The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats

Gastroenterology

Volumn 123, Issue 1, 2002, Pages 325-335

  Bardag Gorce, Fawzia ^a   French, Barbara A ^a   Li, Jun ^a   Riley, Nora E ^a   Yuan, Qi X ^a   Valinluck, Vimonrat ^a   Fu, Paul ^a   Ingelman Sundberg, Magnus ^b   Yoon, Seokjoo ^b   French, Samuel W ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALCOHOL; ALCOHOL DEHYDROGENASE; CHYMOTRYPSIN; CYTOCHROME P450 2E1; NICOTINAMIDE ADENINE DINUCLEOTIDE; NITRITE; PIMONIDAZOLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; VASCULOTROPIN;

ALCOHOL BLOOD LEVEL; ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; EXPERIMENTAL MODEL; GRANULOCYTE; LIVER INJURY; LIVER ISCHEMIA; LIVER WEIGHT; MALE; NONHUMAN; OXIDATION REDUCTION STATE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0036304584     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.34177     Document Type: Article

References (45)

1. Mechanism of the alcohol cyclin pattern: Role of the hypothalamic-pituitary-thyroid axis
2. Correlation of cyclic pattern of blood alcohol levels with progression of alcoholic liver injury
3. The effect of chronic consumption of ethanol on the redox state of the rat liver
4. Hepatic alcohol oxidation and its metabolic liability
5. Pathways responsible for the adaptive increase in ethanol utilization following chronic treatment with ethanol: Inhibitor studies with the hemoglobin-free perfused rat liver
6. Effect of acute and chronic ethanol consumption on hepatic tissue oxygen tension in rats
7. Centrilobular liver necrosis induced by hypoxia in chronic ethanol-fed rats
8. Hepatic adenosine nucleotide metabolism measured in vivo in rats fed ethanol and a high fat-low protein diet
9. 31p nuclear magnetic resonance study in rats
10. Chronic ethanol treatment causes hypoxia in rat liver tissue in vivo
11. Hypoxia reperfusion liver injury in a alcoholic binge drinking model
12. Effect of ethanol on cytochrome P450 2E1 (CYP2E1) lipid peroxidation and serum protein adduct formation in relation to liver pathology pathogenesis
13. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
14. A simple procedure for gel electrophoresis and Northern blotting of RNA
15. Analysis of RNA: Electrophoresis of RNA through gels containing formaldehyde
16. Changes in 20S proteasome activity during aging of the Lou rat
17. Cycling assay for nicotinamide adenine dinucleotides: NaCl precipitation and ethanol solubilization of the reduced tetrazolium
18. Extraction of adenosine triphosphate from microbial and somatic cells
19. The enzymatic measurement of a derivative nucleotides and P-creatine in picamole amounts
20. Enzymatic microanalysis of glycogen
21. Inhibition of hepatic gluconeogenesis by ethanol
22. Influence of ethanol on the liver metabolism of fed and starved rats
23. Uber metabolitgehalte und metabolit-konzentrationen in der leben der ratte
24. Dependence of ethanol-induced redox shift on hepatic oxygen tensions prevailing in vivo
25. Control of a secondary pathway of ethanol metabolism by differences in redox state: A story of the failure to arrest the Krebscycle for drunkeness
26. The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver
27. Hypermetabolic state and hypoxic liver damage
28. 2 homeostasis by hypoxia-inducible factor
29. Endothelial cell response to hypoxia: Initiation of a cascade of cellular interactions
30. Mammalian oxygen sensing signaling and gene regulation
31. Cyclic expression of class 1 alcohol dehydrogenase in male rats treated with alcohol
32. Induction of cytochrome P450 2E1 during ethanol exposure occurs via transcription of the CYP2E1 gene when blood alcohol concentrations are high
33. Alcohol elimination and the regulation of alcohol consumption in AA and ANA rats
34. Hyperthyroid and ethanol
35. Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state
36. Nitric oxide induces tyrosine nitration and release of cytochrome c preceeding an increase of mitochondrial transmembrane potented in macrophages
37. Dual influence of nitric oxide on gene regulation during hypoxia
38. Effect of ethanol cycling on gene expression in intragastric ethanol feeding rat model of alcohol liver disease
39. Increased monocyte MCP-1 production in acute alcoholic hepatitis
40. Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia
41. Essential role of induced nitric oxide in the initiation of the inflammatory response following hemorrhagic shock
42. The hypoxic response: Huffing and HIFing
43. 2 and cyclooxygenase-2
44. HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
45. To drink or not to drink: An experimental analysis of group drinking decisions for alcoholics