CGRP receptors in the gerbil spiral modiolar artery mediate a sustained vasodilation via a transient cAMP-mediated Ca2+-decrease

Journal of Membrane Biology

Volumn 189, Issue 3, 2002, Pages 225-236

  Herzog, M ^a   Scherer, E Q ^a   Albrecht, B ^a   Rorabaugh, B ^b   Scofield, M A ^b   Wangemann, P ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b CREIGHTON UNIVERSITY   (United States)

Author keywords

Calcitonin gene related peptide; Calcium sensitization; Cochlear blood flow; Endothelin; Forskolin; Glibenclamide; Iberiotoxin

Indexed keywords

BUCLADESINE; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCIUM ION; COMPLEMENTARY DNA; CYCLIC AMP; ENDOTHELIN; ENDOTHELIN 1; FORSKOLIN; GLIBENCLAMIDE; IBERIOTOXIN; NITRIC OXIDE; POTASSIUM CHANNEL BLOCKING AGENT; RNA; CALCIUM; NITROUS OXIDE;

ANIMAL CELL; ARTERY DIAMETER; ARTICLE; CALCIUM TRANSPORT; COCHLEA; COCHLEA BLOOD FLOW; CONTROLLED STUDY; GERBIL; HEARING DISORDER; IMMUNOCYTOCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL; ARTERY; CALCIUM SIGNALING; DRUG EFFECT; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY; VASCULARIZATION;

ANIMALIA; GERBILLINAE;

ANIMALS; ARTERIES; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM; CALCIUM SIGNALING; COCHLEA; CYCLIC AMP; ENDOTHELIN-1; GERBILLINAE; NITROUS OXIDE; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; SENSITIVITY AND SPECIFICITY; VASODILATION;

EID: 0036783284     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00232-002-1017-5     Document Type: Article

References (43)

1. Bell, D., McDermott, B.J. 1996a. Calcitonin gene-related peptide in the cardiovascular system: characterization of receptor populations and their (patho)physiological significance. Pharmacol. Rev. 48:253-288
2. Bell, D., McDermott, B.J. 1996b. Calcitonin gene-related peptide in the cardiovascular system: characterization of receptor populations and their (patho)physiological significance. Pharmacol. Rev. 48:253-288
3. + channels in arterial smooth muscle through protein kinase C. J. Gen. Physiol. 108:315-323
4. Brain, S.D., Williams, T.J., Tippins, J.R., Morris, H.R., MacIntyre, I. 1985. Calcitonin gene-related peptide is a potent vasodilator. Nature 313:54-56
5. Carlisle, L., Aberdeen, J., Forge, A., Burnstock, G. 1990. Neural basis for regulation of cochlear blood flow: peptidergic and adrenergic innervation of the spiral modiolar artery of the guinea pig. Hear. Res. 43:107-113
6. Dennis, T., Fournier, A., St Pierre, S., Quirion, R. 1989. Structure-activity profile of Calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity. J. Pharmacol. Exp. Ther. 251:718-725
7. Essler, M., Staddon, J.M., Weber, P.C., Aepfelbacher, M. 2000. Cyclic AMP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling. J. Immunol. 164:6543-6549
8. Evans, B.N., Rosenblatt, M.I., Mnayer, L.O., Oliver, K.R., Dickerson, I.M. 2000. CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. J. Biol. Chem. 275:31438-31443
9. Fiscus, R.R., Zhou, H.L., Wang, X., Han, C., Ali, S., Joyce, C.D., Murad, F. 1991. calcitonin gene-related peptide (CGRP)-induced cyclic AMP, cyclic GMP and vasorelaxant responses in rat thoracic aorta are antagonized by blockers of endothelium-derived relaxant factor (EDRF). Neuropeptides 20:133-143
10. Garcia, J.G., Lazar, V., Gilbert-McClain, L.I., Gallagher, P.J., Verin, A.D. 1997. Myosin light chain kinase in endothelium: molecular cloning and regulation. Am. J. Respir. Cell Mol. Biol. 16:489-494
11. Goodman, E.C., Iversen, L.L. 1986. Calcitonin gene-related peptide: a novel neuropeptide. Life Sci. 38:2169-2178
12. Grace, G.C., Dusting, G.J., Kemp, B.E., Martin, T.J. 1987. Endothelium and the vasodilator action of rat calcitonin gene-related peptide (CGRP). Br. J. Pharmacol. 91:729-733
13. Gray, D.W., Marshall, I. 1992. Nitric oxide synthesis inhibitors attenuate calcitonin gene-related peptide endothelium-dependent vasorelaxation in rat aorta. Eur. J. Pharmacol. 212:37-42
14. + channels mediate calcitonin-gene-related peptide (CGRP)-induced vasodilation in the spiral modiolar artery (SMA). FASEB J 15:A115
15. Herzog, M., Scherer, E.Q., Albrecht, B., Schimanski, S., Scofield, M.A., and Wangemann, P. 2001b. Calcitonin-gene-related peptide (CGRP) receptors mediate vasodilation of the spiral modiolar artery (SMA). Assoc. Res. Otolaryngol. 24:28
16. Hillerdal, M., Andersson, S.E. 1991. The effects of calcitonin gene-related peptide (CGRP) on cochlear and mucosal blood flow in the albino rabbit. Hear. Res. 52:321-328
17. Jansen, I., Mortensen, A., Edvinsson, L. 1992. Characterization of calcitonin gene-related peptide receptors in human cerebral vessels. Vasomotor responses and cAMP accumulation. Ann. N. Y. Acad. Sci. 657:435-440
18. Juaneda, C., Dumont, Y, Quirion, R. 2000. The molecular pharmacology of CGRP and related peptide receptor subtypes. Trends Pharmacol. Sci. 21:432-438
19. Kageyama, M., Yanagisawa, T, Taira, N. 1993. Calcitonin gene-related peptide relaxes porcine coronary arteries via cyclic AMP-dependent mechanisms, but not activation of ATP-sensitive potassium channels. J. Pharmacol. Exp. Ther. 265:490-497
20. Kawasaki, H., Takasaki, K., Saito, A., Goto, K. 1988. Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature 335:164-167
21. McLatchie, L.M., Fraser, N.J., Main, M.J., Wise, A., Brown, J., Thompson, N., Solari, R., Lee, M.G., Foord, S.M. 1998. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393:333-339
22. + channel of cultured porcine coronary artery smooth muscle cells. Biochem. Biophys. Res. Commun. 190:263-269
23. + channels. Nature 344:770-773
24. Nelson, M.T., Patlak, J.B., Worley, J.R, Standen, N.B. 1990b. Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone. Am. J. Physiol. 259:C3-C18
25. Nelson, M.T., Quayle, J.M. 1995. Physiological roles and properties of potassium channels in arterial smooth muscle. Am. J. Physiol. 268:C799-C822
26. 2+ sensitivity in alpha-toxin-permeabilized rabbit mesenteric artery. Circ. Res. 71:951-959
27. Poyner, D.R. 1992a. Calcitonin gene-related peptide: multiple actions, multiple receptors. Pharmacol. Ther. 56:23-51
28. Poyner, D.R. 1992b. Calcitonin gene-related peptide: multiple actions, multiple receptors. Pharmacol. Ther. 56:23-51
29. Qiu, J., Steyger, P.S., Trune, D.R., Nuttall, A.L. 2001. Co-existence of tyrosine hydroxylase and calcitonin gene-related peptide in cochlear spiral modiolar artery of guinea pigs. Hear. Res. 155:152-160
30. Quayle, J.M., Nelson, M.T., Standen, NB. 1997. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol Rev. 77:1165-1232
31. Quirk, W.S., Seidman, M.D., Laurikainen, E.A., Nuttall, A.L, Miller, J.M. 1994. Influence of calcitonin-gene related peptide on cochlear blood flow and electrophysiology. Am. J. Otol. 15:56-60
32. Reslerova, M., Loutzenhiser, R. 1998. Renal microvascular actions of calcitonin gene-related peptide. Am. J. Physiol 274:F1078-F1085
33. 2+ sensitization of the contractile apparatus and reversed by CGRP. Stroke (in press)
34. A receptors in the gerbil spiral modiolar artery. J. Membrane Biol. 182:183-191
35. Seidman, M.D., Quirk, W.S., Shirwany, N.A. 1999. Mechanisms of alterations in the microcirculation of the cochlea. Ann. N. Y. Acad. Sci. 884:226-232
36. Sheykhzade, M., Berg Nyborg, N.C. 2001. Mechanism of CGRP-induced relaxation in rat intramural coronary arteries. Br. J. Pharmacol. 132:1235-1246
37. Somlyo, A.P., Somlyo, A.V. 2000. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J. Physiol. 522:177-185
38. Somlyo, A.P., Wu, X., Walker, L.A., Somlyo, A.V. 1999. Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. Rev. Physiol. Biochem. Pharmacol. 134:201-234
39. Wangemann, P., Cohn, E., Gruber, D.D., Gratton, M.A. 1998. Calcium-dependence and nifedipine-sensitivity of tone and contractility in the isolated in vitro superfused spiral modiolar artery. Hearing Res. 118:90-100
40. Wangemann, P., Gruber, D.D. 1998. The isolated in-vitro perfused spiral modiolar artery: Pressure dependence of vasoconstriction. Hear. Res. 115:113-118
41. Waugh, D.J., Bockman, C.S., Smith, D.D., Abel, P.W. 1999. Limitations in using peptide drugs to characterize calcitonin gene-related peptide receptors. J. Pharmacol. Exp. Ther. 289:1419-1426
42. + channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle. J. Physiol. 507:8-29
43. Wonneberger, K., Scofield, M.A., Wangemann, P. 2000. Evidence for a calcium sensing receptor in the vascular smooth muscle cells of the spiral modiolar artery. J. Membrane Biol. 175:203-212