Improved Energy Coupling of Human P-glycoprotein by the Glycine 185 to Valine Mutation

Biochemistry

Volumn 43, Issue 13, 2004, Pages 3917-3928

  Omote, Hiroshi ^a   Figler, Robert A ^a   Polar, Mark K ^a   Al Shawi, Marwan K ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; ADENOSINETRIPHOSPHATE; CELLS; ENTHALPY; ENTROPY; ENZYMES; MUTAGENESIS; PROTEINS; SACCHARIFICATION; THERMODYNAMIC PROPERTIES;

ATPASE ACTIVITY; ENERGY COUPLING; TRANSPORT RATE-LIMITING STEP;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATASE; COLCHICINE; CYSTEINE; ETOPOSIDE; GLYCINE; GLYCOPROTEIN P; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; DRUG TRANSPORT; ELECTRON SPIN RESONANCE; ENERGY TRANSFER; ENTHALPY; ENTROPY; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; MOLECULAR MODEL; MULTIDRUG RESISTANCE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SACCHAROMYCES CEREVISIAE; SPIN LABELING; THERMODYNAMICS;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SUBSTITUTION; BIOLOGICAL TRANSPORT; COLCHICINE; CYSTEINE; DRUG RESISTANCE, MULTIPLE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ETOPOSIDE; GLYCINE; HISTORY, ANCIENT; HUMANS; MEMBRANE LIPIDS; MUTAGENESIS, SITE-DIRECTED; P-GLYCOPROTEIN; SACCHAROMYCES CEREVISIAE PROTEINS; SPIN LABELS; SUBSTRATE SPECIFICITY; THERMODYNAMICS; VALINE;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 1842538878     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035365l     Document Type: Article

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