Role of the β1 subunit in large-conductance Ca2+-activated K+ channel gating energetics: Mechanisms of enhanced Ca2+ sensitivity

Journal of General Physiology

Volumn 116, Issue 3, 2000, Pages 411-432

  Cox, D H ^a,c   Aldrich, R W ^b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

Allosteric model; Beta subunit; BK(Ca) channel; Ca2+ binding; mSlo

Indexed keywords

CALCIUM ION; ION CHANNEL; POTASSIUM CHANNEL; POTASSIUM ION; CALCIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM BINDING; MEMBRANE CONDUCTANCE; NONHUMAN; OOCYTE; XENOPUS; ANIMAL; BIOLOGICAL MODEL; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHEMISTRY; ENERGY METABOLISM; FEMALE; GENETICS; IN VITRO STUDY; KINETICS; METABOLISM; PROTEIN QUATERNARY STRUCTURE; XENOPUS LAEVIS;

ANIMALS; CALCIUM; ENERGY METABOLISM; FEMALE; ION CHANNEL GATING; KINETICS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; OOCYTES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 0033624549     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.116.3.411     Document Type: Article

References (58)

1. Calcium-activated potassium channels expressed from cloned complementary DNAs
2. A component of calcium-activated potassium channels encoded by the Drosophila slo locus
3. Properties of single calcium-activated potassium channels in cultured rat muscle
4. A practical guide to the preparation of Ca buffers
5. Cloning and functional characterization of novel potassium channel beta subunits, hKCNMB3 and hKCNMB4
6. mSlo, a complex mouse gene encoding 'maxi' calcium-activated potassium channels
7. + channel
8. + channels
9. + channels
10. + (hslo) channel from smooth muscle
11. Coordination chemistry, of alkali and alkali-earth cations with macrocyclic ligands
12. Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit co-expression: Changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation
13. Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle
14. Functional reconstitution of the large-conductance, calcium-activated potassium channel purified from bovine aortic smooth muscle
15. Transmembrane auxiliary subunits of voltage-dependention channels
16. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
17. 2+
18. 2+
19. Auxiliary subunits of voltage-gated ion channels
20. Human and rodent MaxiK channel beta-subunit genes: Cloning and characterization
21. + channel from smooth muscle
22. Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels
23. Varieties of calcium-activated potassium channels
24. + channel from transverse tubule membranes isolated from rabbit skeletal muscle
25. 2+ concentration jumps in excised inside-out multi-channel patches (myocytes from guinea pig urinary bladder)
26. Ca-dependent K channels with large unitary conductance in chromaffin cell membranes
27. Calcium-activated potassium channels: Regulation by calcium
28. Functional role of the beta subunit of high conductance calcium-activated potassium channels
29. A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV, Ca beta) of maxi K channels
30. + channel resistant to charybdotoxin and iberiotoxin
31. The gating of single calcium-dependent potassium channels is described by an activation/ blockade mechanism
32. 2+ binding reactions
33. On the nature of allosteric transitions: A plausible model
34. Relaxation of arterial smooth muscle by calcium sparks
35. Physiological roles and properties of potassium channels in arterial smooth muscle
36. 2+-activated potassium channels by retaining the gating in the bursting states
37. 2+-independent mechanism
38. Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke
39. Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries
40. A molecular mechanism for electrical tuning of cochlear hair cells
41. Localization of calcium signals by a mobile calcium buffer in frog saccular hair cells
42. Calcium channels and calcium-gated potassium channels at the frog neuromuscular junction
43. Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels
44. Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release
45. + channels suggests that the gating includes transitions through intermediate or secondary states. A mechanism for flickers
46. 2+ suggest a two-tiered allosteric gating mechanism
47. Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: Evidence for tetrameric channel formation
48. + channel (hslo)
49. Molecular constituents of maxi KCa channels in human coronary smooth muscle: Predominant alpha + beta subunit complexes
50. Regulation of ion channel expression by cytoplasmic subunits
51. + channel isoforms from human brain
52. + channel beta-subunit from human brain
53. Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium
54. + channels: A transmembrane beta-subunit homolog
55. A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels
56. Single calcium-dependent potassium channels in clonal anterior pituitary cells
57. 2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells