Effects of NS1608 on MaxiK channels in smooth muscle cells from urinary bladder

Journal of Membrane Biology

Volumn 173, Issue 1, 2000, Pages 57-66

  Siemer, C ^a   Bushfield, M ^b   Newgreen, D ^c   Grissmer, S ^a  

^a UNIVERSITY OF ULM   (Germany)

^b Cambridge Drug Discovery Ltd   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Bladder; Hyperpolarization; MaxiK channels; Muscle relaxation; NS1608; Smooth muscle cells; Urge incontinence

Indexed keywords

CALCIUM ION; CHARYBDOTOXIN; PAXILLINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLADDER; CALCIUM CURRENT; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPOLARIZATION; MEMBRANE CURRENT; MEMBRANE POTENTIAL; MUSCLE RELAXATION; MUSCLE TONE; NONHUMAN; PATCH CLAMP; RAT; SMOOTH MUSCLE FIBER; URGE INCONTINENCE;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; CHARYBDOTOXIN; CYTOSKELETAL PROTEINS; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE POTENTIALS; MUSCLE, SMOOTH; PATCH-CLAMP TECHNIQUES; PAXILLIN; PHENYLUREA COMPOUNDS; PHOSPHOPROTEINS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; URINARY BLADDER;

ANIMALIA;

EID: 0033988117     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002320001007     Document Type: Article

References (39)

1. + channels as modulators of human myometrial contractile activity. Am. J. Physiol. 265:C976-C985
2. + channels. J. Gen. Physiol. 109:633-646
3. + channels. J. Gen. Physiol. 109:647-673
4. Fabiato, A. 1988. Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands. Methods Enzymol. 157:378-417
5. + channels: structure function analysis. Pfluegers Arch. 434:R83.
6. + channel gene. Proc. Natl. Acad. Sci. USA 87:9411-9415
7. + channel in T cells. J. Biol. Chem. 267:20971-20979
8. + channels in human leukemic T cells. J. Gen. Physiol. 99:63-84
9. + channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol. Pharmacol. 45:1227-1234
10. Grissmer, S., Nguyen, A.N., Cahalan, M.D. 1993. Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology. J. Gen. Physiol. 102:601-630
11. Hamill, O.P., Marty, A., Neher, E., Sakmann, B., Sigworth, F.J. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluegers Arch. 391:85-100
12. Hanner, M., Schmalhofer, W.A., Munujos, P., Knaus, H.G., Kaczorowski, G.J., Garcia, M.L. 1997. The beta subunit of the high-conductance calcium-activated potassium channel contributes to the high-affinity receptor for charybdotoxin. Proc. Natl. Acad. Sci. USA 94:2853-2858
13. 2+-activated potassium channels in human leukemic T lymphocytes. J. Physiol. 496:627-637
14. + channels regulate action potential repolarization in urinary bladder smooth muscle. Am. J. Physiol. 273:C110-C117
15. Ca channel activator, NS1619, on rat cerebral artery smooth muscle. Br. J. Pharmacol. 117(1):119-129
16. Ca channel openers NS004 and NS1608 in porcine coronary arterial cells. Eur. J. Pharmacol. 294:357-360
17. Hu, S., Kim, H.S. 1996. On the mechanism of the differential effects of NS004 and NS1608 in smooth muscle cells from guinea pig bladder. Eur. J. Pharmacol. 318:461-468
18. Ishii, T.M., Silvia, C., Hirschberg, B., Bond, C.T., Adelman, J.P., Maylie, J. 1997. A human intermediate conductance calcium-activated potassium channel. Proc. Natl. Acad. Sci. USA 94:11651-11656
19. 2+-activated potassium channels in human leukemic T Cells and activated human peripheral blood T lymphocytes. Cell. Physiol. Biochem. 7:179-187
20. + channels: evidence for non-conducting closed and non-conducting inactivated states. J. Physiol. 506:291-301
21. Joiner, W.J., Wang, L.Y., Tang, M.D., Kaczmarek, L.K. 1997. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proc. Natl. Acad. Sci. USA 94:11013-11018
22. + channel inhibitor. J. Pharmacol. Exp. Ther. 255:697-706
23. Klöckner, U., Isenberg, G. 1985. Action potentials and net membrane currents of isolated smooth muscle cells (urinary bladder of the guinea pig). Pfluegers Arch. 405:329-339
24. Knaus, H.G., McManus, O.B., Lee, S.H., Schmalhofer, W.A., Garcia Calvo, M., Helms, L.M., Sanchez, M., Giangiacomo, K., Reuben, J.P., Smith, A.B. III, Kaczorowski, G.J., Garcia, M.L. 1994. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 33:5819-5828
25. + channel activity in tracheal myocytes by phosphorylation. Nature 341:152-154
26. Logsdon, N.J., Kang, J., Togo, J.A., Christian, E.P., Aiyar, J. 1997. A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. J. Biol. Chem. 272:32723-32726
27. V,Caβ) of maxi Κ channels. FEBS Lett. 382:84-88
28. + channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. Proc. Natl. Acad. Sci. USA 94:14066-14071
29. + channels from mammalian skeletal muscle. Nature 313:316-318
30. Nelson, M.T., Cheng, H., Rubart, M., Santana, L.F., Bonev, A.D., Knot, H.J., Lederer, W.J. 1995. Relaxation of arterial smooth muscle by calcium sparks. Science 270:633-637
31. Olesen, S.-P., Moldt, P., Pedersen, O. 1994. Urea and amide derivatives and their use in the control of cell membrane potassium channels. World Patent Application WO94/22807
32. Rauer, H., Grissmer, S. 1996. Evidence for an internal phenylalkylamine action on the voltage-gated potassium channel Kv1.3. Mol. Pharmacol. 50:1625-1634
33. Siemer, C., Grissmer, S. 1997. NS 1608 activates a charybdotoxin sensitive potassium current in smooth muscle cells from rat urinary bladder. Pfluegers Arch. 433:R85
34. Siemer, C., Grissmer, S. 1998. Effects of BK channel modulators on the membrane potential of rat bladder smooth muscle cells. Biophys. J. 74:A110 (Abstr.)
35. Siemer, C., Grissmer, S. 1999. MaxiΚ channels: molecular structure, function, and tissue distribution. In: Animal Toxins and Potassium Channels. J.M. Sabatier and H. Darbon, editors. Kluwer Academic Publishers, Dordrecht, Netherlands
36. Starrett, J.E., Dworetzky, S.I., Gribkoff, V.K. 1996. Modulators of large-conductance calcium-activated potassium (BK) channels as potential therapeutic targets. Current Pharmaceutical Design 2:413-428
37. Steinert, M., Grissmer, S. 1997. Novel activation stimulus of chloride channels by potassium in human osteoblasts and human leukemic T lymphocytes. J. Physiol. 500:653-660
38. 2+. Neuropharmacology 35:903-914
39. + channels: An additional transmembrane region at the N terminus. Proc. Natl. Acad. Sci. USA 93:14922-14927