Role of mitochondria in alcoholic liver injury

Free Radical Biology and Medicine

Volumn 32, Issue 6, 2002, Pages 487-491

  Adachi, Masayuki ^a   Ishii, Hiromasa ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cytochrome c; Free radicals; Glutathione; Mitochondria; Mitochondrial permeability transition; Oxidative stress

Indexed keywords

ALCOHOL; ANTIOXIDANT; CASPASE; CYTOCHROME C; OXIDIZING AGENT;

ALCOHOL LIVER CIRRHOSIS; ALCOHOL METABOLISM; APOPTOSIS; ARTICLE; CELL MEMBRANE DEPOLARIZATION; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME RELEASE; HUMAN; LIVER CELL; LIVER CELL CULTURE; LIVER MITOCHONDRION; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMALS; APOPTOSIS; ETHANOL; HEPATOCYTES; HUMANS; LIVER DISEASES, ALCOHOLIC; MEMBRANE POTENTIALS; MITOCHONDRIA; OXIDATIVE STRESS; PERMEABILITY;

EID: 0037087202     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00740-2     Document Type: Article

References (23)

1. Subcellular changes and apoptosis induced by ethanol in rat liver
2. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis
3. Apoptosis and alcoholic liver disease
4. Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress
5. Oxidative stress and liver disease
6. Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol
7. Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication
8. The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes
9. Acute ethanol intoxication stimulates superoxide anion production by in situ perfused rat liver
10. Lipid hydroperoxide induced mitochondrial dysfunction following acute ethanol intoxication in rats: The critical role for mitochondrial reduced glutathione
11. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1
12. Impaired uptake of GSH by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidative stress
13. Hepatic mitochondrial GSH depletion and progression of experimental alcoholic liver disease in rats
14. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor
15. Increased loss and decreased synthesis of hepatic glutathione after acute ethanol administration
16. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease
17. Mitochondria as a regulator of apoptosis: Doubt no more
18. The permeability transition pore. Control points of cyclosporin A-sensitive mitochondrial channel involved in cell death
19. The mitochondrial permeability transition
20. Mitochondria and apoptosis
21. Mitochondrial control of apoptosis
22. Potentiation by chronic ethanol treatment of the mitochondrial permeability transition
23. Bax interacts with permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria