Effects of alcohol and oxidative stress on liver pathology: The role of the mitochondrion

Alcoholism: Clinical and Experimental Research

Volumn 26, Issue 6, 2002, Pages 907-915

  Cahill, Alan ^a   Cunningham, Carol C ^b   Adachi, Masayuki ^c   Ishii, Hiromasa ^c   Bailey, Shannon M ^d   Fromenty, Bernard ^e   Davies, Adrian ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c KEIO UNIVERSITY   (Japan)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e BEAUJON HOSPITAL   (France)

Author keywords

Apoptosis; Ethanol; Mitochondria; Mitochondrial DNA; Oxidative stress

Indexed keywords

ALCOHOL; ANTIOXIDANT; MITOCHONDRIAL DNA; PROTEIN BAX; PROTEIN BCL 2;

ALCOHOL METABOLISM; ALCOHOLISM; APOPTOSIS; CONFERENCE PAPER; DNA DAMAGE; HUMAN; LIVER CELL; LIVER DISEASE; LIVER MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN MODIFICATION; ANIMAL; DRUG EFFECT; LIVER; PATHOLOGY; PHYSIOLOGY; REVIEW;

ANIMAL; ETHANOL; HUMAN; LIVER; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; ANIMALS; HUMANS;

EID: 0035998920     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000374-200206000-00022     Document Type: Conference Paper

References (48)

1. Mitochondrial decay in aging
2. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
3. Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes
4. Effect of dietary fat on chronic ethanol-induced oxidative stress in hepatocytes
5. Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver
6. Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III
7. Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart
8. Protein oxidation in aging, disease, and oxidative stress
9. Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion
10. Cellular sources and steady-state levels of reactive oxygen species
11. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
12. Chronic ethanol consumption causes alterations in the structural integrity of mitochondrial DNA in aged rats
13. Mitochondrial abnormalities in non-alcoholic steatohepatitis
14. Effects of chronic ethanol consumption on the synthesis of polypeptides encoded by the hepatic mitochondrial genome
15. Primers for mitochondrial DNA replication generated by endonuclease G
16. Mitochondrial DNA repair pathways
17. The effects of chronic ethanol consumption on hepatic mitochondrial energy metabolism
18. Hepatic mitochondrial DNA deletion in alcoholics: Association with microvesicular steatosis
19. Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
20. The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: Cryptic signals revealed by comparative analysis between vertebrates
21. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
22. Levels of the mitochondrial endonuclease during rat cardiac development implicate a role for the enzyme in repair of oxidative damage in mitochondrial DNA
23. The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes
24. Mitochondrial energy metabolism in chronic alcoholism
25. Coupled leading- and laggingstrand synthesis of mammalian mitochondrial DNA
26. Mitochondrial endonuclease activity in the rat varies markedly among tissues in relation to the rate of tissue metabolism
27. Action of mitochondrial endonuclease G on DNA damage by L-ascorbic acid, peplomycin and cisdiamminedichloroplatinum (II)
28. Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress
29. Oxidative stress in alcoholic liver injury
30. Effect of chronic ethanol consumption on the energy state and structural stability of periportal and perivenous hepatocytes
31. Bax directly induces release of cytochrome c from isolated mitochondria
32. Electron microscopic study of liver mitochondria from human alcoholics
33. Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication
34. Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: Protective effects of antioxidants
35. Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholic patients
36. An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice
37. Apoptosis and alcoholic liver disease
38. Mitochondrial DNA: I. Intramitochondrial distribution and structural relations of single- and double-length circular DNA
39. Hepatic changes associated with chronic alcoholism in rats
40. Differential expression of mitochondrial DNA replication factors in mammalian tissues
41. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
42. Rearrangements of human mitochondrial DNA (mtDNA): New insights into the regulation of mtDNA copy number and gene expression
43. Characterization of iron-sulfur clusters in rat liver submitochondrial particles by electron paramagnetic resonance spectroscopy. Alterations produced by chronic ethanol consumption
44. Molecular alterations in the respiratory chain of rat liver after chronic ethanol consumption
45. Study of mitochondrial DNA deletion in alcoholics
46. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria
47. Movement of Bax from the cytosol to mitochondria during apoptosis
48. Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis