On the mechanism of the differential effects of NS004 and 1608 in smooth muscle cells from guinea pig bladder

European Journal of Pharmacology

Volumn 318, Issue 2-3, 1996, Pages 461-468

  Hu, Shiling ^a   Kim, Helen S ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

BK(Ca) channel; Bladder detrusor, guinea pig; Inside out single channel recording; Open state probability; Patch clamp; Whole cell recording

Indexed keywords

1 (5 CHLORO 2 HYDROXYPHENYL) 5 TRIFLUOROMETHYL 2 BENZIMIDAZOLONE; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BLADDER; CHANNEL GATING; CONTROLLED STUDY; DOSE RESPONSE; GUINEA PIG; IN VITRO STUDY; MALE; NONHUMAN; PATCH TEST; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

ANIMALS; BENZIMIDAZOLES; CALCIUM; CHLOROPHENOLS; EGTAZIC ACID; GUINEA PIGS; MALE; MUSCLE, SMOOTH; PHENYLUREA COMPOUNDS; POTASSIUM CHANNELS; URINARY BLADDER;

EID: 0030607673     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00776-5     Document Type: Article

References (18)

1. Brayden, J.E. and M.T. Nelson, 1992, Regulation of arterial tone by activation of calcium-activated potassium channels, Science 256, 532.
2. Ca channel opener, in vascular smooth muscle, Br. J. Pharmacol. 113, 1538.
3. Hamill, O.P., A. Marty, E. Neher, B. Sakmann and F.J. Sigworth, 1981, Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pflügers Arch. 391, 85.
4. Ca channel activator, NS1619, on rat cerebral artery smooth muscle, Br. J. Pharmacol. 117, 119.
5. Hille, B., 1992, Ionic channels of excitable membranes, 2nd edn. (Sinauer, Sunderland, MA).
6. Ca channel openers NS004 and NS1608 in porcine coronary arterial cells, Eur. J. Pharmacol. 294, 357.
7. Imai, S. and K. Takeda, 1967, Calcium and contraction of heart and smooth muscle, Nature 313, 1044.
8. Isenberg, G. and U. Klockner, 1982, Calcium tolerant ventricular myocytes prepared by preincubation in a 'KB' medium, Pflügers Arch. 395, 6.
9. Ca channel activity in rat cortical neurons, Eur. J. Pharmacol. 280, 215.
10. McKay, M.C., S.I. Dworetzky, N.A. Meanwell, S.P. Olesen, P.M. Reinhart, I.B. Levitan, J.P. Adelman and V.K. Gribkoff, 1994, Opening of large-conductance calcium-activated potassium channels by the substituted benzimidazolone NS004, J. Neurophysiol. 71, 1873.
11. Olesen, S.P. and F. Watjen, 1992, EPA 0477819A2, Benzimidazole derivatives, their preparation and use, NeuroSearch.
12. Olesen, S.P., 1994a, WO94/22807, Urea and amide derivatives and their use in the control of cell membrane potassium channels, NeuroSearch.
13. + channels, Exp. Opin. Drugs 3, 1181.
14. + channels by novel benzimidazolone, Eur. J. Pharmacol. 251, 53.
15. + channels in cerebellar granule cells, NeuroReport 5, 1001.
16. + channel, in: Proceedings of IBC Conferences on Potassium Channel Modulators, Washington, DC, USA, January, 23-25.
17. + channels, Eur. J. Pharmacol. 295, 53.
18. + currents in canine coronary artery smooth muscle cells by NS-004, or 1-(2′-hydroxy-5′-chlorophenyl)-5-trifluoromethyl-2-(3H)-benzimidazolone, J. Pharmacol. Exp. Ther. 271, 369.