Endothelial dysfunction precedes hypertension in diet-induced insulin resistance

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 275, Issue 3 44-3, 1998, Pages

  Katakam, Prasad V G ^a,b   Ujhelyi, Michael R ^a,b,c   Hoenig, Margarethe E ^a   Miller, Allison Winecoff ^a,b,c  

^a UNIVERSITY OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Fructose; Sprague Dawley; Vasodilation

Indexed keywords

FRUCTOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY DIAMETER; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; SUGAR INTAKE; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0031711458     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.275.3.r788     Document Type: Article

References (17)

1. Bhanot, S., J. H. McNeill, and M. Bryer-Ash. Vanadyl sulfate prevents fructose-induced hyperinsulinemia and hypertension in rats. Hypertension 23: 308-312, 1994.
2. Dall'Aglio, E., P. Tosini, P. Ferrari, I. Zavaroni, M. Passeri, and G. M. Reaven. Abnormalities of insulin and lipid metabolism in Milan hypertensive rats. Am. J. Hypertens. 4: 773-775, 1991.
3. Ferrannini, E., G. Buzzigoli, R. Bonadonna, M. A. Giorico, M. Oleggini, L. Graziadei, R. Pedrinelli, L. Brandi, and S. Bevilacqua. Insulin resistance in essential hypertension. N. Engl. J. Med. 317: 350-357, 1987.
4. Grunfeld, B., M. Balzareti, M. Romo, M. Gimenez, and R. Gutman. Hyperinsulinemia in normotensive offspring of hypertensive parents. Hypertension. 3, Suppl. 1: 112-115, 1994.
5. Herbert, V., K. Lau, C. W. Gottlieb, and S. J. Bleicher. Coated charcoal immunoassay of insulin. J. Clin. Endocrinol. Metab. 25: 1375-1384, 1965.
6. Hwang, I. S., H. Ho, B. Hoffman, and G. M. Heaven. Fructose-induced insulin resistance and hypertension in rats. Hypertension 10: 512-516, 1987.
7. Konishi, M., and C. Su. Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension 5: 881-886, 1983.
8. Kotchen, T. A., S. Reddy, and H. Y. Zhang. Increasing insulin sensitivity lowers blood pressure in the fructose-fed rat. Am. J. Hypertens. 10: 1020-1026, 1997.
9. Lee, M. K., P. D. Miles, M. Khoursheed, K. M. Gao, A. R. Moossaa, and J. M. Olefsky. Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes 43: 1435-1439, 1994.
10. Lind, L., C. Berne, and H. Lithell. Prevalence of insulin resistance in essential hypertension. J. Hypertens. 13: 1457-1462, 1995.
11. Lockette, W. E., Y. Otsuha, and O.A. Carretero. Endothelium-dependent relaxation in hypertension. Hypertension 8, Suppl. II: 1161-1166, 1986.
12. Luscher, T. F., F. Raij, and P. M. Vanhoutte. Endothelium-dependent responses in normotensive and hypertensive Dahl rats. Hypertension 9: 157-163, 1987.
13. Miller, A. W., M. E. Hoenig, and M. R. Ujhelyi. Mechanisms of impaired endothelial function associated with insulin resistance. J. Cardiovasc. Pharmacol. Therapeutics 3: 125-134, 1998.
14. Mondon, C. E., and G. M. Reaven, Evidence of abnormalities of insulin metabolism in rats with spontaneous hypertension. Metabolism 37: 303-305, 1988.
15. Panza, J. A., A. A. Quyyumi, S. E. Brush, Jr., and S. E. Epstein. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N. Engl. J. Med. 323: 22-27, 1990.
16. Panza, J. A., A. A. Quyyumi, T. S. Callahan, and S. E. Epstein. Effects of antihypertensive treatment on endothelium-dependent vascular relaxation in patients with essential hypertension. J. Am. Coll. Cardiol. 21: 1145-1151, 1993.
17. Pettrie, J. R., S. Ueda, D. J. Webb, H. L. Elliott, and J. M. C. Connell. Endothelial nitric oxide production and insulin sensitivity: a physiological link with implications for pathogenesis of cardiovascular disease. Circulation 93: 1331-1333, 1996.