Synthesis and evaluation of inhibitors of bacterial D-alanine:D-alanine ligases

Chemistry and Biology

Volumn 3, Issue 1, 1996, Pages 37-44

  Ellsworth, Bruce A ^a   Tom, Norma J ^a   Bartlett, Paul A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Inhibition; Kinetics; Mechanism; Phosphorus peptide analogs

Indexed keywords

D-ALANYLALANINE SYNTHETASE; DEXTRO ALANINE DEXTRO ALANINE LIGASE; ENZYME INHIBITOR; PEPTIDE SYNTHASE;

ARTICLE; BACTERIUM; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; SYNTHESIS;

BACTERIA; ENZYME INHIBITORS; PEPTIDE SYNTHASES; SUBSTRATE SPECIFICITY;

EID: 0029678335     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(96)90082-4     Document Type: Article

References (9)

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8. Neuhaus, F.C., & Lynch, J.L. (1964). The enzymatic synthesis of D-alanyl-D-alanine. III. On the inhibition of D-alanyl-D-alanine synthetase by the antibiotic D-cycloserine. Biochemistry 3, 471-480.
9. Duncan, K., & Walsh, C.T. (1988). ATP-dependent inactivation and slow binding inhibition of Salmonella typhimurium D-alanine: D-alanine ligase (ADP) by (aminoalkyl)phosphinate and amino-phosphonate analogues of D-alanine. Biochemistry 27, 3709-3714.