Genetic approaches to memory storage

Trends in Genetics

Volumn 15, Issue 11, 1999, Pages 463-470

  Mayford, Mark ^a   Kandel, Eric R ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b The New York Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN;

AMNESIA; APLYSIA; COGNITION; DROSOPHILA; GENE DELETION; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC MANIPULATION; GENETIC TRANSCRIPTION; LANGUAGE ABILITY; LEARNING DISORDER; LONG TERM MEMORY; MEMORY CONSOLIDATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSGENE;

AGING; ANIMALS; ANIMALS, GENETICALLY MODIFIED; APLYSIA; BRAIN DAMAGE, CHRONIC; CALCINEURIN; CALMODULIN; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DROSOPHILA MELANOGASTER; FORECASTING; HIPPOCAMPUS; HUMANS; LONG-TERM POTENTIATION; MEMORY; MEMORY DISORDERS; MICE; MICE, KNOCKOUT; TRANSGENES;

APLYSIA; GASTROPODA;

EID: 0033230601     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(99)01846-6     Document Type: Review

References (50)

1. Scoville, W. and Milner, B. (1957) Loss of recent memory after bilateral hippocampal lesions. J. Neural. Neurosurg. Psychiatry 20, 11-21
2. Milner, B. et al. (1998) Cognitive neuroscience and the study of memory. Neuron 20, 445-468
3. Dudai, Y. et al. (1976) dunce, a mutant of Drosophila deficient in learning. Proc. Natl. Acad. Sci. U. S. A. 73, 1684-1688
4. Dubnau, J. and Tully, T. (1998) Gene discovery in Drosophila: new insights for learning and memory. Annu. Rev. Neurosci. 21, 407-444
5. Drain, P. et al. (1991) cAmp-dependent protein kinase and the disruption of learning in transgenic flies. Neuron 6, 71-82
6. Castellucci, V. et al. (1970) Neuronal mechanisms of habituation and dishabituation of the gill-withdrawal reflex in Aplysia. Science 167, 1745-1748
7. Davis, H. and Squire, L. (1984) Protein synthesis and memory: A review. Psychol. Bull. 96, 518-559
8. Dash, P.K. et al. (1990) Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature 345, 718-721
9. Yin, J. et al. (1994) Induction of a dominant-negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79, 49-58
10. Yin, J. et al. (1995) CREB as a memory modulator: induced expression of dCREB2 activator isoform enhances long-term memory in Drosophila. Cell 81, 107-115
11. Bartsch, D. et al. (1995) Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell 83, 979-992
12. Bartsch, D. et al. (1998) CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell 95, 211-223
13. Alberini, C.M. et al. (1995) A molecular switch for the consolidation of long-term memory: cAMP-inducible gene expression. Ann. New York Acad. Sci. 758, 261-286
14. Hegde, A.N. et al. (1997) Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell 89, 115-126
15. Bliss, T.V. and Collingridge, G.L (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39
16. Silva, A.J. et al. (1992) Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257, 206-211
17. Silva, A.J. et al. (1992) Deficient hippocampal long-term potentiation in alpha-calcium- calmodulin kinase II mutant mice. Science 257, 201-206
18. Reed, J.M. and Squire, L.R. (1997) Impaired recognition memory in patients with lesions limited to the hippocampal formation. Behav. Neurosci. 111, 1-9
19. Morris, R.G. et al. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 277, 681-683
20. Grant, S.G. et al. (1992) Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258, 1903-1910
21. Frey, U. et al. (1988) Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro. Brain Res. 452, 57-65
22. Frey, U. et al. (1993) Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 260, 1661-1664
23. Abel, T. et al. (1997) Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88, 615-626
24. Rudolph, D. et al. (1998) Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc. Natl. Acad. Sci. U. S. A. 95, 4481-4486
25. Bourtchuladze, R. et al. (1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79, 59-68
26. Impey, S. et al. (1996) Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus. Neuron 16, 973-982
27. Impey, S. et al. (1998) Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nat. Neurosci. 7, 595-601.
28. Tsien, J.Z. et al. (1996) Subregion- and cell-type-restricted gene knockout in mouse brain. Cell 87, 1317-1326
29. Tsien, J.Z. et al. (1996) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87, 1327-1338
30. Li, Y. et al. (1994) Whisker-related neuronal patterns fail to develop inthetrigeminal brainstem nuclei of NMDAR1 knockout mice. Cell 76, 427-437
31. Mayford, M. et al. (1996) The 3′-untranslated region of CaMKII alpha is a as-acting signal for the localization and translation of mRNA in dendrites. Proc. Natl. Acad. Sci. U. S. A. 93, 13250-13255
32. Kuhn, R. et al. (1995) Inducible gene targeting in mice. Science 269, 1427-1429
33. Kellendonk, C. et al. (1999) Inducible site-specific recombination in the brain. J. Mol. Biol. 285, 175-182
34. Giese, K.P. et al. (1998)Autophosphorylation at thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science 279, 870-873
35. Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells bytetracycline-responsive promoters. Proc. Natl. Acad. Sci. U. S. A. 89, 5547-5551
36. Bach, M.E. et al. (1995) Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell 81, 905-915
37. Mayford, M. et al. (1995) CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell 81, 891-904
38. Mayford, M. et al. (1996) Control of memory formation through regulated expression of a CaMKII transgene. Science 274, 1678-1683
39. Gossen, M. et al. (1995) Transcriptional activation by tetracyclines in mammalian cells. Science 268, 1766-1769
40. Mansuy, I.M. et al. (1998) Inducibleand reversible gene expression with the rtTA system for the study of memory. Neuron 21, 257-265
41. Mulkey, R.M. et al. (1994) Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature 369, 486-488
42. Mansuy, I.M. et al. (1998) Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92, 39-49
43. Winder, D.G. et al. (1998) Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell 92, 25-37
44. Grotewiel, M.S. et al. (1998) Integrin-mediated short-term memory in Drosophila. Nature 351, 455-460
45. McHugh, T.J. et al. (1996) Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell 87, 1339-1349
46. Rotenberg, A. et al. (1996) Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. Cell 87, 1351-1361
47. Cho, Y.H. et al. (1998) Abnormal hippocampal spatial representations in αCaMKIIT286A and CREBαΔ - mice. Science 279, 867-869
48. Bailey, C.H. and Handel, E.R. (1993) Structural changes accompanying memory storage. Annu. Rev. Physiol. 55, 397-426
49. Zamanillo, D. et al. (1999) Importance of AMPA receptors for hippocampal LTP but not for spatial learning. Science (in press) Reference added in proof
50. Tank, Y.P. et al. (1999) Genetic enhancement of learning and memory in mice. Nature 401, 63-69