Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BKCa channels

Circulation

Volumn 107, Issue 5, 2003, Pages 769-776

  Archer, Stephen L ^a   Gragasin, Ferrante S ^a   Wu, Xichen ^a   Wang, Shaohua ^a   McMurtry, Sean ^a   Kim, Daniel H ^a   Platonov, Michael ^a   Koshal, Arvind ^a   Hashimoto, Kyoko ^a   Campbell, William B ^b   Falck, J R ^c   Michelakis, Evangelos D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Bypass; Cytochromes; Ion channels; Lasers

Indexed keywords

11,12 EPOXY 5,8,14 ICOSATRIENOIC ACID; 17 OCTADECYNOIC ACID; 4,15 EPOXYEICOSA 5 ENOIC ACID; ARACHIDIC ACID; CYTOCHROME P450 2C; CYTOCHROME P450 INHIBITOR; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; MESSENGER RNA; N METHYLSULFONYL 6 (2 PROPARGYLOXYPHENYL)HEXANAMIDE; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; ELECTROPHYSIOLOGY; HUMAN; HUMAN TISSUE; HYPERPOLARIZATION; IMMUNOHISTOCHEMISTRY; INTERNAL MAMMARY ARTERY; ION CURRENT; LASER; NUCLEOTIDE SEQUENCE; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAPHENOUS VEIN; SMOOTH MUSCLE; SYNTHESIS;

8,11,14-EICOSATRIENOIC ACID; ACETYLCHOLINE; BIOLOGICAL FACTORS; BRADYKININ; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MAMMARY ARTERIES; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SIGNAL TRANSDUCTION; VASODILATION; VASODILATOR AGENTS;

EID: 0037432150     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000047278.28407.C2     Document Type: Article

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