Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

Hepatology

Volumn 41, Issue 2, 2005, Pages 336-344

  Bradford, Blair U ^a   Kono, Hiroshi ^b,c   Isayama, Fuyumi ^b   Kosyk, Oksana ^a   Wheeler, Michael D ^b   Akiyama, Taro E ^d   Bleye, Lisa ^e   Krausz, Kristopher W ^d   Gonzalez, Frank J ^d   Koop, Dennis R ^e   Rusyn, Ivan ^a,f  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF YAMANASHI   (Japan)

^d NATIONAL CANCER INSTITUTE   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CYTOCHROME P450; CYTOCHROME P450 2E1; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; LIVER CARCINOGENESIS; MALE; MALIGNANT NEOPLASTIC DISEASE; MOUSE; MUTAGENIC ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; UPPER GASTROINTESTINAL TRACT;

ANIMALS; CYTOCHROME P-450 CYP2E1; DNA DAMAGE; DNA REPAIR; ETHANOL; GENE EXPRESSION; LIVER; MICE; MICE, TRANSGENIC; NADPH OXIDASE; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 19944432987     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20532     Document Type: Article

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