Large-conductance, calcium-activated potassium channels: Structural and functional implications

Pharmacology and Therapeutics

Volumn 110, Issue 1, 2006, Pages 103-116

  Ghatta, Srinivas ^a   Nimmagadda, Deepthi ^a   Xu, Xiaoping ^b   O'Rourke, Stephen T ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

BK; BK blockers; BK openers; Calcium; Voltage sensitivity

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 1 (5 CHLORO 2 HYDROXYPHENYL) 5 TRIFLUOROMETHYL 2 BENZIMIDAZOLONE; 1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)INDAZOLE; 3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; ACETAZOLAMIDE; ARACHIDONIC ACID; CHARYBDOTOXIN; EPOXYICOSATRIENOIC ACID; ESTRADIOL; FENAMIC ACID DERIVATIVE; FLAVONOID; FLUFENAMIC ACID; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MAGNOLOL; MEFENAMIC ACID; NIFLUMIC ACID; NS 1608; NS 8; PAXILLINE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; PROSTACYCLIN; RUTHENIUM RED; SOMATOSTATIN; TAMOXIFEN; TETRABUTYLAMMONIUM; TETRANDRINE; TETRYLAMMONIUM; UNCLASSIFIED DRUG; UNINDEXED DRUG;

DRUG INHIBITION; DRUG STRUCTURE; ELECTRIC POTENTIAL; GLYCOSYLATION; HEART ARRHYTHMIA; HUMAN; HYPOTENSION; NEGATIVE FEEDBACK; NONHUMAN; OXIDATION REDUCTION REACTION; PH; PHOSPHORYLATION; PRIORITY JOURNAL; QT PROLONGATION; REVIEW; TACHYCARDIA;

ANIMALS; ELECTROPHYSIOLOGY; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; POTASSIUM CHANNEL BLOCKERS;

EID: 32644488717     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2005.10.007     Document Type: Review

References (167)

1. J.P. Adelman, K.Z. Shen, M.P. Kavanaugh, R.A. Warren, Y.N. Wu, and A. Lagrutta Calcium-activated potassium channels expressed from cloned complementary DNAs Neuron 9 1992 209 216
2. D.S. Ahn, Y.B. Kim, Y.H. Lee, B.S. Kang, and D.H. Kang Fatty acids directly increase the activity of Ca(2+)-activated K+ channels in rabbit coronary smooth muscle cells Yonsei Med J 35 1994 10 24
3. A. Alioua, J.P. Huggins, and E. Rousseau PKG-I alpha phosphorylates the alpha-subunit and upregulates reconstituted GKCa channels from tracheal smooth muscle Am J Physiol 268 1995 L1057 L1063
4. G.C. Amberg, and L.F. Santana Downregulation of the BK channel beta1 subunit in genetic hypertension Circ Res 93 2003 965 971
5. G.C. Amberg, A.D. Bonev, C.F. Rossow, M.T. Nelson, and L.F. Santana Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension J Clin Invest 112 2003 717 724
6. S.L. Archer, F.S. Gragasin, X. Wu, S. Wang, S. McMurtry, and D.H. Kim Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels Circulation 107 2003 769 776
7. D.L. Armstrong, and R.E. White An enzymatic mechanism for potassium channel stimulation through pertussis-toxin-sensitive G proteins Trends Neurosci 15 1992 403 408
8. N.S. Atkinson, G.A. Robertson, and B. Ganetzky A component of calcium-activated potassium channels encoded by the Drosophila slo locus Science 253 1991 551 555
9. A.A. Azenabor, and A.U. Chaudhry 17 Beta-estradiol induces L-type Ca2+ channel activation and regulates redox function in macrophages J Reprod Immunol 59 2003 17 28
10. F. Bezanilla, E. Perozo, D.M. Papazian, and E. Stefani Molecular basis of gating charge immobilization in Shaker potassium channels Science 254 1991 679 683
11. G. Biagi, V. Calderone, I. Giorgi, O. Livi, E. Martinotti, and A. Martelli 1,5-Diarylsubstituted 1,2,3-triazoles as potassium channel activators: VI Farmaco 59 2004 397 404
12. G. Biagi, I. Giorgi, O. Livi, A. Nardi, V. Calderone, and A. Martelli Synthesis and biological activity of novel substituted benzanilides as potassium channel activators: V Eur J Med Chem 39 2004 491 498
13. S. Bian, I. Favre, and E. Moczydlowski Ca2+ -binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+ -dependent activation Proc Natl Acad Sci U S A 98 2001 4776 4781
14. A.L. Blatz, and K.L. Magleby Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle Nature 323 1986 718 720
15. R.A. Bohm, B. Wang, R. Brenner, and N.S. Atkinson Transcriptional control of Ca(2+)-activated K(+) channel expression: identification of a second, evolutionarily conserved, neuronal promoter J Exp Biol 203 2000 693 704
16. V.M. Bolotina, S. Najibi, J.J. Palacino, P.J. Pagano, and R.A. Cohen Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle Nature 368 1994 850 853
17. K.M. Boy, J.M. Guernon, S.Y. Sit, K. Xie, P. Hewawasam, and C.G. Boissard 3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction Bioorg Med Chem Lett 14 2004 5089 5093
18. T.I. Brelidze, and K.L. Magleby Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages J Gen Physiol 123 2004 305 319
19. R. Brenner, T.J. Jegla, A. Wickenden, Y. Liu, and R.W. Aldrich Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4 J Biol Chem 275 2000 6453 6461
20. R. Brenner, G.J. Perez, A.D. Bonev, D.M. Eckman, J.C. Kosek, and S.W. Wiler Vasoregulation by the beta1 subunit of the calcium-activated potassium channel Nature 407 2000 870 876
21. A. Butler, S. Tsunoda, D.P. McCobb, A. Wei, and L. Salkoff mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels Science 261 1993 221 224
22. F. Cabell, D.S. Weiss, and J.M. Price Inhibition of adenosine-induced coronary vasodilation by block of large-conductance Ca(2+)-activated K+ channels Am J Physiol 267 1994 H1455 H1460
23. V. Calderone, S. Chericoni, C. Martinelli, L. Testai, A. Nardi, and I. Morelli Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels Naunyn-Schmiedeberg's Arch Pharmacol 370 2004 290 298
24. H.T. Chiang, and S.N. Wu Inhibition of large-conductance calcium-activated potassium channel by 2-methoxyestradiol in cultured vascular endothelial (HUV-EC-C) cells J Membr Biol 182 2001 203 212
25. G.J. Christ, N.S. Day, M. Day, C. Santizo, W. Zhao, and T. Sclafani Bladder injection of "naked" hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo Am J Physiol Regul Integr Comp Physiol 281 2001 R1699 R1709
26. S.G. Clark, and L.C. Fuchs BK(Ca) channels compensate for loss of NOS-dependent coronary artery relaxation in cardiomyopathy Am J Physiol Heart Circ Physiol 279 2000 H2598 H2603
27. D.H. Cox, and R.W. Aldrich Role of the beta1 subunit in large-conductance Ca(2+)-activated K(+) channel gating energetics. Mechanisms of enhanced Ca(2+) sensitivity J Gen Physiol 116 2000 411 432
28. D.J. Darkow, L. Lu, and R.E. White Estrogen relaxation of coronary artery smooth muscle is mediated by nitric oxide and cGMP Am J Physiol 272 1997 H2765 H2773
29. V.P. Deenadayalu, R.E. White, J.N. Stallone, X. Gao, and A.J. Garcia Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel Am J Physiol Heart Circ Physiol 281 2001 H1720 H1727
30. D.D. Denson, P. Duchatelle, and D.C. Eaton The effect of racemic ketamine on the large conductance Ca(+2)-activated potassium (BK) channels in GH3 cells Brain Res 638 1994 61 68
31. R. Derand, L. Bulteau-Pignoux, and F. Becq Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004 J Membr Biol 194 2003 109 117
32. G.M. Dick, I.D. Kong, and K.M. Sanders Effects of anion channel antagonists in canine colonic myocytes: comparative pharmacology of Cl-, Ca2+ and K+ currents Br J Pharmacol 127 1999 1819 1831
33. G.M. Dick, C.F. Rossow, S. Smirnov, B. Horowitz, and K.M. Sanders Tamoxifen activates smooth muscle BK channels through the regulatory beta 1 subunit J Biol Chem 276 2001 34594 34599
34. C. Dimitropoulou, G. Han, A.W. Miller, M. Molero, L.C. Fuchs, and R.E. White Potassium (BK(Ca)) currents are reduced in microvascular smooth muscle cells from insulin-resistant rats Am J Physiol Heart Circ Physiol 282 2002 H908 H917
35. J.P. Ding, Z.W. Li, and C.J. Lingle Inactivating BK channels in rat chromaffin cells may arise from heteromultimeric assembly of distinct inactivation-competent and noninactivating subunits Biophys J 74 1998 268 289
36. E. Dubuis, M. Potier, R. Wang, and C. Vandier Continuous inhalation of carbon monoxide attenuates hypoxic pulmonary hypertension development presumably through activation of BKCa channels Cardiovasc Res 65 2005 751 761
37. K. Duerson, R.E. White, F. Jiang, A. Schonbrunn, and D.L. Armstrong Somatostatin stimulates BKCa channels in rat pituitary tumor cells through lipoxygenase metabolites of arachidonic acid Neuropharmacology 35 1996 949 961
38. S.I. Dworetzky, J.T. Trojnacki, and V.K. Gribkoff Cloning and expression of a human large-conductance calcium-activated potassium channel Brain Res Mol Brain Res 27 1994 189 193
39. S.I. Dworetzky, C.G. Boissard, J.T. Lum-Ragan, M.C. McKay, D.J. Post-Munson, and J.T. Trojnacki Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation J Neurosci 16 1996 4543 4550
40. T.M. Egan, D. Dagan, and I.B. Levitan Properties and modulation of a calcium-activated potassium channel in rat olfactory bulb neurons J Neurophysiol 69 1993 1433 1442
41. J.M. Fernandez-Fernandez, M. Tomas, E. Vazquez, P. Orio, R. Latorre, and M. Senti Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension J Clin Invest 113 2004 1032 1039
42. Y. Fukami, Y. Toki, Y. Numaguchi, Y. Nakashima, H. Mukawa, and H. Matsui Nitroglycerin-induced aortic relaxation mediated by calcium-activated potassium channel is markedly diminished in hypertensive rats Life Sci 63 1998 1047 1055
43. M. Fukao, H.S. Mason, F.C. Britton, J.L. Kenyon, B. Horowitz, and K.D. Keef Cyclic GMP-dependent protein kinase activates cloned BKCa channels expressed in mammalian cells by direct phosphorylation at serine 1072 J Biol Chem 274 1999 10927 10935
44. M. Garcia-Calvo, H.G. Knaus, O.B. McManus, K.M. Giangiacomo, G.J. Kaczorowski, and M.L. Garcia Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle J Biol Chem 269 1994 676 682
45. J. Garcia-Valdes, F.Z. Zamudio, L. Toro, and L.D. Possani Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha + beta (beta1 or beta4) complexes FEBS Lett 505 2001 369 373
46. G. Gardos The function of calcium in the potassium permeability of human erythrocytes Biochim Biophys Acta 30 1958 653 654
47. K.M. Giangiacomo, M.L. Garcia, and O.B. McManus Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle Biochemistry 31 1992 6719 6727
48. H. Gogelein, D. Dahlem, H.C. Englert, and H.J. Lang Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas FEBS Lett 268 1990 79 82
49. G.J. Grover, A.J. D'Alonzo, P.G. Sleph, S. Dzwonczyk, T.A. Hess, and R.B. Darbenzio The cardioprotective and electrophysiological effects of cromakalim are attenuated by meclofenamate through a cyclooxygenase-independent mechanism J Pharmacol Exp Ther 269 1994 536 540
50. B.M. Hagen, O. Bayguinov, and K.M. Sanders Beta 1-subunits are required for regulation of coupling between Ca2+ transients and Ca2+-activated K+ (BK) channels by protein kinase C Am J Physiol Cell Physiol 285 2003 C1270 C1280
51. M. Hanner, R. Vianna-Jorge, A. Kamassah, W.A. Schmalhofer, H.G. Knaus, and G.J. Kaczorowski The beta subunit of the high conductance calcium-activated potassium channel. Identification of residues involved in charybdotoxin binding J Biol Chem 273 1998 16289 16296
52. A.A. Harper, L. Catacuzzeno, C. Trequattrini, A. Petris, and F. Franciolini Verapamil block of large-conductance Ca-activated K channels in rat aortic myocytes J Membr Biol 179 2001 103 111
53. J. He, M.E. Kargacin, G.J. Kargacin, and C.A. Ward Tamoxifen inhibits Na+ and K+ currents in rat ventricular myocytes Am J Physiol Heart Circ Physiol 285 2003 H661 H668
54. M. Herzog, E.Q. Scherer, B. Albrecht, B. Rorabaugh, M.A. Scofield, and P. Wangemann CGRP receptors in the gerbil spiral modiolar artery mediate a sustained vasodilation via a transient cAMP-mediated Ca2+-decrease J Membr Biol 189 2002 225 236
55. P. Hewawasam, M. Erway, G. Thalody, H. Weiner, C.G. Boissard, and V.K. Gribkoff The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence Bioorg Med Chem Lett 12 2002 1117 1120
56. P. Hewawasam, V.K. Gribkoff, Y. Pendri, S.I. Dworetzky, N.A. Meanwell, and E. Martinez The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels Bioorg Med Chem Lett 12 2002 1023 1026
57. M.T. Hsieh, F.Y. Chueh, S.M. Lin, F.S. Chueh, C.F. Chen, and M.T. Lin Catecholaminergic mechanisms-mediated hypothermia induced by magnolol in rats Jpn J Pharmacol 78 1998 501 504
58. S. Hu, and H.S. Kim On the mechanism of the differential effects of NS004 and NS1608 in smooth muscle cells from guinea pig bladder Eur J Pharmacol 318 1996 461 468
59. S. Hu, M.Z. Labuda, M. Pandolfo, G.G. Goss, H.E. McDermid, and D.W. Ali Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation Physiol Genomics 15 2003 191 198
60. Y. Imaizumi, K. Sakamoto, A. Yamada, A. Hotta, S. Ohya, and K. Muraki Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit Mol Pharmacol 62 2002 836 846
61. T.M. Ishii, C. Silvia, B. Hirschberg, C.T. Bond, J.P. Adelman, and J. Maylie A human intermediate conductance calcium-activated potassium channel Proc Natl Acad Sci U S A 94 1997 11651 11656
62. J.H. Jaggar, V.A. Porter, W.J. Lederer, and M.T. Nelson Calcium sparks in smooth muscle Am J Physiol Cell Physiol 278 2000 C235 C256
63. Z. Jiang, M. Wallner, P. Meera, and L. Toro Human and rodent MaxiK channel beta-subunit genes: cloning and characterization Genomics 55 1999 57 67
64. Y. Jiang, A. Pico, M. Cadene, B.T. Chait, and R. MacKinnon Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel Neuron 29 2001 593 601
65. Y. Jiang, A. Lee, J. Chen, M. Cadene, B.T. Chait, and R. MacKinnon Crystal structure and mechanism of a calcium-gated potassium channel Nature 417 2002 515 522
66. W. Jin, A. Sugaya, T. Tsuda, H. Ohguchi, and E. Sugaya Relationship between large conductance calcium-activated potassium channel and bursting activity Brain Res 860 2000 21 28
67. P. Jin, T.M. Weiger, and I.B. Levitan Reciprocal modulation between the alpha and beta 4 subunits of hSlo calcium-dependent potassium channels J Biol Chem 277 2002 43724 43729
68. P. Jin, T.M. Weiger, Y. Wu, and I.B. Levitan Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit J Biol Chem 277 2002 10014 10020
69. P.V. Katakam, M.R. Ujhelyi, M.E. Hoenig, and A.W. Miller Endothelial dysfunction precedes hypertension in diet-induced insulin resistance Am J Physiol 275 1998 R788 R792
70. H.G. Knaus, K. Folander, M. Garcia-Calvo, M.L. Garcia, G.J. Kaczorowski, and M. Smith Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle J Biol Chem 269 1994 17274 17278
71. H.G. Knaus, O.B. McManus, S.H. Lee, W.A. Schmalhofer, M. Garcia-Calvo, and L.M. Helms Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels Biochemistry 33 1994 5819 5828
72. H. Kobayashi, S. Adachi-Akahane, and T. Nagao Involvement of BK(Ca) channels in the relaxation of detrusor muscle via beta-adrenoceptors Eur J Pharmacol 404 2000 231 238
73. H. Kume, A. Takai, H. Tokuno, and T. Tomita Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation Nature 341 1989 152 154
74. H. Kume, I.P. Hall, R.J. Washabau, K. Takagi, and M.I. Kotlikoff Beta-adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and-independent mechanisms J Clin Invest 93 1994 371 379
75. Y.T. Lee, and Q. Wang Inhibition of hKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid Eur J Pharmacol 378 1999 349 356
76. W. Li, and R.W. Aldrich Unique inner pore properties of BK channels revealed by quaternary ammonium block J Gen Physiol 124 2004 43 57
77. P.L. Li, and W.B. Campbell Epoxyeicosatrienoic acids activate K+ channels in coronary smooth muscle through a guanine nucleotide binding protein Circ Res 80 1997 877 884
78. Y.C. Liu, Y.C. Lo, C.W. Huang, and S.N. Wu Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery Biochem Pharmacol 66 2003 2053 2063
79. N.J. Logsdon, J. Kang, J.A. Togo, E.P. Christian, and J. Aiyar A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes J Biol Chem 272 1997 32723 32726
80. T. Lu, X.L. Wang, T. He, W. Zhou, T.L. Kaduce, and Z.S. Katusic Impaired arachidonic acid-mediated activation of large-conductance Ca2+-activated K+ channels in coronary arterial smooth muscle cells in Zucker diabetic fatty rats Diabetes 54 2005 2155 2163
81. E. Magidovich, and O. Yifrach Conserved gating hinge in ligand-and voltage-dependent K+ channels Biochemistry 43 2004 13242 13247
82. K.L. Magleby Gating mechanism of BK (Slo1) channels: so near, yet so far J Gen Physiol 121 2003 81 96
83. A.P. Malykhina, F. Shoeb, and H.I. Akbarali Fenamate-induced enhancement of heterologously expressed HERG currents in Xenopus oocytes Eur J Pharmacol 452 2002 269 277
84. A. Marty Ca-dependent K channels with large unitary conductance in chromaffin cell membranes Nature 291 1981 497 500
85. O.B. McManus, G.H. Harris, K.M. Giangiacomo, P. Feigenbaum, J.P. Reuben, and M.E. Addy An activator of calcium-dependent potassium channels isolated from a medicinal herb Biochemistry 32 1993 6128 6133
86. O.B. McManus, L.M. Helms, L. Pallanck, B. Ganetzky, R. Swanson, and R.J. Leonard Functional role of the beta subunit of high conductance calcium-activated potassium channels Neuron 14 1995 645 650
87. N.A. Meanwell, S.Y. Sit, J. Gao, C.G. Boissard, J. Lum-Ragan, and S.I. Dworetzky N-benzylated benzimidazol-2-one derivatives: activators of large-conductance Ca2+-dependent K+ channels Bioorg Med Chem Lett 6 1996 1641 1646
88. R.W. Meech, and F. Strumwasser Intracellular calcium injection activates potassium conductance in Aplysia nerve cells Fed Proc 29 1970 834a
89. P. Meera, M. Wallner, Z. Jiang, and L. Toro A calcium switch for the functional coupling between alpha (hslo) and beta subunits (Kv,cabeta) of maxi K channels FEBS Lett 385 1996 127 128
90. P. Meera, M. Wallner, and L. Toro A neuronal beta subunit (KCNMB4) makes the large conductance, voltage-and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin Proc Natl Acad Sci U S A 97 2000 5562 5567
91. A.L. Meredith, K.S. Thorneloe, M.E. Werner, M.T. Nelson, and R.W. Aldrich Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel J Biol Chem 279 2004 36746 36752
92. H. Meves Modulation of ion channels by arachidonic acid Prog Neurobiol 43 1994 175 186
93. D.K. Mistry, and C.J. Garland Nitric oxide (NO)-induced activation of large conductance Ca2+-dependent K+ channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery Br J Pharmacol 124 1998 1131 1140
94. H. Miyoshi, and Y. Nakaya Calcitonin gene-related peptide activates the K+ channels of vascular smooth muscle cells via adenylate cyclase Basic Res Cardiol 90 1995 332 336
95. M.T. Nelson Regulation of arterial tone by potassium channels Jpn J Pharmacol 58 Suppl 2 1992 238P 242P
96. C.M. Nimigean, and K.L. Magleby The beta subunit increases the Ca2+ sensitivity of large conductance Ca2+-activated potassium channels by retaining the gating in the bursting states J Gen Physiol 113 1999 425 440
97. T. Ohwada, T. Nonomura, K. Maki, K. Sakamoto, S. Ohya, and K. Muraki Dehydroabietic acid derivatives as a novel scaffold for large-conductance calcium-activated K+ channel openers Bioorg Med Chem Lett 13 2003 3971 3974
98. S.P. Olesen, E. Munch, P. Moldt, and J. Drejer Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone Eur J Pharmacol 251 1994 53 59
99. M. Ottolia, and L. Toro Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids Biophys J 67 1994 2272 2279
100. B.S. Pallotta N-bromoacetamide removes a calcium-dependent component of channel opening from calcium-activated potassium channels in rat skeletal muscle J Gen Physiol 86 1985 601 611
101. D.M. Papazian, L.C. Timpe, Y.N. Jan, and L.Y. Jan Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence Nature 349 1991 305 310
102. D.M. Papazian, X.M. Shao, S.A. Seoh, A.F. Mock, Y. Huang, and D.H. Wainstock Electrostatic interactions of S4 voltage sensor in Shaker K+ channel Neuron 14 1995 1293 1301
103. Y.B. Park Ion selectivity and gating of small conductance Ca(2+)-activated K+ channels in cultured rat adrenal chromaffin cells J Physiol 481 Pt 3 1994 555 570
104. G.V. Petkov, and M.T. Nelson Differential regulation of Ca2+-activated K+ (BK) channels by {beta}-adrenoceptors in guinea pig urinary bladder smooth muscle Am J Physiol Cell Physiol 288 2005 1255 1263
105. G.V. Petkov, A.D. Bonev, T.J. Heppner, R. Brenner, R.W. Aldrich, and M.T. Nelson Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle J Physiol 537 2001 443 452
106. R. Piskorowski, and R.W. Aldrich Calcium activation of BK(Ca) potassium channels lacking the calcium bowl and RCK domains Nature 420 2002 499 502
107. S. Pluger, J. Faulhaber, M. Furstenau, M. Lohn, R. Waldschutz, and M. Gollasch Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure Circ Res 87 2000 E53 E60
108. J.L. Pluznick, P. Wei, P.K. Carmines, and S.C. Sansom Renal fluid and electrolyte handling in BKCa-beta1-/- mice Am J Physiol Renal Physiol 284 2003 F1274 F1279
109. J.L. Pluznick, P. Wei, P.R. Grimm, and S.C. Sansom BK-{beta}1 subunit: immunolocalization in the mammalian connecting tubule and its role in the kaliuretic response to volume expansion Am J Physiol Renal Physiol 288 2005 F846 F854
110. J.C. Quirk, and P.H. Reinhart Identification of a novel tetramerization domain in large conductance K(ca) channels Neuron 32 2001 13 23
111. K. Ramanathan, T.H. Michael, G.J. Jiang, H. Hiel, and P.A. Fuchs A molecular mechanism for electrical tuning of cochlear hair cells Science 283 1999 215 217
112. K. Ramanathan, T.H. Michael, and P.A. Fuchs beta subunits modulate alternatively spliced, large conductance, calcium-activated potassium channels of avian hair cells J Neurosci 20 2000 1675 1684
113. B.E. Robertson, R. Schubert, J. Hescheler, and M.T. Nelson cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells Am J Physiol 265 1993 C299 C303
114. L. Ruttiger, M. Sausbier, U. Zimmermann, H. Winter, C. Braig, and J. Engel Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss Proc Natl Acad Sci U S A 101 2004 12922 12927
115. M. Sausbier, H. Hu, C. Arntz, S. Feil, S. Kamm, and H. Adelsberger Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency Proc Natl Acad Sci U S A 101 2004 9474 9478
116. M. Sausbier, C. Arntz, I. Bucurenciu, H. Zhao, X.B. Zhou, and U. Sausbier Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice Circulation 112 2005 60 68
117. M. Schreiber, and L. Salkoff A novel calcium-sensing domain in the BK channel Biophys J 73 1997 1355 1363
118. R. Schubert, V.N. Serebryakov, H. Engel, and H.H. Hopp Iloprost activates KCa channels of vascular smooth muscle cells: role of cAMP-dependent protein kinase Am J Physiol 271 1996 C1203 C1211
119. R. Schubert, U. Krien, and H. Gagov Protons inhibit the BK(Ca) channel of rat small artery smooth muscle cells J Vasc Res 38 2001 30 38
120. S.A. Seoh, D. Sigg, D.M. Papazian, and F. Bezanilla Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel Neuron 16 1996 1159 1167
121. K.Z. Shen, A. Lagrutta, N.W. Davies, N.B. Standen, J.P. Adelman, and R.A. North Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: evidence for tetrameric channel formation Pflugers Arch 426 1994 440 445
122. E.G. Shesely, N. Maeda, H.S. Kim, K.M. Desai, J.H. Krege, and V.E. Laubach Elevated blood pressures in mice lacking endothelial nitric oxide synthase Proc Natl Acad Sci U S A 93 1996 13176 13181
123. C. Siemer, M. Bushfield, D. Newgreen, and S. Grissmer Effects of NS1608 on MaxiK channels in smooth muscle cells from urinary bladder J Membr Biol 173 2000 57 66
124. S.B. Singh, M.A. Goetz, D.L. Zink, A.W. Dombrowski, J.D. Polishook, and M.L. Garcia Maxikdiol: a novel dihydroxyisoprimane as an agonist of maxi-K channels J Chem Soc (Perkin 1) 1 1994 3349 3352
125. E. Stefani, M. Ottolia, F. Noceti, R. Olcese, M. Wallner, and R. Latorre Voltage-controlled gating in a large conductance Ca2+-sensitive K+ channel (hslo) Proc Natl Acad Sci U S A 94 1997 5427 5431
126. C.W. Sun, M. Alonso-Galicia, M.R. Taheri, J.R. Falck, D.R. Harder, and R.J. Roman Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles Circ Res 83 1998 1069 1079
127. P. Tammaro, A.L. Smith, S.R. Hutchings, and S.V. Smirnov Pharmacological evidence for a key role of voltage-gated K+ channels in the function of rat aortic smooth muscle cells Br J Pharmacol 143 2004 303 317
128. X.D. Tang, M.L. Garcia, S.H. Heinemann, and T. Hoshi Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing Nat Struct Mol Biol 11 2004 171 178
129. J. Taniguchi, K.I. Furukawa, and M. Shigekawa Maxi K+ channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells Pflugers Arch 423 1993 167 172
130. C.M. Teng, S.M. Yu, C.C. Chen, Y.L. Huang, and T.F. Huang EDRF-release and Ca+(+)-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb Magnolia officinalis, in rat thoracic aorta Life Sci 47 1990 1153 1161
131. D. Thomas, B. Gut, S. Karsai, A.B. Wimmer, K. Wu, and G. Wendt-Nordahl Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen Naunyn-Schmiedeberg's Arch Pharmacol 368 2003 41 48
132. K.S. Thorneloe, A.L. Meredith, A.M. Knorn, R.W. Aldrich, and M.T. Nelson Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder Am J Physiol Renal Physiol 289 2005 F604 F610
133. L. Tian, L.S. Coghill, S.H. MacDonald, D.L. Armstrong, and M.J. Shipston Leucine zipper domain targets cAMP-dependent protein kinase to mammalian BK channels J Biol Chem 278 2003 8669 8677
134. L. Toro, M. Wallner, P. Meera, and Y. Tanaka Maxi-K(Ca), a unique member of the voltage-gated K channel superfamily News Physiol Sci 13 1998 112 117
135. D. Tricarico, R. Capriulo, and D.C. Camerino Involvement of K(Ca2+) channels in the local abnormalities and hyperkalemia following the ischemia-reperfusion injury of rat skeletal muscle Neuromuscul Disord 12 2002 258 265
136. D. Tricarico, M. Barbieri, A. Mele, G. Carbonara, and D.C. Camerino Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK channel of K+-deficient rats FASEB J 18 2004 760 761
137. S.C. Turner, W.A. Carroll, T.K. White, M. Gopalakrishnan, M.J. Coghlan, and C.C. Shieh The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: synthesis and structure-activity relationships of 2-amino-4-azaindoles Bioorg Med Chem Lett 13 2003 2003 2007
138. M.A. Valverde, P. Rojas, J. Amigo, D. Cosmelli, P. Orio, and M.I. Bahamonde Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit Science 285 1999 1929 1931
139. R. Vianna-Jorge, C.F. Oliveira, C.G. Ponte, and G. Suarez-Kurtz WIN 17317-3 blocks Ca2+-activated K+ channels and enhances motility of guinea-pig detrusor muscle Eur J Pharmacol 428 2001 45 49
140. M. Wallner, P. Meera, M. Ottolia, G.J. Kaczorowski, R. Latorre, and M.L. Garcia Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium Recept Channels 3 1995 185 199
141. M. Wallner, P. Meera, and L. Toro Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus Proc Natl Acad Sci U S A 93 1996 14922 14927
142. M. Wallner, P. Meera, and L. Toro Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog Proc Natl Acad Sci U S A 96 1999 4137 4142
143. R. Wang, L. Wu, and Z. Wang The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cells Pflugers Arch 434 1997 285 291
144. J. Wang, Y. Zhou, H. Wen, and I.B. Levitan Simultaneous binding of two protein kinases to a calcium-dependent potassium channel J Neurosci 19 1999 RC4
145. Z.W. Wang, O. Saifee, M.L. Nonet, and L. Salkoff SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction Neuron 32 2001 867 881
146. A. Wei, C. Solaro, C. Lingle, and L. Salkoff Calcium sensitivity of BK-type KCa channels determined by a separable domain Neuron 13 1994 671 681
147. A. Wei, T. Jegla, and L. Salkoff Eight potassium channel families revealed by the C. elegans genome project Neuropharmacology 35 1996 805 829
148. M.M. White, and M. Aylwin Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl-channels in Xenopus oocytes Mol Pharmacol 37 1990 720 724
149. R.E. White, A.B. Lee, A.D. Shcherbatko, T.M. Lincoln, A. Schonbrunn, and D.L. Armstrong Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation Nature 361 1993 263 266
150. S.N. Wu Large-conductance Ca2+-activated K+ channels: physiological role and pharmacology Curr Med Chem 10 2003 649 661
151. S.N. Wu, C.R. Jan, and H.F. Li Ruthenium red-mediated inhibition of large-conductance Ca2+-activated K+ channels in rat pituitary GH3 cells J Pharmacol Exp Ther 290 1999 998 1005
152. S.N. Wu, H.F. Li, C.R. Jan, and A.Y. Shen Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells Neuropharmacology 38 1999 979 989
153. S.N. Wu, T. Hwang, C.M. Teng, H.F. Li, and C.R. Jan The mechanism of actions of 3-(5′-(hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) on Ca(2+)-activated K(+) currents in GH(3) lactotrophs Neuropharmacology 39 2000 1788 1799
154. S.N. Wu, H.F. Li, and H.T. Chiang Actions of epoxyeicosatrienoic acid on large-conductance Ca(2+)-activated K(+) channels in pituitary GH(3) cells Biochem Pharmacol 60 2000 251 262
155. S.N. Wu, H.F. Li, and Y.C. Lo Characterization of tetrandrine-induced inhibition of large-conductance calcium-activated potassium channels in a human endothelial cell line (HUV-EC-C) J Pharmacol Exp Ther 292 2000 188 195
156. S.N. Wu, H.F. Li, and H.T. Chiang Vinpocetine-induced stimulation of calcium-activated potassium currents in rat pituitary GH3 cells Biochem Pharmacol 61 2001 877 892
157. S.N. Wu, C.C. Chen, H.F. Li, Y.K. Lo, S.A. Chen, and H.T. Chiang Stimulation of the BK(Ca) channel in cultured smooth muscle cells of human trachea by magnolol Thorax 57 2002 67 74
158. X.M. Xia, J.P. Ding, and C.J. Lingle Molecular basis for the inactivation of Ca2+-and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells J Neurosci 19 1999 5255 5264
159. X.M. Xia, X. Zeng, and C.J. Lingle Multiple regulatory sites in large-conductance calcium-activated potassium channels Nature 418 2002 880 884
160. X.M. Xia, J.P. Ding, and C.J. Lingle Inactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residues J Gen Physiol 121 2003 125 148
161. W. Xu, Y. Liu, S. Wang, T. McDonald, J.E. Van Eyk, and A. Sidor Cytoprotective role of Ca2+-activated K+ channels in the cardiac inner mitochondrial membrane Science 298 2002 1029 1033
162. C.Q. Xu, B. Brone, D. Wicher, O. Bozkurt, W.Y. Lu, and I. Huys BmBKTx1, a novel Ca2+-activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch J Biol Chem 279 2004 34562 34569
163. J. Yao, X. Chen, H. Li, Y. Zhou, L. Yao, and G. Wu BmP09, a "long chain" scorpion peptide blocker of BK channels J Biol Chem 280 2005 14819 14828
164. D. Ye, J.A. Pospisilik, and D.A. Mathers Nitroblue tetrazolium blocks BK channels in cerebrovascular smooth muscle cell membranes Br J Pharmacol 129 2000 1035 1041
165. X.H. Zeng, X.M. Xia, and C.J. Lingle Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels Nat Struct Biol 10 2003 448 454
166. X.H. Zeng, X.M. Xia, and C.J. Lingle Divalent cation sensitivity of BK channel activation supports the existence of three distinct binding sites J Gen Physiol 125 2005 273 286
167. X.B. Zhou, C. Arntz, S. Kamm, K. Motejlek, U. Sausbier, and G.X. Wang A molecular switch for specific stimulation of the BKCa channel by cGMP and cAMP kinase J Biol Chem 276 2001 43239 43245