Oxidants and antioxidants in alcohol-induced liver disease

Gastroenterology

Volumn 124, Issue 3, 2003, Pages 778-790

  Arteel, Gavin E ^a  

^a UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALCOHOL; ALLOPURINOL; ANTIOXIDANT; COPPER ZINC SUPEROXIDE DISMUTASE; DIPHENYLIODONIUM SALT; EBSELEN; I KAPPA B; MANGANESE SUPEROXIDE DISMUTASE; MEDIUM CHAIN TRIACYLGLYCEROL; OXIDIZING AGENT; POLYPHENOL DERIVATIVE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ALCOHOL LIVER DISEASE; DISEASE COURSE; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; HYPOTHESIS; INFLAMMATORY CELL; LIVER CELL; LIVER INJURY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

EID: 0037371816     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2003.50087     Document Type: Review

References (120)

1. Lelbach WK. Liver damage in chronic alcoholism: results of a clinical, clinical-chemical and bioptic-histological study in 526 alcoholic patients during a low calorie diet in an open drinking sanatorium. Acta Hepatosplenol 1966;13:321-349.
2. NIAAA/NIDA. The economic costs of alcohol and drug abuse in the United States: 1992. NIAAA/NIDA News Release 1998. Bethesda, MD: National Institutes of Health, 1998.
3. Sies H. Oxidative stress: introductory remarks. In: Sies H, ed. Oxidative stress. London: Academic Press, 1985:1-8.
4. Di Luzio NR. A mechanism of the acute ethanol-induced fatty liver and the modification of liver injury by antioxidants. Lab Invest 1966;15:50-63.
5. Shaw S, Jayatilleke E, Ross WA, Gordon ER, Lieber S. Ethanolinduced lipid peroxidation: potentiation by long-term alcohol feeding and attenuation by methionine. J Lab Clin Med 1981;98;417-424.
6. Tomasi A, Albano E, Biasi F, Slater TF, Vannini V, Dianzani MU. Activation of chloroform and related trihalomethanes to free radical intermediates in isolated hepatocytes and in the rat in vivo as detected by the ESR-spin trapping technique. Chem Biol Interact 1985;55:303-316.
7. Reinke LA, Lai EK, DuBose CM, McCay PB. Reactive free radical generation in the heart and liver of ethanol-fed rats: correlation with in vitro radical formation. Proc Natl Acad Sci U S A 1987;84:9223-9227.
8. Rashba-Step J, Turro NJ, Cederbaum AI. Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment. Arch Biochem Biophys 1993;300:401-408.
9. Knecht KT, Bradford BU, Mason RP, Thurman RG. In vivo formation of a free radical metabolite of ethanol. Mol Pharmacol 1990;38:26-30.
10. Patek AJ Jr. Alcohol, malnutrition, and alcoholic cirrhosis. Am J Clin Nutr 1979;32:1304-1312.
11. Bujanda L. The effects of alcohol consumption upon the gastrointestinal tract. Am J Gastroenterol 2000;95:3374-3382.
12. Lieber CS, Alcohol: its metabolism and interaction with nutrients. Annu Rev Nutr 2000;20:395-430.
13. Kono H, Rusyn I, Connor H, Mason RP, Thurman RG. Allopurinol prevents early alcohol-induced liver injury in rats. J Pharmacol Exp Therapeut 2000;293:296-303.
14. Kono H, Rusyn I, Uesugi T, Yamashina S, Connor HD, Dikalova A, Mason RP, Thurman RG. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol 2001;280:G1005-G1012.
15. Kono H, Arteel GE, Rusyn I, Sies H, Thurman RG. Ebselen prevents early alcohol-induced liver injury in rats. Free Radic Biol Med 2001;30:403-411.
16. McCord JM, Fridovich I. Superoxide dismutase: an enzymatic function of erythrocuprein (hemocuprein). J Biol Chem 1969;244:6049-6055.
17. Polavarapu R, Follansbee MH, Spitz DR, Sim JE, Nanji AA. Hepatic antioxidant enzymes in experimental alcoholic liver disease (ALD). Hepatology 1996;24:1259.
18. Wheeler MD, Kono H, Yin M, Rusyn I, Froh M, Connor HD, Mason RP, Samulski RJ, Thurman RG. Delivery of Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. Gastroenterology 2001;120:1241-1250.
19. Wheeler MD, Nakagami M, Bradford BU, Uesugi T, Mason RP, Connor HD, Dikalova A, Kadiiska M, Thurman RG. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J Biol Chem 2001;276:36664-36672.
20. Knecht KT, Thurman RG, Mason RP. Role of superoxide and trace transition metals in the production of α-hydroxyethl radical from ethanol by microsomes from alcohol dehydrogenase-deficient deer mice. Arch Biochem Biophys 1993;303:339-348.
21. Fridovich I. Superoxide radical and superoxide dismutases. Annu Rev Biochem 1995;64:97-112.
22. Klebanoff SJ. Myeloperoxidase-halide-hydrogen peroxide anti-bacterial system. J Bacteriol 1968;95:2131-2138.
23. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 1990;87:1620-1624.
24. Beckman JS. The physiological and pathophysiological chemistry of nitric oxide. In: Lancaster J, ed. Nitric oxide: principles and actions. San Diego, CA: Academic Press, 1996:1-82.
25. Hon WM, Lee KH, Khoo HE. Nitric oxide in liver diseases: friend, foe, or just passerby? Ann N Y Acad Sci 2002;962:275-295,
26. Oshita M, Takei Y, Kawano S, Hijioka T, Masuda E, Goto M, Nishimura Y, Nagai H, Iio S, Tsuji S. Endogenous nitric oxide attenuates ethanol-induced perturbation of hepatic circulation in the isolated perfused rat liver. Hepatology 1994;20:961-965.
27. Wiest R, Groszmann RJ. The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. Hepatology 2002;35:478-491.
28. Kim YM, Kim TH, Chung HT, Talanian RV, Yin XM, Billiar TR. Nitric oxide prevents tumor necrosis factor α-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8. Hepatology 2000;32;770-778.
29. Rai RM, Lee FY, Rosen A, Yang SQ, Lin HZ, Koteish A, Liew FY, Zaragoza C, Lowenstein C, Diehl AM. Impaired liver regeneration in inducible nitric oxide synthase-deficient mice. Proc Natl Acad Sci U S A 1998;95:13829-13834.
30. Rubbo H, Radi R, Anselmi D, Kirk M, Barnes S, Butler J, Eiserich JP, Freeman BA. Nitric oxide reaction with lipid peroxyl radicals spares α-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/alpha-tocopherol than α-tocopherol/ascorbate. J Biol Chem 2000;275:10812-10818.
31. Nanji AA, Greenberg SS, Tahan SR, Fogt F, Loscalzo J, Sadrzadeh SM, Xie J, Stamler JS. Nitric oxide production in experimental alcoholic liver disease in the rat: role in protection from injury. Gastroenterology 1995;109:899-907.
32. Nanji AA, Jokelainen K, Lau GK, Rahemtulla A, Tipoe GL, Polavarapu R, Lalani E. Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration. J Pharmacol Exp Ther 2001;299:832-839.
33. Gatti RM, Alvarez B, Vasquez-Vivar J, Radi R, Augusto O. Formation of spin trap adducts during the decomposition of peroxynitrite. Arch Biochem Biophys 1998;349:36-46.
34. Chen GW, Chung JG, Hsieh CL, Lin JG. Effects of the garlic components diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity in human colon tumour cells. Food Chem Toxicol 1998;36:761-770.
35. Hu X, Benson PJ, Srivastava SK, Mack LM, Xia H, Gupta V, Zaren HA, Singh SV. Glutathione S-transferases of female A/J mouse liver and forestomach and their differential induction by anti-carcinogenic organosulfides from garlic. Arch Biochem Biophys 1996;336:199-214.
36. Yang CS, Chhabra SK, Hong JY, Smith TJ. Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. J Nutr 2001;131:1041S-1045S.
37. Fausto N. Lessons from genetically engineered animal models. V. Knocking out genes to study liver regeneration: present and future. Am J Physiol 1999;277:G917-G921.
38. Thurman RG. Mechanisms of hepatic toxicity. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 1998;275:G605-G611.
39. Martinez F, Abril ER, Earnest DL, Watson RR. Ethanol and cytokine secretion. Alcohol 1992;9:455-458.
40. Goto M, Lemasters JJ, Thurman RG. Activation of voltage-dependent calcium channels in Kupffer cells by chronic treatment with alcohol in the rat. J Pharmacol Exp Therapeut 1994;267:1264-1268.
41. McClain CJ, Hill DB, Song Z, Deaciuc I, Barve S. Monocyte activation in alcoholic liver disease. Alcohol 2002;27:53-61.
42. Kono H, Rusyn I, Yin M, Gabele E, Yamashina S, Dikalova A, Kadiiska MB, Connor HD, Mason RP, Segal BH, Bradford BU, Holland SM, Thurman RG. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest 2000;106:867-872.
43. Arteel GE, Gaebele E, Wheeler MD, Uesugi T, Kadiiska M, Connor HD, Mason RP, Thurman RG. Inducible nitric oxide synthase is necessary for alcohol-induced liver injury: studies with knock-out mice. Hepatology 2001;36:339A.
44. Boer R, Ulrich WR, Klein T, Mirau B, Haas S, Baur I. The inhibitory potency and selectivity of arginine substrate site nitricoxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol 2000;58:1026-1034.
45. Eiserich JP, Hristova M, Cross CE, Jones AD, Freeman BA, Halliwell B, van der Vlict A. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 1998;391:393-397.
46. Kono H, Uesugi T, Froh M, Rusyn I, Bradford BU, Thurman RG. ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice. Am J Physiol 2001;280:G1289-G1295.
47. Noguchi N, Nakano K, Aratani Y, Koyama H, Kodama T, Niki E. Role of myeloperoxidase in the neutrophil-induced oxidation of low density lipoprotein as studied by myeloperoxidase-knockout mouse. J Biochem (Tokyo) 2000;127:971-976.
48. Albano E, Clot P, Morimoto M, Tomasi A, Ingelman-Sundberg M, French SW. Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology 1996;23:155-163.
49. Ekstrom G, Ingelman-Sundberg M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1). Biochem Pharmacol 1989;38:1313-1319.
50. Cederbaum AI, Wu D, Mari M, Bai J. CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free Radic Biol Med 2001;31:1539-1543.
51. Kono H, Bradford BU, Yin M, Sulik KK, Koop DR, Peters JM, Gonzalez FJ, Mcdonald T, Dikolova A, Kadiiska MB, Mason RP, Thurman RG. CYP2E1 is not involved in early alcohol-induced liver injury. Am J Physiol 1999;277:G1259-G1267.
52. Bardag-Gorce F, Yuan QX, Li J, French BA, Fang C, Ingelman-Sundberg M, French SW. The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol. Biochem Biophys Res Commun 2000;279:23-29.
53. Isayama F, Uesugi T, Froh M, Bradford BU, McKim SE, Gaebele E, Connor HD, Mason RP, Koop CR, Thurman RG, Arteel GE. The cytochrome P450 inhibitor 1-aminobenzotriazole does not prevent early alcohol-induced liver injury in rats and mice. Alcohol Clin Exp Res 2002;26:180A.
54. Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR. The CYP2E1 knockout delivers another punch: first ASH, now NASH. Hepatology 2001;33:311-312.
55. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973;134:707-716.
56. Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000;29:222-230.
57. Bailey SM, Pietsch EC, Cunningham CC. Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III. Free Radic Biol Med 1999;27:891-900.
58. Cunningham CC, Bailey SM. Ethanol consumption and liver mitochondria function. Biol Signals Recept 2001;10:271-282.
59. Hoek JB, Cahill A, Pastorino JG. Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 2002;122:2049-2063.
60. Lemasters JJ, Qian T, Bradham CA, Brenner DA, Cascio WE, Trost LC, Nishimura Y, Nieminen AL, Herman B. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J Bioenerg Biomembr 1999;31:305-319.
61. Fernandez-Checa JC, Kaplowitz N, Garcia-Ruiz C, Colell A, Miranda M, Mari M, Ardite E, Morales A. GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol 1997;273:G7-G17.
62. Colell A, Garcia-Ruiz C, Miranda M, Ardite E, Mari M, Morales A, Corrales F, Kaplowitz N, Fernandez-Checa JC. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 1998;115:1541-1551.
63. Poli G. Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med 2000;21:49-98.
64. Kim KY, Rhim T, Choi I, Kim SS. N-acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity. J Biol Chem 2001;276:40591-40598.
65. Reeves HL, Dack CL, Peak M, Burt AD, Day CP. Stress-activated protein kinases in the activation of rat hepatic stellate cells in culture. J Hepatol 2000;32:465-472.
66. Adams PC, Agnew S. Alcoholism in hereditary hemochromatosis revisited: prevalence and clinical consequences among homozygous siblings. Hepatology 1996;23:724-727.
67. Tsukamoto H, Horne W, Kamimura S, Niemela O, Parkkila S, Yla-Herttuala S, Brittenham GM, Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest 1995;96:620-630.
68. Tsukamoto H, Xi XP. Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis. Hepatology 1989;9:302-306.
69. Arteel GE, Iimuro Y, Yin M, Raleigh JA, Thurman RG. Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo. Hepatology 1997;25:920-926.
70. Jones DP. The role of oxygen concentration in oxidative stress: hypoxic and hyperoxic models. In: Sies H, ed. Oxidative stress. London: Academic Press, 1985:151-195.
71. Shan X, Aw TY, Shapira R, Jones DP. Oxygen dependence of glutathione synthesis in hepatocytes. Toxicol Appl Pharmacol 1989;101:261-270.
72. Nakanishi T, Tajima F, Nakamura A, Yagura S, Ookawara T, Yamashita H, Suzuki K, Taniguchi N, Ohno H. Effects of hypobaric hypoxia on antioxidant enzymes in rats. J Physiol 1995;489:869-876.
73. Bardag-Gorce F, Yuan QX, Li J, French BA, Fang C, Ingelman-Sundberg M, French SW. The effect of ethanol-induced cytochrome p4502E1 on the inhibition of proteasome activity by alcohol. Biochem Biophys Res Commun 2000;279:23-29.
74. Donohue TM Jr. The ubiquitin-proteasome system and its role in ethanol-induced disorders. Addict Biol 2002;7:15-28.
75. Klassen LW, Tuma D, Sorrell MF. Immune mechanisms of alcohol-induced liver disease. Hepatology 1995;22:355-357.
76. Thiele GM, Worrall S, Tuma DJ, Klassen LW, Wyatt TA, Nagata N. The chemistry and biological effects of malondialdehyde-acetaldehyde adducts. Alcohol Clin Exp Res 2001;25:218S-224S,
77. Jaeschke H, Smith CV, Mitchell JR. Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver. J Clin Invest 1988;81:1240-1246.
78. Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med 2000;28:463-499.
79. Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002;82:47-95.
80. Forman HJ, Torres M. Redox signaling in macrophages. Mol Aspects Med 2001;22:189-216.
81. Kamata H, Hirata H. Redox regulation of cellular signalling. Cell Signal 1999;11:1-14.
82. Ermak G, Davies KJ. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol 2002;38:713-721.
83. Suzuki YJ, Forman HJ, Sevanian A. Oxidants as stimulators of signal transduction. Free Radic Biol Med 1997;22:269-285.
84. D'Angio CT, Finkelstein JN. Oxygen regulation of gene expression: a study in opposites. Mol Genet Metab 2000;71:371-380.
85. Hoek JB, Pastorino JG. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 2002;27:63-68.
86. Sen CK. Cellular thiols and redox-regulated signal transduction. Curr Top Cell Regul 2000;36:1-30.
87. Shi L, Kishore R, McMullen MR, Nagy LE. Lipopolysaccharide stimulation of ERK1/2 increases TNF-alpha production via Egr-1. Am J Physiol 2002;282:C1205-C1211.
88. Chen J, Ishac EJ, Dent P, Kunos G, Gao B. Effects of ethanol on mitogen-activated protein kinase and stress-activated protein kinase cascades in normal and regenerating liver. Biochem J 1998;334:669-676.
89. Bradham CA, Qian T, Streetz K, Trautwein C, Brenner DA, Lemasters JJ. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome C release. Mol Cell Biol 1998;18:6353-6364.
90. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ, Brenner DA. The mitochondrial permeability transition augments Fasinduced apoptosis in mouse hepatocytes. J Biol Chem 2000;275:11814-11823.
91. Uesugi T, Froh M, Arteel GE, Bradford BU, Gabele E, Wheeler MD, Thurman RG. Delivery of IκB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats. Hepatology 2001;34:1149-1157.
92. Torres M, Forman HJ. Nitric oxide, oxidative stress, and signal transduction. In: Ignarro LJ, ed. Nitric oxide: biology and pathobiology. San Diego, CA: Academic, 2000:329-342.
93. Deaciuc IV, Fortunato F, D'Souza NB, Hill DB, Schmidt J, Lee EY, McClain CJ. Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide. Alcohol Clin Exp Res 1999;23:349-356.
94. Colell A, Garcia-Ruiz C, Miranda M, Ardite E, Mari M, Morales A, Corrales F, Kaplowitz N, Fernandez-Checa JC. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 1998;115:1541-1551.
95. Pastorino JG, Hoek JB. Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition. Hepatology 2000;31:1141-1152.
96. Liu H, Jones BE, Bradham C, Czaja MJ. Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-α. Am J Physiol 2002;282:G257-G266.
97. Uesugi T, Froh M, Arteel GE, Bradford BU, Wheeler MD, Gabele E, Isayama F, Thurman RG. Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice. J Immunol 2002;168:2963-2969.
98. Haddad JJ. Pharmaco-redox regulation of cytokine-related pathways: from receptor signaling to pharmacogenomics. Free Radic Biol Med 2002;33:907-926.
99. McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis 1999;19:205-219.
100. Yin M, Wheeler MD, Kono H, Bradford BU, Gallucci RM, Luster MI, Thurman RG. Essential role of tumor necrosis factor α in alcohol-induced liver injury. Gastroenterology 1999;117:942-952.
101. Yin M, Gabele E, Wheeler MD, Connor H, Bradford BU, Dikalova A, Rusyn I, Mason R, Thurman RG. Alcohol-induced free radicals in mice: direct toxicants or signaling molecules? Hepatology 2001;34:935-942.
102. Garcia-Ruiz C, Colell A, Morales A, Calvo M, Enrich C, Fernandez-Checa JC. Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-α. J Biol Chem 2002;277:36443-36448.
103. McKim S, Konno A, Gabele E, Uesugi T, Froh M, Sies H, Thurman R, Arteel G. Cocoa extract protects against early alcohol-induced liver injury in the rat. Arch Biochem Biophys 2002;406:40.
104. Kono H, Enomoto N, Connor HD, Bradford BU, Rivera CA, Kadiiska M, Mason RP, Thurman RG. Medium-chain triglycerides inhibit free radical formation and TNF-α production by isolated Kupffer cells in rats given enteral ethanol. Am J Physiol 1999;278:G467-G476.
105. Yin M, Bradford BU, Wheeler MD, Uesugi T, Froh M, Goyert SM, Thurman RG. Reduced early alcohol-induced liver injury in cd14-deficient mice. J Immunol 2001;166:4737-4742.
106. Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 2001;34:101-108.
107. Valenti L, Fracanzani AL, Dongiovanni P, Santorelli G, Branchi A, Taioli E, Fiorelli G, Fargion S. Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology 2002;122:274-280.
108. Grove J, Daly AK, Bassendine MF, Day CP. Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis. Hepatology 1997;26:143-146.
109. Pessayre D, Mansouri A, Fromenty B. Nonalcoholic steatosis and steatohepatitis. V. Mitochondrial dysfunction in steatohepatitis. Am J Physiol 2002;282:G193-G199.
110. Hardardottir I, Doerrler W, Feingold KR, Grunfeld C. Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism. Biochem Biophys Res Commun 1992;186:237-243.
111. Feingold KR, Grunfeld C. Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo. J Clin Invest 1987;80:184-190.
112. Nachiappan V, Curtiss D, Corkey BE, Kilpatrick L. Cytokines inhibit fatty acid oxidation in isolated rat hepatocytes: synergy among TNF, IL-6, and IL-1. Shock 1994;1:123-129.
113. Navasa M, Gordon DA, Hariharan N, Jamil H, Shigenaga JK, Moser A, Fiers W, Pollock A, Grunfeld C, Feingold KR. Regulation of microsomal triglyceride transfer protein mRNA expression by endotoxin and cytokines. J Lipid Res 1998;39:1220-1230.
114. Perez MJ, Cederbaum AI. Antioxidant and pro-oxidant effects of a manganese porphyrin complex against CYP2E1-dependent toxicity. Free Radic Biol Med 2002;33:111-127.
115. Sies H. Strategies of antioxidant defense. Eur J Biochem 1993;215:213-219.
116. Lieber CS. Hepatic, metabolic, and nutritional disorders of alcoholism: from pathogenesis to therapy. Crit Rev Clin Lab Sci 2000;37:551-584.
117. Avila MA, Garcia-Trevijano ER, Martinez-Chantar ML, Latasa MU, Perez-Mato I, Martinez-Cruz LA, del Pino MM, Corrales FJ, Mato JM. S-Adenosylmethionine revisited: its essential role in the regulation of liver function. Alcohol 2002;27:163-167.
118. Fernandez-Checa JC, Colell A, Garcia-Ruiz C. S-Adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease. Alcohol 2002;27:179-183.
119. Dhakshinamoorthy S, Long DJ, Jaiswal AK. Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens. Curr Top Cell Regul 2000;36:201-216.
120. Nanji AA, Mendenhall CL, French SW. Beef fat prevents alcoholic liver disease in the rat. Alcohol Clin Exp Res 1989;13:15-19.