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Volumn 200, Issue , 2004, Pages 261-271

New concepts in the regulation of an ancient reaction: Transposition by RAG1/RAG2

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; ENDONUCLEASE; IMMUNOGLOBULIN; LYMPHOCYTE ANTIGEN RECEPTOR; RAG1 PROTEIN; RAG2 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSPOSASE;

EID: 3242886493     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2004.00167.x     Document Type: Review
Times cited : (18)

References (71)
  • 1
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity. Nature 1983;302:575-581.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 2
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene, RAG-1
    • Schatz DG, Oettinger MA, Baltimore D. The V(D)J recombination activating gene, RAG-1. Cell 1989;59:1035-1048.
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 3
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger MA, Schatz DG, Gorka C, Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 1990;248:1517-1523.
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 4
    • 0030994385 scopus 로고    scopus 로고
    • Stimulation of V(D)J cleavage by high mobility group proteins
    • van Gent DC, Hiom K, Paull TT, Gellert M. Stimulation of V(D)J cleavage by high mobility group proteins. EMBO J 1997;16:2665-2670.
    • (1997) EMBO J , vol.16 , pp. 2665-2670
    • Van Gent, D.C.1    Hiom, K.2    Paull, T.T.3    Gellert, M.4
  • 5
    • 0030980386 scopus 로고    scopus 로고
    • V(D)J recombination: Modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins
    • Sawchuk DJ, et al. V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins. J Exp Med 1997;185:2025-2032.
    • (1997) J Exp Med , vol.185 , pp. 2025-2032
    • Sawchuk, D.J.1
  • 6
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • McBlane JF, et al. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 1995;83:387-395.
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1
  • 7
    • 0035008189 scopus 로고    scopus 로고
    • RAG1 and RAG2 in V(D)J recombination and transposition
    • Fugmann SD. RAG1 and RAG2 in V(D)J recombination and transposition. Immunol Res 2001;23:23-39.
    • (2001) Immunol Res , vol.23 , pp. 23-39
    • Fugmann, S.D.1
  • 8
    • 0030964130 scopus 로고    scopus 로고
    • A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
    • Hiom K, Gellert M. A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage. Cell 1997;88:65-72.
    • (1997) Cell , vol.88 , pp. 65-72
    • Hiom, K.1    Gellert, M.2
  • 9
    • 0031826699 scopus 로고    scopus 로고
    • Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences
    • Akamatsu Y, Oettinger MA. Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences. Mol Cell Biol 1998;18:4670-4678.
    • (1998) Mol Cell Biol , vol.18 , pp. 4670-4678
    • Akamatsu, Y.1    Oettinger, M.A.2
  • 10
    • 0033548653 scopus 로고    scopus 로고
    • RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro
    • Mo X, Bailin T, Sadofsky MJ. RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro. J Biol Chem 1999;274:7025-7031.
    • (1999) J Biol Chem , vol.274 , pp. 7025-7031
    • Mo, X.1    Bailin, T.2    Sadofsky, M.J.3
  • 11
    • 0031770944 scopus 로고    scopus 로고
    • The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step
    • West RB, Lieber MR. The RAG-HMG1 complex enforces the 12/23 rule of V(D)J recombination specifically at the double-hairpin formation step. Mol Cell Biol 1998;18:6408-6415.
    • (1998) Mol Cell Biol , vol.18 , pp. 6408-6415
    • West, R.B.1    Lieber, M.R.2
  • 12
    • 0030678531 scopus 로고    scopus 로고
    • Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage
    • Eastman QM, Schatz DG. Nicking is asynchronous and stimulated by synapsis in 12/23 rule-regulated V(D)J cleavage. Nucleic Acids Res 1997;25:4370-4378.
    • (1997) Nucleic Acids Res , vol.25 , pp. 4370-4378
    • Eastman, Q.M.1    Schatz, D.G.2
  • 13
    • 0001316589 scopus 로고    scopus 로고
    • Functional analysis of coordinated cleavage in V(D)J recombination
    • Kim DR, Oettinger MA. Functional analysis of coordinated cleavage in V(D)J recombination. Mol Cell Biol 1998;18:4679-4688.
    • (1998) Mol Cell Biol , vol.18 , pp. 4679-4688
    • Kim, D.R.1    Oettinger, M.A.2
  • 14
    • 0032084698 scopus 로고    scopus 로고
    • Assembly of a 12/23 paired signal complex: A critical control point in V(D)J recombination
    • Hiom K, Gellert M. Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination. Mol Cell 1998;1:1011-1019.
    • (1998) Mol Cell , vol.1 , pp. 1011-1019
    • Hiom, K.1    Gellert, M.2
  • 15
    • 0036682980 scopus 로고    scopus 로고
    • Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination
    • Tsai CL, Drejer AH, Schatz DG. Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination. Genes Dev 2002;16:1934-1949.
    • (2002) Genes Dev , vol.16 , pp. 1934-1949
    • Tsai, C.L.1    Drejer, A.H.2    Schatz, D.G.3
  • 16
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • Agrawal A, Schatz DG. RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell 1997;89:43-53.
    • (1997) Cell , vol.89 , pp. 43-53
    • Agrawal, A.1    Schatz, D.G.2
  • 17
    • 0028801363 scopus 로고
    • Formation and resolution of double-strand break intermediates in V(D)J rearrangement
    • Ramsden DA, Gellert M. Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes Dev 1995;9:2409-2420.
    • (1995) Genes Dev , vol.9 , pp. 2409-2420
    • Ramsden, D.A.1    Gellert, M.2
  • 19
    • 0035997348 scopus 로고    scopus 로고
    • V(D)J recombination: RAG proteins, repair factors, and regulation
    • Gellert M. V(D)J recombination: RAG proteins, repair factors, and regulation. Annu Rev Biochem 2002;71:101-132.
    • (2002) Annu Rev Biochem , vol.71 , pp. 101-132
    • Gellert, M.1
  • 20
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D)J recombination
    • Bassing CH, Swat W, Alt FW. The mechanism and regulation of chromosomal V(D)J recombination. Cell 2002;109:S45-S55.
    • (2002) Cell , vol.109
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 21
    • 0027491330 scopus 로고
    • Characterization of broken DNA molecules associated with V(D)J recombination
    • Roth DB, Zhu C, Gellert M. Characterization of broken DNA molecules associated with V(D)J recombination. Proc Natl Acad Sci USA 1993;90:10788-10792.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10788-10792
    • Roth, D.B.1    Zhu, C.2    Gellert, M.3
  • 22
    • 0035818603 scopus 로고    scopus 로고
    • Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends
    • Jones JM, Gellert M. Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends. Proc Natl Acad Sci USA 2001;98:12926-12931.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12926-12931
    • Jones, J.M.1    Gellert, M.2
  • 23
    • 0027770854 scopus 로고
    • Expression and V(D)J recombination activity of mutated RAG-1 proteins
    • Sadofsky MJ, Hesse JE, McBlane JF, Gellert M, Expression and V(D)J recombination activity of mutated RAG-1 proteins. Nucleic Acids Res 1993;21:5644-5650.
    • (1993) Nucleic Acids Res , vol.21 , pp. 5644-5650
    • Sadofsky, M.J.1    Hesse, J.E.2    McBlane, J.F.3    Gellert, M.4
  • 24
    • 0027197151 scopus 로고
    • Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
    • Silver DPSE, Mulligan RC, Baltimore D. Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination. Proc Natl Acad Sci USA 1993;90:6100-6104.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6100-6104
    • Silver, D.P.S.E.1    Mulligan, R.C.2    Baltimore, D.3
  • 25
    • 0028237683 scopus 로고
    • Definition of a core region of RAG-2 that is functional in V(D)J recombination
    • Sadofsky MJ, Hesse JE, Gellert M. Definition of a core region of RAG-2 that is functional in V(D)J recombination. Nucleic Acids Res 1994;22:1805-1809.
    • (1994) Nucleic Acids Res , vol.22 , pp. 1805-1809
    • Sadofsky, M.J.1    Hesse, J.E.2    Gellert, M.3
  • 26
    • 0028307661 scopus 로고
    • Analysis of regions of RAG-2 important for V(D)J recombination
    • Cuomo CA, Oettinger MA. Analysis of regions of RAG-2 important for V(D)J recombination. Nucleic Acids Res 1994;22:1810-1814.
    • (1994) Nucleic Acids Res , vol.22 , pp. 1810-1814
    • Cuomo, C.A.1    Oettinger, M.A.2
  • 27
    • 0036850786 scopus 로고    scopus 로고
    • The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development
    • Liang HE, Hsu LY, Cado D, Cowell LG, Kelsoe G, Schlissel MS. The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development. Immunity 2002;17:639-651.
    • (2002) Immunity , vol.17 , pp. 639-651
    • Liang, H.E.1    Hsu, L.Y.2    Cado, D.3    Cowell, L.G.4    Kelsoe, G.5    Schlissel, M.S.6
  • 28
    • 0037417795 scopus 로고    scopus 로고
    • Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
    • Akamatsu Y, et al. Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proc Natl Acad Sci USA 2003;100:1209-1214.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1209-1214
    • Akamatsu, Y.1
  • 29
    • 0242610985 scopus 로고    scopus 로고
    • Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice
    • Dudley DD, et al. Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. J Exp Med 2003;198:1439-1450.
    • (2003) J Exp Med , vol.198 , pp. 1439-1450
    • Dudley, D.D.1
  • 30
    • 0032913232 scopus 로고    scopus 로고
    • Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination
    • Steen SB, Han JO, Mundy C, Oettinger MA, Roth DB. Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination. Mol Cell Biol 1999;19:3010-3017.
    • (1999) Mol Cell Biol , vol.19 , pp. 3010-3017
    • Steen, S.B.1    Han, J.O.2    Mundy, C.3    Oettinger, M.A.4    Roth, D.B.5
  • 31
    • 0035161258 scopus 로고    scopus 로고
    • V(D)J recombination defects in lymphocytes due to RAG mutations: Severe immunodeficiency with a spectrum of clinical presentations
    • Villa A, et al. V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations. Blood 2001;97:81-88.
    • (2001) Blood , vol.97 , pp. 81-88
    • Villa, A.1
  • 32
    • 0347994908 scopus 로고    scopus 로고
    • Autoubiquitylation of the V(D)J recombinase protein RAG1
    • Jones JM, Gellert M. Autoubiquitylation of the V(D)J recombinase protein RAG1. Proc Natl Acad Sci USA 2003;100:15446-15451.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15446-15451
    • Jones, J.M.1    Gellert, M.2
  • 33
    • 0037335702 scopus 로고    scopus 로고
    • The RAG1 N-terminal domain is an E3 ubiquitin ligase
    • Yurchenko V, Xue Z, Sadofsky M. The RAG1 N-terminal domain is an E3 ubiquitin ligase. Genes Dev 2003;17:581-585.
    • (2003) Genes Dev , vol.17 , pp. 581-585
    • Yurchenko, V.1    Xue, Z.2    Sadofsky, M.3
  • 34
    • 0030498092 scopus 로고    scopus 로고
    • A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle
    • Li Z, Dordai DI, Lee J, Desiderio S. A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle. Immunity 1996;5:575-589.
    • (1996) Immunity , vol.5 , pp. 575-589
    • Li, Z.1    Dordai, D.I.2    Lee, J.3    Desiderio, S.4
  • 35
    • 0025324784 scopus 로고
    • Chromosomal translocations in lymphoid neoplasia: A reappraisal of the recombinase model
    • Tycko B, Sklar J. Chromosomal translocations in lymphoid neoplasia: a reappraisal of the recombinase model. Cancer Cells 1990;2:1-8.
    • (1990) Cancer Cells , vol.2 , pp. 1-8
    • Tycko, B.1    Sklar, J.2
  • 36
    • 0026721505 scopus 로고
    • Choromosomal translocations in lymphoid malignancies reveal novel protooncogenes
    • Korsemeyer S. Choromosomal translocations in lymphoid malignancies reveal novel protooncogenes. Annu Rev Immunol 1992; 10:785-807.
    • (1992) Annu Rev Immunol , vol.10 , pp. 785-807
    • Korsemeyer, S.1
  • 37
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998;396:643-649.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 38
    • 0037660900 scopus 로고    scopus 로고
    • The role of DNA breaks in genomic instability and tumorigenesis
    • Mills KD, Ferguson DO, Alt FW. The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev 2003;194:77-95.
    • (2003) Immunol Rev , vol.194 , pp. 77-95
    • Mills, K.D.1    Ferguson, D.O.2    Alt, F.W.3
  • 39
    • 0141720776 scopus 로고    scopus 로고
    • Restraining the V(D)J recombinase
    • Roth DB. Restraining the V(D)J recombinase. Nat Rev Immunol 2003;3:656-666.
    • (2003) Nat Rev Immunol , vol.3 , pp. 656-666
    • Roth, D.B.1
  • 40
    • 1542287213 scopus 로고    scopus 로고
    • A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex
    • Raghavan SC, Swanson PC, Wu X, Hsieh CL, Lieber MR. A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex. Nature 2004;428:88-93.
    • (2004) Nature , vol.428 , pp. 88-93
    • Raghavan, S.C.1    Swanson, P.C.2    Wu, X.3    Hsieh, C.L.4    Lieber, M.R.5
  • 41
    • 0032555758 scopus 로고    scopus 로고
    • DNA transposition by the RAG1 and RAG2 proteins: A possible source of oncogenic translocations
    • Hiom K, Melek M, Gellert M. DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations. Cell 1998;94:463-470.
    • (1998) Cell , vol.94 , pp. 463-470
    • Hiom, K.1    Melek, M.2    Gellert, M.3
  • 42
    • 0034625261 scopus 로고    scopus 로고
    • RAG1/2-mediated resolution of transposition intermediates: Two pathways and possible consequences
    • Melek M, Gellert M. RAG1/2-mediated resolution of transposition intermediates: two pathways and possible consequences. Cell 2000;101:625-633.
    • (2000) Cell , vol.101 , pp. 625-633
    • Melek, M.1    Gellert, M.2
  • 43
    • 0029967722 scopus 로고    scopus 로고
    • Similarities between initiation of V(D)J recombination and retroviral integration
    • van Gent DC, Mizuuchi K, Gellert M. Similarities between initiation of V(D)J recombination and retroviral integration. Science 1996;271:1592-1594.
    • (1996) Science , vol.271 , pp. 1592-1594
    • Van Gent, D.C.1    Mizuuchi, K.2    Gellert, M.3
  • 44
    • 0024255703 scopus 로고
    • Novel strand exchanges in V(D)J recombination
    • Lewis SM, Hesse JE, Mizuuchi K, Gellert M. Novel strand exchanges in V(D)J recombination. Cell 1988;55:1099-1107.
    • (1988) Cell , vol.55 , pp. 1099-1107
    • Lewis, S.M.1    Hesse, J.E.2    Mizuuchi, K.3    Gellert, M.4
  • 45
    • 0033954892 scopus 로고    scopus 로고
    • Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex
    • Fugmann SD, Villey IJ, Ptaszek LM, Schatz DG. Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. Mol Cell 2000;5:97-107.
    • (2000) Mol Cell , vol.5 , pp. 97-107
    • Fugmann, S.D.1    Villey, I.J.2    Ptaszek, L.M.3    Schatz, D.G.4
  • 46
    • 0032551829 scopus 로고    scopus 로고
    • Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
    • Agrawal A, Eastman QM, Schatz DG. Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature 1998;394:744-751.
    • (1998) Nature , vol.394 , pp. 744-751
    • Agrawal, A.1    Eastman, Q.M.2    Schatz, D.G.3
  • 47
    • 0242636324 scopus 로고    scopus 로고
    • The outs and ins of transposition: From mu to kangaroo
    • Curcio MJ, Derbyshire KM. The outs and ins of transposition: from mu to kangaroo. Nat Rev Mol Cell Biol 2003;4:865-877.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 865-877
    • Curcio, M.J.1    Derbyshire, K.M.2
  • 48
    • 0004224917 scopus 로고
    • Washington DC: American Society for Microbiology
    • Berg D, Howe M. Mobile DNA. Washington DC: American Society for Microbiology, 1989.
    • (1989) Mobile DNA
    • Berg, D.1    Howe, M.2
  • 50
    • 0032723359 scopus 로고    scopus 로고
    • Integrating DNA: Transposases and retroviral integrases
    • Haren L, Ton-Hoang B, Chandler M. Integrating DNA: transposases and retroviral integrases. Annu Rev Microbiol 1999;53:245-281.
    • (1999) Annu Rev Microbiol , vol.53 , pp. 245-281
    • Haren, L.1    Ton-Hoang, B.2    Chandler, M.3
  • 51
    • 0033179759 scopus 로고    scopus 로고
    • Resident aliens: The Tc1/mariner superfamily of transposable elements
    • Plasterk RH, Izsvak Z, Ivics Z. Resident aliens: the Tc1/mariner superfamily of transposable elements. Trends Genet 1999;15:326-332.
    • (1999) Trends Genet , vol.15 , pp. 326-332
    • Plasterk, R.H.1    Izsvak, Z.2    Ivics, Z.3
  • 52
    • 0345146909 scopus 로고    scopus 로고
    • In vivo transposition mediated by V(D)J recombinase in human T lymphocytes
    • Messier TL, O'Neill JP, Hou SM, Nicklas JA, Finette BA. In vivo transposition mediated by V(D)J recombinase in human T lymphocytes. EMBO J 2003;22:1381-1388.
    • (2003) EMBO J , vol.22 , pp. 1381-1388
    • Messier, T.L.1    O'Neill, J.P.2    Hou, S.M.3    Nicklas, J.A.4    Finette, B.A.5
  • 54
    • 0026762509 scopus 로고
    • V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor delta rearrangement signals
    • Roth DB, Nakajima PB, Menetski JP, Bosma MJ, Gellert M. V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor delta rearrangement signals. Cell 1992;69:41-53.
    • (1992) Cell , vol.69 , pp. 41-53
    • Roth, D.B.1    Nakajima, P.B.2    Menetski, J.P.3    Bosma, M.J.4    Gellert, M.5
  • 55
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated
    • Schlissel M, Constantinescu A, Morrow T, Baxter M, Peng A. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′- phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev 1993;7:2520-2532.
    • (1993) Genes Dev , vol.7 , pp. 2520-2532
    • Schlissel, M.1    Constantinescu, A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 56
    • 0030069149 scopus 로고    scopus 로고
    • T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells
    • Livak F, Schatz DG. T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol Cell Biol 1996;16:609-618.
    • (1996) Mol Cell Biol , vol.16 , pp. 609-618
    • Livak, F.1    Schatz, D.G.2
  • 57
    • 0036242313 scopus 로고    scopus 로고
    • The V(D)J recombinase efficiently cleaves and transposes signal joints
    • Neiditch MB, Lee GS, Huye LE, Brandt VL, Roth DB. The V(D)J recombinase efficiently cleaves and transposes signal joints. Mol Cell 2002;9:871-878.
    • (2002) Mol Cell , vol.9 , pp. 871-878
    • Neiditch, M.B.1    Lee, G.S.2    Huye, L.E.3    Brandt, V.L.4    Roth, D.B.5
  • 58
    • 1542289024 scopus 로고    scopus 로고
    • Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteinsY
    • Jiang H, Ross AE, Desiderio S. Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteinsY. J Biol Chem 2004;279:8478-8486.
    • (2004) J Biol Chem , vol.279 , pp. 8478-8486
    • Jiang, H.1    Ross, A.E.2    Desiderio, S.3
  • 59
    • 0032555695 scopus 로고    scopus 로고
    • VDJ recombination: A transposase goes to work
    • Roth DB, Craig NL. VDJ recombination: a transposase goes to work. Cell 1998;94:411-414.
    • (1998) Cell , vol.94 , pp. 411-414
    • Roth, D.B.1    Craig, N.L.2
  • 60
    • 0032502886 scopus 로고    scopus 로고
    • Rejoining of DNA by the RAG1 and RAG2 proteins
    • Melek M, Gellert M, van Gent DC. Rejoining of DNA by the RAG1 and RAG2 proteins. Science 1998;280:301-303.
    • (1998) Science , vol.280 , pp. 301-303
    • Melek, M.1    Gellert, M.2    Van Gent, D.C.3
  • 61
    • 0035697242 scopus 로고    scopus 로고
    • Increased accumulation of hybrid V(D)J joins in cells expressing, truncated versus full-length RAGs
    • Sekiguchi JA, Whitlow S, Alt FW. Increased accumulation of hybrid V(D)J joins in cells expressing, truncated versus full-length RAGs. Mol Cell 2001;8:1383-1390.
    • (2001) Mol Cell , vol.8 , pp. 1383-1390
    • Sekiguchi, J.A.1    Whitlow, S.2    Alt, F.W.3
  • 62
    • 0030837472 scopus 로고    scopus 로고
    • V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation
    • Bogue MA, Wang C, Zhu C, Roth DB. V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation. Immunity 1997;7:37-47.
    • (1997) Immunity , vol.7 , pp. 37-47
    • Bogue, M.A.1    Wang, C.2    Zhu, C.3    Roth, D.B.4
  • 63
    • 0030934860 scopus 로고    scopus 로고
    • Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products
    • Han JO, Steen SB, Roth DB. Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products. Mol Cell Biol 1997;17:2226-2234.
    • (1997) Mol Cell Biol , vol.17 , pp. 2226-2234
    • Han, J.O.1    Steen, S.B.2    Roth, D.B.3
  • 64
    • 0037447298 scopus 로고    scopus 로고
    • Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2
    • Tsai CL, Schatz DG. Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2. EMBO J 2003;22:1922-1930.
    • (2003) EMBO J , vol.22 , pp. 1922-1930
    • Tsai, C.L.1    Schatz, D.G.2
  • 65
    • 0037447338 scopus 로고    scopus 로고
    • The C-terminal portion of RAG2 protects against transposition in vitro
    • Elkin SK, Matthews AG, Oettinger MA. The C-terminal portion of RAG2 protects against transposition in vitro. EMBO J 2003;22:1931-1938.
    • (2003) EMBO J , vol.22 , pp. 1931-1938
    • Elkin, S.K.1    Matthews, A.G.2    Oettinger, M.A.3
  • 66
    • 1042301422 scopus 로고    scopus 로고
    • Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition, but not hybrid joint formation or disintegrations
    • Swanson PC, Volkmer D, Wang L. Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition, but not hybrid joint formation or disintegrations. J Biol Chem 2004;279:4034-4044.
    • (2004) J Biol Chem , vol.279 , pp. 4034-4044
    • Swanson, P.C.1    Volkmer, D.2    Wang, L.3
  • 67
    • 1842472070 scopus 로고    scopus 로고
    • Ordered DNA release and target capture in RAG transposition
    • Matthews AG, Elkin SK, Oettinger MA. Ordered DNA release and target capture in RAG transposition. EMBO J 2004;23:1198-1206.
    • (2004) EMBO J , vol.23 , pp. 1198-1206
    • Matthews, A.G.1    Elkin, S.K.2    Oettinger, M.A.3
  • 68
    • 0034967436 scopus 로고    scopus 로고
    • RAG transposase can capture and commit to target DNA before or after donor cleavage
    • Neiditch MB, Lee GS, Landree MA, Roth DB. RAG transposase can capture and commit to target DNA before or after donor cleavage. Mol Cell Biol 2001;21:4302-4310.
    • (2001) Mol Cell Biol , vol.21 , pp. 4302-4310
    • Neiditch, M.B.1    Lee, G.S.2    Landree, M.A.3    Roth, D.B.4
  • 69
    • 0032429191 scopus 로고    scopus 로고
    • Mobile DNA elements: Controlling transposition with ATP-dependent molecular switches
    • Stellwagen AE, Craig NL. Mobile DNA elements: controlling transposition with ATP-dependent molecular switches. Trends Biochem Sci 1998;23:486-490.
    • (1998) Trends Biochem Sci , vol.23 , pp. 486-490
    • Stellwagen, A.E.1    Craig, N.L.2
  • 70
    • 0028143584 scopus 로고
    • Physiological concentrations of purines and pyrimidines
    • Traut TW. Physiological concentrations of purines and pyrimidines. Mol Cell Biochem 1994;140:1-22.
    • (1994) Mol Cell Biochem , vol.140 , pp. 1-22
    • Traut, T.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.