RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 8, 1999, Pages 4330-4335

  Dive, Vincent ^a   Cotton, Joël ^a   Yiotakis, Athanasios ^b   Michaud, Annie ^c   Vassiliou, Stamatia ^b   Jiracek, Jiri ^a,d   Vazeux, Gilles ^a   Chauvet, Marie Thérèse ^c   Cuniasse, Philippe ^a   Corvol, Pierre ^c  

^a CE Saclay ^*  (France)

^b UNIVERSITY OF ATHENS   (Greece)

^c INSERM   (France)

^d INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PHOSPHINIC ACID DERIVATIVE; RXP 407; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CHEMISTRY; DISSOCIATION CONSTANT; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ANALYSIS; ENZYME INHIBITION; HUMAN; HYDROLYSIS; INTRAVENOUS DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; RAT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; HUMANS; KINETICS; METABOLIC CLEARANCE RATE; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; PEPTIDE LIBRARY; PEPTIDYL-DIPEPTIDASE A; PHOSPHINIC ACIDS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 13044297058     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.8.4330     Document Type: Article

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