The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development

Immunity

Volumn 17, Issue 5, 2002, Pages 639-651

  Liang, Hong Erh ^a,b   Hsu, Lih Yun ^a,b   Cado, Dragana ^a   Cowell, Lindsay G ^c   Kelsoe, Garnett ^c   Schlissel, Mark S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; RAG2 PROTEIN; RECOMBINASE; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CATALYST; CELL CYCLE PHASE; CELL DIVISION; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE LOCUS; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC RECOMBINATION; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REDUCTION; T LYMPHOCYTE; THYMOCYTE;

EID: 0036850786     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00448-X     Document Type: Article

References (43)

1. Akamatsu Y., Oettinger M.A. Distinct roles of RAG1 and RAG2 in binding the V(D)J recombination signal sequences. Mol. Cell. Biol. 18:1998;4670-4678.
2. Bassing C.H., Alt F.W., Hughes M.M., D'Auteuil M., Wehrly T.D., Woodman B.B., Gartner F., White J.M., Davidson L., Sleckman B.P. Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature. 405:2000;583-586.
3. Connor A.M., Fanning L.J., Celler J.W., Hicks L.K., Ramsden D.A., Wu G.E. Mouse VH7183 recombination signal sequences mediate recombination more frequently than those of VHJ558. J. Immunol. 155:1995;5268-5272.
4. Constantinescu A., Schlissel M.S. Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development. J. Exp. Med. 185:1997;609-620.
5. Corcoran A.E., Riddell A., Krooshoop D., Venkitaraman A.R. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature. 391:1998;904-907.
6. Cowell L.G., Davilla M., Kepler T.B., Kelsoe G. Identification and utilization of arbitrary correlations in models of recombination signal sequences. Genome Biol. in press:2002.
7. Eastman Q.M., Leu T.M., Schatz D.G. Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature. 380:1996;85-88.
8. Eastman Q.M., Villey I.J., Schatz D.G. Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking. Mol. Cell. Biol. 19:1999;3788-3797.
9. Fugmann S.D., Schatz D.G. Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex. Mol. Cell. 8:2001;899-910.
10. Fugmann S.D., Lee A.I., Shockett P.E., Villey I.J., Schatz D.G. The RAG proteins and V(D)J recombination. complexes, ends, and transposition Annu. Rev. Immunol. 18:2000;495-527.
11. Han S., Dillon S.R., Zheng B., Shimoda M., Schlissel M.S., Kelsoe G. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science. 278:1997;301-305.
12. Hardy R.R., Carmack C.E., Shinton S.A., Kemp J.D., Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1991;1213-1225.
13. Hempel W.M., Stanhope-Baker P., Mathieu N., Huang F., Schlissel M.S., Ferrier P. Enhancer control of V(D)J recombination at the TCRbeta locus. differential effects on DNA cleavage and joining Genes Dev. 12:1998;2305-2317.
14. Hernandez-Munain C., Sleckman B.P., Krangel M.S. A developmental switch from TCRδ enhancer to TCRα enhancer function during thymocyte maturation. Immunity. 10:1999;723-733.
15. Hesslein D.G., Schatz D.G. Factors and forces controlling V(D)J recombination. Adv. Immunol. 78:2001;169-232.
16. Kirch S.A., Sudarsanam P., Oettinger M.A. Regions of RAG1 protein critical for V(D)J recombination. Eur. J. Immunol. 26:1996;886-891.
17. Kirch S.A., Rathbun G.A., Oettinger M.A. Dual role of RAG2 in V(D)J recombination. catalysis and regulation of ordered Ig gene assembly EMBO J. 17:1998;4881-4886.
18. Landree M.A., Wibbenmeyer J.A., Roth D.B. Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. Genes Dev. 13:1999;3059-3069.
19. Lauzurica P., Krangel M.S. Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene. J. Exp. Med. 179:1994;43-55.
20. Levchenko I., Yamauchi M., Baker T.A. ClpX and MuB interact with overlapping regions of Mu transposase. implications for control of the transposition pathway Genes Dev. 11:1997;1561-1572.
21. Li Z., Dordai D.I., Lee J., Desiderio S. A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle. Immunity. 5:1996;575-589.
22. Lieber M.R., Hesse J.E., Lewis S., Bosma G.C., Rosenberg N., Mizuuchi K., Bosma M.J., Gellert M. The defect in murine severe combined immune deficiency. joining of signal sequences but not coding segments in V(D)J recombination Cell. 55:1988;7-16.
23. Lin W.C., Desiderio S. Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation. Science. 260:1993;953-959.
24. McMahan C.J., Difilippantonio M.J., Rao N., Spanopoulou E., Schatz D.G. A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity. Mol. Cell. Biol. 17:1997;4544-4552.
25. McMurry M.T., Krangel M.S. A role for histone acetylation in the developmental regulation of VDJ recombination. Science. 287:2000;495-498.
26. Mo X., Bailin T., Sadofsky M.J. RAG1 and RAG2 cooperate in specific binding to the recombination signal sequence in vitro. J. Biol. Chem. 274:1999;7025-7031.
27. Naramura M., Hu R.J., Gu H. Mice with a fluorescent marker for interleukin 2 gene activation. Immunity. 9:1998;209-216.
28. Qiu J.X., Kale S.B., Yarnell Schultz H., Roth D.B. Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination. Mol. Cell. 7:2001;77-87.
29. Roman C.A., Cherry S.R., Baltimore D. Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1. Immunity. 7:1997;13-24.
30. Schlissel M.S. Structure of nonhairpin coding-end DNA breaks in cells undergoing V(D)J recombination. Mol. Cell. Biol. 18:1998;2029-2037.
31. Schlissel M.S., Baltimore D. Activation of immunoglobulin κ gene rearrangement correlates with induction of germline κ gene transcription. Cell. 58:1989;1001-1007.
32. Schlissel M.S., Corcoran L.M., Baltimore D. Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J. Exp. Med. 173:1991;711-720.
33. Schlissel M., Constantinescu A., Morrow T., Baxter M., Peng A. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7:1993;2520-2532.
34. Schlissel M.S., Durum S.D., Muegge K. The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinase. J. Exp. Med. 191:2000;1045-1050.
35. Sekiguchi J.A., Whitlow S., Alt F.W. Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs. Mol. Cell. 8:2001;1383-1390.
36. Sleckman B.P., Gorman J.R., Alt F.W. Accessibility control of antigen-receptor variable-region gene assembly. role of cis-acting elements Annu. Rev. Immunol. 14:1996;459-481.
37. Stanhope-Baker P., Hudson K.M., Shaffer A.L., Constantinescu A., Schlissel M.S. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell. 85:1996;887-897.
38. Steen S.B., Han J.O., Mundy C., Oettinger M.A., Roth D.B. Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination. Mol. Cell. Biol. 19:1999;3010-3017.
39. Swanson P.C., Desiderio S. V(D)J recombination signal recognition. distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2 Immunity. 9:1998;115-125.
40. Swanson P.C., Desiderio S. RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex. Mol. Cell. Biol. 19:1999;3674-3683.
41. Tillman R.E., Wooley A.L., Hughes M.M., Wehrly T.D., Swat W., Sleckman B.P. Restrictions limiting the generation of DNA double strand breaks during chromosomal V(D)J recombination. J. Exp. Med. 195:2002;309-316.
42. von Boehmer H., Aifantis I., Feinberg J., Lechner O., Saint-Ruf C., Walter U., Buer J., Azogui O. Pleiotropic changes controlled by the pre-T-cell receptor. Curr. Opin. Immunol. 11:1999;135-142.
43. Williams G.S., Martinez A., Montalbano A., Tang A., Mauhar A., Ogwaro K.M., Merz D., Chevillard C., Riblet R., Feeney A.J. Unequal VH gene rearrangement frequency within the large VH7183 gene family is not due to recombination signal sequence variation, and mapping of the genes shows a bias of rearrangement based on chromosomal location. J. Immunol. 167:2001;257-263.