Highly potent and selective inhibitors of endothelin converting enzyme

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 11, 1996, Pages 1257-1260

  Chackalamannil, Samuel ^a   Chung, Shin ^a   Stamford, Andrew W ^a   McKittrick, Brian A ^a   Wang, Yuguang ^a   Tsai, Hsingan ^a   Cleven, Renée ^a   Fawzi, Ahmad ^a   Czarniecki, Michael ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN CONVERTING ENZYME; ENZYME INHIBITOR; PHOSPHORAMIDON;

ARTICLE; ATHEROSCLEROSIS; BRAIN VASOSPASM; CONGESTIVE HEART FAILURE; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; ENZYME INHIBITION; GUINEA PIG; HYPERTENSION; KIDNEY FAILURE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

CAVIA PORCELLUS; SUS SCROFA;

EID: 0029927216     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00211-9     Document Type: Article

References (16)

1. Yanagisawa, M.; Kurihara, H.; Kimura, S.; Tomobe, Y.; Kobayashi, M.; Mitsuit, Y.; Yazaki, Y.; Goto, K.; Masaki, T. Nature 1988, 322, 411.
2. Two additional isoforms of endothelin (endothelin-2 and endothelin-3) have been identified. Inoue, A.; Yanagisawa, M.; Kimura, S.; Kasuya, Y.; Miyauchi, T.; Goto, K.; Masaki, T. Proc. Natl. Acad. Sci. U.S.A. 1989, 86, 2863.
3. Epstein, F. H. N. Engl. J. Med. 1995, 333, 356 and references cited therein.
4. Doherty, A. M. J. Med. Chem. 1992, 35, 1493.
5. Rubanyi, G. M.; Polokoff, M. A. Pharmacol Rev. 1994, 46, 325.
6. Battistini, B.; Botting, R.; Warner, T. Trends Pharmacol. Sci. 1995, 16, 217.
7. Chan, L.; Chittanada, A.; Shapiro, J. I.; Shanley, P. F.; Schrier, R.W. Am. J. Physiol. 1994, 266, F135.
8. Bihovsky, R.; Levinson, B. L.; Loewi, R. C.; Erhardt, P. W.; Polokoff, M. A. J. Med. Chem. 1995, 38, 2119.
9. Tsurumi, Y.; Fujie, K.; Nishikawa, M.; Kiyoto, S.; Okuhara, M. J. Antibiotics 1995, 48, 169.
10. Bertensaw, S. R.; Talley, J. J.; Rogers, R. S.; Carter, J. S.; Moore, W. M.; Branson, L. M.; Koboldt, C. M. Bioorg. Med. Chem. Lett. 1993, 3, 1953.
11. Bertenshaw, S. R.; Rogers, R. S.; Stern, M. K.; Norman, B. H.; Moore, W. M.; Jerome, G. M.; Branson, L. M.; McDonald, J. F.; McMahon, E. G.; Palomo, M. A. J. Med. Chem. 1993, 36, 173.
12. Fukami, T.; Hayama, T.; Amano, Y.; Nakamura, Y.; Arai, Y.; Matsuyama, K.; Yano, M.; Ishikawa, K. Bioorg. Med. Chem. Lett. 1994, 4, 1257.
13. Baylis, E. K.; Campbell, C. D.; Dingwall, J. G. J. Chem. Soc. Perkin I, 1984, 2845.
14. 1′ centers, in approximately equal ratio, as judged by NMR data.
15. 50 determinations, see: Fawzi, A. B.; Cleven, R. M.; Wright, D. L. Anal. Biochem. 1994, 222, 342.
16. Syberts, E. J.; Chiu, P. J. S.; Watkins, R. W.; Vemulapalli, S. J. Hypertens. 1990, 8 (suppl 7), S161.