-
3
-
-
0034807728
-
Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1
-
Caro A.A., Cederbaum A.I. Synergistic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1. Mol Pharmacol. 60:2001;742-752.
-
(2001)
Mol Pharmacol
, vol.60
, pp. 742-752
-
-
Caro, A.A.1
Cederbaum, A.I.2
-
4
-
-
0026697981
-
Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation
-
Castillo T., Koop D.R., Kamimura S., Triadafilopoulos G., Tsukamoto H. Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation. Hepatology. 16:1992;992-996.
-
(1992)
Hepatology
, vol.16
, pp. 992-996
-
-
Castillo, T.1
Koop, D.R.2
Kamimura, S.3
Triadafilopoulos, G.4
Tsukamoto, H.5
-
5
-
-
0035894083
-
Introduction - Serial review: Alcohol, oxidative stress and cell injury
-
Cederbaum A.I. Introduction - serial review: alcohol, oxidative stress and cell injury. Free Radic Biol Med. 31:2001;1524-1526.
-
(2001)
Free Radic Biol Med
, vol.31
, pp. 1524-1526
-
-
Cederbaum, A.I.1
-
6
-
-
0031958219
-
Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells
-
Chen Q., Cederbaum A.I. Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells. Mol Pharmacol. 53:1998;638-648.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 638-648
-
-
Chen, Q.1
Cederbaum, A.I.2
-
7
-
-
0030965155
-
Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P4502E1
-
Chen Q., Galleano M., Cederbaum A.I. Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P4502E1. J Biol Chem. 272:1997;14532-14541.
-
(1997)
J Biol Chem
, vol.272
, pp. 14532-14541
-
-
Chen, Q.1
Galleano, M.2
Cederbaum, A.I.3
-
8
-
-
0024392071
-
Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals
-
Clejan L., Cederbaum A.I. Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals. Biochem Pharmacol. 38:1989;1779-1786.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 1779-1786
-
-
Clejan, L.1
Cederbaum, A.I.2
-
9
-
-
0029002112
-
Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells
-
Dai Y., Cederbaum A.I. Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells. J Pharmacol Exp Ther. 273:1995a;1497-1505.
-
(1995)
J Pharmacol Exp Ther
, vol.273
, pp. 1497-1505
-
-
Dai, Y.1
Cederbaum, A.I.2
-
10
-
-
0029553016
-
Inactivation and degradation of human cytochrome P4502E1 by CC14 in a transfected HepG2 cell line
-
Dai Y., Cederbaum A.I. Inactivation and degradation of human cytochrome P4502E1 by CC14 in a transfected HepG2 cell line. J Pharmacol Exp Ther. 275:1995b;1614-1622.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 1614-1622
-
-
Dai, Y.1
Cederbaum, A.I.2
-
11
-
-
0027185531
-
Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates
-
Dai Y., Rashba-Step J., Cederbaum A.I. Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates. Biochemistry. 32:1993;6928-6937.
-
(1993)
Biochemistry
, vol.32
, pp. 6928-6937
-
-
Dai, Y.1
Rashba-Step, J.2
Cederbaum, A.I.3
-
12
-
-
0023513042
-
Hydroxyl radical generation by microsomes after chronic ethanol consumption
-
Dicker E., Cederbaum A.I. Hydroxyl radical generation by microsomes after chronic ethanol consumption. Alcohol Clin Exp Res. 11:1987;309-314.
-
(1987)
Alcohol Clin Exp Res
, vol.11
, pp. 309-314
-
-
Dicker, E.1
Cederbaum, A.I.2
-
13
-
-
0023707433
-
Increased oxygen radical-dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption
-
Dicker E., Cederbaum A.I. Increased oxygen radical-dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption. FASEB J. 2:1988;2901-2906.
-
(1988)
FASEB J
, vol.2
, pp. 2901-2906
-
-
Dicker, E.1
Cederbaum, A.I.2
-
14
-
-
0025743946
-
NADH-dependent generation of reactive oxygen species by microsomes in the presence of iron and redox cycling agents
-
Dicker E., Cederbaum A.I. NADH-dependent generation of reactive oxygen species by microsomes in the presence of iron and redox cycling agents. Biochem Pharmacol. 42:1991;529-535.
-
(1991)
Biochem Pharmacol
, vol.42
, pp. 529-535
-
-
Dicker, E.1
Cederbaum, A.I.2
-
15
-
-
0024546914
-
Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P450 (P-450IIE1)
-
Ekstrom G., Ingelman-Sundberg M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P450 (P-450IIE1). Biochem Pharmacol. 38:1989;1313-1319.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 1313-1319
-
-
Ekstrom, G.1
Ingelman-Sundberg, M.2
-
16
-
-
0344710499
-
Inactivation of key metabolic enzymes by mixed function oxidation reactions: Possible implication in protein turnover and ageing
-
Fucci L., Oliver C.N., Coon M.J., Stadtman E.R. Inactivation of key metabolic enzymes by mixed function oxidation reactions: possible implication in protein turnover and ageing. Proc Natl Acad Sci U S A. 80:1983;1521-1525.
-
(1983)
Proc Natl Acad Sci U S A
, vol.80
, pp. 1521-1525
-
-
Fucci, L.1
Oliver, C.N.2
Coon, M.J.3
Stadtman, E.R.4
-
17
-
-
0026035519
-
Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects
-
Guengerich F.P., Kim D.H., Iwasaki M. Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol. 4:1991;168-179.
-
(1991)
Chem Res Toxicol
, vol.4
, pp. 168-179
-
-
Guengerich, F.P.1
Kim, D.H.2
Iwasaki, M.3
-
18
-
-
0029910233
-
Vitamin C: Antioxidant or pro-oxidant in vivo?
-
Halliwell B. Vitamin C: antioxidant or pro-oxidant in vivo? Free Radic Res. 25:1996;439-454.
-
(1996)
Free Radic Res
, vol.25
, pp. 439-454
-
-
Halliwell, B.1
-
19
-
-
0021351203
-
Oxygen toxicity, oxygen radicals, transition metals and disease
-
Halliwell B., Gutteridge J.M.C. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J. 219:1984;1-14.
-
(1984)
Biochem J
, vol.219
, pp. 1-14
-
-
Halliwell, B.1
Gutteridge, J.M.C.2
-
20
-
-
0015032258
-
Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions
-
Hildebrandt A., Estabrook R.W. Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions. Arch Biochem Biophys. 143:1971;66-79.
-
(1971)
Arch Biochem Biophys
, vol.143
, pp. 66-79
-
-
Hildebrandt, A.1
Estabrook, R.W.2
-
21
-
-
0027408080
-
Free radicals as mediators of tissue injury and disease
-
Kehrer J.P. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol. 23:1993;21-48.
-
(1993)
Crit Rev Toxicol
, vol.23
, pp. 21-48
-
-
Kehrer, J.P.1
-
22
-
-
0020541375
-
Increased microsomal oxidation of hydroxyl radical scavenging agents and ethanol after chronic consumption of ethanol
-
Klein S.M., Cohen G., Lieber C.S., Cederbaum A.I. Increased microsomal oxidation of hydroxyl radical scavenging agents and ethanol after chronic consumption of ethanol. Arch Biochem Biophys. 223:1983;425-432.
-
(1983)
Arch Biochem Biophys
, vol.223
, pp. 425-432
-
-
Klein, S.M.1
Cohen, G.2
Lieber, C.S.3
Cederbaum, A.I.4
-
23
-
-
0033370831
-
CYP2E1 is not involved in early alcohol-induced liver injury
-
Kono H., Bradford B.U., Yin M., Sulik K.K., Koop D.R., Peters J.M., Gonzalez F.J., McDonald T., Dikalova A., Kadiiska M.B., Mason R.P., Thurman R.G. CYP2E1 is not involved in early alcohol-induced liver injury. Am J Physiol. 277:1999;G1259-G1267.
-
(1999)
Am J Physiol
, vol.277
-
-
Kono, H.1
Bradford, B.U.2
Yin, M.3
Sulik, K.K.4
Koop, D.R.5
Peters, J.M.6
Gonzalez, F.J.7
McDonald, T.8
Dikalova, A.9
Kadiiska, M.B.10
Mason, R.P.11
Thurman, R.G.12
-
24
-
-
0026567713
-
Oxidative and reductive metabolism by cytochrome P450 2E1
-
Koop D.R. Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J. 6:1992;724-730.
-
(1992)
FASEB J
, vol.6
, pp. 724-730
-
-
Koop, D.R.1
-
25
-
-
0030914902
-
Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1
-
Koop D.R., Klopfenstein B., Iimuro Y., Thurman R.G. Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Mol Pharmacol. 51:1997;944-950.
-
(1997)
Mol Pharmacol
, vol.51
, pp. 944-950
-
-
Koop, D.R.1
Klopfenstein, B.2
Iimuro, Y.3
Thurman, R.G.4
-
26
-
-
0024785789
-
NADH-dependent microsomal interaction with ferric complexes and production of reactive oxygen intermediates
-
Kukielka E., Cederbaum A.I. NADH-dependent microsomal interaction with ferric complexes and production of reactive oxygen intermediates. Arch Biochem Biophys. 275:1989;540-550.
-
(1989)
Arch Biochem Biophys
, vol.275
, pp. 540-550
-
-
Kukielka, E.1
Cederbaum, A.I.2
-
27
-
-
0028102264
-
DNA strand cleavage as a sensitive assay for the production of hydroxyl radicals by microsomes: Role of cytochrome P4502E1 in the increased activity after ethanol treatment
-
Kukielka E., Cederbaum A.I. DNA strand cleavage as a sensitive assay for the production of hydroxyl radicals by microsomes: role of cytochrome P4502E1 in the increased activity after ethanol treatment. Biochem J. 302:1994;773-779.
-
(1994)
Biochem J
, vol.302
, pp. 773-779
-
-
Kukielka, E.1
Cederbaum, A.I.2
-
28
-
-
0020188453
-
Oxidase and oxygenase function of the microsomal cytochrome P450 monooxygenase system
-
Kuthan H., Ullrich V. Oxidase and oxygenase function of the microsomal cytochrome P450 monooxygenase system. Eur J Biochem. 126:1982;583-588.
-
(1982)
Eur J Biochem
, vol.126
, pp. 583-588
-
-
Kuthan, H.1
Ullrich, V.2
-
29
-
-
0014962167
-
Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vitro
-
Lieber C.S., DeCarli L.M. Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vitro. J Biol Chem. 245:1970;2505-2512.
-
(1970)
J Biol Chem
, vol.245
, pp. 2505-2512
-
-
Lieber, C.S.1
DeCarli, L.M.2
-
30
-
-
0026597915
-
Redox cycling of iron and lipid peroxidation
-
Minotti G., Aust S.D. Redox cycling of iron and lipid peroxidation. Lipids. 27:1992;219-226.
-
(1992)
Lipids
, vol.27
, pp. 219-226
-
-
Minotti, G.1
Aust, S.D.2
-
31
-
-
0029016297
-
Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors
-
Morimoto M., Hagbjork A.L., Wan Y.J., Fu P.C., Clot P., Albano E., Ingelman-Sundberg M., French S.W. Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors. Hepatology. 21:1995;1610-1617.
-
(1995)
Hepatology
, vol.21
, pp. 1610-1617
-
-
Morimoto, M.1
Hagbjork, A.L.2
Wan, Y.J.3
Fu, P.C.4
Clot, P.5
Albano, E.6
Ingelman-Sundberg, M.7
French, S.W.8
-
32
-
-
0027986662
-
Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats
-
Nanji A.A., Zhao S., Sadrzadeh S.M.H., Dannenberg A.J., Tahan S.R., Waxman D.J. Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats. Alcohol Clin Exp Res. 18:1994;1280-1285.
-
(1994)
Alcohol Clin Exp Res
, vol.18
, pp. 1280-1285
-
-
Nanji, A.A.1
Zhao, S.2
Sadrzadeh, S.M.H.3
Dannenberg, A.J.4
Tahan, S.R.5
Waxman, D.J.6
-
33
-
-
0023854288
-
Characterization and identification of a pyrazole-inducible form of cytochrome P-450
-
Palakodety R.B., Clejan L.A., Krikun G., Feierman D.E., Cederbaum A.I. Characterization and identification of a pyrazole-inducible form of cytochrome P-450. J Biol Chem. 263:1988;878-884.
-
(1988)
J Biol Chem
, vol.263
, pp. 878-884
-
-
Palakodety, R.B.1
Clejan, L.A.2
Krikun, G.3
Feierman, D.E.4
Cederbaum, A.I.5
-
34
-
-
0023682012
-
Comparison of the ability of ferric complexes to catalyze microsomal chemiluminescence, lipid peroxidation, and hydroxyl radical generation
-
Puntarulo S., Cederbaum A.I. Comparison of the ability of ferric complexes to catalyze microsomal chemiluminescence, lipid peroxidation, and hydroxyl radical generation. Arch Biochem Biophys. 264:1988a;482-491.
-
(1988)
Arch Biochem Biophys
, vol.264
, pp. 482-491
-
-
Puntarulo, S.1
Cederbaum, A.I.2
-
35
-
-
0023807969
-
Increased NAPH-dependent chemiluminescence by microsomes after chronic ethanol consumption
-
Puntarulo S., Cederbaum A.I. Increased NAPH-dependent chemiluminescence by microsomes after chronic ethanol consumption. Arch Biochem Biophys. 266:1988b;435-445.
-
(1988)
Arch Biochem Biophys
, vol.266
, pp. 435-445
-
-
Puntarulo, S.1
Cederbaum, A.I.2
-
36
-
-
0027218413
-
Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment
-
Rashba-Step J., Turro N.J., Cederbaum A.I. Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment. Arch Biochem Biophys. 300:1993;401-408.
-
(1993)
Arch Biochem Biophys
, vol.300
, pp. 401-408
-
-
Rashba-Step, J.1
Turro, N.J.2
Cederbaum, A.I.3
-
37
-
-
0032407621
-
Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1
-
Sakurai K., Cederbaum A.I. Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1. Mol Pharmacol. 54:1998;1024-1035.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 1024-1035
-
-
Sakurai, K.1
Cederbaum, A.I.2
-
38
-
-
0030272970
-
Hepatotoxicity induced by iron overload and alcohol. Studies on the role of chelatable iron, cytochrome P450 2E1 and lipid peroxidation
-
Stal P., Johansson I., Ingelman-Sundberg M., Hagen K., Hultcrantz R. Hepatotoxicity induced by iron overload and alcohol. Studies on the role of chelatable iron, cytochrome P450 2E1 and lipid peroxidation. J Hepatol. 25:1996;538-546.
-
(1996)
J Hepatol
, vol.25
, pp. 538-546
-
-
Stal, P.1
Johansson, I.2
Ingelman-Sundberg, M.3
Hagen, K.4
Hultcrantz, R.5
-
39
-
-
0034965409
-
Ethanol and oxidative stress
-
Sun A.Y., Ingelman-Sundberg M., Neve E., Matsumoto H., Nishitani Y., Minowa Y., Fukui Y., Bailey S.M., Patel V.B., Cunningham C.C., Zima T., Fialova L., Mikulikova L., Popov P., Malbohan I., Janebova M., Nespor K., Sun G.Y. Ethanol and oxidative stress. Alcohol Clin Exp Res. 25:2001;2375-2435.
-
(2001)
Alcohol Clin Exp Res
, vol.25
, pp. 2375-2435
-
-
Sun, A.Y.1
Ingelman-Sundberg, M.2
Neve, E.3
Matsumoto, H.4
Nishitani, Y.5
Minowa, Y.6
Fukui, Y.7
Bailey, S.M.8
Patel, V.B.9
Cunningham, C.C.10
Zima, T.11
Fialova, L.12
Mikulikova, L.13
Popov, P.14
Malbohan, I.15
Janebova, M.16
Nespor, K.17
Sun, G.Y.18
-
40
-
-
0034221172
-
CYP2E1 and ALD
-
Tsukamoto H. CYP2E1 and ALD. Hepatology. 32:2000;154-156.
-
(2000)
Hepatology
, vol.32
, pp. 154-156
-
-
Tsukamoto, H.1
-
41
-
-
0029160569
-
Experimental liver cirrhosis induced by alcohol and iron
-
Tsukamoto H., Horne W., Kamimura S., Niemela O., Parkkila S., Yla-Herttuala S., Brittenham G.M. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest. 96:1995;620-630.
-
(1995)
J Clin Invest
, vol.96
, pp. 620-630
-
-
Tsukamoto, H.1
Horne, W.2
Kamimura, S.3
Niemela, O.4
Parkkila, S.5
Yla-Herttuala, S.6
Brittenham, G.M.7
-
42
-
-
0035013288
-
Current concepts in the pathogenesis of alcoholic liver injury
-
Tsukamoto H., Lu S.C. Current concepts in the pathogenesis of alcoholic liver injury. FASEB J. 15:2001;1335-1349.
-
(2001)
FASEB J
, vol.15
, pp. 1335-1349
-
-
Tsukamoto, H.1
Lu, S.C.2
-
43
-
-
10544223746
-
Alcohol mediates increases in hepatic and serum nonheme iron stores in a rat model for alcohol-induced liver injury
-
Valerio L.G., Parks T., Petersen D.R. Alcohol mediates increases in hepatic and serum nonheme iron stores in a rat model for alcohol-induced liver injury. Alcohol Clin Exp Res. 20:1996;1352-1361.
-
(1996)
Alcohol Clin Exp Res
, vol.20
, pp. 1352-1361
-
-
Valerio, L.G.1
Parks, T.2
Petersen, D.R.3
-
44
-
-
0020534553
-
NADPH-dependent production of oxy-radicals by purified components of the rat liver mixed function oxidase system: I. Oxidation of hydroxyl radical scavenging agents
-
Winston G.W., Cederbaum A.I. NADPH-dependent production of oxy-radicals by purified components of the rat liver mixed function oxidase system I. Oxidation of hydroxyl radical scavenging agents . J Biol Chem. 258:1983a;1508-1513.
-
(1983)
J Biol Chem
, vol.258
, pp. 1508-1513
-
-
Winston, G.W.1
Cederbaum, A.I.2
-
45
-
-
0020561176
-
NADPH-dependent production of oxy-radicals by purified components of the rat liver mixed function oxidase system: II. Role in microsomal oxidation of ethanol
-
Winston G.W., Cederbaum A.I. NADPH-dependent production of oxy-radicals by purified components of the rat liver mixed function oxidase system II. Role in microsomal oxidation of ethanol . J Biol Chem. 258:1983b;1514-1519.
-
(1983)
J Biol Chem
, vol.258
, pp. 1514-1519
-
-
Winston, G.W.1
Cederbaum, A.I.2
-
46
-
-
0021454859
-
The role of iron chelates in hydroxyl radical production by rat liver microsomes, NADPH-cytochrome P-450 reductase and xanthine oxidase
-
Winston G.W., Feierman D.E., Cederbaum A.I. The role of iron chelates in hydroxyl radical production by rat liver microsomes, NADPH-cytochrome P-450 reductase and xanthine oxidase. Arch Biochem Biophys. 232:1984;378-390.
-
(1984)
Arch Biochem Biophys
, vol.232
, pp. 378-390
-
-
Winston, G.W.1
Feierman, D.E.2
Cederbaum, A.I.3
-
47
-
-
0029816454
-
Ethanol toxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1
-
Wu D., Cederbaum A.I. Ethanol toxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. J Biol Chem. 271:1996;23914-23919.
-
(1996)
J Biol Chem
, vol.271
, pp. 23914-23919
-
-
Wu, D.1
Cederbaum, A.I.2
|