In vitro exposure to malondialdehyde-acetaldehyde adducted protein inhibits cell proliferation and viability

Alcoholism: Clinical and Experimental Research

Volumn 26, Issue 2, 2002, Pages 158-164

  Willis, Monte S ^a,c   Klassen, Lynell W ^a,b   Tuma, Dean J ^a,b   Sorrell, Michael F ^a,b   Thiele, Geoffrey M ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Aldehydes; Cell Death; Hapten; Immune System; Liver

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETALDEHYDE; HAPTEN; LYSOZYME; MALONALDEHYDE; THYMIDINE;

ALCOHOL CONSUMPTION; ALCOHOL LIVER CIRRHOSIS; ALCOHOL LIVER DISEASE; ANIMAL CELL; ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; EXPOSURE; FEMALE; IMMUNOGENICITY; IN VITRO STUDY; LIVER CELL; LYMPHOCYTE; MALE; MIXED CONNECTIVE TISSUE DISEASE; MOUSE; MYOSITIS; NONHUMAN; PRIORITY JOURNAL; RAT; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALIA;

EID: 0036168647     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2002.tb02520.x     Document Type: Article

References (56)

1. Recent advances in the isolation of liver cells
2. Apoptosis in systemic lupus erythematosus. Clinical implications
3. Dehydroascorbic acid prevents apoptosis induced by oxidized low-density lipoprotein in human monocytederived macrophages
4. Processing of engulfed apoptotic bodies yields T cell epitopes
5. Acetaldehyde-serum protein adducts inhibit interleukin-2 secretion in concanavalin A-stimulated murine splenocytes: A potential common pathway for ethanol-induced immunomodulation
6. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: Implications for coagulation events and antigenic spread in systemic lupus erythematosus
7. Cell-mediated immunity in alcoholic liver disease. Veterans Administration Cooperative Study 275
8. Human 60-kDa heat-shock protein: A danger signal to the innate immune system
9. Lymphocyte cytotoxicity for isolated hepatocytes in alcoholic liver disease
10. Loss of the CD5+ and CD45RAhi B cell subsets in alcoholics
11. Granulocyte-macrophage colony-stimulating factor-cultured bone marrow-derived macrophages reveal accessory cell function and synthesis of MHC class II determinants in the absence of external stimuli
12. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix
13. Apoptosis in liver disease
14. Functional comparison of spleen dendritic cells and dendritic cells cultured in vitro from bone marrow precursors
15. Use of MTT colorimetric assay to measure cell activation
16. Apoptotic bodies in a murine model of alcoholic liver disease: Reversibility of ethanol-induced changes
17. Factors influencing individual susceptibility to alcohol liver disease
18. Oxidation-dependent effects of oxidized LDL: Proliferation or cell death
19. Ethanol-induced apoptosis and oxidative stress in hepatocytes
20. DNA vaccination using coexpression of cytokine genes with a bacterial gene encoding a 60-kDa heat shock protein
21. The role of apoptosis in the initiation of the autoimmune response in Sjogren's syndrome
22. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
23. Heat shock proteins and the immune response
24. Studies on peroxidized lipids: V. Formation and characterization of 1,3-dihydropyridine-3,5-dicarbaledhydes as model of fluorescent components in lipofusion
25. Autoantibodies in alcoholic liver disease
26. The role of apoptosis in autoimmunity: Immunogen, antigen, and accelerant
27. Generation of DC from mouse spleen cell cultures in response to GM-CSF: Immunophenotypic and functional analyses
28. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
29. Apoptosis and autoimmune disease
30. Immunologic reactions in alcoholic liver disease
31. Transformed cell lines susceptible or resistant to in vivo surveillance against tumorigenesis
32. Dysregulation of apoptosis as a mechanism of liver disease: An overview
33. Cellular cytotoxicity against autologous hepatocytes in alcoholic liver disease
34. Electron transport chain activity in normal and activated rat macrophages
35. Cell death: A trigger of autoimmunity?
36. Detection of circulating antibodies against malondialdehydeacetaldehyde adducts in patients with alcohol-induced liver disease
37. Novel packages of viral and self-antigens are generated during apoptosis
38. Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function
39. Caspases: Intracellular signaling by proteolysis
40. The synthesis of proteoglycans in fat-storing cells of rat liver
41. Dendritic cells from mouse bone marrow: In vitro differentiation using low doses of recombinant granulocyte-macrophage colony-stimulating factor
42. Ethanol-induced macrophage apoptosis: The role of TGF-beta
43. Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation
44. Detection of cell death of cultured mouse mesangial cells induced by oxidized low-density lipoprotein
45. Soluble proteins modified with acetaldehyde and malondialdehyde are immunogenic in the absence of adjuvant
46. Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration
47. Acetaldehyde adducts and autoantibodies against VLDL and LDL in alcoholics
48. N-acetylcysteine protects lymphocytes from nitrogen mustardinduced apoptosis
49. Acetaldehyde-modified serum proteins inhibit mitogen-stimulated human lymphocyte transformation
50. Cytotoxic protein molecules generated as a consequence of ethanol metabolism in vitro and in vivo
51. Circulating cytotoxic protein generated after ethanol consumption: Identification and mechanism of reaction with cells
52. Acetaldehydemodified albumin as hepatotoxic factor
53. Malondialdehydeacetaldehyde (MAA) haptenated protein induces cell death by induction of necrosis and apoptosis in immune cells
54. Adduction of soluble proteins with malondialdehyde-acetaldehyde (MAA) induces antibody productions and enhances T-cell proliferation
55. Apoptosis and bcl-2 protein expression in experimental alcoholic liver disease in the rat