BmBKTx1, a novel Ca2+-activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch

Journal of Biological Chemistry

Volumn 279, Issue 33, 2004, Pages 34562-34569

  Xu, Chen Qi ^a   Brône, Bert ^b   Wicher, Dieter ^c   Bozkurt, Özlem ^b   Lu, Wu Yuan ^d   Huys, Isabelle ^e   Han, Yu Hong ^a   Tytgat, Jan ^e   Van Kerkhove, Emmy ^b   Chi, Cheng Wu ^a,f  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b HASSELT UNIVERSITY   (Belgium)

^c Saxon Academy of Sciences   (Germany)

^d UNIVERSITY OF MARYLAND   (United States)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f TONGJI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED ALUMINA; CLONING; CONCENTRATION (PROCESS); IONS; PHYSIOLOGY; PURIFICATION;

CHANNEL BLOCKING; ION CHANNELS; MEDIAN NEURONS;

TOXIC MATERIALS;

AMINO ACID; BMBKTX1; CALCIUM ION; ION CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SCORPION VENOM; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; BKTX1 PROTEIN, BUTHUS MARTENSI; CALCIUM ACTIVATED POTASSIUM CHANNEL; COMPLEMENTARY RNA; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; NEUROTOXIN; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COCKROACH; CONTROLLED STUDY; DOSE RESPONSE; DROSOPHILA; EMBRYO; FEMALE; HUMAN; HUMAN CELL; IC 50; MALE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; POTASSIUM CURRENT; PRIORITY JOURNAL; PURIFICATION; SCORPION; STRUCTURE ANALYSIS; SYNTHESIS; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSECT; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; OOCYTE; PATCH CLAMP; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; TIME; XENOPUS LAEVIS;

ANIMALIA; BLATTARIA; BUTHUS; DROSOPHILA MELANOGASTER; INSECTA; LOCUSTA MIGRATORIA; MESOBUTHUS MARTENSII; SCORPIONES;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INHIBITORY CONCENTRATION 50; INSECTS; ION CHANNELS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEURONS; NEUROTOXINS; OOCYTES; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROTEIN CONFORMATION; RNA, COMPLEMENTARY; SCORPION VENOMS; SCORPIONS; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; XENOPUS LAEVIS;

EID: 4544374077     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312798200     Document Type: Article

References (43)

1. Rodriguez de la Vega, R. C., Merino, E., Becerril, B., and Possani, L. D. (2003) Trends Pharmacol. Sci. 24, 222-227
2. Tytgat, J., Chandy, K. G., Garcia, M. L., Gutman, G. A., Martin-Eauclaire, M. F., van der Walt, J. J., and Possani, L. D. (1999) Trends Pharmacol. Sci. 20, 444-447
3. Corona, M., Gurrola, G. B., Merino, E., Cassulini, R. R., Valdez-Cruz, N. A., Garcia, B., Ramirez-Dominguez, M. E., Coronas, F. I., Zamudio, F. Z., Wanke, E., and Possani, L. D. (2002) FEBS Lett. 532, 121-126
4. Vergara, C., Latorre, R., Marrion, N. V., and Adelman, J. P. (1998) Curr. Opin. Neurobiol. 8, 321-329
5. Wickenden, A. (2002) Pharmacol. Ther. 94, 157-182
6. Ahluwalia, J., Tinker, A., Clapp, L. H., Duchen, M. R., Abramov, A. Y., Pope, S., Nobles, M., and Segal, A. W. (2004) Nature 427, 853-858
7. Ashcroft, F. M. (2000) Ion Channels and Disease, Academic Press, San Diego
8. Zeng, X. H., Xia, X. M., and Lingle, C. J. (2003) Nat. Struct. Biol. 10, 448-454
9. Schroeder, N., Mullmann, T. J., Schmalhofer, W. A., Gao, Y. D., Garcia, M. L., and Giangiacomo, K. M. (2002) FEBS Lett. 527, 298-302
10. Giangiacomo, K. M., Sugg, E. E., Garcia-Calvo, M., Leonard, R. J., McManus, O. B., Kaczorowski, G. J., and Garcia, M. L. (1993) Biochemistry 32, 2363-2370
11. Goldstein, S. A., Pheasant, D. J., and Miller, C. (1994) Neuron 12, 1377-1388
12. Munujos, P., Knaus, H. G., Kaczorowski, G. J., and Garcia, M. L. (1995) Biochemistry 34, 10771-10776
13. Wicher, D., Walther, C., and Wicher, C. (2001) Prog. Neurobiol. 64, 431-525
14. Goudet, C., Chi, C. W., and Tytgat, J. (2002) Toxicon 40, 1239-1258
15. Wang, C. G., He, X. L., Shao, F., Liu, W., Ling, M. H., Wang, D. C., and Chi, C. W. (2001) Eur. J. Biochem. 268, 2480-2485
16. Schnolzer, M., Alewood, P., Jones, A., Alewood, D., and Kent, S. B. (1992) Int. J. Pept. Protein Res. 40, 180-193
17. Ashby, G. J. (1972) in The UFAW Handbook on the Care and Management of Laboratory Animals (UFAW, ed) pp. 582-587, Churchill Livingstone, Edinburgh
18. Brone, B., Tytgat, J., Wang, D. C., and Van Kerkhove, E. (2003) J. Insect Physiol. 49, 171-182
19. Hamill, O. P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F. J. (1981) Pflugers Arch. 391, 85-100
20. Huys, I., Dyason, K., Waelkens, E., Verdonck, F., van Zyl, J., du Plessis, J., Muller, G. J., van der Walt, J., Clynen, E., Schoofs, L., and Tytgat, J. (2002) Eur. J. Biochem. 269, 1854-1865
21. Tytgat, J., Buyse, G., Eggermont, J., Droogmans, G., Nilius, B., and Daenens, P. (1996) FEBS Lett. 390, 280-284
22. Sabatier, J. M., Zerrouk, H., Darbon, H., Mabrouk, K., Benslimane, A., Rochat, H., Martin-Eauclaire, M. F., and Van Rietschoten, J. (1993) Biochemistry 32, 2763-2770
23. Sabatier, J. M., Fremont, V., Mabrouk, K., Crest, M., Darbon H., Rochat, H., Van Rietschoten, J., and Martin-Eauclaire, M. F. (1994) Int. J. Pept. Protein Res. 43, 486-495
24. Schneider, M. J., Rogowski, R. S., Krueger, B. K., and Blaustein, M. P. (1989) FEBS Lett. 250, 433-436
25. Flinn, J. P., Murphy, R., Johns, R. B., Kunze, W. A., and Angus, J. A. (1995) Int. J. Pept. Protein Res. 45, 320-325
26. Shakkottai, V. G., Regaya, I., Wulff, H., Fajloun, Z., Tomita, H., Fathallah, M., Cahalan, M. D., Gargus, J. J., Sabatier, J. M., and Chandy, K. G. (2001) J. Biol. Chem. 276, 43145-43151
27. Grolleau, F., and Lapied, B. (1995) J. Neurophysiol. 73, 160-171
28. Wegener, J. W., Tareilus, E., and Breer, H. (1992) J. Insect Physiol. 38, 237-239
29. Derst, C., Messutat, S., Walther, C., Eckert, M., Heinemann, S. H., and Wicher, D. (2003) Eur. J. Neurosci. 17, 1197-1212
30. Giangiacomo, K. M., Fremont, V., Mullmann, T. J., Hanner, M., Cox, R. H., and Garcia, M. L. (2000) Biochemistry 39, 6115-6122
31. Gao, Y. D., and Garcia, M. L. (2003) Proteins 52, 146-154
32. Myers, M. P., and Stampe, P. (2000) Neuropharmacology 39, 11-20
33. Possani, L. D., Becerril, B., Delepierre, M., and Tytgat, J. (1999) Eur. J. Biochem. 264, 287-300
34. Cai, Z., Xu, C. Q., Xu, Y. Q., Lu, W. Y., Chi, C. W., Shi, W. Y., and Wu, J. H. (2004) Biochemistry 43, 3764-3771
35. Bontems, F., Roumestand, C., Gilquin, B., Menez, A., and Toma, F. (1991) Science 254, 1521-1523
36. Wu, J. J., He, L. L., Zhou, Z., and Chi, C. W. (2002) Biochemistry 41, 2844-2849
37. Auguste, P., Hugues, M., Mourre, C., Moinier, D., Tartar, A., and Lazdunski, M. (1992) Biochemistry 31, 648-654
38. Aiyar, J., Withka, J. M., Rizzi, J. P., Singleton, D. H., Andrews, G. C., Lin, W., Boyd, J., Hanson, D. C., Simon, M., Dethlefs, B., Lee, C. L., Hall, J. E., Gutman, G. A., and Chandy, K. G. (1995) Neuron 15, 1169-1181
39. Romi-Lebrun, R., Lebrun, B., Martin-Eauclaire, M. F., Ishiguro, M., Escoubas, P., Wu, F. Q., Hisada, M., Pongs, O., and Nakajima, T. (1997) Biochemistry 36, 13473-13482
40. Romi-Lebrun, R., Martin-Eauclaire, M. F., Escoubas, P., Wu, F. Q., Lebrun, B., Hisada, M., and Nakajima, T. (1997) Eur. J. Biochem. 245, 457-464
41. Gimenez-Gallego, G., Navia, M. A., Reuben, J. P., Katz, G. M., Kaczorowski, G. J., and Garcia, M. L. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 3329-3333
42. Galvez, A., Gimenez-Gallego, G., Reuben, J. P., Roy-Contancin, L., Feigenbaum, P., Kaczorowski, G. J., and Garcia, M. L. (1990) J. Biol. Chem. 265, 11083-11090
43. Novick, J., Leonard, R. J., King, V. F., Schmalhofer, W. A., Kaczorowski, G. J., and Garcia, M. L. (1991) Biophys. J. 59, 78a