Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein

Neurobiology of Disease

Volumn 22, Issue 1, 2006, Pages 10-24

  Lee, Kang Woo ^a,b   Im, Joo Young ^a,b   Song, Jin Sook ^c   Lee, Si Hyoung ^a   Lee, Ho Jeong ^a   Ha, Hye Yeong ^a   Koh, Jae Young ^d   Gwag, Byoung Joo ^e   Yang, Sung Don ^c   Paik, Sang Gi ^b   Han, Pyung Lim ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Chungnam National University   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

^e Ajou University School of Medicine   (South Korea)

Author keywords

AD model; Cognitive deficits; CTF; Neuronal loss; Transgenic animal

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CALBINDIN; CALCIUM BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PROTEIN BAX; PROTEIN BCL XL; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR DISORDER; BRAIN; BRAIN CORTEX; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL DENSITY; CELL LOSS; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LOCOMOTION; MOUSE; NERVE CELL; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC ORGANISM; UPREGULATION;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANXIETY DISORDERS; APOPTOSIS; BEHAVIORAL SYMPTOMS; BRAIN; CELL LINE; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOWN-REGULATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE DEGENERATION; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 33645092125     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.09.011     Document Type: Article

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