Phosphinic peptides: Synthetic approaches and biochemical evaluation as Zn-metalloprotease inhibitors

Current Organic Chemistry

Volumn 8, Issue 12, 2004, Pages 1135-1158

  Yiotakis, A ^a   Georgiadis, D ^a   Matziari, M ^a   Makaritis, A ^a   Dive, V ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b DIF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMATIC HYDROLYSIS; STRUCTURAL OPTIMIZATION;

ACID MOIETY; BIOCHEMICAL PROPERTIES; MEDICINAL CHEMISTRY; METALLOPROTEASE INHIBITORS; PHOSPHINIC ACID; PHYSICOCHEMICAL PROPERTY; SYNTHETIC APPROACH; TETRAHEDRAL STRUCTURES; TRANSITION STATE THEORIES; TRANSITION-STATE ANALOGUES;

PEPTIDES;

AMINOACYLASE; ANION; ANTIHYPERTENSIVE AGENT; CAPTOPRIL; CARBAPENEM DERIVATIVE; CILASTATIN; CILASTATIN PLUS IMIPENEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENALAPRILAT; FOSINOPRIL; FOSINOPRILAT; FUNCTIONAL GROUP; ION; LEUCINE ENKEPHALINAMIDE; LISINOPRIL; MATRIX METALLOPROTEINASE INHIBITOR; PEPSIN A; PEPSTATIN; PEPTIDASE; PEPTIDE DERIVATIVE; PHOSPHINIC ACID DERIVATIVE; PRODRUG; PROTEINASE; PROTEINASE INHIBITOR; PSEUDOPEPTIDE; RENIN INHIBITOR; UNINDEXED DRUG; VANCOMYCIN; ZINC ION;

ANTIBACTERIAL ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ANTIMICROBIAL ACTIVITY; BINDING AFFINITY; CARDIOVASCULAR DISEASE; CATALYSIS; CHEMICAL BOND; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CLINICAL TRIAL; CRYSTALLOGRAPHY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE; GEOMETRY; HUMAN; HYDROLYSIS; MOLECULAR STABILITY; NONHUMAN; PHYSICAL CHEMISTRY; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 3242767802     PISSN: 13852728     EISSN: None     Source Type: Journal    
DOI: 10.2174/1385272043370177     Document Type: Review

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