Novel inhibitors of trypanothione biosynthesis: Synthesis and evaluation of a phosphinate analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 5, 1997, Pages 505-510

  Chen, Shoujun ^a   Lin, Chun Hung ^b   Walsh, Christopher T ^b   Coward, James K ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROTOZOAL AGENT; ENZYME INHIBITOR; PHOSPHINIC ACID DERIVATIVE; SYNTHETASE; TRYPANOTHIONE;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; IN VITRO STUDY; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

EID: 0031552157     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00061-9     Document Type: Article

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