Dehydroabietic acid derivatives as a novel scaffold for large-conductance calcium-activated K+ channel openers

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 22, 2003, Pages 3971-3974

  Ohwada, Tomohiko ^a   Nonomura, Taro ^a   Maki, Keisuke ^a   Sakamoto, Kazuho ^b   Ohya, Susumu ^b   Muraki, Katsuhiko ^b   Imaizumi, Yuji ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CARBOXYL GROUP; DEHYDROABIETIC ACID; PIMARIC ACID; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; HYDROPHOBICITY; POTASSIUM CONDUCTANCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0242348701     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.072     Document Type: Article

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23. The ClogP values, the calculated partition coefficients between octanol and water of the relevant carboxylic acid compounds are as follows: the dichloro derivative 4 (7.52), 12-(5a) and 14-monochloro (5b) derivative (6.81), 12-(6b) and 14-monobromo (7b) derivative (6.96), and dehydroabietic acid 3 (6.09). This larger hydrophobicity of 4 will be partially attributed to the strong activity which will increase membrane permeability.