Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala

Journal of Neuroscience

Volumn 21, Issue 7, 2001, Pages 2404-2412

  Josselyn, Sheena A ^a,c   Shi, Chanjun ^a,d   Carlezon Jr , William A ^a,b   Neve, Rachael L ^b   Nestler, Eric J ^a   Davis, Michael ^a,d  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MCLEAN HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amygdala; CREB; Fear conditioning; Memory; Startle; Viral vector

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONDITIONING; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; GENE TRANSFER; LONG TERM MEMORY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SHORT TERM MEMORY; TRAINING;

EID: 0035313501     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-07-02404.2001     Document Type: Article

References (56)

1. Genetic demonstration of a role for PKA in the later phase of LTP in hippocampus-based long-term memory
2. Transsynaptic control of gene expression
3. The MAPK cascade is required for mammalian associative learning
4. Theoretical mechanisms underlying the trial-spacing effect in Pavlovian fear conditioning
5. CREB1 encodes a nuclear activator, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation
6. 2+- and stimulus duration-dependent switch for hippocampal gene expression
7. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element binding protein
8. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each which requires protein synthesis and PKA
9. Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli
10. Molecular enhancement of memory
11. Long-term habituation of a defensive withdrawal reflex in Aplysia
12. Sensitization to morphine induced by viral-mediated gene transfer
13. Role of CREB in cocaine reward
14. zensDistinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1
15. The design and calibration of a startle measurement system
16. Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
17. 2+/calmoldulin as well as cAMP-dependent protein kinase
18. Protein synthesis and memory
19. The role of the amygdala in fear and anxiety
20. Signaling routes to CREM and CREB: Plasticity in transcriptional activation
21. Role of PKA and CaM kinase in fear conditioning assessed with fear-potentiated startle using local infusion of Rp-8-Br-cAMP, KN-62, or KN-93 into the amygdala
22. Contextual conditioning with massed versus distributed unconditional stimuli in the absence of explicit conditional stimuli
23. CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
24. Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus
25. Trans-synaptic regulation of gene expression
26. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
27. Antisense oligodeoxynucleotide-mediated disruption of hippocampal CREB protein levels impairs memory of a spatial task
28. Stimulation of cAMP element (CREB)-mediated transcription during contextual learning
29. 2+ stimulation of CREB-dependent transcription and ERK nuclear translocation
30. Activation of cAMP-responsive genes by stimuli that produce long-tem facilitation in Aplysia sensory neurons
31. Spaced training induces normal long-term memory in CREB mutant mice
32. cAMP response element-binding protein in the amygdala is required for long- but not short-term conditioned taste aversion memory
33. Emotion circuits in the brain
34. The lateral amygdaloid nucleus: Sensory interface of the amygdala in fear conditioning
35. Generation of high-titer defective HSV-1 vectors using an IE 2 deletion mutant and quantitative study of expression in cultured cortical cells
36. The amygdala and fear conditioning: Has the nut been cracked?
37. Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression
38. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala
39. Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor
40. Overview of gene delivery into cells using HSV-1-based vectors
41. Introduction of the glutamate receptor subunit 1 into motor neurons in vitro and in vivo using a recombinant herpes simples virus
42. The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus
43. Somatosensory and auditory convergence in the lateral nucleus of the amygdala
44. Transcription factors responsive to cAMP
45. Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala
46. Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA and MAP kinase
47. A necessity for MAP kinase activation in mammalian spatial learning
48. 2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases
49. CREB and memory
50. Modulation of rat rotational behavior by direct gene transfer of constitutively active protein kinase C into nigrostriatal neurons
51. Genetic dissection of consolidated memory in Drosophila
52. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
53. Induction of a dominant-negative CREB transgene specifically blocks long-term memory in Drosophila
54. CREB as a memory modulator: Induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila