A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol

Biochemistry

Volumn 38, Issue 20, 1999, Pages 6630-6639

  Dey, Saibal ^a   Hafkemeyer, Peter ^a   Pastan, Ira ^a   Gottesman, Michael M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYCLOSPORIN A; DOPAMINE RECEPTOR BLOCKING AGENT; FLUPENTIXOL; GLYCOPROTEIN P; PHENYLALANINE; VERAPAMIL;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; DRUG RESISTANCE; DRUG TRANSPORT; HUMAN; HUMAN CELL; HYDROLYSIS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ALANINE; AMINO ACID SUBSTITUTION; AZIDES; BIOLOGICAL TRANSPORT; DOPAMINE ANTAGONISTS; FLUPENTHIXOL; HELA CELLS; HUMANS; HYDROLYSIS; IODINE RADIOISOTOPES; MUTAGENESIS, SITE-DIRECTED; P-GLYCOPROTEIN; PHENYLALANINE; PHOTOAFFINITY LABELS; PRAZOSIN; RECEPTORS, DOPAMINE; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED; VERAPAMIL;

EID: 0033580634     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi983038l     Document Type: Article

References (43)

1. Horio, M., Gottesman, M. M., and Pastan, I. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 3580-3584.
2. Gottesman, M. M., and Pastan, I. (1993) Annu. Rev. Biochem. 62, 385-427.
3. Endicott, J. A., and Ling, V. (1989) Annu. Rev. Biochem. 58, 137-171.
4. Ford, J. M., and Hait, W. N. (1990) Pharmacol. Rev. 42, 155-199.
5. Beck, W. T. (1991) Cancer. Treat. Res. 57, 151-170.
6. Ford, J. M., Prozialeck, W. C., and Hait, W. N. (1989) Mol. Pharmacol. 35, 105-115.
7. Chiba, P., Ecker, G., Schmid, D., Drach, J., Tell, B., Goldenberg, S., and Gekeler, V. (1996) Mol. Pharmacol. 49, 1122-1130.
8. Ford, J. M., Bruggemann, E. P., Pastan, I., Gottesman, M. M., and Hait, W. N. (1990) Cancer Res. 6, 1748-1756.
9. Chen, C., Chin, J. E., Ueda, K., Clark, D. P., Pastan, I., Gottesman, M. M., and Roninson, I. B. (1986) Cell 47, 381-389.
10. Zhang, X., Collins, K. I., and Greenberger, L. M. (1995) J. Biol. Chem. 270, 5441-5448.
11. Loo, T. W., and Clarke, D. M. (1994) Biochemistry 33, 14049-14057.
12. Loo, T. W., and Clarke, D. M. (1996) J. Biol. Chem. 271, 27482-27487.
13. Loo, T. W., and Clarke, D. M. (1997) J. Biol. Chem. 272, 31945-31948.
14. Hamada, H., and Tsuruo, T. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 7785-7789.
15. Georges, E., Bradley, G., Gariepy, J., and Ling, V. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 152-156.
16. Hrycyna, C. A., Ramachandra, M., Pastan, I., and Gottesman, M. M. (1998) Methods Enzymol. 292, 456-473.
17. Elroy-Stein, O., and Moss, B. (1991) in Current Protocols in Molecular Biology (Ausubel, F. M., Brent, R., Kinston, R. E., Moore, D. D., Smith, J. A., Seidman, J. C., and Struhl, K., Eds.) pp 16.19.11-16.19.19, John Wiley and Sons, New York.
18. Earl, P. E., Cooper, N., and Moss, B. (1991) in Current Protocols in Molecular Biology (Ausubel, F. M., Brent, R., Kinston, R. E., Moore, D. D., Smith, J. A., Seidman, J. C., and Struhl, K., Eds.) pp 16.16.11-16.16.17, John Wiley and Sons, New York.
19. Ramachandra, M., Ambudkar, S. V., Gottesman, M. M., Pastan, I., and Hrycyna, C. A. (1996) Mol. Biol. Cell. 7, 1485-1498.
20. Elroy-Stein, O., Fuerst, T. R., and Moss, B. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 6126-6130.
21. Fuerst, T. R., Niles, E. G., Studier, F. W., and Moss, B. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 8122-8126.
22. Higuchi, R., Dollinger, G., Walsh, P. S., and Griffith, R. (1992) Bio Technology 10, 413-417.
23. Hafkemeyer, P., Dey, S., Ambudkar, S. V., Hrycyna, C. A., Pastan, I., and Gottesman, M. M. (1998) Biochemistry 37, 16400-16409.
24. Moss, B. (1991) Science 252, 1662-1667.
25. Hrycyna, C. A., Airan, L. E., Germann, U. A., Ambudkar, S. V., Pastan, I., and Gottesman, M. M. (1998) Biochemistry 37, 13660-13673.
26. Laemmli, U. K. (1970) Nature 227, 680-685.
27. Bailey, J. L. (1967) Techniques in Protein Chemistry, pp 340-341, Elsevier Publishing Co., New York.
28. Germann, U. A., Chambers, T. C., Ambudkar, S. V., Licht, T., Cardarelli, C. O., Pastan, I., and Gottesman, M. M. (1996) J. Biol. Chem. 271, 1708-1716.
29. Sarkadi, B., Price, E. M., Boucher, R. C., Germann, U. A., and Scarborough, G. A. (1992) J. Biol. Chem. 267, 4854-4858.
30. Dey, S., Ramachandra, M., Pastan, I., Gottesman, M. M., and Ambudkar, S. V. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 10594-10599.
31. Safa, A. R., Agresti, D. B., and Tamai, I. (1994) Biochemistry 33, 256-265.
32. Greenberger, L. M., Yang, C. P., Gindin, E., and Horwitz, S. B. (1990) J. Biol. Chem. 265, 4394-4401.
33. Levin, R. M., and Weiss, B. (1978) Biochim. Biophys. Acta. 540, 197-204.
34. Liu, Q., Hirono, S., and Moriguchi, I. (1990) Chem. Pharm. Bull. (Tokyo) 38, 2184-2189.
35. Hyttel, J. (1981) Life Sci. 28, 563-569.
36. Hyttel, J. (1980) Psychopharmacology (Berlin) 67, 107-109.
37. Froimowitz, M., and Cody, V. (1993) J. Med. Chem. 36, 2219-2227.
38. Schatzman, R. C., Wise, B. C., and Kuo, J. F. (1981) Biochem. Biophys. Res. Commun. 98, 669-676.
39. Prozialeck, W. C., and Weiss, B. (1982) J. Pharmacol. Exp. Ther. 222, 509-516.
40. Hait, W. N., and Aftab, D. T. (1992) Biochem. Pharmacol. 43, 103-107.
41. Loo, T. W., and Clarke, D. M. (1993) J. Biol. Chem. 268, 19965-19972.
42. Chen, G., Duran, G. E., Steger, K. A., Lacayo, N. J., Jaffrezou, J. P., Dumontet, C., and Sikic, B. I. (1997) J. Biol. Chem. 272, 5974-5982.
43. Gottesman, M. M., Pastan, I., and Ambudkar, S. V. (1996) Curr. Opin. Genet. Dev. 6, 610-617.