메뉴 건너뛰기




Volumn 25, Issue 4, 1996, Pages 538-546

Hepatotoxicity induced by iron overload and alcohol. Studies on the role of chelatable iron, cytochrome P450 2E1 and lipid peroxidation

Author keywords

Alcohol; Cytochrome P450 2E1; Desferrioxamine; Hemochromatosis; Hepatotoxicity; Iron

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; CARBONYL IRON; CYTOCHROME P450; DEFEROXAMINE MESYLATE; GLUTATHIONE; MALONALDEHYDE; POLYCLONAL ANTIBODY;

EID: 0030272970     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80214-5     Document Type: Article
Times cited : (49)

References (40)
  • 2
    • 0027534329 scopus 로고
    • Iron increases ethanol toxicity in rat liver
    • St→l P, Hultcrantz R. Iron increases ethanol toxicity in rat liver. J Hepatol. 17:1993;108-115.
    • (1993) J Hepatol , vol.17 , pp. 108-115
    • Stål, P.1    Hultcrantz, R.2
  • 3
    • 0028920115 scopus 로고
    • Ethane exhalation and vitamin E/ubiquinol status as markers of lipid peroxidation in ferrocene iron-loaded rats
    • Dresow B, Albert C, Zimmerman I, Nielsen P. Ethane exhalation and vitamin E/ubiquinol status as markers of lipid peroxidation in ferrocene iron-loaded rats. Hepatology. 21:1995;1099-1105.
    • (1995) Hepatology , vol.21 , pp. 1099-1105
    • Dresow, B.1    Albert, C.2    Zimmerman, I.3    Nielsen, P.4
  • 4
    • 0024427480 scopus 로고
    • Effects of iron loading on free radical scavenging enzymes and lipid peroxidation in rat liver
    • Fletcher LM, Roberts FD, Irving MG, Powell LW, Halliday JW. Effects of iron loading on free radical scavenging enzymes and lipid peroxidation in rat liver. Gastroenterology. 97:1989;1011-1018.
    • (1989) Gastroenterology , vol.97 , pp. 1011-1018
    • Fletcher, L.M.1    Roberts, F.D.2    Irving, M.G.3    Powell, L.W.4    Halliday, J.W.5
  • 5
    • 0024546914 scopus 로고
    • Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450IIE1
    • Ekström G, Ingelman-Sundberg M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450IIE1. Biochem Pharmacol. 38:1989;1313-1319.
    • (1989) Biochem Pharmacol , vol.38 , pp. 1313-1319
    • Ekström, G.1    Ingelman-Sundberg, M.2
  • 7
    • 0020566102 scopus 로고
    • Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease. Evidence of lipid peroxidation
    • Shaw S, Rubin KP, Lieber CS. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease. Evidence of lipid peroxidation. Dig Dis Sci. 28:1983;585-589.
    • (1983) Dig Dis Sci , vol.28 , pp. 585-589
    • Shaw, S.1    Rubin, K.P.2    Lieber, C.S.3
  • 8
    • 0025157647 scopus 로고
    • The pathology of hepatic iron overload: A free radical mediated process?
    • Bacon BR, Britton RS. The pathology of hepatic iron overload: a free radical mediated process? Hepatology. 11:1990;127-137.
    • (1990) Hepatology , vol.11 , pp. 127-137
    • Bacon, B.R.1    Britton, R.S.2
  • 9
    • 0025925346 scopus 로고
    • Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload
    • Myers BM, Prendergast FG, Holman R, Kuntz SM, LaRusso NF. Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload. J Clin Invest. 88:1991;1207-1215.
    • (1991) J Clin Invest , vol.88 , pp. 1207-1215
    • Myers, B.M.1    Prendergast, F.G.2    Holman, R.3    Kuntz, S.M.4    LaRusso, N.F.5
  • 11
    • 0025243552 scopus 로고
    • Liver cell damage and lysosomal iron storage in patients with idiopathic hemochromatosis. A light and electron microscopic study
    • St→l P, Hultcrantz R, Glaumann H. Liver cell damage and lysosomal iron storage in patients with idiopathic hemochromatosis. A light and electron microscopic study. J Hepatol. 11:1990;172-180.
    • (1990) J Hepatol , vol.11 , pp. 172-180
    • Stål, P.1    Hultcrantz, R.2    Glaumann, H.3
  • 12
    • 0026717172 scopus 로고
    • Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Assocation of lipid peroxidation with liver fibrogenesis
    • Kamimura S, Gaal K, Britton RS, Bacon BR, Triadafilopoulos G, Tsukamoto H. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: assocation of lipid peroxidation with liver fibrogenesis. Hepatology. 16:1992;448-453.
    • (1992) Hepatology , vol.16 , pp. 448-453
    • Kamimura, S.1    Gaal, K.2    Britton, R.S.3    Bacon, B.R.4    Triadafilopoulos, G.5    Tsukamoto, H.6
  • 13
    • 0021215327 scopus 로고
    • Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450
    • Ingelman-Sundberg M, Johansson I. Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450. J Biol Chem. 259:1984;6447-6458.
    • (1984) J Biol Chem , vol.259 , pp. 6447-6458
    • Ingelman-Sundberg, M.1    Johansson, I.2
  • 14
    • 0026697981 scopus 로고
    • Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation
    • Castillo T, Koop DR, Kamimura S, Triadafilopoulos G, Tsukamoto H. Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation. Hepatology. 16:1992;992-996.
    • (1992) Hepatology , vol.16 , pp. 992-996
    • Castillo, T.1    Koop, D.R.2    Kamimura, S.3    Triadafilopoulos, G.4    Tsukamoto, H.5
  • 15
    • 0019511768 scopus 로고
    • Ethanol-induced lipid peroxidation: Potentiation by long-term alcohol feeding and attenuation by methionine
    • Shaw S, Jayatilleke E, Ross WA, Gordon E, Lieber CS. Ethanol-induced lipid peroxidation: potentiation by long-term alcohol feeding and attenuation by methionine. J Lab Clin Med. 98:1981;417-425.
    • (1981) J Lab Clin Med , vol.98 , pp. 417-425
    • Shaw, S.1    Jayatilleke, E.2    Ross, W.A.3    Gordon, E.4    Lieber, C.S.5
  • 16
    • 0025324230 scopus 로고
    • The role of aldehyde oxidase in ethanol-induced hepatic lipid peroxidation in the rat
    • Shaw S, Jayatilleke E. The role of aldehyde oxidase in ethanol-induced hepatic lipid peroxidation in the rat. Biochem J. 268:1990;579-583.
    • (1990) Biochem J , vol.268 , pp. 579-583
    • Shaw, S.1    Jayatilleke, E.2
  • 17
    • 0024791954 scopus 로고
    • Lipid peroxidation, iron mobilization and radical generation induced by alcohol
    • Shaw S. Lipid peroxidation, iron mobilization and radical generation induced by alcohol. Free Rad Biol Med. 7:1989;541-547.
    • (1989) Free Rad Biol Med , vol.7 , pp. 541-547
    • Shaw, S.1
  • 18
    • 0023853227 scopus 로고
    • Association between alcoholism and increased hepatic iron stores
    • Irving MG, Halliday JW, Powell LW. Association between alcoholism and increased hepatic iron stores. Alcohol Clin Exp Res. 12:1988;7-13.
    • (1988) Alcohol Clin Exp Res , vol.12 , pp. 7-13
    • Irving, M.G.1    Halliday, J.W.2    Powell, L.W.3
  • 20
  • 21
    • 0020039871 scopus 로고
    • Studies on the rat liver following iron overload. Biochemical studies after iron removal
    • Hultcrantz R, Glaumann H. Studies on the rat liver following iron overload. Biochemical studies after iron removal. Lab Invest. 46:1982;383-393.
    • (1982) Lab Invest , vol.46 , pp. 383-393
    • Hultcrantz, R.1    Glaumann, H.2
  • 23
    • 0023685311 scopus 로고
    • Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes
    • Johansson I, Ingelman-Sundberg M. Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes. Cancer Res. 18:1988;5387-5390.
    • (1988) Cancer Res , vol.18 , pp. 5387-5390
    • Johansson, I.1    Ingelman-Sundberg, M.2
  • 24
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 95:1979;351.
    • (1979) Anal Biochem , vol.95 , pp. 351
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 25
    • 0027977403 scopus 로고
    • Biliary excretion of plasma non-transferrin-bound iron in rats: Pathogenetic importance in iron-overload disorders
    • Brissot P, Zanninelli G, D Guyader, Zeind J, Gollan J. Biliary excretion of plasma non-transferrin-bound iron in rats: pathogenetic importance in iron-overload disorders. Am J Physiol. 267:1994;G135-G142.
    • (1994) Am J Physiol , vol.267
    • Brissot, P.1    Zanninelli, G.2    Guyader, D.3    Zeind, J.4    Gollan, J.5
  • 26
    • 0025302726 scopus 로고
    • Increased prooxidant action of hepatic cytosolic low-molecular-weight iron in experimental iron overload
    • Britton RS, Ferrali M, Magiera CJ, Recknagel RO, Bacon BR. Increased prooxidant action of hepatic cytosolic low-molecular-weight iron in experimental iron overload. Hepatology. 11:1990;1038-1043.
    • (1990) Hepatology , vol.11 , pp. 1038-1043
    • Britton, R.S.1    Ferrali, M.2    Magiera, C.J.3    Recknagel, R.O.4    Bacon, B.R.5
  • 27
    • 0027511812 scopus 로고
    • Non-transferrin-bound-iron in serum and low-molecular-weight-iron in the liver of dietary iron-loaded rats
    • Nielsen P, Düllmann J, Wulfhekel U, Heinrich HC. Non-transferrin-bound-iron in serum and low-molecular-weight-iron in the liver of dietary iron-loaded rats. Int J Biochem. 25:1993;223-232.
    • (1993) Int J Biochem , vol.25 , pp. 223-232
    • Nielsen, P.1    Düllmann, J.2    Wulfhekel, U.3    Heinrich, H.C.4
  • 29
    • 0029039555 scopus 로고
    • A long-term study of the interaction between iron and alcohol in an animal model of iron overload
    • Olynyk J, Hall P, Reed W, Williams P, Kerr R, Mackinnon M. A long-term study of the interaction between iron and alcohol in an animal model of iron overload. J Hepatol. 22:1995;671-676.
    • (1995) J Hepatol , vol.22 , pp. 671-676
    • Olynyk, J.1    Hall, P.2    Reed, W.3    Williams, P.4    Kerr, R.5    Mackinnon, M.6
  • 30
    • 0027529461 scopus 로고
    • Electron paramagnetic resonance spectroscopy of stable free radicals in the liver compared with ultrastructural and functional damage in a rat model of alcohol- and iron-overload
    • Butcher GP, Deighton N, Batt RM, Ding B, Haywood S, Hoffman J, Jackson MJ, Symons MCR, Rhodes JM. Electron paramagnetic resonance spectroscopy of stable free radicals in the liver compared with ultrastructural and functional damage in a rat model of alcohol- and iron-overload. Clin Sci. 84:1993;339-348.
    • (1993) Clin Sci , vol.84 , pp. 339-348
    • Butcher, G.P.1    Deighton, N.2    Batt, R.M.3    Ding, B.4    Haywood, S.5    Hoffman, J.6    Jackson, M.J.7    Symons, M.C.R.8    Rhodes, J.M.9
  • 31
    • 0011921699 scopus 로고
    • Additive effect of iron overload and ethanol on hepatic damage. (Abstract)
    • Tector AJ, Britton RS, O'Neill R, Bacon BR. Additive effect of iron overload and ethanol on hepatic damage. (Abstract). Gastroentrology. 102:1993;A944.
    • (1993) Gastroentrology , vol.102 , pp. 944
    • Tector, A.J.1    Britton, R.S.2    O'Neill, R.3    Bacon, B.R.4
  • 33
    • 0028957757 scopus 로고
    • Iron overload facilitates hepatic fibrosis in the rat alcohol/low-dose carbon tetrachloride model
    • Mackinnon M, Clayton C, Plummer J, Ahern M, Cmielewski P, Ilsley A, Hall P. Iron overload facilitates hepatic fibrosis in the rat alcohol/low-dose carbon tetrachloride model. Hepatology. 21:1995;1083-1088.
    • (1995) Hepatology , vol.21 , pp. 1083-1088
    • Mackinnon, M.1    Clayton, C.2    Plummer, J.3    Ahern, M.4    Cmielewski, P.5    Ilsley, A.6    Hall, P.7
  • 34
    • 0023097762 scopus 로고
    • Involvement of iron and iron-catalysed free radical production in ethanol metabolism and toxicity
    • Nordmann R, Ribière C, Rouach H. Involvement of iron and iron-catalysed free radical production in ethanol metabolism and toxicity. Enzyme. 37:1987;57-69.
    • (1987) Enzyme , vol.37 , pp. 57-69
    • Nordmann, R.1    Ribière, C.2    Rouach, H.3
  • 35
    • 0024402573 scopus 로고
    • Protective effects of glutathione against lipid peroxidation in chronically iron-loaded mice
    • Kawabata T, Ogino T, Awai M. Protective effects of glutathione against lipid peroxidation in chronically iron-loaded mice. Biochim Biophys Acta. 1004:1989;89-94.
    • (1989) Biochim Biophys Acta , vol.1004 , pp. 89-94
    • Kawabata, T.1    Ogino, T.2    Awai, M.3
  • 36
    • 0023607035 scopus 로고
    • Hepatic heme synthesis in a new model of experimental hemochromatosis: Studies in rats fed finely divided elemental iron
    • Bonkovsky HL, Healey JF, Lincoln B, Bacon BR, Bishop DF, Elder GH. Hepatic heme synthesis in a new model of experimental hemochromatosis: studies in rats fed finely divided elemental iron. Hepatology. 7:1987;1195-1203.
    • (1987) Hepatology , vol.7 , pp. 1195-1203
    • Bonkovsky, H.L.1    Healey, J.F.2    Lincoln, B.3    Bacon, B.R.4    Bishop, D.F.5    Elder, G.H.6
  • 37
    • 0024453029 scopus 로고
    • Lipid peroxidation and anti-oxidant defense systems in rat liver after chronic ethanol feeding
    • Kawase T, Kato S, Lieber CS. Lipid peroxidation and anti-oxidant defense systems in rat liver after chronic ethanol feeding. Hepatology. 10:1989;815-821.
    • (1989) Hepatology , vol.10 , pp. 815-821
    • Kawase, T.1    Kato, S.2    Lieber, C.S.3
  • 38
    • 0021884007 scopus 로고
    • Effects of chronic ethanol feeding on glutathione turnover in the rat
    • Morton S, Mitchell MC. Effects of chronic ethanol feeding on glutathione turnover in the rat. Biochem Pharmacol. 34:1985;1559-1563.
    • (1985) Biochem Pharmacol , vol.34 , pp. 1559-1563
    • Morton, S.1    Mitchell, M.C.2
  • 39
    • 0026493715 scopus 로고
    • Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats
    • Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology. 16:1992;1423-1427.
    • (1992) Hepatology , vol.16 , pp. 1423-1427
    • Hirano, T.1    Kaplowitz, N.2    Tsukamoto, H.3    Kamimura, S.4    Fernandez-Checa, J.C.5
  • 40
    • 0024604102 scopus 로고
    • Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration
    • Fernandez-Checa JC, Ookhtens M, Kaplowitz N. Effects of chronic ethanol feeding on rat hepatocytic glutathione. Relationship of cytosolic glutathione to efflux and mitochondrial sequestration. J Clin Invest. 83:1989;1247-1252.
    • (1989) J Clin Invest , vol.83 , pp. 1247-1252
    • Fernandez-Checa, J.C.1    Ookhtens, M.2    Kaplowitz, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.