Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing

Nature Structural and Molecular Biology

Volumn 11, Issue 2, 2004, Pages 171-178

  Tang, Xiang Dong ^a   Garcia, Maria L ^b   Heinemann, Stefan H ^c   Hoshi, Toshinori ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; CYSTEINE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE;

ARTICLE; BETA CHAIN; BLOOD VESSEL TONE; CALCIUM TRANSPORT; CONTROLLED STUDY; DIABETES MELLITUS; HUMAN; HUMAN CELL; INFLAMMATION; ISCHEMIC HEART DISEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; STROKE; VASCULAR DISEASE;

AMINO ACID SEQUENCE; CALCIUM; CYSTEINE; HYDROGEN PEROXIDE; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROTEIN CONFORMATION; REACTIVE OXYGEN SPECIES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0742305296     PISSN: 15459993     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsmb725     Document Type: Article

References (47)

1. Anderson, R.N. & Smith, B.L. Deaths: leading causes for 2001. Natl. Vital Stat. Rep. 52, 86 (2003).
2. Halliwell, B. & Gutteridge, J.M.C. Free Radicals in Biology and Medicine (Oxford University Press, New York, 1999).
3. Ross, R. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340, 115-126 (1999).
4. Hensley, K., Robinson, K.A., Gabbita, S.P., Salsman, S. & Floyd, R.A. Reactive oxygen species, cell signaling, and cell injury. Free Radic. Biol. Med. 28, 1456-1462 (2000).
5. Clarke, R. & Armitage, J. Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials. Cardiovasc. Drugs. Ther. 16, 411-415 (2002).
6. Fennell, J.P. et al. Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension. Gene Ther. 9, 110-117 (2002).
7. Nelson, M.T. et al. Relaxation of arterial smooth muscle by calcium sparks. Science 270, 633-637 (1995).
8. Ca channels in smooth muscle cells from rat cerebral arteries. J. Gen. Physiol. 113, 229-238 (1999).
9. 2+ current. J. Gen. Physiol. 116, 845-864 (2000).
10. Lohn, M. et al. Regulation of calcium sparks and spontaneous transient outward currents by RyR3 in arterial vascular smooth muscle cells. Circ. Res. 89, 1051-1057 (2001).
11. Shen, K.Z. et al. Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: evidence for tetrameric channel formation. Pflügers Arch. 426, 440-445 (1994).
12. + channels. J. Neurosci. 22, 1550-1561 (2002).
13. Brenner, R., Jegla, T.J., Wickenden, A., Liu, Y. & Aldrich, R.W. Cloning and functional characterization of novel large conductance calcium-activated potassium channel subunits, hKCNMB3 and hKCNMB4. J. Biol. Chem. 275, 6453-6461 (2000).
14. Brenner, R. et al. Vasoregulation by the β1 subunit of the calcium-activated potassium channel. Nature 407, 870-876 (2000).
15. 2+ spark/STOC coupling and elevated blood pressure. Circ. Res. 87, E53-60 (2000).
16. Patterson, A.J., Henrie-Olson, J. & Brenner, R. Vasoregulation at the molecular level: a role for the β1 subunit of the calcium-activated potassium (BK) channel. Trends Cardiovasc. Med. 12, 78-82 (2002).
17. Cai, H. & Harrison, D.G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. 87, 840-844 (2000).
18. + channels in smooth muscle cells. J. Gen. Physiol. 110, 35-44 (1997).
19. + channels in rat cerebral artery smooth muscle cells. Am. J. Physiol. 278, H1883-H1890 (2000).
20. Tang, X.D. et al. Oxidative regulation of large conductance calcium-activated potassium channels. J. Gen. Physiol. 117, 253-274 (2001).
21. + channel activity in smooth muscle of human coronary arterioles. Circ. Res. 91, 1070-1076 (2002).
22. + channel inhibition by reactive oxygen species. Am. J. Physiol. 232, C461-C471 (2002).
23. + channels in vascular smooth muscle during hypertension. J. Clin. Invest. 112, 717-724 (2003)
24. Gilbert, D.L. & Colton, C.A. Overview of reactive oxygen species. In Reactive Oxygen Species in Biological Systems (eds. Gilbert, D.L. & Colton, C.A.) 679-695 (Plenum, New York, 1999).
25. Avdonin, V., Tang, X.D. & Hoshi, T. Stimulatory action of internal protons on Slo1 BK channels. Biophys. J. 84, 2969-2980 (2003).
26. Tang, X.D. et al. Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature 425, 531-535 (2003).
27. Lacy, F., Gough, D.A. & Schmid-Schonbein, G.W. Role of xanthine oxidase in hydrogen peroxide production. Free Radic. Biol. Med. 25, 720-727 (1998).
28. Dröge, W. Free radicals in the physiological control of cell function. Physiol Rev 82, 47-95, (2002).
29. + channels. J. Neurosci. 17, 4942-4955 (1997).
30. Jiang, Y. et al. Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417, 515-522, (2002),
31. 2+ binding and channel opening in large conductance (BK) potassium channels. J. Gen. Physiol. 120, 267-305 (2002).
32. Magleby, K.L. Gating mechanism of BK (Slo1) channels: so near, yet so far. J. Gen. Physiol. 121, 81-96 (2003).
33. Xia, X.M., Zeng, X. & Lingle, C.J. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature 418, 880-884 (2002).
34. Schreiber, M. & Salkoff, L. A novel calcium-sensing domain in the BK channel. Biophys. J. 73, 1355-1363 (1997).
35. 2+-dependent activation. Proc. Natl. Acad. Sci. USA 98, 4776-4781 (2001).
36. 2+. Proc. Natl. Acad. Sci. USA 99, 11441-11446 (2002).
37. Beckman, J.S. & Koppenol, W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol. 271, C1424-C1437 (1996).
38. Erxleben, C. et al. Interacting effects of N-terminal variation and strex exon splicing on slo potassium channel regulation by calcium, phosphorylation, and oxidation. J. Biol. Chem. 277, 27045-27052 (2002).
39. Zeng, X.H., Xia, X.M. & Lingle, C.J. Redox-sensitive extracellular gates formed by auxiliary β subunits of calcium-activated potassium channels. Nat. Struct. Biol. 10, 448-454 (2003).
40. Gribkoff, V.K. et al. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels. Nat. Med. 7, 471-477 (2001).
41. Giasson, B.I., Ischiropoulos, H., Lee, V.M. & Trojanowski, J.Q. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radic. Biol. Med. 32, 1264-1275 (2002).
42. Kaczorowski, G.J., Knaus, H.G., Leonard, R.J., McManus, O.B. & Garcia, M.L. High-conductance calcium-activated potassium channels; structure, pharmacology, and function. J. Bioenerg. Biomembr. 28, 255-267 (1996).
43. + channels. Biochemistry 39, 15612-15619. (2000).
44. 2+ through a nonselective, low affinity divalent cation site. J. Gen. Physiol. 118, 607-635 (2001).
45. + channel. J. Physiol. 533, 681-695 (2001).
46. 2+ sensitivity. J. Gen. Physiol. 120, 173-189 (2002).
47. Ca potassium channels lacking the calcium bowl and RCK domains. Nature 420, 499-502 (2002).