Modulator-induced interference in functional cross talk between the substrate and the ATP sites of human P-glycoprotein

Biochemistry

Volumn 45, Issue 8, 2006, Pages 2739-2751

  Maki, Nazli ^a   Moitra, Karobi ^a   Silver, Cara ^a   Ghosh, Pratiti ^a   Chattopadhyay, Apurba ^a   Dey, Saibal ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DISSOCIATION; HYDROLYSIS; HYDROPHOBICITY; MICROORGANISMS; MODULATORS;

ANTIMICROBIAL AGENTS; HUMAN P-GLYCOPROTEIN (PGP, ABCB1); NUCLEOTIDE BINDING DOMAINS (NBDS OR ATP SITES); SUBSTRATE RECOGNITION;

PROTEINS;

ADENOSINE TRIPHOSPHATE; CLOPENTHIXOL; CYCLOSPORIN A; FLUPENTIXOL; GLYCOPROTEIN P; IODINE 125; PRAZOSIN; THIOXANTHENE; VANADIC ACID;

ANIMAL CELL; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CONTROLLED STUDY; DISSOCIATION; DRUG BIOAVAILABILITY; DRUG PROTEIN BINDING; DRUG RESISTANCE; DRUG TRANSPORT; HYDROLYSIS; IMMUNOBLOTTING; INSECT CELL; MOLECULAR INTERACTION; NONHUMAN; PHOTOAFFINITY LABELING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; ANIMALS; AZIDES; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUPENTHIXOL; HUMANS; HYDROLYSIS; INSECTS; MODELS, BIOLOGICAL; P-GLYCOPROTEIN; PHOTOAFFINITY LABELS; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; TIME FACTORS; TRANSFECTION;

ANIMALIA; INSECTA;

EID: 33644538904     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0521745     Document Type: Article

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