Peroxisome Proliferator-Activated Receptors, Coactivators, and Downstream Targets

Cell Biochemistry and Biophysics

Volumn 32, Issue , 2000, Pages 187-204

  Qi, Chao ^a   Zhu, Yijun ^a   Reddy, Janardan K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIVER; METABOLISM; PATHOLOGY; PEROXISOME; REVIEW; SIGNAL TRANSDUCTION; ULTRASTRUCTURE;

ANIMALS; GENE EXPRESSION REGULATION; HUMANS; LIVER; PEROXISOMES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0034569799     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/CBB:32:1-3:187     Document Type: Article

References (97)

1. DeDuve, C. and Baudhuin, P. (1966) Microbodies (peroxisomes) and related particles. Physiol. Rev. 46, 323-357.
2. Tolbert, N. E. (1981) Metabolic pathways in peroxisomes and glyoxysomes. Annu. Rev. Biochem. 50, 133-57.
3. Reddy, J. K. and Mannaerts, G. P. (1994) Peroxisomal lipid metabolism. Annu. Rev. Nutr. 14, 343-370.
4. Reddy, J. K. and Krishnakantha, T. P. (1975) Hepatic peroxisome proliferation: Induction by two novel compounds structurally unrelated to clofibrate. Science 200, 787-789.
5. Reddy, J. K. and Lalwani, N. D. (1983) Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to human. CRC Crit. Rev. Toxicol. 12, 1-58.
6. Reddy, J. K., Rao, M. S., and Moody, D. E. (1976) Hepatocellular carcinomas in acatalasemic mice treated with nafenopin, a hypolipidemic peroxisome proliferator. Cancer Res. 36, 1211.
7. Reddy, J. K., Azarnoff, D. L., and Hignite, C. F. (1980) Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature 283, 397-398.
8. Reddy, J. K., Goel, S. K., Nemali, M. R., Carrino, J. J., Laffler, T. G., Reddy, M. K., et al. (1986) Transcriptional regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators. Proc. Natl. Acad. Sci. USA 83, 1747-1751.
9. 2α. J. Lipid Res. 31, 1477-1482.
10. Muerhoff, A. S., Griffin, K. J., and Johnson, E. F. (1992) The peroxisome proliferator activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid. J. Biol. Chem. 267, 19051-19053.
11. Kaikaus, R. M., Chan, W. K., Lysenko, N., Ray, R., Ortiz de Montellano, P. R., and Bass, N. M. (1993) Induction of peroxisomal fatty acid β-oxidation and liver fatty acid-binding protein by peroxisome proliferators: mediation via the cytochrome P-450IVA1 ω-hydroxylase pathway. J. Biol. Chem. 268, 9593-9603.
12. Gulick, T., Cresci, S. Caira, T., Moore, D. D., and Kelly, D. P. (1994) The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc. Natl. Acad. Sci. USA 91, 11012-11016.
13. Reddy, J. K. and Rao, M. S. (1986) Peroxisome proliferators and cancer; mechanisms and implications. Trends Pharmacol. Sci. 7, 438-443.
14. Reddy, J. K. and Rao, M. S. (1987) Peroxisome proliferation-related oxidative stress and hepatocarcinogenesis, in Anticarcinogenesis and Radiation Protection (Cerutti, P. A., Nygaard, O. F., Simic, M. G., eds.) Plenum, New York, pp. 85-91.
15. Lalwani, N. D., Fahl, W. E., and Reddy, J. K. (1983) Detection of nafenopin binding protein in rat liver cytosol associated with the induction of peroxisome proliferation by hypolipidemic compounds. Biochem. Biophys. Res. Commun. 116, 388-393.
16. Lalwani, N. D., Alvares, K., Reddy, M. K., Reddy, M. N., Parikh, I., and Reddy, J. K. (1987) Peroxisome proliferator binding protein: identification and partial characterization of nafenopin, clofibric acid and ciprofibrate binding proteins from rat liver. Proc. Natl. Acad. Sci. USA 84, 5142-5246.
17. Alvares, K., Carrillo, A., Yuan, P. M., Kawano, H., Morimoto, R. I., and Reddy, J. K. (1990) Identification of peroxisome proliferator binding protein as a member of HSP70 protein family. Proc. Natl. Acad. Sci. USA 87, 5293-5297.
18. Issemann, I. and Green, S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645-650.
19. Dreyer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G., and Wahli, W. (1992) Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68, 879-887.
20. Zhu, Y., Alvares, K., Huang, Q., Rao, M. S., and Reddy, J. K. (1993) Cloning of a new member of peroxisome proliferator activated receptor gene family from mouse liver. J. Biol. Chem. 268, 26817-26820.
21. Sher, T., Yi, H. F., McBride, W., and Gonzalez, F. J. (1993) cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 32, 5598-5604.
22. Kliewer, S. A., Forman, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., and Evans, R. M. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 91, 7355-7359.
23. Lee, S. S.-T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., et al. (1995) Targeted disruption of the isoform of the peroxisomal proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15, 3012-3022.
24. Chatterjee, B., Demyan, W. F., Lalwani, N. D., Reddy, J. K., and Roy, A. K. (1983) Reversible alteration of hepatic messenger RNAs for peroxisomal and non-peroxisomal proteins induced by hypolipidemic drug Wy-14,643. Biochem. J. 241, 879-883.
25. Huang, Q., Alvares, K., Chu, R., Bradfield, C. A., and Reddy, J. K. (1994) Association of peroxisome-proliferator-activated receptor and HSP72. J. Biol. Chem. 269, 8493-8497.
26. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., et al. (1995) The nuclear receptor superfamily: the second decade. Cell 83, 835-839.
27. Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., and Spiegelman, B. M. (1994) mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8, 1224-1234.
28. Zhu, Y., Qi, C., Korenberg, J. R., Chen, Z.-N., Noya, D., Rao, M. S., and Reddy, J. K. (1995) Structural organization of mouse peroxisome proliferator-activated receptorγ (mPPARγ) gene: alternative promoter use and different splicing yield two mPPARγ isoforms. Proc. Natl. Acad. Sci. USA 92, 7921-7925.
29. Danielian, P. S., White, R., Lees, J. A., and Parker, M. G. (1992) Identification of a conserved region required for hormone-dependent transcriptional activation by steroid hormone receptors. EMBO J. 11, 1025-1033.
30. Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A., and Evans, R. M. (1992) Convergence of 9-cis-retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (London) 358, 771-774.
31. Palmer, C. N. A., Hsu, M.-H., Griffin, K. J., Johnson, and E. F. (1995) Novel sequence determinants in peroxisome proliferator signaling. J. Biol. Chem. 270, 16114-16121.
32. Reddy, J. K. and Chu, R. (1996) Peroxisome proliferator-induced pleiotropic responses: Pursuit of a phenomenon. Ann. New York Acad. Sci. 804, 176-201.
33. Chu, R., Lin, Y., Rao, M. S., and Reddy, J. K. (1995) Cooperative formation of higher order peroxisome proliferator-activated receptor and retinoid X receptor complexes on the peroxisome proliferator responsive element of the rat hydratase-dehydrogenase gene. J. Biol. Chem. 270, 29636-29639.
34. Nemali, M. R., Reddy, M. K., Usuda, N., Reddy, P. G., Comeau, L. D., Rao, M. S., and Reddy, J. K. (1989) Differential induction and regulation of peroxisomal enzymes: predictive value of peroxisomal proliferation in identifying certain nonmutagenic carcinogens. Toxicol. Appl. Pharmacol. 97, 72-87.
35. Krey, G., Braissant, O., L'Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., and Wahli, W. (1997) Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Endocrinology 11, 779-791.
36. Forman, B. M., Chen, J., and Evans, R. M. (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and β. Proc. Natl Acad. Sci. USA 94, 4312-4317.
37. Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., et al. (1997) Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc. Natl. Acad. Sci. USA 94, 4318-4323.
38. Fan, C.-Y., Pan, J., Usuda, N., Yeldandi, A. V., Rao, M. S., and Reddy, J. K. (1998) Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. J. Biol. Chem. 273, 15639-15645.
39. Mosser, J., Lutz, Y., Stoeckel, M. E., Sarde, C. O., Kretz, C., Douar, A. M., Lopez, J., Aubourg, P., and Mandel, J. L. (1994) The gene responsible for adrenoleukodystrophy encodes a peroxisomal membrane protein. Hum. Mol. Genet. 2, 285-271.
40. Lu, J.-F., Lawler, A. M., Watkins, P. A., Powers, J. M., Moser, A. B., Moser, H. W., and Smith, K. D. (1997) A mouse model for X-linked adrenoleukodystrophy. Proc. Natl. Acad. Sci. USA 94, 9366-9371.
41. Kobayashi, T., Shinonoh, N., Kondo, A., and Yamada, T. (1997) Adrenoleukodystrophy protein deficient mice represent abnormality of very long chain fatty acid metabolism. Biochem. Biophys. Res. Commun. 232, 631-636.
42. Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Stimulation of adipogenesis in fibroblasts by PPAR_2, a lipid-activated transcription factor. Cell 79, 1147-1156.
43. Mansen, A., Guardiola-Diaz, H., Rafter, J., Branting, C., and Gustafsson, J.-A. (1996) Expression of the peroxisome proliferator-activated receptor (PPAR) in the mouse colonic mucosa. Biochem. Biophys. Res. Commun. 222, 844-851.
44. Braissant, O., Foufelle, F., Scotto, C., Dauca, M., and Wahli, W. (1996) Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β, and -γ in the adult rat. Endocrinology 137, 354-366.
45. Jain, S., Pulikuri, S., Zhu, Y., Qi, C., Kanwar, Y. S., Yeldandi, A. V., Rao, M. S., and Reddy, J. K. (1998) Differential expression of the peroxisome proliferator-activated receptorγ (PPARα) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse. Amer. J. Pathol. 153, 349-354.
46. Guan, Y., Zhang, Y., Davis, L., and Breyer, M. D. (1997) Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans. Am. J. Physiol. 273, F1013-F1022.
47. Gottlicher, M., Widmark, K., Li, Q., and Gustafsson, J. A. (1992) Fatty acids activate chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 89, 4653-4657.
48. 2 is a ligand for the adipocyte determination factor PPAR. Cell 83, 803-812.
49. 2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell 83, 813-819.
50. Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M., and Kliewer, S. A. (1997) Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 272, 3406-3410.
51. Huang, Q., Yeldandi, A. V., Alvares, K., Ide, H., Reddy, J. K., and Rao, M. S. (1995) Localization of peroxisome proliferator-activated receptor in mouse and rat tissues and demonstration of its nuclear translocation in transfected CV-1 cells. Int. J. Oncol. 6, 307-312.
52. Tontonoz, P., Singer, S., Forman, B., Sarraf, P., Fletcher, J., Fletcher, C. D. M., et al. (1997) Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor γ and the retinoid X receptor. Proc. Natl. Acad. Sci. USA 94, 237-241.
53. Sarraf, P., Mueller, E., Jones, D., King, F. J., DeAngelo, D. J., Partridge, J. B., et al. (1998) Differentiation and reversal of malignant changes in colon cancer through PPARγ. Nature Med. 4, 1046-1052.
54. Glass, C. K., Rose, D. W., and Rosenfeld, M. G. (1997) Nuclear receptor coactivators. Curr. Opin. Cell Biol. 9, 222-232.
55. Onate, S. A., Tsai, S. Y., Tsai, M.-J., and O'Malley, B. W. (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270, 1354-1357.
56. Voegel, J. J., Heine, M. J. S., Zechel, C., Chambon, P., and Gronemeyer, H. (1996) TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 15, 3667-3675.
57. Torchia, J., Rose, D. W., Inostroza, J., Kamei, Y., Westin, S., Glass, C. K., and Rosenfeld, M. G. (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387, 677-684.
58. Hong, H., Kohli, K., Trivedi, A., Johnson, D. L., and Stallcup, M. R. (1996) GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc. Natl. Acad. Sci. USA 93, 4948-1952.
59. Chen, H., Lin, R. J., Schiltz, R. L., Chakravarti, D., Nash, A., Nagy, L., et al. (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90, 569-580.
60. Anzick, S. L., Kononen, J., Walker, R. L., Azorsa, D. O., Tanner, M. M., Guan, X. Y., et al. (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277, 965-968.
61. Li, H., Gomes, P. J., and Chen, J. D. (1997) RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc. Natl. Acad. Sci. USA 94, 8479-8484.
62. Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., et al. (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85, 403-414.
63. Zhu, Y., Qi, C., Jain, S., Rao, M. S., and Reddy, J. K. (1997) Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J. Biol. Chem. 272, 25,500-25,506.
64. Yuan, C.-X., Ito, M., Fondell, J. D., Fu, Z.-Y., and Roeder, R. G. (1998) The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc. Natl. Acad. Sci. USA 95, 7939-7944.
65. Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., and Spiegelman, B. M. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839.
66. Yeh, S. and Chang, C. (1997) Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. USA 93, 5517-5521.
67. Zhu, Y., Qi, C., Calandra, C., Rao, M. S., and Reddy, J. K. (1996) Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor γ. Gene Express. 6, 185-195.
68. Yao, T.-P., Ku, G., Zhou, N., Scully, R., and Livingston, D. M. (1996) The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. Proc. Natl. Acad. Sci. USA 93, 10626-10631.
69. Takeshita, A., Yen, P. M., Misiti, S., Cardona, G. R., Liu, Y., and Chin, W. W. (1996) Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. Endocrinology 137, 3594-3597.
70. Heery, D. M., Kalkhoven, E., Hoare, S., and Parker, M. G. (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387, 733-736.
71. Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., and Nakatani, Y. (1996) The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87, 953-959.
72. Brownell, J. E. and Allis, C. D. (1996) Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation. Curr. Opin. Genet. Dev. 6, 176-184.
73. Chakravarti, D., LaMorte, V. J., Nelson, M. C., Nakajima, T., Schulman, I. G., Juguilon, H., Montminy, M., and Evans, R. M. (1996) Role of CBP/P300 in nuclear receptor signalling. Nature 383, 99-102.
74. Dowell, P., Ishmael, J. E., Avram, D., Peterson, V. J., Nevrivy, D. J., and Leid, M. (1997) p300 Functions as a coactivator for the peroxisome proliferator-activated receptor α. J. Biol. Chem. 272, 33435-33443.
75. Mizukami, J. and Taniguchi, T. (1997) The antidiabetic agent thiazolidinedione stimulates the interaction between PPAR and CBP Biochem. Biophys. Res. Commun. 240, 61-64.
76. Cavailles, V., Dauvois, S., L'Horset, F., Lopez, G., Hoare, S., Kushner, P. J., and Parker, M. G. (1995) Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J. 14, 3741-3751.
77. Treuter, E., Albrektsen, T., Johansson, L., Leers, J., and Gustafsson, J.-A. (1998) A regulator role for RIP140 in nuclear receptor activation. Mol. Endocrinol. 12, 864-881.
78. Chu, R., Lin, Y., Rao, M. S., and Reddy, J. K. (1996) Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor α. J. Biol. Chem. 271, 27670-27675.
79. Brun, R. P., Kim, J. B., Hu, E., and Spiegelman, B. M. (1997) Peroxisome proliferator-activated receptor gamma and the control of adipogenesis. Curr. Opin. Lipid. 8, 212-218.
80. Schoonjans, K., Staels, B., and Auwerx, J. (1996) The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim. Biophys. Acta 1302, 93-109.
81. Hashimoto, T. (1982) Individual peroxisomal β-oxidation enzymes. Ann. NY Acad. Sci. 386, 5-12.
82. Martin, G., Schoonjans, K., Lefebvre, A.-M., Staels, B., and Auwerx, J. (1997) Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators. J. Biol. Chem. 272, 28210-28217.
83. Ren, B., Thelen, A. P., Peters, J. M., Gonzalez, F. J., and Jump, D. B. (1997) Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 272, 26827-26832.
84. 3H]-thymidine and salmonella mutagenesis assays. Cancer Res. 40, 36-41.
85. Rao, M. S. and Reddy, J. K. (1996) Hepatocarcinogenicity of peroxisome proliferators. Ann. NY Acad. Sci. 804, 573-587, 1996.
86. Ashby, J., Brady, A., Elcombe, C. R., Elliot, B. M., Ishmael, J., Odum, J., Tugwood, J. M., Kettle, S., and L. F. H. Purchase. (1994) Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis. Hum. Exp. Toxicol. 13(Suppl. 2), S1-S117.
87. Rao, M. S. and Reddy, J. K. (1987) Peroxisome proliferation and hepatocarcinogenesis. Carcinogenesis 8, 631-636.
88. Lazarow, P. B. and deDuve, C. (1976) A fatty acyl-CoA oxidizing system in rat liver peroxisomes: Enhancement by clofibrate, a hypolipidemic drug. Proc. Natl. Acad. Sci. USA 73, 2043-2046.
89. 2-generating peroxisomal fatty acyl-CoA oxidase. Proc. Natl. Acad. Sci. USA 92, 7080-7084.
90. Dadras, S. S., Thorgeirsson, S. S., Rao, M. S., and Reddy, J. K. (1998) Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase. Int. J. Oncol. 12, 37-44.
91. 2-generating peroxisomal fatty acyl-CoA oxidase. Int. J. Cancer 70, 716-721.
92. 3 signaling pathways. Proc. Natl. Acad. Sci. USA 92, 11593-11597.
93. Juge-Aubry, C. E., Gorla-Bajszczak, A., Pernin, A., Lemberger, T., Wahli, W., Burger, A. G., and Meier, C. A. (1995) Peroxisome proliferator-activated receptor mediates cross-talk with thyroid hormone receptor by competition for retinoid X receptor. J. Biol. Chem. 270, 18,117-18,122.
94. Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., and Glass, C. K. (1998) The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391, 79-82.
95. Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H., and Evans, R. M. (1998) Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell 93, 229-240.
96. Tontonoz, P., Nagy L., Alvarez, J. G. A., Thomazy, V. A., and Evans, R. M. (1998) PPARy promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93, 241-252.
97. Wu, Z., Xie, Y., Bucher, N. L., and Farmer, S. R. (1995) Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev 9, 2350-2363.