The synthesis and characterization of BMS-204352 (MaxiPost™) and related 3-fluorooxindoles as openers of maxi-K potassium channels

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 7, 2002, Pages 1023-1026

  Hewawasam, Piyasena ^a   Gribkoff, Valentin K ^a   Pendri, Yadagiri ^a   Dworetzky, Steven I ^a   Meanwell, Nicholas A ^a   Martinez, Eduardo ^a   Boissard, Christopher G ^a   Post Munson, Debra J ^a   Trojnacki, Joanne T ^a   Yeleswaram, Krishnaswamy ^a   Pajor, Lorraine M ^a   Knipe, Jay ^a   Gao, Qi ^a   Perrone, Robert ^a   Starrett Jr , John E ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; FUNCTIONAL GROUP; INDOLE DERIVATIVE; ISATIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; CYCLOADDITION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG ISOLATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR CLONING; NONHUMAN;

ANIMALS; BRAIN; CALCIUM; CELLS, CULTURED; DIAZONIUM COMPOUNDS; HUMANS; INDOLES; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MICROINJECTIONS; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; XENOPUS;

EID: 18344365176     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00101-4     Document Type: Article

References (14)