Alcohol and oxidative liver injury

Hepatology

Volumn 43, Issue 2 SUPPL. 1, 2006, Pages

  Dey, Aparajita ^a   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CYTOCHROME P450 2E1; GLUTATHIONE; GROWTH FACTOR RECEPTOR; IRON; PROTEIN HER; UNCLASSIFIED DRUG;

ALCOHOL LIVER DISEASE; CELL REGENERATION; HUMAN; KUPFFER CELL; LIVER CELL DAMAGE; LIVER INJURY; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW;

ALDEHYDES; ANIMALS; CYTOCHROME P-450 CYP2E1; ETHANOL; FREE RADICALS; GLUTATHIONE; HUMANS; IRON; KUPFFER CELLS; LIVER DISEASES, ALCOHOLIC; MALONDIALDEHYDE; MITOCHONDRIA, LIVER; NITRIC OXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 33644527617     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20957     Document Type: Review

References (158)

1. Nordmann R, Ribiere C, Rouach H. Implication of free radical mechanisms in ethanol-induced cellular injury. Free Radic Biol Med 1992;12:219-240.
2. Bondy SC. Ethanol toxicity and oxidative stress. Toxicol Lett 1992;63:231-241.
3. Cederbaum AI. Introduction-serial review: alcohol, oxidative stress and cell injury. Free Radic Biol Med 2001;31:1524-1526.
4. Di Luzio NR, Hartman AD. Role of lipid peroxidation in the pathogenesis of the ethanol-induced fatty liver. Fed Proc 1967;26:1436-1442.
5. Dianzani MU. Lipid peroxidation in ethanol poisoning: a critical reconsideration. Alcohol Alcohol 1985;20:161-173.
6. Tsukamoto H, Lu SC. Current concepts in the pathogenesis ot alcoholic liver injury. FASEB J 2001;15:1335-1349.
7. Ishii H, Kurose I, Kato S. Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress. J Gastroemerol Hepatol 1997;12: S272-S282.
8. Arteel GE. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 2003;124:778-790.
9. Rouach H, Fataccioli V, Gentil M, French SW, Morimoto M, Nordmann R. Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. HEPATOLOGY 1997;25:351-355.
10. French SW, Wong K, Jui L, Albano E, Hagbjork AL, Ingelman-Sundberg M. Effect of ethanol on cytochrome P450 2E1 (CYP2E1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis. Exp Mol Pathol 1993;58:61-75.
11. Polavarapu R, Spitz DR, Sim JE, Follansbee MH, Oberley LW, Rahemtulla A, et al. Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil. HEPATOLOGY 1998;27:1317-1323.
12. Knecht KT, Adachi Y, Bradford BU, Iimuro Y, Kadiiska M, Xuang QH, et al. Free radical adducts in the bile of rats treated chronically with intragastric alcohol: inhibition by destruction of Kupffer cells. Mol Pharmacol 1995;47:1028-1034
13. Nanji AA, Zhao S, Sadrzadeh SM, Dannenberg AJ, Tahan SR, Waxman DJ. Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury m fish oil-ethanol-fed rats. Alcohol Clin Exp Res 1994;18:1280-1285.
14. Nanji AA, Jokelainen K, Tipoe GL, Rahemtulla A, Dannenberg AJ. Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration. J Pharmacol Exp Ther 2001;299:638-644.
15. Tsukamoto H, Home W, Kamimura S, Niemela O, Parkkila S, Yla-Herttuala S, et al. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest 1995;96:620-630.
16. Nanji AA, Yang EK, Fogt F, Sadrzadeh SM, Dannenberg AJ. Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease. J Pharmacol Exp Ther 1996;277:1694-1700.
17. Kono H, Arteel GE, Rusyn I, Sies H, Thurman RG. Ebselen prevents early alcohol-induced liver injury in rats. Free Radic Biol Med 2001;30:403-411.
18. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, et al. The glutathione precursor L-2-oxothiazolidine-4-catboxylic acid protects against liver injury due to chtonic enteral ethanol exposure in the rat. HEPATOLOGY 2000;31:391-398.
19. Wheeler MD, Kono H, Yin M, Rusyn I, Froh M, Connor HD, et al. Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. Gastroenterology 2001;120:1241-1250.
20. Kessova IG, Ho Y, Thung S, Cederbaum AI. Alcohol-induced liver injury in mice lacking Cu, Zn- superoxide dismutase. HEPATOLOGY 2003;38:1136-1145.
21. Nordmann R. Oxidative stress from alcohol in the brain. Alcohol Alcohol 1987;(Suppl 1):75-82.
22. Kannan M, Wang L, Kang YJ. Myocardial oxidative stress and toxicity induced by acute ethanol exposure in mice. Exp Biol Med 2004;229:553-559.
23. Norton ID, Apte MV, Lux O, Haber PS, Pirola RC, Wilson JS. Chronic ethanol administration causes oxidative stress in the rat pancteas. J Lab Clin Med 1998;131:442-446.
24. Rosenblum ER, Gavaler JS, Van Thiel DH. Lipid peroxidation: a mechanism for alcohol-induced testicular injury. Free Radic Biol Med 1989;7:569-577.
25. Nordmann R, Ribiere C, Rouach H. Ethanol-induced lipid peroxidation and oxidative stress in extrahepatic tissues. Alcohol Alcohol 1990;25:231-237.
26. Adachi Y, Bradford BU, Gao W, Bojes HK, Thurman RG. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. HEPATOLOGY 1994;20:453-460.
27. Iimuro Y, Gallucci RM, Luster MI, Kono H, Thurman RG. Antibodies to tumor necrosis factor alpha attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. HEPATOLOGY 1997;26:1530-1537.
28. Nanji AA, Khettry U, Sadrzadeh SM. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease. Proc Soc Exp Biol Med 1994;205:243-247.
29. Kono H, Rusyn I, Uesugi T, Yamashina S, Connor HD, Dikalova A, et al. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol Gastrointest Liver Physiol 2001;280:G1005-G1012.
30. Kono H, Rusyn I, Yin M, Gabele E, Yamashina S, Dikalova A, et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 2000;106:867-872.
31. Yin M, Wheeler MD, Kono H, Bradford BU, Gallucci RM, Luster MI, et al. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology 1999;117:942-952.
32. Yin M, Gabele E, Wheeler MD, Connor H, Bradford BU, Dikalova A, et al. Alcohol-induced free radicals in mice: direct toxicants or signaling molecules? HEPATOLOGY 2001;34:935-942.
33. Uesugi T, Froh M, Arteel GE, Bradford BU, Gabele E, Wheeler MD, et al. Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats. HEPATOLOGY 2001;34:1149-1157.
34. Thurman RG. Mechanisms of hepatic toxicity. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 1998;275: G605-G611.
35. Wheeler MD, Kono H, Yin M, Nakagami M, Uesugi T, Arteel GE, et al. The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med 2001;31:1544-1549.
36. Takei Y, Arteel GE, Bergheim I, Lambert JC, McMullen MR, Nagy LE, et al. Roles of Kupffer cells in alcoholic liver disease. Alcoholism: Clin Exp Res 2005;29:1116-1120.
37. Chapman RW, Morgan MY, Bell R, Sherlock S. Hepatic iron uptake in alcoholic liver disease. Gastroenterology 1983;84:143-147.
38. Whitfield JB, Zhu G, Heath AC, Powell LW, Martin NG. Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers. Alcohol Clin Exp Res 2001;25:1037-1045.
39. Sergent O, Morel I, Cogrel P, Chevanne M, Pasdeloup N, Brissot P, et al. Increase in cellular pool of low-molecular-weight iron during ethanol metabolism in rat hepatocyte cultures: relationship with lipid peroxidation. Biol Trace Elem Res 1995;47:185-192.
40. Rouach H, Houze P, Orfanelli MT, Gentil M, Bourdon R, Nordmann R. Effect of acute ethanol administration on the subcellular distribution of iron in rat liver and cerebellum. Biochem Pharmacol 1990;39:1095-1100.
41. Zhang H, Loney LA, Potter BJ. Effect of chronic alcohol feeding on hepatic iron status and ferritin uptake by rat hepatocytes. Alcohol Clin Exp Res 1993;17:394-400.
42. Valerio LG Jr, Parks T, Petersen DR. Alcohol mediates increases in hepatic and serum nonheme iron stores in a rat model for alcohol-induced liver injury. Alcohol Clin Exp Res 1996;20:1352-1361.
43. Stal P, Johansson I, Ingelman-Sundberg M, Hagen K, Hultcrantz R. Hepatotoxicity induced by iron overload and alcohol: studies on the role of chelatable iron, cytochrome P450 2E1 and lipid peroxidation. J Hepatol 1996;25:538-546.
44. Tsukamoto H, Lin M, Ohata M, Giulivi C, French SW, Brittenham G. Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury. Am J Physiol 1999;277:G1240-G1250.
45. She H, Xiong S, Lin M, Zandi E, Giulivi C, Tsukamoto H. Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol 2002;283:G719-G726.
46. Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, et al. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem 2003;278:17646-17654.
47. Sadrzadeh SM, Nanji AA, Price PL. The oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats. J Pharmacol Exp Ther 1994;269:632-636.
48. Cederbaum AI. Iron and CYP2E1-dependent oxidative stress and toxicity. Alcohol 2003;30:115-120.
49. Albano E, Tomasi A, Goria-Gatti L, Dianzani MU. Spin trapping of free radical species produced during the microsomal metabolism of ethanol. Chem Biol Interact 1988;65:223-234.
50. Knecht KT, Thurman RG, Mason RP. Role of superoxide and trace transition metals in the production of alpha-hydroxyethyl radical from ethanol by microsomes from alcohol dehydrogenase-deficient deer mice. Arch Biochem Biophys 1993;303:339-348.
51. Reinke IA, Rau JM, McCay PB. Possible roles of free radicals in alcoholic tissue damage. Free Radic Res Commun 1990;9:205-211.
52. Rashba-Step J, Cederbaum AI. Generation of reactive oxygen intermediates by human liver microsomes in the presence of NADPH or NADH. Mol Pharmacol 1994;45:150-157.
53. Albano E, Tomasi A, Persson JO, Terelius Y, Goria-Gatti L, Ingelman-Sundberg M, et al. Role of ethanol-inducible cytochrome P450 (P450IIE1) in catalysing the free radical activation of aliphatic alcohols. Biochem Pharmacol 1991;41:1895-1902.
54. Knecht KT, Bradford BU, Mason RP, Thurman RG. In vivo formation of a free radical metabolite of ethanol. Mol Pharmacol 1990;38:26-30.
55. Moore DR, Reinke LA, McCay PB. Metabolism of ethanol to 1-hydroxyethyl radicals in vivo: detection with intravenous administration of alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone. Mol Pharmacol 1995;47:1224-1230.
56. Moncada C, Torres V, Varghese G, Albano E, Israel Y. Ethanol-derived immunoreactive species formed by free radical mechanisms. Mol Pharmacol 1994;46:786-791.
57. Clot P, Bellomo G, Tabone M, Arico S, Albano E. Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis. Gastroenterology 1995;108:201-207.
58. Puntarulo S, Stoyanovsky DA, Cederbaum AI. Interaction of 1-hydroxyethyl radical with antioxidant enzymes. Arch Biochem Biophys 1999;372:355-359.
59. Reinke LA. Spin trapping evidence for alcohol-associated oxidative stress. Free Radic Biol Med 2002;32:953-957.
60. Fernandez-Checa JC, Ookhtens M, Kaplowitz N. Effects of chronic ethanol feeding on rat hepatocytic glutathione: relationship of cytosolic glutathione to efflux and mitochondrial sequestration. J Clin Invest 1989;83:1247-1252.
61. Iimuro Y, Bradford BU, YamashinaS, Rusyn I, Nakagami M, Enomoto N, et al. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. HEPATOLOGY 2000;31:391-398.
62. Oh SI, Kim CI, Chun HJ, Park SC. Chronic ethanol consumption affects glutathione status in rat liver. J Nutr 1998;128:758-763.
63. Fernandez-Checa JC, Garcia-Ruiz C, Ookhtens M, Kaplowitz N. Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats: tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest. 1991;87:397-405.
64. Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. HEPATOLOGY 1992;16:1423-1427.
65. Garcia-Ruiz C, Morales A, Colell A, Rodes J, Yi JR, Kaplowitz N, et al. Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione: expression studies in Xenopus laevis oocytes. J Biol Chem 1995;270:15946-15949.
66. Garcia-Ruiz C, Morales A, Colell A, Ballesta A, Rodes J, Kaplowitz N, et al. Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. HEPATOLOGY 1995;21:207-214.
67. Colell A, Garcia-Ruiz C, Miranda M, Ardite E, Mari M, Morales A, et al. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 1998;115:1541-1551.
68. Bailey SM, Patel VB, Young TA, Asayama K, Cunningham CC. Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcohol Clin Exp Res 2001;25:726-733.
69. Deaciuc IV, Fortunato F, D'Souza NB, Hill DB, Schmidt J, Lee EY, et al. Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysacchande. Alcohol Clin Exp Res 1999;23:349-356.
70. Reed DJ. Mitochondrial glutathione and chemically induced stress including ethanol. Drug Metab Rev 2004;36:569-582.
71. Fernandez-Checa JC, Kaplowitz N. Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol 2005;204:263-273.
72. Bardag-Gorce F, French BA, Li J, Riley NE, Yuan QX, Valinluck V, et al. The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats. Gastroenterology 2002;123:325-335.
73. Cunningham CC, Coleman WB, Spach PI. The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism. Alcohol Alcohol 1990;25:127-136.
74. Kamimura S, Gaal K, Britton RS, Bacon BR, Triadafilopoulos G, Tsukamoto H. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis. HEPATOLOGY 1992;16:448-453.
75. Satre J, Minana JB, Alguacil P, Malet G. Gomez-Cambronero L, Marin JA, et al. Chronic erhanol feeding causes oxidative stress in rat liver mirochondria: prevention by S-adenosyl methionine. Free Radic Res 1999;30:325-337.
76. Boveris A, Fraga CG, Varsavsky AI, Koch OR. Increased chemiluminescence and superoxide production in the liver of chronically ethanol-treated rats. Arch Biochem Biophys 1983;227:534-541.
77. Kukielka E, Dicker E, Cederbaum AI. Increased production of reactive oxygen species by rat liver mitochondria after chronic erhanol treatment. Arch Biochem Biophys 1994;309:377-386.
78. Bailey SM, Cunningham CC. Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes. HEPATOLOGY 1998;28:1318-1326.
79. Bailey SM, Pietsch EC, Cunningham CC. Erhanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III. Free Radic Biol Med 1999;27:891-900.
80. Bailey SM, Cunningham CC. Contribution of mitochondria to oxidative stress associated with alcoholic liver disease. Free Radic Biol Med 2002;32:11-16.
81. Venkatraman A, Landar A, Davis AJ, Chamlee L, Sanderson I. Kim H, et al. Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity. J Biol Chem 2004;279:22092-22101.
82. Mansouri A, Gaou I, De Kerguenec C, Amsellem S, Haouzi D, Berson A, et al. An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice. Gastroenterology 1999;117:181-190.
83. Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J Pharmacol Exp Ther 2001;298:737-743.
84. Demeilliers C, Maisonneuve C, Grodet A, Mansouri A, Nguyen R, Tinel M, et al. Impaired adaptive resynthesis and prolonged depletion or hepatic mitochondrial DNA after repeated alcohol binges in mice. Gastroenterology 2002;123:1278-1290.
85. Mansouri A, Fromenty B, Berson A, Robin MA, Gnmbert S, Beaugrand M, et al. Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients. J Hepatol 1997;27:96-102.
86. Cahill A, Stabley GJ, Wang X, Hoek JB. Chronic ethanol consumption causes alterations in the structural integrity of mitochondrial DNA in aged rats. HEPATOLOGY 1999;30:881-888.
87. Kurose I, Higuchi H, Kato S, Miura S, Watanabe N, Kamegaya Y, et al. Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol. Gastroenterology 1997;112:1331-1343.
88. Kurose I, Higuchi H, Miura S, Saito H, Watanabe N, Hokari R, et al. Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication. HEPATOLOGY 1997;25:368-378.
89. Higuchi H, Adachi M, Miura S, Gores GJ, Ishii H. The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes. HEPATOLOGY 2001;34:320-328.
90. Pastorino JG, Marcineviciute A, Cahill A, Hoek JB. Potentiation by chronic ethanol treatment of the mitochondrial permeability transition. Biochem Biophys Res Commun 1999;265:405-409.
91. Adachi M, Ishii H. Role of mitochondria in alcoholic liver injury. Free Radic Biol Med 2002;32:487-491.
92. Cahill A, Cunningham CC, Adachi M, Ishii H, Bailey SM, Fromenty B, et al. Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion. Alcohol Clin Exp Res 2002;26:907-915.
93. Hoek JB, Cahill A, Pastorino JG. Alcohol and mitochondria: a dysfunctional elationship. Gastroenterology 2002;122:2049-2063.
94. Bailey SM. A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction. Free Radic Res 2003;37:585-596.
95. Wiest R, Groszmann RJ. The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. HEPATOLOGY 2002;35:478-491.
96. Kim YM, Kim TH, Chung HT, Talanian RV, Yin XM, Billiar TR. Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylarion of caspase-8. HEPATOLOGY 2000;32:770-778.
97. Rai RM, Lee FY, Rosen A, Yang SQ, Lin HZ, Koteish A, et al. Impaired liver regeneration in inducible nitric oxide synthase deficient mice. Proc Natl Acad Sci USA 1998;95:13829-13834.
98. Hon WM, Lee KH, Khoo HE. Nitric oxide in liver diseases: friend, foe, or just passerby? Ann N Y Acad Sci 2002;962:275-295.
99. Wang JF, Greenberg SS, Spitzer JJ. Chronic alcohol administration stimulates nitric oxide formation in the rat liver with or without pretreatment by lipopolysaccharide. Alcohol Clin Exp Res 1995;19:387-393.
100. Arteel GE, Kadiiska MB, Rusyn I, Bradford BU, Mason RP, Raleigh JA, et al. Oxidative stress occurs in perfused rat liver at low oxygen tension by mechanisms involving peroxynitrite. Mol Pharmacol 1999;55:708-715.
101. Sergent O, Griffon B, Morel I, Chevanne M, Dubos MP, Cillard P, et al. Effect of nitric oxide on iron-mediated oxidative stress in primary rat hepatocyte culture. HEPATOLOGY 1997;25:122-127.
102. Nanji AA, Greenberg SS, Tahan SR, Fogt F, Loscalzo J, Sadrzadeh SM, et al. Nitric oxide production in experimental alcoholic liver disease in the rat: role in protection from injury. Gastroenterology 1995;109:899-907.
103. Nanji AA, Jokelainen K, Lau GK, Rahemtulla A, Tipoe GL, Polavarapu R, et al. Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration. J Pharmacol Exp Ther 2001;299:832-839.
104. McKim SE, Gabele E, Isayama F, Eambert JC, Tucker EM, Wheeler MD, et al. Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroentetology 2003;125:1834-1844.
105. Ei J, Fu P, Deleon M, French BA, French SW. The effect of Viagra (sildenafil citrate) on liver injury caused by chronic ethanol intragastric feeding in rats. Exp Mol Pathol 2005;78:101-108.
106. Venkatraman A, Shiva S, Davis AJ, Bailey SM, Brookes PS, Darley-Usmar VM. Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide. HEPATOLOGY 2003;38:141-147.
107. Venkatraman A, Shiva S, Wigley A, Ulasova E, Chhieng D, Bailey SM, et al. The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice. HEPATOLOGY 2004;40:565-573.
108. Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem 1998;67:425-479.
109. Baraona E, Leo MA, Borowsky SA, Lieber CS. Pathogenesis of alcohol-induced accumulation of protein in the liver. J Clin Invest 1977;60:546-554.
110. Donohue TM Jr, Zetterman RK, Tuma DJ. Effect of chronic ethanol administration on protein catabolism in rat liver. Alcohol Clin Exp Res 1989;13:49-57.
111. Donohue TM J r, Zetterman RK, Zhang-Gouillon ZQ, French SW. Peptidase activities of the multicatalytic protease in rat liver after voluntary and intragastric ethanol administration. HEPATOLOGY 1998;28:486-491.
112. Fataccioli V, Andraud E, Gentil M, French SW, Rouach H. Effects of chronic ethanol administration on rat liver proteasome activities: relationship with oxidative stress. HEPATOLOGY 1999;29:14-20.
113. Bardag-Gorce F, Yuan QX, Li J, French BA, Fang C, Ingelman-Sundberg M, et al. The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol. Biochem Biophys Res Commun 2000;279:23-29.
114. Gouillon Z, Lucas D, Li J, Hagbjork AL, French BA, Fu P, et al. Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. Proc Soc Exp Biol Med 2000;224:302-308.
115. Goasduff T, Cederbaum AI. NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: role of reactive oxygen species. Arch Biochem Biophys 1999;370:258-270.
116. Roberts BJ. Evidence of proteasome-mediated cytochrome P-450 degradation. J Biol Chem 1997;272:9771-9778.
117. Donohue TM Jr. The ubiquitin-proteasome system and its role in ethanol-induced disorders. Addict Biol 2002;7:15-28.
118. Bradford BU, Kono H, Isayama F, Kosyk O, Wheeler MD, Akiyama TE, et al. Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. HEPATOLOGY 2005;41:336-344.
119. Rusyn I, Asakura S, Pachkowski B, Bradford BU, Denissenko MF, Peters JM, et al. Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators. Cancer Res 2004;64:1050-1057.
120. Niemela O. Distribution of ethanol-induced protein adducts in vivo: relationship to tissue injury. Free Radic Biol Med 2001;31:1533-1538.
121. Niemela O, Juvonen T, Parkkila S. Immunohistochemical demonstration of acetaldehyde-modined epitopes in human liver after alcohol consumption. J Clin Invest 1991;87:1367-1374.
122. Niemela O, Parkkila S, Yla-Herttuala S, Halsted C, Witztum JL, Lanca A, et al. Covalent protein adducts in the liver as a result of ethanol metabolism and hpid peroxidation. Lab Invest 1994;70:537-546.
123. Niemela O, Parkkila S, Yla-Herttuala S, Villanueva J, Ruebner B, Halsted CH. Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease. HEPATOLOGY 1995;22:1208-1214.
124. Israel Y, Hurwitz E, Niemela O, Arnon R. Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts. Proc Natl Acad Sci USA 1986;83:7923-7927.
125. Xu D, Thiele GM, Beckenhauer JL, Klassen LW, Sorrell MF, Tuma DJ. Detection of circulating antibodies to malondialdehyde-acetaldehyde adducts in ethanol-fed rats. Gastroenterology 1998;115:686-692.
126. Viitala K, Makkonen K, Israel Y, Lehtimaki T, Jaakkola O, Koivula T, et al. Autoimmune responses against oxidant stress and acetaldehyde-derived epitopes in human alcohol consumers. Alcohol Clin Exp Res 2000;24:1103-1109.
127. Viitala K, Israel Y, Blake JE, Niemela O. Serum IgA, IgG, and IgM antibodies directed against acetaldehyde-derived epitopes: relationship to liver disease severity and alcohol consumption. HEPATOLOGY 1997;25:1418-1424.
128. Tuma DJ. Role of malondialdehyde-aceraldehyde adducts in liver injury. Free Radic Biol Med 2002 15;32:303-308.
129. Worrall S, de Jersey J, Wilce PA. Comparison of the formation of proteins modified by direct and indirect ethanol metabolites in the liver and blood of rats fed the Lieber-DeCarli liquid diet. Alcohol Alcohol 2000;35:164-170.
130. Willis MS, Klassen LW, Tuma DJ, Sorrell MF, Thiele GM. Adduction of soluble proteins with malondialdehyde-acetaldehyde (MAA) induces antibody production and enhances T-cell proliferation. Alcohol Clin Exp Res 2002;26:94-106.
131. Willis MS, Klassen LW, Tuma DJ, Sorrell MF, Thiele GM. In vitro exposure to malondialdehyde-acetaldehyde adducted protein inhibits cell proliferation and viability. Alcohol Clin Exp Res 2002;26:158-164.
132. Rolla R, Vay D, Mottaran E, Parodi M, Traverse N, Arico S, et al. Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease. HEPATOLOGY 2000;31:878-884.
133. Albano E. Free radical mechanisms in immune reactions associated with alcoholic liver disease. Free Radic Biol Med 2002;32:110-114.
134. Duryee MJ, Willis MS, Freeman TL, Kuszynski CA, Tuma DJ, Klassen LW, et al. Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity. Front Biosci 2004;9:3145-3155.
135. Koop DR. Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J 1992;6:724-730.
136. Lieber CS. Cytochrome P-4502E1: its physiological and pathological role. Physiol Rev 1997;77:517-544.
137. Bolt HM, Roos PH, Thier R. The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine. Int Arch Occup Environ Health 2003;76:174-185.
138. Tanaka E, Terada M, Misawa S. Cytochrome P450 2E1: its clinical and toxicological role. J Clin Pharm Ther 2000;25:165-175.
139. Yang CS, Yoo JS, Ishizaki H, Hong JY. Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation. Drug Metab Rev 1990;22:147-159.
140. Lee SS, Buters JT, Pineau T, Fernandez-Salguero P, Gonzalez FJ. Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 1996;271:12063-12067.
141. Ekstrom G, Ingelman-Sundberg M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1). Biochem Pharmacol 1989;38:1313-1319.
142. Song BJ, Cederbaum AI, Koop DR, Ingelman-Sundberg M, Nanji A. Ethanol-inducible cytochrome P450 (CYP2E1): Biochemistry, molecular biology and clinical relevance. Alcoholism Clin Exp Res 1996;20:138A-146A.
143. Castillo T, Koop DR, Kamimura S, Triadafilopoulos G, Tsukamoto H. Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation. HEPATOLOGY 1992;16:992-996.
144. Morimoto M, Hagbjork AL, Nanji AA, Ingelman-Sundberg M, Lindros KO, Fu PC, et al. Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis. Alcohol 1993;10:459-464.
145. Morimoto M, Hagbjork AL, Wan YJ, Fu PC, Clot P, Albano E, et al. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. HEPATOLOGY 1995;21:1610-1617.
146. Morgan K, French SW, Morgan TR. Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage. HEPATOLOGY 2002;36:122-134.
147. Koop DR, Klopfenstein B, Iimuro Y, Thurman RG. Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of GYP2E1. Mol Pharmacol 1997;51:944-950.
148. Kono H, Bradford BU, Yin M, Sulik KK, Koop DR, Peters JM, et al. CYP2E1 is not involved in early alcohol-induced liver injury. Am J Physiol 1999;277:G1259-G1267.
149. Caro AA, Cederbaum AI. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol 2004;44:27-42.
150. Cederbaum AI, Wu D, Mari M, Bai J. CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free Radic Biol Med 2001;31:1539-1543.
151. Kessova I, Cederbaum AI. CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury. Curr Mol Med 2003;3:509-518.
152. Fink R, Clemens MR, Marjot DH, Patsalos P, Cawood P, Norden AG, et al. Increased free-radical activity in alcoholics. Lancet 1985;2:291-294.
153. Letteron P, Duchatelle V, Betson A, Fromenty B, Fisch C, Degott C, et al. Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol-abusers. Gut 1993;34:409-414.
154. Adachi J, Matsushita S, Yoshioka N, Funae R, Fujita T, Higuchi S, et al. Plasma phosphatidylcholine hydroperoxide as a new marker of oxidative stress in alcoholic patients. J Lipid Res 2004;45:967-971.
155. Ohhira M, Ohtake T, Matsumoto A, Saito H, Ikuta K, Fujimoto Y, et al. Immunohistochemical detection of 4-hydroxy-2-nonenal-modified-protein adducts in human alcoholic liver diseases. Alcohol Clin Exp Res 1998;22:145S-149S.
156. Thome J, Zhang J, Davids E, Foley P, Weijers HG, Wiesbeck GA, et al. Evidence for increased oxidative stress in alcohol-dependent patients provided by quantification of in vivo salicylate hydroxylation products. Alcohol Clin Exp Res 1997;21:82-85.
157. Tanner AR, Bantock I, Hinks L, Lloyd B, Turner NR, Wright R. Depressed selenium and vitamin E levels in an alcoholic population: possible relationship to hepatic injury through increased lipid peroxidation. Dig Dis Sci 1986;31:1307-1312.
158. Meagher EA, Barry OP, Burke A, Lucey MR, Lawson JA, Rokach J, et al. Alcohol-induced generation of lipid peroxidation products in humans. J Clin Invest 1999;104:805-813.