J.M. Ong, W.T. Garvey, R.R. Henry, and P.A. Kern. 1996. The expression of TNFα by human muscle: relationship to insulin resistance. J. Clin. Invest. 97:1111-1116.
42. Zhang, B., J. Berger, E. Hu. D. Szalkowski, S. White-Carrington, B.M. Spiegelman, and D.E. Moller. 1996. Negative regulation of peroxisome proliferator - activated receptor-γ gene expression contributes to the antiadipogenic effects of tumor necrosis factor-α. Mol. Endocrinol. 10:1457-1466.