Detection of circulating antibodies to malondialdehyde-acetaldehyde adducts in ethanol-fed rats

Gastroenterology

Volumn 115, Issue 3, 1998, Pages 686-692

  Xu, D ^a   Thiele, G M ^a   Beckenhauer, J L ^a   Klassen, L W ^a   Sorrell, M F ^a   Tuma, D J ^a  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL; ANTIBODY; BOVINE SERUM ALBUMIN; CARBOHYDRATE; EPITOPE; HYBRID PROTEIN; LIVER PROTEIN; LYSOZYME; MALONALDEHYDE;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; COMPETITIVE INHIBITION; CONJUGATE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT;

EID: 0031708189     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70148-9     Document Type: Article

References (28)

1. DJ Tuma LW Klassen Immune responses to acetaldehyde-protein adducts: role in alcoholic liver disease Gastroenterology 103 1992 1969 1972
2. LW Klassen DJ Tuma MF Sorrell Immune mechanisms of alcohol-induced liver disease Hepatology 22 1995 355 357
3. RK Zetterman MF Sorrell Immunologic aspects of alcoholic liver disease Gastroenterology 81 1981 616 624
4. Y Israel E Hurwitz O Niemela R Arnon Monoclonal and poly-clonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts Proc Natl Acad Sci USA 83 1986 7923 7927
5. O Niemela F Klajner H Orrego E Vidins L Blendis Y Israel Antibodies against acetaldehyde-modified protein epitopes in human alcoholics Hepatology 7 1987 1210 1214
6. M Hoerner UJ Behrens TM Worner I Blasksberg LF Braly F Schaffner CS Lieber The role of alcoholism and liver disease in the appearance of serum antibodies against acetaldehyde ad-ducts Hepatology 8 1988 569 574
7. S Worrall J De Jersey BC Shanley PA Wilce Ethanol induces the production of antibodies to acetaldehyde-modified epitopes in rats Alcohol Alcohol 24 1989 217 223
8. S Worrall J DeJersey BC Shanley PA Wilce Anti-acetaldehyde adduct antibodies generated by ethanol-fed rats react with re-duced and unreduced acetaldehyde-modified proteins Alcohol Alcohol 29 1994 43 50
9. A Trevisan R Cavigli R Melconi GF Stefanini S Zotti M Rugge F Noventa C Betterle G Realdi Detection of immunoglobulins G and A on the cell membrane of hepatocytes from patients with alcoholic liver disease J Clin Pathol 36 1983 530 534
10. H Yokoyama S Nagata S Moriya S Kato T Ito K Kamegaya H Ishii Hepatic fibrosis produced in guinea pigs by chronic ethanol administration and immunization with acetaldehyde adducts Hepatology 21 1995 1438 1442
11. DJ Tuma GM Thiele DS Xu LW Klassen MF Sorrell Acetalde-hyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administra-tion Hepatology 23 1996 872 880
12. DS Xu GM Thiele ML Kearley MD Haugen LW Klassen MF Sorrell DJ Tuma Epitope characterization of malondialdehyde-acetaldehyde adducts using an enzyme-linked immunosorbent assay Chem Res Toxicol 10 1997 978 986
13. MS Willis DJ Tuma TL McDonald LW Klassen GM Thiele Soluble protein modified with acetaldehyde and malondialdehyde become immunogenic (abstr) Alcohol Clin Exp Res 20 1996 120A
14. S Kamimura K Gaal RS Britton BR Bacon G Triadafilopoulus H Tsukamoto Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis Hepatology 16 1992 448 453
15. O Niemela S Parkkila S Yla-Herttula C Halstead JL Witztum A Lanca Y Israel Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation Lab Invest 70 1994 537 546
16. K Kikugawa Y Ido Studies on peroxidized lipids. V. Formation and characterization of 1,4-dihydropyridine-3,5-dicarbaldehyde as model of fluorescent components in lipofuscin Lipids 19 1984 600 608
17. GD Volentine DJ Tuma MF Sorrell Subcellular location of secretory proteins retained in the liver during the ethanol-induced inhibition of hepatic protein secretion in the rat Gastroenterology 90 1986 158 165
18. S Katoh M Hashimoto H Kohno Y Ohkubo Calcium pretreat-ment induces the decrease in epidermal growth factor binding through the activation of transglutaminase in isolated liver membrane Arch Biochem Biophys 303 1993 421 428
19. DS Xu MF Sorrell CA Casey DJ Tuma Impaired attachment of hepatocytes to extracellular matrix components following chronic ethanol administration Lab Invest 67 1992 186 190
20. OH Lowry NJ Rosebrough AL Farr RJ Randall Protein measure-ment with the Folin phenol reagent J Biol Chem 193 1951 265 275
21. K Viitala Y Israel JE Blake O Niemela Serum IgA, IgG, and IgM antibodies directed against acetaldehyde-derived epitopes: rela-tionship to liver disease severity and alcohol consumption Hepatology 25 1997 1418 1424
22. M Souroujon ME White-Scharf J Andre-Schwartz ML Gefter RS Schwartz Preferential autoantibody reactivity of the preim-mune B cell repertoire in normal mice J Immunol 140 1988 4173 4179
23. Y Shoenfeld DA Isenberg Natural autoantibodies. Their physiological role and regulatory significance 1993 CRC Boca Raton, FL
24. DM Klinman Similarities in B cell repertoire development be-tween autoimmune and aging normal mice J Immunol 148 1992 1353 1358
25. MS Willis DJ Tuma TL McDonald LW Klassen GM Thiele Soluble proteins modified with the alcohol metabolites acetalde-hyde and malondialdehyde become immunogenic (abstr) J Al-lergy Clin Immunol 99 1997 S194
26. RS Anthony M Farquharson RNM MacSween Liver membrane antibodies in alcoholic liver disease. II. Antibodies to ethanol-altered hepatocytes J Clin Pathol 36 1983 1302 1308
27. IR Crossley J Newberger M Davis R Williams ALWF Eddleston Ethanol metabolism in the generation of new antigenic determi-nants on liver cells Gut 27 1986 186 189
28. N Izumi Y Sokai W Koyama Y Hasumura Clinical significance of serum antibodies against alcohol-altered hepatocyte membrane in alcoholic liver disease Alcohol Clin Exp Res 13 1989 762 765