The multi-drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P-glycoprotein by an allosteric interaction

British Journal of Pharmacology

Volumn 122, Issue 4, 1997, Pages 765-771

  Martin, Catherine ^a   Berridge, Georgina ^a   Higgins, Christopher F ^a   Callaghan, Richard ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Allosteric; Drug binding; Multidrug resistance; P glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATASE; FANTOFARONE; GLYCOPROTEIN P; INDOLIZINE DERIVATIVE; VERAPAMIL; VINBLASTINE; VINCA ALKALOID;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG POTENTIATION; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; ALLOSTERIC REGULATION; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; INDOLIZINES; P-GLYCOPROTEIN; PHENETHYLAMINES; TRITIUM; VERAPAMIL; VINBLASTINE;

EID: 0030697879     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701429     Document Type: Article

References (39)

1. AL-SHAWI, M.K. & SENIOR, A.E. (1993). Characterization of the adenosine triphosphatase activity of chinese hamster P-glycoprotein. J. Biol. Chem., 268, 4197-4206.
2. AYESH, S., SHAO, Y.-M. & STEIN, W.D. (1996). Co-operative, competitive and non-competitive interactions between modulators of P-glycoprotein. Biochim. Biophys. Acta. 1316, 8-18.
3. BORCHERS, C., ULRICH, W.-R., KLEMM, K., ISE, W., GEKELER, V., HAAS, S., SCHOOL, A., CONRAD, J., PRZYBLYSKI, M. & BOER, R. (1995). B9209-005, an azido derivative of the chemosensitizer Dexniguldipine-HCl photolabels P-glycoprotein. Mol. Pharmacol., 48, 21-29.
4. BRUGGEMAN, E.P., GERMANN, U.A., GOTTESMAN, M.M. & PASTAN, I. (1989). Two different regions of phosphoglycoprotein and photoaffinity labeled by azidopine. J. Biol. Chem., 264, 15483-15488.
5. CALLAGHAN, R., BERRIDGE, G., FERRY, D.R. & HIGGINS, C.F. (1997). Activity of purified, reconstituted P-glyeoprotein requires maintenance of a lipid-protein interface. Biochim. Biophys. Acta, (in press).
6. CANO-GAUCI, D.F. & RIORDAN, J.R. (1987). Action of calcium antagonists on multidrug resistant cells. Biochem. Pharmacol., 36, 2115-2123.
7. CHIFFLET, S., CHIESA, U.T.R. & TOLOSA, S. (1988). A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases. Anal. Biochem., 168, 1-4.
8. DALTON, W.S., GROGAN, T.M., MELTZER, P.S., SCHEPER, R.J., DURIE, B.G., TAYLOR, C.W., MILLER, T.P. & SALMON, S.E. (1989). Drug resistance in multiple myeloma and non-Hodgkins lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. J. Clin. Oncol., 7, 415-424.
9. DE LEAN, A., MUNSON, P.J. & RODBARD, D. (1978). Simultaneous analysis of families of sigmoidal curves: applications to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol., 235, E97-E102.
10. 939/941 position in predicted transmembrane domain 11 of P-glycoprotein. Biochemistry, 32, 9492-9499.
11. DOIGE, C.A., YU, X. & SHAROM. F.J. (1992). ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells. Biochim. Biophys. Acta, 1109, 149-160.
12. ENDICOTT, J.A. & LING, V. (1989). The biochemistry of P-glycoprotein-mediated multidrug resistance. Ann. Rev. Biochem., 58, 137-171.
13. FERRY, D.R., MALKHANDI, J.P., RUSSELL, M.A. & KERR, D.J. (1995). Allosteric regulation of [3H]vinblastine binding to P-glycoprotein of MCF-7 Adr cells by dexniguldipine. Biochem. Pharmacol., 49, 1851-1861.
14. FERRY, D.R., RUSSELL, M.A. & CULLEN, M.H. (1992). P-glycoprotein possesses a 1,4-dihydropyridine selective drug acceptor site which is allosterically coupled to a vinca alkaloid selective binding site. Biochem. Biophys. Res. Commun., 188, 440-445.
15. GARRIGOS, M., MIR, L.M. & ORLOWSKI, S. (1997). Competitive and non-competitive inhibition of the multidrug-resistance-associated P-glycoprotein ATPase. Further experimental evidence for a multisite model. Eur. J. Biochem., 244, 664-673.
16. 2+ channel by photoaffinity labeling. Trends Pharmacol. Sci., 8, 95-100.
17. GOTTESMAN, M.M. & PASTAN, I. (1993). Biochemistry of multidrug resistance by the multidrug transporter. Ann. Rev. Biochem., 62, 385-427.
18. GREENBERGER, L.M., LISANTI, C.J., SILVA, J.T. & HORWITZ, S.B. (1991). Domain mapping of the photoaffinity drug binding sites in P-glycoprotein encoded by mouse mdr1b. J. Biol. Chem., 266, 20744-20751.
19. GROS, P., CROOP, J. & HOUSEMAN, D.E. (1986). Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell, 47, 371-380.
20. JAFFREZOU, J.-P., HERBERT, J.-M., LEVADE, T., GAU, M.-N., CHATELAIN, P. & LAURENT, G. (1991). Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labelling of P-glycoprotein. J. Biol. Chem., 266, 19858-19864.
21. KAJIJI, S., TALBOT, F., GRIZZUTI, K., VAN DYKE-PHILLIPS, V., AGRESTI, M., SAFA, A.R. & GROS, P. (1993). Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site. Biochemistry, 32, 4185-4194.
22. KARTNER, N., RIORDAN, J.R. & LING, V. (1983). Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science, 221, 1285-1288.
23. KOSTENIS, E. & MOHR, K. (1996). Two-point kinetic experiments to quantify allosteric efects on radioligand dissociation. Trends Pharmacol. Sci., 17, 280-283.
24. LEVER, J.E. (1977). Active amino-acid transport in plasma membrane vesicles from Simian virus 40-transformed mouse fibroblasts. Characteristics of electrochemical Na+ gradient stimulated uptake. J. Biol. Chem., 252, 1990-1997.
25. LOO, T.W. & CLARKE, D.M. (1995). Membrane topology of a cysteine-less mutant of human P-glycoprotein. J. Biol. Chem., 270, 843-848.
26. MALKHANDI, J., FERRY, D.R., BOER, R., GEKELER, V., ISE, W. & KERR, D.J. (1994). Dexniguldipine-HCl is a potent allosteric inhibitor [3H]vinblastine binding to P-glycoprotein of CCRF ADR5000 cells. Eur. J. Pharmacol., 288, 105-114.
27. MILLER, T.P., GROGAN, T.M., DALTON, W.S., SPIER, C.M., SCHEPER, R.J. & SALMON, S.E. (1991). P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high dose verapamil. J. Clin. Oncol., 9, 17-24.
28. MOTULSKY, H.J. & MAHAN, L.C. (1983). The kinetics of competitive radioligand binding predicted by the law of mass action. Mol. Pharmacol., 25, 1-9.
29. ORLOWSKI, S., MIR, L.M., BELEHRADEK, J. & GARRIGOS, M. (1996). Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone and verapamil are mutually non-exclusive modulators. Biochem. J., 317, 515-522.
30. PEDERSEN, P.P. & CARAFOLI, E. (1987). Ion motive ATPases. I. Ubiquity, properties, and significance to cell function. Trends Biochem. Sci., 12, 146-150.
31. PEREIRA, E., BORREL, M.N., FIALLO, M. & GARNIER-SUILLEROT, A. (1994). Non-competitive inhibition of P-glycoprotein-associated efflux of THP-adriamycin by verapamil in living K562 leukemia cells. Biochim. Biophys. Acta, 1225, 209-216.
32. SAFA, A.R. (1992). Photoaffinity labelling of P-glycoprotein in multidrug resistant cells. Cancer Invest., 10, 295-305.
33. SARKADI, B., MULLER, M., HOMOLYA, L., HOLLO, Z., SEPRODI, J., GERMANN, U.A., GOTTESMAN, M.M., PRICE, E.M. & BOUCHER, R.C. (1994). Interaction of bioactive hydrophobic peptides with the human multidrug transporter. FASEB J., 8, 766-770.
34. SPOELSTRA, E.C., WESTERHOFF, H.V., DEKKER, H. & LANKELMA, J. (1992). Kinetics of doxurubicin transport by P-glycoprotein of intact cancer cells. Eur. J. Biochem., 207, 567-579.
35. SPOELSTRA, E.C., WESTERHOFF, H.V., PINEDO, H.M., DEKKER, H. & LANKELMA, J. (1994). The multidrug-resistance-reverser verapamil interferes with cellular P-glycoprotein-mediated pumping of daunorubicin as a non-competitive substrate. Eur. J. Biochem., 221, 363-373.
36. TAMAI, I. & SAFA, A.R. (1991). Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells. J. Biol. Chem., 266, 16796-16800.
37. WEILAND, G.A. & MOLINOFF, P.B. (1981). Quantitative analysis of drug-receptor interactions: I. Determination of kinetic and equilibrium properties. Life Sci., 29, 313-330.
38. YOSHINURA, A., KUWAZURU, Y., SUMIZAWA, T., ICHIKAWA, M., IKEDA, S. & UDA, T. (1989). Cytoplasmic orientation and 2-domain structure of the multidrug transporter, P-glycoprotein, demonstrated with sequence-specific antibodies. J. Biol. Chem., 264, 16282-16291.
39. ZAMORA, J.-M., PEARCE, H.L. & BECK, W.T. (1988). Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells. Mol. Pharmacol., 33, 454-462.